Exercise-Induced Excessive Blood Pressure Elevation Is Associated with Cardiac Dysfunction in Male Patients with Essential Hypertension by Binfeng Xia, Pengyu Cao, Li Zhang, Huihui Huang, Rongyu Li, Xia Yin

“…The study was registered with the Chinese Clinical Trials Register, registration number: ChiCTR2100053140.…”
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Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) by Tatsuo Akechi, Yosuke Uchitomi, Saki Harashima, Maiko Fujimori, Tomohiro Matsuda, Kumiko Saika, Takaaki Hasegawa, Keisuke Inoue, Kazuhiro Yoshiuchi, Isao Miyashiro, Yutaka J Matsuoka

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Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Tri... by Agricola Joachim, Agricola Joachim, Asli Bauer, Sarah Joseph, Christof Geldmacher, Patricia J Munseri, Said Aboud, Marco Missanga, Philipp Mann, Britta Wahren, Guido Ferrari, Victoria R Polonis, Merlin L Robb, Jonathan Weber, Roger Tatoud, Leonard Maboko, Michael Hoelscher, Eligius F Lyamuya, Gunnel Biberfeld, Eric Sandström, Arne Kroidl, Muhammad Bakari, Charlotta Nilsson, Sheena McCormack

“…Two weeks after the second HIV-MVA vaccination 34 (97%) of the 35 previously vaccinated developed Env-specific binding antibodies, and 79% and 84% displayed IFN-γ ELISpot responses to Gag and Env, respectively. …”
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Protocol for the RETHINK study: a randomised, double-blind, parallel-group, non-inferiority clinical trial comparing acetaminophen and NSAIDs for treatment of chronic pain in elder... by Tempei Miyaji, Mototsugu Shimokawa, Hiroyuki Aono, Sadamoto Zenda, Makoto Endo, Yasuharu Nakashima, TOSHIHIKO HARA, Shinya Kawahara, Taishi Sato, Masami Tokunaga, Taro Mawatari, Tsutomu Kawano, Sanae Sakamoto, Toshio Takano, Masumi Miyake

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Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial by Emmeline Montane, Nabila Brihmat, Camille Cormier, Claire Thalamas, Vanessa Rousseau, Gerard Tap, Xavier De Boissezon, Evelyne Castel-Lacanal, Philippe Marque

“… BackgroundIndividuals with poststroke hemiplegia often develop spasticity, which increases disability. Antispastic treatments such as baclofen and botulinum toxin are commonly prescribed in poststroke recovery. …”
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Identification of the optimal points for the acupuncture treatment of neck pain in China: protocol for a multicenter, matched, case-control study by Ling Zhao, Hui Zheng, Mingsheng Sun, Guoyan Geng, Jiao Chen, Xingsha Ma, Mingxi Yan, Dingjun Cai, Fan-rong Liang, Chunxia Yang, Siyuan Tao, Jieru Peng

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The effectiveness of providing training and ongoing support to foster cultural humility in volunteers serving as mentors to youth of color: a mixed-methods study protocol by Bernadette Sánchez, Amy J. Anderson, Carla Herrera, David L. DuBois, Kay Thursby Bourke, Jean K. Sack, So Jung Lee, Karen Burchwell, Lidia Y. Monjaras-Gaytan, Yesenia Garcia-Murillo

“…Study findings will have implications for youth mentoring programs and for other settings (e.g., schools, after school programs) in which children and adolescents form relationships with adults. Trial registration www.clinicaltrials.gov —Clinical Trial #NCT05391711; original 05.21.2022; Amendment 07.01.2022: study status was updated and more details were provided on outcome measures; Amendment 11/13/2022: sample size was modified, a few mentor outcome measures were added in the 12-months survey, the timing of a mentor measure was updated.…”
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A structured, home-based exercise programme in kidney transplant recipients (ECSERT): A randomised controlled feasibility study. by Roseanne E Billany, Jamie H Macdonald, Stephanie Burns, Rafhi Chowdhury, Ella C Ford, Zahra Mubaarak, Gurneet K Sohansoha, Noemi Vadaszy, Hannah M L Young, Nicolette C Bishop, Alice C Smith, Matthew P M Graham-Brown

“…<h4>Trial registration</h4>ClinicalTrials.gov NCT04123951.…”
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Methotrexate vs expectant management for treatment of tubal ectopic pregnancy: An individual participant data meta‐analysis by Sarah Annie Solangon, Madelon Van Wely, Norah Van Mello, Ben W. Mol, Jackie A. Ross, Davor Jurkovic

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Association of longitudinal changes in patient-reported health status with return to work in the first 2 years after traumatic injury: a prospective cohort study in the Netherlands by Leonie de Munter, Mariska A C de Jongh, Margot C W Joosen, Koen W W Lansink, Lena Horn, Grigorios Papageorgiou

“…Knowledge on patient-reported outcomes can contribute to the development of tailored RTW treatments. Furthermore, patient-reported outcomes could be used as monitoring tool to guide postinjury care in the clinical setting and RTW process.Trial registration number NCT02508675; Results.…”
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Delayed muscle fatigue during electrical stimulation of the proximal nerve using asymmetric random high-frequency carrier pulse cluster by Rui Yuan, Yang Zheng, Henry Shin, Guanghua Xu, Shengnuo Fan, Zhanhong Du

“…Finger force, high-density electromyographic (EMG) signals of the flexor muscles and the pain score were recorded. In addition, we developed a finite element model of the upper arm and a motor fiber model to simulate motor axon activation of the peripheral nerve induced by the two electrical stimulation modes. …”
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Efficacy and Safety of Electroacupuncture Through Nerve Stimulation in Patients With Anxiety Disorders: Protocol for a Randomized, Assessor-Blind, Three-Arm, Parallel-Group Clinica... by In Chul Jung, Dong-Hoon Kang, Sunyoung Choi, Yujin Choi, Ojin Kwon, Hye Jeong Kook, Daeun Lee, Yang-Chun Park, Jieun Kim

“…Trial RegistrationClinical Research Information Service of the Republic of Korea KCT0008378; https://cris.nih.go.kr/cris/search/detailSearch.do/24503 International Registered Report Identifier (IRRID)DERR1-10.2196/68166…”
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Three decades of progress: evolution of outcomes and prognostic indicators in biliary atresia management by Senol Emre, Yalim Benibol, Ali Ekber Hakalmaz, Buse Karakurt, Ayse Kalyoncu Ucar, Nuray Kepil, Ömer Faruk Beşer, Sebuh Kuruğoğlu, Osman Faruk Senyuz

“…Patients were stratified by preoperative ALBI (originally developed for HCC but applied here for its objective assessment of liver function), preoperative and postoperative APRI, and METAVIR scores. …”
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Randomized, controlled trial comparing the efficacy of intercostal nerve block in thoracoscopic surgery by timing: study protocol for a randomized clinical trial by Yasuharu Sekine, Hideo Ichimura, Sho Ueda, Shinsuke Kitazawa, Naohiro Kobayashi, Yuya Murata, Kumiko Yamada, Shinichi Inomata, Kazushi Maruo, Yukio Sato

“…Discussion A complete evaluation of ICNB efficacy as a preemptive analgesic approach will contribute to the development of improved perioperative pain management techniques. …”
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Study protocol for a randomised trial for atosiban versus placebo in threatened preterm birth: the APOSTEL 8 study by Ben W Mol, Fionnuala McAuliffe, Martijn A Oudijk, Christiana A Naaktgeboren, Jim Thornton, Ewoud Schuit, Job Klumper, Wouter Breebaart, Carolien Roos, Joris van der Post, Judith Bosmans, Anton van Kaam, Jelle Baalman, Marjolein Kok

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Long-term outcomes of an educational intervention to reduce antibiotic prescribing for childhood upper respiratory tract infections in rural China: Follow-up of a cluster-randomise... by Xiaolin Wei, Zhitong Zhang, Joseph P Hicks, John D Walley, Rebecca King, James N Newell, Jia Yin, Jun Zeng, Yan Guo, Mei Lin, Ross E G Upshur, Qiang Sun

“…Our intervention may be adapted to similar resource-poor settings.<h4>Trial registration</h4>ISRCTN registry ISRCTN14340536.…”
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Clinically directed initiation versus routine use of amoxicillin-clavulanate and the risk of local complications among patients with haemotoxic snakebite envenomation treated at a... by Tamilarasu Kadhiravan, Chanaveerappa Bammigatti, Akinchan Bhardwaj, Aditya Gautam, Malayil B Indu, Paramasivam Sabitha, Surendran Deepanjali, Bettadpura Shamanna Suryanarayana

“…However, the frequency of clinical failures was similar, and antibiotic consumption was substantially lower with the clinically directed initiation strategy.Trial registration number ClinicalTrials.gov; NCT02570347.…”
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IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants... by Kristian Reich, Kilian Eyerich, Knut Schäkel, Peter Weisenseel, Andreas Pinter, Khusru Asadullah, Sven Wegner, Ernesto J Muñoz-Elias, Holger Bartz, Friedmann J H Taut

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Impact of consumption of the human milk oligosaccharides 2′-FL and LNnT on reduction of risk of allergic sensitisation by Sébastien Holvoet, Francis Foata, Sophie Nutten, Ellen Ní Cléirigh, Maya Shevlyakova, Cheong Kwong Chung, Gregory Lefevre, Norbert Sprenger, Tristan Bourdeau, Dominique Donnicola, Mario Noti, Severine Combremont, Aristea Binia, Chiara Nembrini, Mandy Vogel, Wieland Kiess, Carine Blanchard

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Effectiveness of team-based care interventions in improving blood pressure outcomes among adults with hypertension in Africa: a systematic review and meta-analysis by Samuel Byiringiro, Yvonne Commodore-Mensah, Hosea Boakye, Oluwabunmi Ogungbe, Cheryl Dennison Himmelfarb, Thomas Hinneh, Faith Metlock, Suratsawadee Kruahong

“…Overall certainty of evidence was determined using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool for only the primary outcome (systolic BP).Results Of the 3375 records screened, 33 studies (16 RCTs and 17 pre-post studies) were included and 11 RCTs were in the meta-analysis. …”
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