The effect of the modified basic package of oral care on adolescent dental caries status in Zambia; a cluster randomized trial by Severine N. Anthony, Severine N. Anthony, Severine N. Anthony, Hawa S. Mbawalla, Febronia K. Kahabuka, Seter Siziya, Anne N. Åstrøm

“…BackgroundThe Basic Package of Oral Care (BPOC) was developed by the World Health Organization (WHO) in order to improve oral health care worldwide, yet evidence of its effectiveness is scarce. …”
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Parenthood in a Swedish prospective cohort of 1,378 adolescents and young adults banking semen for fertility preservation at time of cancer diagnosis by Kristina Weibring, Kristina Weibring, Frida E. Lundberg, Frida E. Lundberg, Gabriella Cohn-Cedermark, Gabriella Cohn-Cedermark, Kenny Alexandra Rodriguez-Wallberg, Kenny Alexandra Rodriguez-Wallberg, Kenny Alexandra Rodriguez-Wallberg

“…Although a low utilization rate of cryopreserved sperm was found in this cohort, its use was highly effective in the group that developed infertility. At present there are no standardized predictors of testicular toxicity after cancer treatment, and inter-individual variability is high. …”
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A systematic review and meta-analysis of shugan jieyu capsule combined with escitalopram in the treatment of senile depression by Xing Tang, Chengcheng Wang, Qinwan Huang, Chunxia Yang, Shoujen Lan, Yeayin Yen, Congcong Yu

“…Finally, the Grading of Recommendations Assessment, Development and Evaluation (GRADE ) system was used to assess the quality of the evidence. …”
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A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever. by Robert T Cartee, Ann Thanawastien, Thomas J Griffin Iv, John J Mekalanos, Stephan Bart, Kevin P Killeen

“…<h4>Background</h4>Typhoid fever remains a significant cause of morbidity and mortality in developing countries especially in children ≤5 years old. …”
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Ethnic minority status as social determinant for COVID-19 infection, hospitalisation, severity, ICU admission and deaths in the early phase of the pandemic: a meta-analysis by Karien Stronks, Charles Agyemang, Maurice P Zeegers, Maria Prins, Evan Yu, Shahab Jolani, Stevie Hendriks, Anke Richters, Saurabh Zalpuri, Bart Pijls

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Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging by Laureen Y. T. Wang, Wee Shiong Lim, Ru-San Tan, Louis L. Y. Teo, Shu Yun Tan, Chun How Ooi, Alvin Cong Wei Ong, Jean-Paul Kovalik, Jorming Goh, Fei Gao, Angela S. Koh

“…Trial registration: ClinicalTrials.gov Identifier: NCT02791139 (06/06/2016).…”
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Assessment of cortisol as a neonatal pain biomarker in the application of non-pharmacological analgesia therapies: systematic review and meta-analysis by Inmaculada García-Valdivieso, Jorge Sánchez-Infante, Pablo Pando Cerra, Benito Yáñez-Araque, Sonsoles Hernández-Iglesias, Fernando Peña Cambón, Celia Álvarez-Bueno, Abel Checa Peñalver, Juan Manuel Pérez-Pozuelo, Sagrario Gómez-Cantarino

“…However, the cortisol results indicate that sucrose was not effective in reducing neonatal pain. Trial registration PROSPERO: CRD42023463831.…”
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Evaluating the Impact of the COVID-19 Pandemic on Telepharmaceutical Service Effectiveness: Systematic Review and Meta-Analysis by Puwen Zhang, Mengting Yang, Siyi He, Xiayan Li, Bingchen Lang, Linan Zeng, Lingli Zhang

“…We used the random-effect model to pool the results and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the certainty of evidence. …”
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Impact of an adapted diabetes prevention program in a spanish primary care setting: protocol for a type II hybrid effectiveness-implementation cluster-randomized trial (ALADIM) by Miquel Bennasar-Veny, Manuela Abbate, Miquel Colom-Rosselló, Laura Capitán-Moyano, Ivonne C. Hernández-Bermúdez, Ignacio Ricci-Cabello, Aina M. Yañez, Maria E. Fernandez, the ALADIM investigators

“…Trial registration ClinicalTrials.gov, NCT06871059. Registered 10 March 2025, https://clinicaltrials.gov/study/NCT06871059…”
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Venous thromboembolism in patients undergoing pancreatic cancer surgery (PaTR-VTE) with curative intent; protocol of a prospective observational study by Maria P. Ntalouka, Dimitrios Symeonidis, Paraskevi Kotsi, Efthymia Petinaki, Miltiadis Matsagkas, Konstantinos Tepetes, Dimitrios Zacharoulis, Eleni M. Arnaoutoglou

“…However, the exact pathophysiological mechanisms involved in the development of VTE in the setting of pancreatic cancer are not yet well understood. …”
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Clinical and cost evaluation of intensive support team (IST) models for adults with intellectual disabilities who display challenging behaviour: a comparative cohort study protocol by Angela Hassiotis, Rebecca Jones, Brynmor Lloyd-Evans, Renee Romeo, Nicola Morant, Ken Courtenay, Ian Hall, Athanasia Kouroupa, Vicky Crossey, Laurence Taggart, Peter Langdon, Victoria Ratti, Vincent Kirchner

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Ketamine for the treatment of prehospital acute pain: a systematic review of benefit and harm by Leif Rognås, Lasse Raatiniemi, Mårten Sandberg, Per Kristian Hyldmo, Poul Kongstad, Kristian Dahl Friesgaard, Robert Larsen, Vidar Magnusson, Jouni Kurola, Marius Rehn, Gunn Elisabeth Vist

“…We used the Cochrane and Grading of Recommendations Assessment, Development and Evaluation methodologies and exclusively assessed patient-centred outcomes. …”
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Validation of the German Life-Space Assessment (LSA-D): cross-sectional validation study in urban and rural community-dwelling older adults by Paul Gellert, Sandra Angelika Mümken, Malte Stollwerck, Julie Lorraine O'Sullivan, Joern Kiselev

“…All parameters were estimated using non-parametric bootstrapping procedure.Results In the multiple adjusted model for the total sample, number of ADL/iADL limitations (β=−0.26; 95% CI=−0.42 to −0.08), Timed Up and Go Test (β=−0.37; 95% CI=−0.68 to −0.14), shared living arrangements (β=0.22; 95% CI=0.01 to 0.44) and history of falls in the past 6 months (β=−0.22; 95% CI=−0.41 to −0.05) showed significant associations with the LSA-D composite score, while living in urban area (β=−0.19; 95% CI=−0.42 to 0.03) and male gender (β=0.15; 95% CI=−0.04 to 0.35) were not significant.Conclusion The LSA-D is a valid tool for measuring life-space mobility in German community-dwelling older adults within the past 4 weeks in ambulant urban and rural settings.Trial registration number DRKS00019023.…”
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Perceived barriers and facilitators of staff recruiting participants to a randomised controlled trial of a community rehabilitation intervention following hip fracture by Kathryn Harvey, Penelope Ralph, Llinos Haf Spencer, Kodchawan Doungsong, Val Morrison, Andrew Lemmey, Miriam Golding-Day, Susanna Dodd, Ben Hardwick, Shanaz Dorkenoo, Sophie Hennessey, Nefyn Williams

“…Strategies to identify and overcome recruitment problems are highlighted and should be implemented and evaluated in further RCTs of complex interventions. Trial registration ISRCTN28376407. November 23, 2018.…”
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Blended palliative and survivorship care intervention (POISE) for patients with metastatic oncogene-driven non-small cell lung cancer: study protocol for a pilot randomised control... by Jennifer S Temel, Joseph A Greer, Vicki Jackson, Dustin J Rabideau, Heather A Richard, Roshni Sarathy, Jill Feldman, Leslie Cartagena, Heather Patel, Lecia V Sequist, Elyse Park, Laura A Petrillo

“…The protocol is reported in accordance with the Standard Protocol Items: Recommendations for Interventional Trials guidelines, and the study will be reported in accordance with the Consolidated Standards of Reporting Trials statement for non-pharmacological trials.Trial registration number NCT04900935.…”
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Safety and immunogenicity after a 30-month boost of a subtype C ALVAC-HIV (vCP2438) vaccine prime plus bivalent subtype C gp120/MF59 vaccine boost (HVTN 100): A phase 1-2 randomize... by Vimla Naicker, Fatima Laher, Linda-Gail Bekker, Kelly E Seaton, Mary Allen, Stephen De Rosa, Nicole L Yates, Nonhlanhla N Mkhize, Kevin Saunders, Jack Heptinstall, Mookho Malahleha, Kathryn Mngadi, Brodie Daniels, Craig Innes, Chenchen Yu, Tandile Modise, Valerie Bekker, Nicole Grunenberg, Briana Furch, Maurine D Miner, Sanjay Phogat, Carlos A Diazgranados, Sanjay Gurunathan, Marguerite Koutsoukos, Olivier Van Der Meeren, Alison C Roxby, Guido Ferrari, Lynn Morris, David Montefiori, M Juliana McElrath, Georgia D Tomaras, Zoe Moodie

“…Induction of broad, durable immune responses is a challenge in HIV vaccine development. HVTN 100 Part A administered subtype C-containing ALVAC-HIV at months 0 and 1, and ALVAC-HIV with bivalent subtype C gp120/MF59 at months 3, 6 and 12. …”
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Impact of resistance training intensity on body composition and nutritional intake among college women with overweight and obesity: a cluster randomized controlled trial by Qiang Wang, Qiang Wang, Wen Sheng Xiao, Mahmoud Danaee, Soh Kim Geok, Wan Ying Gan, Wang Li Zhu, Yi Qiang Mai

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Evaluating the Effectiveness of InsightApp for Anxiety, Valued Action, and Psychological Resilience: Longitudinal Randomized Controlled Trial by Victoria Amo, Falk Lieder

“… BackgroundAnxiety disorders are among the most prevalent mental disorders, and stress plays a significant role in their development. Ecological momentary interventions (EMIs) hold great potential to help people manage stress and anxiety by training emotion regulation and coping skills in real-life settings. …”
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Anorectal manometry and urodynamics in children with spina bifida: can we predict the colonic dysmotility from bladder dysfunction? by Ali İhsan Anadolulu, Ragibe Büşra Erdoğan, Arzu Canmemiş, Şeyhmus Kerem Özel, Çiğdem Ulukaya Durakbaşa

“…Abstract Introduction Spina bifida is a condition that impacts the development of the neural tube leading to urological and gastrointestinal symptoms. …”
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Restaurant interventions for salt reduction in China: protocol for a randomised controlled trial by Yuan Li, Xue Zhou, Feng J He, Graham A MacGregor, Puhong Zhang, Rong Luo, Zhihua Xu, Huijun Wang, Monique Tan, Wei Yan, Wenwen Du, Yifu Gao, Lei Yin, Xiaoyu Chang

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