Feasibility and cross-cultural validation of an adapted social skills group training programme (KONTAKTTM CHILD) for Chinese autistic children: a waitlist RCT protocol by Sven Bölte, Peipei Yin, Uchong Lao, Huilin Zhu, Fengjing Liang, Wuxia Bai, Xiaoqian Huang, Sonya Girdler, Xiaobing Zou

“…Any identifiable personal information will be anonymised to protect confidentiality.Protocol version 2.0, 31 July 2024.Trial registration number ChiCTR2300072136.…”
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Evaluating an evidence-based iSupport for Dementia programme in routine care services: study protocol for a hybrid type II trial by Jing Wang, Shahid Ullah, Ying Yu, Rujun Hu, Lily Dongxia Xiao, Xiaoying Pan, Ada Cheng, Candy Xie, Kam Chiu, Dingxin Xu, Angela Rong Yang Zhang

“…Introduction Disparities in supporting carers of people with dementia exist in carer populations. The WHO developed an evidence-based iSupport for Dementia programme to address the disparities. …”
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High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease by Hao Wang, Junzhao Ye, Youpeng Chen, Yanhong Sun, Xiaorong Gong, Hong Deng, Zhiyong Dong, Lishu Xu, Xin Li, Bihui Zhong

“…Abstract Background Whether include high-sensitivity C-reactive protein (Hs-CRP) in diagnostic flow remains debatable during the updated definition to metabolic dysfunction-associated steatotic liver disease (MASLD) despite systemic inflammation contributes to the disease development and progression. We aimed to identify values of hs-CRP compared to other inflammatory markers derived from routine blood tests in MASLD. …”
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Design of the OverCool study: Lung-conservative liquid ventilation for the induction of Ultra-Rapid Cooling after Cardiac Arrest (OverCool) by Renaud Tissier, Fabio Silvio Taccone, Lionel Lamhaut, Eric Vicaut, Fabrice Paublant, Jean-Damien Ricard, Alain Mercat, Alain Cariou

“…A new medical device system, Vent2Cool, was developed for clinical use in the Intensive Care Unit to achieve ultra-rapid therapeutic hypothermia by total liquid ventilation to patients. …”
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Predicting Deterioration in Patients With Normotensive Acute Pulmonary Embolism Using Clinical‐Imaging Features: A Multicenter Prospective Cohort Study by Yizhuo Gao, Shibo Wei, Yuchen Liu, Zhenglun Yu, Shanshan Zhan, Binze Yang, Chuanxin Qi, Shougang Qi, Minggang Wang, Dong Jia

“…Background Prioritization of management strategies in patients with normotensive acute pulmonary embolism is based on the identification of individuals at risk for early deterioration. This study aims to develop and validate a novel score for deterioration prediction using clinical‐imaging features. …”
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Identifying patients with cerebral infarction within the time window compatible with reperfusion therapy, diagnostic performance of glutathione S-transferase-π (GST-π) and peroxire... by Nicolas Girerd, Arif Karakus, Jean-Charles Sanchez, Sophie Marchal, Anne Aubertin, Sanae Bouali, Kevin Duarte, Sandrine Reymond

“…If confirmed, these molecules could be used to develop rapid and reliable decentralised measurement methods, making it possible to initiate reperfusion therapy before hospital admission. …”
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Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Thus, there is an urgent need to develop more targeted and effective anti-inflammatory treatments. …”
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Randomised, placebo-controlled, double-blinded, four-way crossover trial to demonstrate the comparative pharmacodynamic equivalence of a non-invasive diagnostic test for adrenal in... by Judith Cohen, Miguel Debono, Kathleen Baster, Richard J Ross, Charlotte J Elder, Kathryn L Date, Sharon L Caunt, Jane Fearnside, Trevor N Johnson, Rosie N Taylor

“…A novel formulation, Nasacthin, has been developed, which can be delivered intranasally, with the resultant glucocorticoid levels measured in saliva instead of blood. …”
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Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities by Marie-Claude Bourgeois-Daigneault, Victor Mullins-Dansereau, Marie-Lou Myre, Angelina Bardoul, Karen Geoffroy, Marco J Rallo Pita, Delphine Béland, Kim Leclerc Desaulniers, Dominic Guy Roy

“…Our findings deepen our understanding of the immune mechanisms underlying the use of oncolytic viruses as anticancer vaccination platforms and will allow for the development of a new generation of improved oncolytic virus vaccine adjuvants.Trial registration number NCT02285816.…”
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Coproduction in Social Prescribing Initiatives: Protocol for a Scoping Review by Madeline Dougherty, Tamara Tompkins, Elaine Zibrowski, Jesse Cram, Maureen C Ashe, Le-Tien Bhaskar, Kiffer George Card, Christina Godfrey, Paul Hebert, Ron Lacombe, Caitlin Muhl, Kate Mulligan, Gillian Mulvale, Michelle L A Nelson, Myrna Norman, Bobbi Symes, Gary Teare, Vivian Welch, Anita Kothari

“…Trial RegistrationOpen Science Framework Registries B8U4Z; https://osf.io/b8u4z International Registered Report Identifier (IRRID)DERR1-10.2196/57062…”
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Inspiratory muscle training facilitates liberation from mechanical ventilation in subacute critically ill patients—a randomized controlled trial by Shu-Jane Wang, Tien-Pei Fang, Tien-Pei Fang, Daniel D. Rowley, Nan-Wei Liu, Jui-O Chen, Jui-Fang Liu, Jui-Fang Liu, Hui-Ling Lin, Hui-Ling Lin, Hui-Ling Lin

“…BackgroundPatients undergoing mechanical ventilation often develop rapid diaphragmatic atrophy, respiratory muscle weakness, and dysfunction, which are associated with prolonged duration of ventilation. …”
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Autologous blood products: Leucocyte and Platelets Rich Fibrin (L-PRF) and Platelets Rich Plasma (PRP) gel to promote cutaneous ulcer healing – a systematic review by Paramjit Gill, Anju Adhikari, Samuel I Watson, Richard J Lilford, Dilip Shrestha, Rolina Dhital, Onaedo Ilozumba, Sopna Choudhury, Indra B Napit, Karuna Neupane, Rachita Koirala, Lovin Gopali

“…The risk of bias was high across all studies with one exception and the GRADE showed very low certainty of evidence.Conclusion The findings show potential for better outcomes in the intervention; however, the evidence remains inconclusive highlighting a large research gap in ulcer treatment and warrant better-designed clinical trials.PROSPERO registration number CRD42022352418.…”
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Differences in the incidence and mortality of tracheal, bronchus, and lung cancer between the Global Cancer Observatory 2022 and the Global Burden of Disease 2021 by Zhifei Li, Runze Li, Jianchuan Chen, Ruida Yang, Peng Li, Bin Qiu

“…Additionally, some populous developing countries, including China, South Africa, Brazil and India, showed smaller differences in ASRs. …”
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Non-operative treatment for lumbar spinal stenosis with neurogenic claudication: an updated systematic review by Carlo Ammendolia, Andrea D Furlan, André Bussières, Carol Cancelliere, James J Young, Corey Hofkirchner, Joshua Plener, Michael J Schneider, Kent Stuber, Aksa Ahmed, Aleisha Adeboyejo, Joseph Ornelas

“…All other non-operative interventions provided insufficient quality evidence to make conclusions on their effectiveness.PROSPERO registration number CRD42020191860.…”
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Evidence-based general practice: a scoping review by Yu Cheng, Chuan Zou, Chaojie Liu, Yu Jia, Rong Yang, Yonggang Zhang, Jianjun Han, Yi Lei, Xiaoyang Liao

“…This definition provides a solid foundational framework for the development of EBGP guidelines and policies. Registration number https://doi.org/10.17605/OSF.IO/2UNX7 .…”
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Outcomes of perfluorocarbon liquid vs. posterior retinotomy as adjuncts during pars-plana vitrectomy for the surgical repair of rhegmatogenous retinal detachment: a randomized clin... by Ehab Mohamed Elsayed Saad, Hazem Elbadry Mohammed Mohammed, Mohamed Mohamed-Aly Ibrahim, Omar Hassan Salama Selim, Sayed Mostafa Elsayed Abdelhafeez, Ahmed Mohammed Sakr, Fathy Mohamed Abo Elftouh Elsalhy, Ahmed Abdelmohsen Ali Ayoub, Ehab Abdelsamea Alazab, Ehab Tharwat, Tamer Gamal El Sayed Mostafa

“…These findings guide surgical decision-making and highlight the need for further research. Trial registration The study was retrospectively registered at ClinicalTrials.gov (NCT06919211) on April 4, 2025.…”
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Prevalence of hematological malignancies in Africa: A systematic review and meta-analysis by Zewudu Mulatie, Dereje Mengesha Berta, Alemu Gedefie, Hussen Ebrahim, Brukitawit Eshetu, Tesfaye Gessese, Mihret Tilahun, Seada Ali, Habtu Debash, Yeshimebet Kassa, Ermiyas Alemayehu

“…Abstract Hematological malignancies are a class of neoplasms that include a variety of diverse diseases that all develop from and change into lymphatic and bone marrow cells. …”
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Practical Anemia Bundle for Sustained Blood Recovery (PABST-BR) in critical illness: a protocol for a randomised controlled trial by Laurie Meade, Andrea Cheville, Matthew A Warner, Phillip J Schulte, Daryl J Kor, Ognjen Gajic, Ronald S Go, William B Beam, Jonathan E Charnin, Kim A Droege, Brenda K Anderson, Matthew L Johnson, Brad Karon

“…The PABST-BR trial will inform the development of a larger multicentre clinical trial.Trial registration number NCT05167734.…”
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Blinding assessment in randomised sham-controlled trials of acupuncture:protocol for a systematic survey by Ling Li, Xin Sun, Jiali Liu, Minghong Yao, Yong Fu, Jiahui Yang, Xiaochao Luo

“…The findings of this study will be disseminated through peer-reviewed publications, conference presentations and condensed summaries for clinicians, health policymakers and guideline developers regarding the design, conduct, analysis and interpretation of blinded assessment of sham acupuncture RCTs.Study registration Open Science Framework (https://doi.org/10.17605/OSF.IO/B3U7K).…”
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Tripartite prehabilitation of patients with acute myeloid leukaemia and high-risk myelodysplastic syndromes during intensive chemotherapy before allogeneic haematopoietic stem cell... by Jean-Marie Boher, Norbert Vey, Colombe Saillard, Sarah Cuvelier, Charlène Villaron-Goetgheluck, Leonor Almeida-Lopez, Anne-Gaelle Le Corroller, Pauline Denis, Céline Rivieccio, Sarah Calvin, Cécile Bannier-Braticevic

“…The results of this protocol will be published in a scientific paper and communicated to the medical staff of the medical centre.Trial registration number NCT03595787.…”
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