Pharmacokinetic Profiles of Lansoprazole in Patients With Morbid Obesity Post‐Roux‐en‐Y Gastric Bypass Surgery by Suthep Udomsawaengsup, Sathienrapong Chantawibul, Naranon Boonyuen, Sarunnuch Panyavorakhunchai, Pattharasai Kachornvitaya, Wasu Wisanuyothin, Pittawat Somvanapanich, Warittha Lertwatthiphong, Napatsanan Tanathitiphuwarat, Pajaree Chariyavilaskul

“…Trial Registration: ClinicalTrials.gov identifier: TCTR20220118001…”
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Evaluation of the efficacy of angiotensin receptor–neprilysin inhibitor in patients with aortic stenosis undergoing transcatheter aortic valve implantation: protocol for a randomis... by Hideki Hanaoka, Yoshio Kobayashi, Hideki Kitahara, Takeshi Sugawara, Goro Matsumiya, Yosuke Inaba, Shogo Okita, Hiroaki Yaginuma, Hiroki Goto, Hiroaki Yamamoto, Tomoyoshi Kanda, Kaoru Matsuura

“…Introduction There are a substantial number of patients developing heart failure after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS), even though AS has been successfully treated. …”
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Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study by Carlo Volf, Anne Sofie Aggestrup, Paul Michael Petersen, Carsten Dam-Hansen, Ulla Knorr, Ema Erkocevic Petersen, Janus Engstrøm, Janus C Jakobsen, Torben Skov Hansen, Helle Østergaard Madsen, Ida Hageman, Klaus Martiny

“…Results will be published in peer-reviewed journals, disseminated electronically and in print and presented at symposia.Trial registration number NCT03821506; Pre-results.…”
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Effectiveness of resistance training of masticatory muscles for patients with temporomandibular disorders: protocol for a systematic review by Deborah Falla, Filippo Maselli, Giacomo Asquini, Andrea Giusti, Giulia Pisacane, Giovanni Galeoto, Firas Mourad, Paolo Bizzarri, Edoardo Balli, Cecilia Bagnoli, Anna Manzari, Marco Pernici

“…The results will be disseminated through presentations at scientific conferences and publication in a peer-reviewed journal.PROSPERO registration number CRD42023476269.…”
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Effects of an extended therapeutic strategy versus standard-of-care therapy on persistent acute kidney injury in high-risk patients after major surgery: study protocol for the rand... by Joachim Gerss, Melanie Meersch, Carola Wempe, Alexander Zarbock, John Kellum, Christian Strauss, Thilo von Groote, Mahan Sadjadi, Hendrik Booke, Ludwig Maximilian Schöne, Leonie Sauermann

“…The primary endpoint is a composite of the development of persistent severe (stage 3) AKI, need for renal replacement therapy or death within 72 hours. …”
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Comprehensive spinal correction rehabilitation (CSCR) study: a randomised controlled trial to investigate the effectiveness of CSCR in children with early-onset idiopathic scoliosi... by Tongtong Zhang, Xin Li, Xuan Zhou, Qing Du, Yingxian Li, Qimeng Fan, Juping Liang, Zhengquan Chen, Haibin Guo, Lili Cai

“…Any interim analyses and full results will be published in an international peer-reviewed journal.Trial registration number The study protocol was registered at www. …”
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Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementing the TREAT INTERACT intervention for primary school teachers an... by Ane-Marthe Solheim Skar, Ingunn Marie S. Engebretsen, Nora Braathu, Harriet Aber, Harald Bækkelund, Melf-Jakob Kühl, Marjorie Mukisa, Joyce Sserunjogi Nalugya, Norbert Skokauskas, Vilde Skylstad, Tore Wentzel-Larsen, TREAT research consortium, Juliet Ndimwibo Babirye

“…Discussion Based on the results, we will develop sustainable and scalable implementation advice on mental health promotion and draft implementation guidelines in line with current WHO guidelines. …”
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Combined chemoimmunotherapy of patients with mature B-cell non-Hodgkin lymphomas age group until 18 years: results of multicenter study NHL 2004 m with rituximab and modified B-NHL... by E. V. Samochatova, L. N. Schelikhova, M. B. Belogurova, A. V. Schamardina, E. V. Bascharova, D. V. Litvinov, N. V. Myakova, L. G. Fechina, O. P. Chlebnikova, E. V. Inuschkina, O. V. Riskal, P. Z. Schammasov, I. M. Yunusova, S. Yu. Umnova, D. M. Konovalov, A. G. Talalaev, J. V. Roumiantseva, A. A. Maschan

“…There was no case of remission death; relapse has developed only at one patient (neuroleukemia in patient with Burkitt lymphoma). 54 patients (88%) are in continuous complete remission. …”
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Middle meningeal artery (MMA) embolisation for chronic subdural haematomas: rationale and design for the STOp Recurrence of MMA Bleeding (STORMM) randomised control trial—a study p... by Granit Molliqaj, Gianmarco Bernava, Andrea Rosi, Karl Schaller, Paolo Machi, Jeremy Hofmeister, Aria Nouri, Sandrine Morel, Andrea Cardia, Abdullah Al Awadhi, Caterina Mollica, Michele Da Broi, Torstein Ragnar Meling

“…Surgery is typically performed once neurological symptoms develop. Recent studies suggest that arteries nourished by the middle meningeal artery (MMA) may be responsible for haematoma progression and that MMA embolisation is clinically useful. …”
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Comparative efficacy and complication rates after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network... by Orestis Efthimiou, Georgia Salanti, Huseyin Naci, Philip Bennett, Antonios Athanasiou, Areti Angeliki Veroniki, Ilkka Kalliala, Sarah Bowden, Maria Paraskevaidi, Pierre Martin-Hirsch, Evangelos Paraskevaidis, Maria Kyrgiou

“…We will disseminate findings to clinicians, policy-makers, patients and the public.PROSPERO registration number CRD42018115508.…”
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The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects c... by Elisabeth F C van Rossum, Amir H Zamanipoor Najafabadi, Wouter A Moojen, Nienke R Biermasz, Wouter R van Furth, Onno C Meijer, Clemens M F Dirven, Anne-Sophie C A M Koning, Djaina D Satoer, Christiaan H Vinkers, Rishi D S Nandoe Tewarie, Alberto M Pereira

“…It is an investigator-initiated study with financial support by The Netherlands Organisation for Health Research and Development (ZonMw) and the Dutch Brain Foundation. …”
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Cost-effectiveness of a patient-centred approach to managing multimorbidity in primary care: a pragmatic cluster randomised controlled trial by Peter Bower, Bruce Guthrie, Stewart W Mercer, Daisy Gaunt, Sara Brookes, Joanna Thorn, Chris Salisbury, Mei-See Man, Katherine Chaplin, Bridie Fitzpatrick, Caroline Gardner, Sandra Hollinghurst, Victoria Lee

“…The incremental cost-effectiveness ratio was £18 499, with a 50.8% chance of being cost-effective at a willingness-to-pay threshold of £20 000 per QALY (55.8% at £30 000 per QALY).Conclusions The small differences in costs and outcomes were consistent with chance, and the uncertainty was substantial; therefore, the evidence for the cost-effectiveness of the 3D approach from the NHS/PSS perspective should be considered equivocal.Trial registration number ISCRTN06180958…”
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Impact of increasing post-filter ionised calcium target on regional citrate anticoagulation efficacy in ICU continuous renal replacement therapy: the non-inferiority randomised con... by Mona Assefi, Jean-Michel Constantin, Elodie Baron, Noemie Clavieras, Rayan Braik, Arthur James, Florian Blanchard

“…All procedures were developed in order to assure data protection and confidentiality.Trial registration number NCT05814341.…”
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Predictive utilities of lipid traits, lipoprotein subfractions and other risk factors for incident diabetes: a machine learning approach in the Diabetes Prevention Program by Samuel Dagogo-Jack, Søren Brunak, Carlos Lorenzo, Kieren J Mather, Marinella Temprosa, Tibor V Varga, Jinxi Liu, Ronald B Goldberg, Guannan Chen, Xavier Pi-Sunyer

“…Machine learning algorithms provided no meaningful improvement for discrimination compared with logistic regression, which suggests a lack of influential latent interactions among the analytes assessed in this study.Trial registration number Diabetes Prevention Program: NCT00004992; Diabetes Prevention Program Outcomes Study: NCT00038727.…”
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Ambulatory cancer care electronic symptom self-reporting (ACCESS) for surgical patients: a randomised controlled trial protocol by Andrea L Pusic, Daniel Stein, Cara Stabile, Larissa K Temple, Jessica S Ancker, Ethan Basch, Jeanne Carter, Magen Miranda, Peter D Stetson, Andrew Vickers, Brett A Simon

“…Findings will be relevant in designing future coordinated care models targeting improved healthcare quality and patient experience.Trial registration number NCT03178045…”
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Evaluation of a 1-hour troponin algorithm for diagnosing myocardial infarction in high-risk patients admitted to a chest pain unit: the prospective FAST-MI cohort study by Michael Amann, Felix Gaiser, Sandra Iris Schwenk, Faridun Rahimi, Roland Schmitz, Kambis Mashayekhi, Miroslaw Ferenc, Franz-Josef Neumann, Christian Marc Valina, Willibald Hochholzer

“…However, discrimination between patients needing an early invasive strategy or not is limited.Trial registration number DRKS00009713.…”
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Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia by Nutchaninad Tanuphol B.ATM, Neti Waranuch PhD, Vanuchawan Wisuitiprot PhD, Wudtichai Wisuitiprot PhD, Kamonlak Insumrong PhD, Prapapan Temkitthawon PhD, Nungruthai Suphrom PhD, Katechan Jampachaisri PhD, Corine Girard PhD, Kornkanok Ingkaninan PhD

“…A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. …”
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Evaluation of the effects of pre-exposure treatment with hydroxychloroquine on the risk of COVID-19 infection and on the efficacy of anti-COVID-19 vaccination during lupus or Gouge... by Patrice Cacoub, David Ribes, Laurent Alric, Dominique Chauveau, Grégory Pugnet, Laurent Sailler, Estibaliz Lazaro, Martin Michaud, Marion Migueres, Mathieu Vautier, Kim Ly, Anne Laure Fauchais, Emilie Berard, Morgane Mourguet, Clara Brusq, Stephanie Faure, Pascal Lebray, Jean François Viallard, Carle Paul, Arnaud Constatin, Adeline Ruysen Wittrand, Marie Irles Depe

“…Only two or more doses of vaccine result in a good vaccine response.Trial registration number NCT04481633.…”
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MIKROBE: a feasibility study for a randomised controlled trial of one-stage or two-stage surgery for prosthetic knee infection by Rohini Terry, Sarah Dean, Patrick Hourigan, Hugh Ben Waterson, Vikki Wylde, Natalie Carpenter, Bethany Whale, Roy J. Powell, Polly Tarrant, Antonieta Medina-Lara, Abtin Alvand, Andrew D. Toms

“…After surgery, about 1% of patients develop a deep infection, known as a prosthetic joint infection. …”
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A weather-forecast driven early warning system for wheat blast disease: User-centered design, validation, and scaling in Bangladesh and Brazil by Timothy J. Krupnik, José Mauricio Cunha Fernandes, Felipe Vargas, Emerson Medeiros Del Ponte, Khaled Hossain, Mustafa Kamal, Mutasim Billah, Md. Harun-Or-Rashid, Sk. Ghulam Hussain, Pawan Kumar Singh, Krishna Kanta Roy, Carlos Augusto Pizolotto, Md. Shah Kamal Khan, Willingthon Pavan, Golam Faruq

“…This process also enabled the registration and training of over 14,500 extension officers, lead farmers, and farmers' cooperative members who now receive advisories via email, SMS, agro-meteorological bulletins, smartphone applications, WhatsApp and social media messages. …”
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