Transcriptional signatures of human peripheral blood mononuclear cells can identify the risk of tuberculosis progression from latent infection among individuals with silicosis by Qiao-ling Ruan, Qing-luan Yang, Yi-xin Gao, Jing Wu, Si-ran Lin, Jing-Yu Zhou, Ling-yun Shao, Sen Wang, Qian-qian Liu, Yan Gao, Ning Jiang, Wen-hong Zhang

“…Therefore, the PBMC transcriptome profiles analyzed in this study may help identify LTBI individuals who are at risk of progressing to active TB among silicosis patients and may provide new insights for targeted intervention to prevent disease progression.Clinical trial registration www.clinicaltrials.gov (NCT02430259)…”
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Viral evolution sustains a dengue outbreak of enhanced severity by Catherine Inizan, Marine Minier, Matthieu Prot, Olivia O’Connor, Carole Forfait, Sylvie Laumond, Ingrid Marois, Antoine Biron, Ann-Claire Gourinat, Marie-Amélie Goujart, Elodie Descloux, Anavaj Sakuntabhai, Arnaud Tarantola, Etienne Simon-Lorière, Myrielle Dupont-Rouzeyrol

“…These mutations, however, may have modified DENV strains antigenicity, altering the anti-DENV immune response in some patients, in turn favoring the development of severe forms.Trial registration: ClinicalTrials.gov identifier: NCT04615364.…”
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Transmural collaborative care model for cardiovascular risk management and medication review in patients using antipsychotics in primary care (TACTIC): A study protocol of an incom... by Kirsti M. Jakobs, Karlijn J. van den Brule-Barnhoorn, Jan van Lieshout, Joost G.E. Janzing, Wiepke Cahn, Wietske Kievit, Steven Teerenstra, Maria van den Muijsenbergh, Marion C.J. Biermans, Erik W.M.A. Bischoff

“…Conclusion: This study will assess TACTIC's (cost)effectiveness and provide insights for successful delivery in general practice. Clinical trials registration: clinicaltrials.gov NCT05647980.…”
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Unraveling the role of gut microbiome in predicting adverse events in neoadjuvant therapy for rectal cancer by Jingxin Ma, Shengbo Sun, Xin Cheng, Cong Meng, Hanzheng Zhao, Wentao Fu, Yan Gao, Liyan Ma, Zhengyang Yang, Hongwei Yao, Jianrong Su

“…Some patients may develop adverse events during neoadjuvant chemoradiotherapy combined with immunotherapy, influencing response rates. …”
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A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland by Juliette Besson, Régine Audran, Maxime Karlen, Alix Miauton, Hélène Maby-El Hajjami, Loane Warpelin-Decrausaz, Loredana Sene, Sylvain Schaufelberger, Vincent Faivre, Mohamed Faouzi, Mary-Anne Hartley, François Spertini, Blaise Genton

“…Conclusions The favourable safety profile and cellular responses observed support further development of PepGNP-Covid19. Trial registration ClinicalTrials.gov, NCT05113862, approved 09.11.2021.…”
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Crohn’s disease therapeutic dietary intervention (CD-TDI): study protocol for a randomised controlled trial by Subrata Ghosh, Levinus A Dieleman, Christopher Ma, Ian Lewis, Herman W Barkema, Humberto Jijon, Kathy D McCoy, Georgios V Gkoutos, Maitreyi Raman, Lorian M Taylor, Jeff K Vallance, Derek M McKay, David M Mutch, Deanna Gibson, Marcus Rauch

“…Study findings will be presented at national and international conferences, submitted for publication in abstracts and manuscripts, shared on social media and disseminated through patient-education materials.Trial registration number NCT04596566.…”
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Effectiveness and safety of acupuncture for angina pectoris: An overview of systematic reviews by Wen-Chuan Qi, Hong-Juan Fu, Rui-Rui Sun, Xiang Li, Ding-Jun Cai, Chao Wang, Fan-Rong Liang

“…Further researches with more critical design and methodology are needed for providing more convincing evidence. Registration: This review was registered at PROSPERO (www.crd.york.ac.uk/prospero/): CRD42021219367.…”
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The Australian Traumatic Brain Injury Initiative: Review and Recommendations for Outcome Measures for Use With Adults and Children After Moderate-to-Severe Traumatic Brain Injury by Jennie L. Ponsford, Amelia J. Hicks, Matthew K. Bagg, Ruby Phyland, Sarah Carrier, Amelia C. James, Natasha A. Lannin, Nick Rushworth, Terence J. O'Brien, Peter A. Cameron, D. Jamie Cooper, Regina Hill, Belinda J Gabbe, Melinda Fitzgerald

“…These 11 outcome measures will be included as common data elements in the AUS-TBI data dictionary. Review Registration PROSPERO (CRD42022290954).…”
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CITRINO: phase 1 dose escalation study of anti-LAG-3 antibody encelimab alone or in combination with anti-PD-1 dostarlimab in patients with advanced/metastatic solid tumours by J. Randolph Hecht, Jean-Marie Michot, David Bajor, Amita Patnaik, Ki Y. Chung, Judy Wang, Gerald Falchook, James M. Cleary, Richard Kim, Anuradha Krishnamurthy, Omkar Marathe, Hagop Youssoufian, Catherine Ellis, Angela Waszak, Srimoyee Ghosh, Hailei Zhang, Kaitlin Yablonski, Shruti D. Shah, Ivan Diaz-Padilla, Susanna Ulahannan

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Evaluating a brief imagery-based intervention for adolescent depression: study protocol for a Phase IIB randomised control trial (INDIGO) in secondary schools by Victoria Pile, Rose Tinch-Taylor, Ben Carter, Jessica Richardson, Lisa De Rijk, Mary Leamy, Simon E. Blackwell, Richard Meiser-Stedman, Barnaby D. Dunn, Sarah Byford, Emily A. Holmes, Cathy Creswell, Patrick Smith

“…Schools have been identified as a promising setting to enhance access to interventions and offer support earlier. We have co-developed a novel intervention, IMAGINE, that targets key cognitive mechanisms implicated in depression across the lifespan. …”
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Evaluation of a telehealth service to support breast cancer prevention medication uptake: a protocol of a mixed methods study by Tim Spelman, Stephanie Best, Christobel Saunders, Paul A James, Sarah Latham, Louise A Keogh, Sarah Mason, Katrina Louise West, Wanda Cui, Sabine Deij, Sandy Minck, Catherine Poliness, Greg Wheeler, Kelly Anne Phillips

“…Research findings will be disseminated at scientific meetings and in peer-reviewed journals.Trial registration number ISRCTN15718519.…”
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An investigator-blinded, 24-month, parallel-group, non-inferiority study to compare aesthetic restorations in primary anterior teeth in a paediatric dental clinic: study protocol f... by Ana Paula Taboada Sobral, Elaine Marcilio Santos, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Elza Padilha Ferri, Juliana Maria Altavista Sagretti Gallo, Thais Gimenez, José Carlos Pettorossi Imparato

“…Introduction Children who suffer from severe caries in childhood may have negative impacts on the growth, development, nutritional problems and quality-of-life problems related to the oral health of the child and their family. …”
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Structured home-based exercise programme and concentric versus eccentric-based stair training programme for pain and function in knee osteoarthritis: a two-phase, double-blinded, r... by Feroz Kabir, Sharmila Jahan, Ehsanur Rahman, Kazi Md Azman Hossain, Kazi Md Amran Hossain, Ambika Kormoker, Md Zahirul Islam, Md Kabir Hossain, Jannatul Ferdous Rikti, Abid Hasan Khan, Sharna Yesmin Suraiya, Md Zahid Hossain

“…The findings will be published in peer-reviewed journals and disseminated at international conferences.Trial registration number CTRI/2025/03/081574.…”
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Prehospital triage of patients with suspected stroke symptoms (PRESTO): protocol of a prospective observational study by Hester F Lingsma, Aad van der Lugt, Diederik W J Dippel, Vicky Chalos, Esmee Venema, Martijne H C Duvekot, Anouk D Rozeman, Walid Moudrous, Frederique H Vermeij, Marileen Biekart, Henk Kerkhoff, Bob Roozenbeek, Cees L Alblas, Laus Jjm Mulder, Bruno JM van Moll, Lisette Maasland, Roeland PJ van Eijkelenburg, Frits GJ Weijschede, Bianca Buijck, Amber Hoek, Jeanette Bakker, Erick Oskam, Rezan Demir, Mandy MA van der Zon, Egon D Zwets, Mirjam Woudenberg, Anja Noordam-reijm, Timo Bevelander, Eveline JA Wiegers

“…Several prehospital stroke scales were developed to identify patients that are likely to have an LVO, which could allow for direct transportation of EVT eligible patients to an endovascular-capable centre without delaying IVT for the other patients. …”
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Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol by Daniel Oros, Jon Schoorlemmer, Cristina Paules, Jesús Gonzalez, Marta Fabre, Sara Ruiz-Martínez, Lina Youssef, Natalia Abadía-Cuchí, Marcos Clavero-Adell, Ana Medel-Martinez, Ariadna Ayerza-Casas, Juan Lerma-Irureta, Pilar Maestro-Quibus, Jesús Rodriguez-Calvo, Diego Lerma

“…More than half of women with SPL deliver a premature baby which is a known risk factor for developing cardiovascular and metabolic disorders in childhood and later in adult life. …”
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Protocol for the implementation evaluation of an integrated paediatric and primary care model: Strengthening Care for Children (SC4C) by Yvonne Zurynski, Susan Woolfenden, Peter D Hibbert, Harriet Hiscock, Raghu Lingam, Karen Wheeler, Michael Hodgins, Jade Burley, Rachel Pelly, Jane Le, Sonia Khano, Tammy Meyers Morris, Stephanie Germano

“…Results will be submitted for publication in peer-reviewed journals and presented at relevant conferences.Trial registration number Australia New Zealand Clinical Trials Registry 12620001299998 on 1 December 2020.…”
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Implementation of a diagnostic decision aid for people with memory complaints and their general practitioners: a protocol of a before and after pilot trial by Marcel Olde Rikkert, Marieke Perry, Marjolein de Vugt, Rudolf W H M Ponds, Ron Handels, Job Metsemakers, Trudy van der Weijden, Frans R Verhey, Iris Linden, Claire Wolfs, Carmen Dirksen

“…This study was funded by the public funded Dutch Research Institute for Care and Medical Sciences (ZonMw).Trial registration number NCT04531956.…”
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Predicting postoperative pulmonary infection in elderly patients undergoing major surgery: a study based on logistic regression and machine learning models by Jie Liu, Xia Li, Yanting Wang, Zhenzhen Xu, Yong Lv, Yuyao He, Lu Chen, Yiqi Feng, Guoyang Liu, Yunxiao Bai, Wanli Xie, Qingping Wu

“…Results Of the 9481 older adults in our study, 951 developed POI. Among the different algorithms, LR performed the best with an AUC of 0.80, whereas the decision tree performed the worst with an AUC of 0.75. …”
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Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded... by Jing Zhao, Hui Zhang, Ziyu Zheng, Baobao Gao, Lini Wang, Chong Lei, Hailong Dong, Taoyuan Zhang, Jiao Gao, Lihong Hou

“…Results will be submitted for publication in peer-reviewed journals and presented at academic meetings.Trial registration number ClinicalTrials.gov, NCT05920967.…”
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From traditional medicine to modern medicine: the importance of TCM regulatory science (TCMRS) as an emerging discipline by Hua Hua, Jian-Yuan Tang, Jun-Ning Zhao, Ting Wang, Jun-Hua Zhang, Jiang-Yong Yu, Chang-Ming Yang, Yan-Ling Ai, Qiao-Xian Luo

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