PEP4LEP study protocol: integrated skin screening and SDR-PEP administration for leprosy prevention: comparing the effectiveness and feasibility of a community-based intervention t... by Stephen E Mshana, Jan Hendrik Richardus, Liesbeth Mieras, Artur Manuel Muloliwa, Anne Schoenmakers, Thomas Hambridge, Robin van Wijk, Christa Kasang, Kidist Bobosha, Fernando Mitano, Ephrem Mamo, Abdoulaye Marega, Nelly Mwageni, Taye Letta, Deus Vedastus Kamara, Ahmed Mohammed Eman, Litos Raimundo, Blasdus Njako

“…Post-exposure prophylaxis with single-dose rifampicin (SDR-PEP) reduces the risk of developing leprosy when administered to screened contacts of patients. …”
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Pilot study to evaluate the use of remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): study prot... by James M Cotton, Derek Kyte, Nazish Khan, Winnie Chua, Larissa Fabritz, Richard P Steeds, Yongzhong Sun, Samir Mehta, Katie Kirkham, Philip Collis, Clive Stubbs, Mary Nulty

“…Introduction Aortic stenosis (AS) is common affecting >13% of adults over the age of 75 years. In people who develop symptoms, without valve replacement, prognosis is dismal with mortality as high as 50% at 1 year. …”
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A score prediction model for predicting the heterogeneity symptom trajectories among lung cancer patients during perioperative period: a longitudinal observational study by Yong Yang, Xueqi Tian, Huiling Zhou, Yichao Wang, Yifeng Gu, Ao Qi, Decai Wang, Zhiying Wang, Yabin Gong, Lijing Jiao, Ling Xu

“…By Logistic regression analysis, a score prediction model was developed based on predictive factors, which was internally validated utilizing 1000 bootstrap samples. …”
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Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP): Protocol for a Phase 2 Feasibility Randomised Trial [version 1; peer review: 1 approved, 2 approved with rese... by Orlaith Doherty, Conor White, Nanna Brix Finnerup, Eimear Smith, Mark Pollock, Nathan Kirwan, Olive Lennon, Catherine Blake

“…The findings of this feasibility trial will inform the development of a future multicentre, international RCT, Trial Registration NCT06463418, 08/07/2024, https://clinicaltrials.gov/study/NCT06463418.…”
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Headache after pediatric traumatic brain injury: a comparison between a post-acute sample of children and adolescents and general population by Marina Zeldovich, Leonie Krol, Katrin Cunitz, Christian Auer, Daniel Pinggera, Victoria Schön, Philipp Geiger, Joachim Suss, Inga K. Koerte, Emilie Isager Howe, Nada Andelic, Anna Buchheim, Matthias Gondan, Nicole von Steinbüchel

“…In addition, factors associated with the development of pediatric post-TBI headache are investigated to improve the understanding of this condition. …”
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The Basilar Artery Collateral Simplified Score: a Novel Collateral Circulation Score Associated With Outcomes in Patients With Basilar Artery Occlusion: Results From the ATTENTION... by Cong Luo, Rui Li, Chunrong Tao, Ming Cai, Lang Chen, Peng Hao, Xinfeng Liu, Wei Hu

“…Background The aim of the current study was to develop a simplified collateral score for basilar artery occlusion and assess its impact on the relationship between procedure time and outcomes. …”
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The long-term general practice healthcare of women with a history of gestational diabetes: A Scoping Review Protocol [version 2; peer review: 2 approved] by James O'Flynn, Rita Forde, Rita McMorrow, Sheena McHugh, Aisling A. Jennings, Christine Newman, Tony Foley

“…GDM is strongly associated with future development of type 2 diabetes and cardiovascular disease. …”
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Evaluating the impact of a champion on implementation of the Back Skills Training (BeST) programme in Canada: a mixed methods feasibility study protocol by Amanda Hall, Sarah Lamb, Charlotte Albury, Shabnam Asghari, Bethan Copsey, Andrea Pike, Holly Etchegary, Zara Hansen, Esther Williamson, Helen Richmond, Krystal Bursey, Vernon Curran

“…A minimum champion training package has been developed based on known barriers in the literature. …”
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Tuberculosis-associated respiratory impairment and disability in children, adolescents and adults: protocol for a systematic review and individual participant data meta-analysis by Andrea Benedetti, Dick Menzies, Kamila Romanowski, Faiz Ahmad Khan, Mayara Lisboa Bastos, Silvia S. Chiang, James C. Johnston, Alexandre Petiquan, Sierra A. Land, Marieke M. van der Zalm, Jonathon R. Campbell

“…Results will be disseminated through open-access, peer-reviewed publications and conference presentations.PROSPERO registration number CRD42024529906.…”
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Predictors of chronic pain and level of physical function in total knee arthroplasty: a protocol for a systematic review and meta-analysis by Jens Ivar Brox, Christopher James Rose, Anners Lerdal, Øystein Skare, Unni Olsen, Maren Falch Lindberg, Eva Marie-Louise Denison, Caryl Lynn Gay, Arild Aamodt, Ove Furnes, Kathryn A Lee

“…The results from this review will be published in peer-reviewed journals and presented at international conferences.PROSPERO registration number CRD42018079069.…”
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Spanish Nurses’ Knowledge and Perceptions of Climate Change: A Qualitative Study by Antonio Miguel Caraballo-Betancort, Irene Marcilla-Toribio, Blanca Notario-Pacheco, Maria Leopolda Moratalla-Cebrian, Ana Perez-Moreno, Alba del Hoyo-Herraiz, Raquel Poyatos-Leon, Maria Martinez-Andres

“…Through care provision, education, management, policy development, and research, nurses can undertake a variety of specific actions in response to climate change. …”
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Antithrombotic management of patients with acute coronary syndrome and atrial fibrillation undergoing coronary stenting: a prospective, observational, nationwide study by Leonardo Bolognese, Pasquale Caldarola, Andrea Rubboli, Leonardo De Luca, Lucio Gonzini, Stefano Urbinati, Adriano Murrone, Fortunato Scotto di Uccio, Fabio Ferrari, Fabiana Lucà, Donata Lucci, Domenico Gabrielli, Andrea Di Lenarda, Michele Massimo Gulizia

“…At multivariable analysis, a major bleeding event (OR: 5.40; 95% CI: 2.42 to 12.05; p<0.0001) and malignancy (OR: 5.11; 95% CI: 1.77 to 14.78; p=0.003) resulted the most important independent predictors of DAT prescription.Conclusions In this contemporary registry of patients with ACS with AF treated with coronary stents, TAT still resulted as the antithrombotic strategy of choice, DAT was reserved for high bleeding risk and DAPT was mainly prescribed in those developing AF during hospitalisation.Trial registration number NCT03656523.…”
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Protocol for a hybrid effectiveness-implementation clinical trial evaluating video-assisted electronic consent vs standard consent for patients initiating and continuing haemodialy... by Helen Healy, Ann Bonner, Rebecca B Saunderson, Martin Wolley, Chenlei Kelly Li, Pedro Henrique Franca Gois, Marina Wainstein, Matthew J Damasiewicz, Vera Y Miao, Kirsten Hepburn, Clyson Mutatiri, Bobby Chacko

“…The aims of this study are to (1) develop a digital information interface to better equip patients in the decision-making process to undergo HD; (2) evaluate the effectiveness of the co-designed digital information interface to improve patient outcomes; and (3) evaluate an implementation strategy.Methods and analysis First, a co-design process involving consumers and clinicians to develop audio-visual content for an innovative digital platform. …”
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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. …”
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Safety, immunogenicity, and effectiveness of chikungunya vaccines in pregnant persons, children, and adolescents: a protocol for a living systematic review and meta-analysis by Mabel Berrueta, Agustín Ciapponi, Agustina Mazzoni, Jamile Ballivian, Ariel Bardach, Juan M. Sambade, Martin Brizuela, Katharina Stegelman, Daniel Comandé, Edward P. K. Parker, Andy Stergachis, Xu Xiong, Flor M. Munoz, Pierre M. Buekens

“…With recent advancements in vaccine development, there is a need to systematically evaluate the emerging evidence on the safety, immunogenicity, and efficacy of chikungunya vaccine candidates. …”
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Smartphone intervention for pregnancy smoking cessation with peer support: the study protocol of the SmokeFree Together 2.0 (SFT 2.0) randomised controlled trial by Ken Resnicow, Kristie Foley, Daniel Muresan, Oana M Blaga, Marina D Dascal, Alexandra Onișor, Teodora Frățilă, Andreea Morar, Dan Mihu, Cristian I Iuhas, Gabriela Caracostea, Cristian I Meghea

“…Building on these findings, we developed an innovative smartphone application (app) that combines the power of social support with artificial intelligence. …”
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Uptake and use of a minimum data set (MDS) for older people living and dying in care homes in England: a realist review protocol by Claire Goodman, Julienne Meyer, Karen Spilsbury, Barbara Hanratty, Lisa Irvine, Sarah Kelly, Massirfufulay Kpehe Musa, Gizdem Akdur, Adam Gordon, Guy Peryer, Anne Killett, Jennifer Burton, Sue Fortescue, Ann-Marie Towers

“…The aim of this realist review is to develop a theory-driven understanding of how care home staff implement and use MDS to plan and deliver care of individual residents.Methods and analysis A realist review will be conducted in three research stages.Stage 1 will scope the literature and develop candidate programme theories of what ensures effective uptake and sustained implementation of an MDS.Stage2 will test and refine these theories through further iterative searches of the evidence from the literature to establish how effective uptake of an MDS can be achieved.Stage 3 will consult with relevant stakeholders to test or refine the programme theory (theories) of how an MDS works at the resident level of care for different stakeholders and in what circumstances. …”
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Improving transitions in care for children and youth with mental health concerns: implementation and evaluation of an emergency department mental health clinical pathway by Alexandra Tucci, Paula Cloutier, Christine Polihronis, Allison Kennedy, Roger Zemek, Clare Gray, Sarah Reid, Kathleen Pajer, William Gardner, Nicholas Barrowman, Mario Cappelli, Mona Jabbour

“…Successful implementation requires integration into existing workflows. Trial registration ClinicalTrials.gov (NCT02590302). Registered on 29 October 2015.…”
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Effectiveness of HAPA-based multidomain fall risk management for older adults with declining intrinsic capacity in nursing homes: protocol of a randomised controlled trial by Jing Yang, Qinghua Zhang, Mei Cheng, Siyi Shang, Shengguang Cheng, Lingxia Qi, Tongtong Liu, Yuhan Yang, Xinuo Yao, Danyan Lu, Xiaoyu Cheng

“…The results will be submitted for publication in a peer-reviewed journal and presented at conferences.Trial registration number NCT05891782.…”
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Protocol for the challenge non-typhoidal Salmonella (CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection mo... by Melita A Gordon, Christopher Smith, Xinxue Liu, Andrew J Pollard, Emma Smith, Graham S Cooke, Robert K M Choy, Anna Rydlova, Robert Varro, Jay C D Hinton, Christopher Chiu, Malick M Gibani

“…Study outcome summaries will be provided to both funders and participants.Trial registration number NCT05870150…”
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