Relationship between acute pain trajectories after an emergency department visit and chronic pain: a Canadian prospective cohort study by Judy Morris, Alexis Cournoyer, Gilles Lavigne, Raoul Daoust, Jean Paquet, Éric Piette, Justine Lessard, Jean-Marc Chauny

“…Controlling for age, sex and pain condition, patients with moderate or severe pain trajectories and those with only a severe pain trajectory were respectively 5.1 (95% CI 2.2 to 11.8) and 8.2 (95% CI 3.4 to 20.0) times more likely to develop chronic pain 3 months later compared with patients in the low final pain trajectories.Conclusion Specific acute pain trajectories following an ED visit are closely related to the development of chronic pain 3 months later.Trial registration number NCT02799004; Results.…”
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Barriers to and enablers of the early diagnosis of breast cancer among women from ethnic minority backgrounds in the UK: protocol for a qualitative evidence synthesis by Nia Roberts, Toral Gathani, Shoba Dawson, S Shepperd, Priya Sajjad, Bep Dhaliwal

“…A search strategy was developed by two researchers and an information specialist. …”
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Unraveling the link between birth order and blood pressure: insights from a comprehensive systematic review and meta-analysis by Danial Habibi, Amir Hossein Koochekian, Hamid Reza Marateb, Homayoon masoudi, Hanifeh Mirtavoos-Mahyari, Muhammadhosein Moradi, Mahdi Akbarzadeh, Marjan Mansourian, Miguel Ángel Mañanas, Roya Kelishadi

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Efficacy of the Foodbot Factory digital curriculum-based nutrition education intervention in improving children’s nutrition knowledge, attitudes and behaviours in elementary school... by Wendy Lou, Michael Farkouh, JoAnne Arcand, Jacqueline Marie Brown, Saman Tahir, Beatriz Franco-Arellano, Ann LeSage, Janette Hughes, Bill Kapralos, Ellen Vogel, Claire Tugault-Lafleur

“…Introduction Schools are an important setting for supporting children’s development of food literacy, but minimal research has assessed which strategies are most suitable for school nutrition education. …”
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Research participants and stakeholders’ views on feedback of genetic research findings: a qualitative study of the H3Africa Kidney Disease Research Network in Ghana by Grace Larbie Gafa, Vincent Boima, Isabella Rockson, Samuel T. Chatio, Anita Ghansah, Babatunde L. Salako, Akinlolu Ojo, Paulina Onvomaha Tindana, Dwomoa Adu, as members of the H3Africa CEBioGen Project

“…Relatives of patients with CKD may be at increased risk of developing CKD. Researchers of this project are faced with an ethical dilemma of whether, study participants and their relatives should be informed about their risk of developing CKD. …”
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School-based enhanced hearing screening and specialty telehealth follow-up for hearing loss among children in rural Alaska: study protocol for a hybrid effectiveness-implementation... by Samantha Kleindienst Robler, Janet Prvu Bettger, Elizabeth Turner, Alyssa Platt, David Arthur, Philip Hofstetter, Hannah Lane, Tarika Srinivasan, Shayu Deshpande, Matthew Hirschfeld, Susan D. Emmett

“…Abstract Background Childhood hearing loss has well-known profound implications for language development, school achievement, and future employment opportunities. …”
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Disability-inclusive graduation programme intervention on social participation among ultra-poor people with disability in North Uganda: a cluster randomized trial by Shanquan Chen, Lena Morgon Banks, Mark T. Carew, Elijah Kipchumba, Calum Davey, Munshi Sulaiman, Hannah Kuper

“…Trial registration Registry for International Development Impact Evaluations (RIDIE-STUDY-ID-626008898983a) and ISRCTN (ISRCTN-78592382).…”
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Regular meta-analysis of the impact of sports activities intervention on some items of the national student physical health standards for adolescents by Jikun Sun, Zhiyuan Sun, Jianda Kong, Jianda Kong, Xuewen Tian, Liping Wang, Qinglu Wang, Jun Xu

“…BackgroundBy using meta-analysis to evaluate the effects of exercise on adolescent body mass index (BMI), standing long jump, sit ups, lung capacity, sitting forward bending, 50 m running, and 800 m running, a large amount of literature will be reviewed to reveal the key role of exercise in the healthy development of adolescents. This study aims to promote the development of adolescent physical health and solve the common problem of declining physical fitness, comprehensively improve the physical fitness of adolescents, and provide decision-making support for policymakers. …”
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Promoting Hand Hygiene During the COVID-19 Pandemic: Randomized Controlled Trial of the Optimized Soapp+ App by Dario Baretta, Carole Lynn Rüttimann, Melanie Alexandra Amrein, Jennifer Inauen

“…ConclusionsSoapp+ was developed through a rigorous experimental method during the ongoing COVID-19 pandemic. …”
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SPIRIT 2025声明解读：开放科学 Interpretation of the SPIRIT 2025 Statement: Open Science by 李辉1，2，谢雪微1，3 (LI Hui1,2, XIE Xuewei1,3)

“…This article elucidates the definition, historical development, and challenges of open science, enabling readers to deeply understand, support, and participate in open science initiatives in the development of clinical trial protocols.…”
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Enablers and barriers of clinical trial participation in adult patients from minority ethnic groups: a systematic review by Germán Andrés Alarcón Garavito, Katie Gilchrist, Coziana Ciurtin, Sanjay Khanna, Pinkie Chambers, Nick McNally, Edward Merivale, Edi Carr, Rosamund Yu, Cecilia Vindrola-Padros

“…Abstract Background Clinical trials are essential to the development of healthcare innovations that advance life expectancy and improve quality of life. …”
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Theory-Based Social Media Intervention for Nonmedical Use of Prescription Opioids in Young Adults: Protocol for a Randomized Controlled Trial by Cheuk Chi Tam, Sean D Young, Sayward Harrison, Xiaoming Li, Alain H Litwin

“…These findings will then be used to develop and evaluate the feasibility and preliminary efficacy of a peer-led social media intervention to reduce NMUPO among young adults. …”
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Core outcome set for studies on pregnant women with vasa previa (COVasP): a study protocol by Rohan D’Souza, Linda Villani, Chelsea Hall, Meron Seyoum, John Kingdom, Michael Krznaric, Natasha Donnolley, Nasrin Javid

“…Through this project, we will be developing a core outcome set for studies on pregnant women with vasa previa (COVasP).Methods and analysis The development of COVasP will involve five steps. …”
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M. tuberculosis Infection in Patients with HIV Infection and Incidence of Tuberculosis: 8-year Follow-up by E. M. Bogorodskaya, E. M. Belilovskiy, L. B. Ayusheeva, E. N. Posadskaya

“…According to WHO, the presence of HIV infection increases the likelihood of developing tuberculosis by 26 times and is the second factor in the world after malnutrition that affects the number of cases of tuberculosis. …”
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Identification of major trauma using the simplified abbreviated injury scale to estimate the injury severity score: a diagnostic accuracy and validation study by David Eidenbenz, Tobias Gauss, Tobias Zingg, Vincent Darioli, Cécile Vallot, Pierre-Nicolas Carron, Pierre Bouzat, François-Xavier Ageron

“…Trial registration: Retrospectively registered.…”
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Neural network-based prediction of incident atrial fibrillation using the trans-thoracic echocardiography parameters: a prospective study by Stanislav N. Kotlyarov, Alexandr V. Lyubavin

“…Background: Myocardial remodeling facilitates the development and maintenance of atrial fibrillation (AF). …”
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What factors are associated with informal carers’ psychological morbidity during end-of-life home care? A systematic review and thematic synthesis of observational quantitative stu... by Tracey Shield, Kerin Bayliss, Alexander Hodkinson, Maria Panagioti, Alison Wearden, Jackie Flynn, Christine Rowland, Penny Bee, Morag Farquhar, Danielle Harris, Gunn Grande

“…Understanding what factors may affect carers’ mental health is important in developing strategies to maintain their psychological well-being during caregiving. …”
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Vitamin D and depression in adults: A systematic review by Vlad Dionisie, Mihnea Alexandru Gaman, Cristina Anghele, Mihnea Costin Manea, Maria Gabriela Puiu, Iulia-Ioana Stanescu-Spinu, Octavian-Ilarian Baiu, Florian Antonescu, Mirela Manea, Adela Magdalena Ciobanu

“…However, it remains to be established through future research whether acute or chronic vitamin D supplementation could have a protective effect against the development of depression. …”
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Improvement of Care Cascade for Hypertension and Diabetes in Rural China: Protocol for an Implementation Study by Xuejun Yin, Zhenzhong Wang, Jingsong Yang, Jia Li, Shasha Han, Wenshuai Feng, Qinglan Liu, Ning Li, Lihui Zhang, Jiawen Ke, Xiaoxia Wei, Juan Zhang, Nizal Sarrafzadegan, Ruitai Shao

“…Intervention villages will implement interventions developed in Phase 2 for 1 year, while control villages will continue with usual care. …”
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Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum conce... by Kevin T Batty, Jonathan Carapetis, Thomas L Snelling, Julie A Marsh, Andrew C Steer, Laurens Manning, Joshua Osowicki, Sam Salman, James McCarthy, Joseph Kado, Thel Khin Hla, Renae Barr, Stephanie L Enkel

“…Findings will be reported in peer-reviewed publications and presented at national/international stakeholder forums.Trial registration number ACTRN12621000751875.…”
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