Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta va... by Timothy W Russell, Hermaleigh Townsley, Sam Abbott, Joel Hellewell, Edward J Carr, Lloyd A C Chapman, Rachael Pung, Billy J Quilty, David Hodgson, Ashley S Fowler, Lorin Adams, Chris Bailey, Harriet V Mears, Ruth Harvey, Bobbi Clayton, Nicola O'Reilly, Yenting Ngai, Jerome Nicod, Steve Gamblin, Bryan Williams, Sonia Gandhi, Charles Swanton, Rupert Beale, David L V Bauer, Emma C Wall, Adam J Kucharski

“…Using data from a prospective observational cohort study of healthy adult volunteers undergoing weekly occupational health PCR screening, we developed a Bayesian hierarchical model to reconstruct individual-level viral kinetics and estimate how different factors shaped viral dynamics, measured by PCR cycle threshold (Ct) values over time. …”
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Detection, linkage to care, treatment and monitoring of hypertension in coastal communities in Accra, Ghana: protocol for a quasi-experimental study (The Ghana Heart Initiative Hyp... by Charles Agyemang, Vincent Boima, Charles Hayfron-Benjamin, Alfred Doku, Afua A A Twumasi, Doris Ottie-Boakye, Juliette Edzeame Selom

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Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease by Gabriel L Ketron, Felix Grun, Joshua D Grill, Howard H Feldman, Robert A Rissman, Gregory J Brewer

“…Both the bioavailability and rapid metabolic methylation need to be addressed if nicotinamide is further developed as a potential intervention for AD. Trial registration NCT03061474, last updated 2023–10-17. https://clinicaltrials.gov/study/NCT03061474 .…”
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Measurement, determinants and outcomes of maternal care satisfaction in Nigeria: a systematic review by Jane E Hirst, Robyn Norton, Margaret Peden, Edward Mullins, Beatrice Wuraola Ope, Tavleen Wasan

“…It also highlights the need for robust methodologies that accurately measure women’s experiences, which is essential for enhancing the quality of maternal health services.PROSPERO registration number A protocol was developed for this study and published on PROSPERO, the International Prospective Register of Systematic Reviews (CRD42023414771).…”
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Investigating the feasibility of an 8-week mindful breathing programme on breathlessness and self-efficacy in chronic obstructive pulmonary disease: an open-label study by Shirley Harris, Jennifer Jordan, Amanda Wilkinson, Philippa Seaton

“…Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR)  ACTRN12623000560695 . …”
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Prior information guided deep-learning model for tumor bed segmentation in breast cancer radiotherapy by Peng Huang, Hui Yan, Jiawen Shang, Xin Xie

“…To facilitate this process, a deep learning model is developed to segment TB from CT with the guidance of prior tumor location. …”
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A Systematic Review of Guidelines for Emergency Department Care of Sexual Minorities: Implementable Actions to Improve Care by Michael I. Kruse, Sawyer Karabelas-Pittman, Grace Northrop, Joanna Stuart, Suneel Upadhye, Blair L. Bigham

“…We coded recommendations for the relevant point of care while in the ED (triage, registration, rooming, investigations, etc). Results: We excluded 2,413 of 2,534 unique articles. …”
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Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis by Waleed Alhazzani, Jessica Spence, Emilie Belley-Cote, Richard Whitlock, Jack Young, Kevin Um, David Mazer, Chris Beaver, Eric Jacobsohn

“…We will disseminate the findings of our systematic review through the presentation at peer-reviewed conferences and by seeking publication in a peer-reviewed journal.PROSPERO registration number CRD42019128144…”
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Focused low-intensity hippocampal transcranial ultrasound stimulation (TUS) for sleep disturbances in patients with chronic tinnitus: A study protocol for a pilot randomized contro... by Xi Ni, Yuk Shan Yuen, Zeyan Li, Kaipeng Wang, Natalie Shu Yang, Yi Yuan, Lin Meng, Liwei Guo, Hanna Lu

“…This proposed clinical trial will provide high-level and valuable clinical evidence that could inform the effect size and personalized modeling of focused low-intensity TUS for different types of brain diseases.<h4>Trial registration</h4>ClinicalTrials.gov Identifier: NCT06776705.…”
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Automated pipeline for linear and volumetric assessment of facial swelling after third molar surgery by Selene Barone, Paolo Zaffino, Marianna Salviati, Michela Destito, Alessandro Antonelli, Francesco Bennardo, Lucia Cevidanes, Maria Francesca Spadea, Amerigo Giudice

“…The open-source software 3DSlicer facilitated automated analysis, including data anonymization, orientation, surface registration, qualitative comparisons, linear measurements, and volumetric quantification. …”
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Digital gamification-based pursed lip breathing exercises driven by Behaviour Change Wheel in patients with COPD: a feasibility trial protocol using pre-post study design by Mark Hayter, Min Huang, Roger Watson, Houqiang Huang, Fake Liu, Mohannad Mohammad, Zihui Li

“…If successful, DT-PLB will be directly applied to the Affiliated Hospital of Southwest Medical University to manage PLB exercises.Trial registration number NCT06063733.…”
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Paediatric goal management training in patients with acquired brain injury: study protocol for a randomised controlled trial by Eva Skovlund, Ruth Elizabeth Hypher, Anne Elisabeth Brandt, Kari Risnes, Torstein Baade Rø, Stein Andersson, Torun Gangaune Finnanger, Jan Stubberud

“…The study has been approved by the Regional Committees for Medical and Health Research Ethics Norway (2017/772).Trial registration number NCT03215342.…”
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Different Approaches to requesting Consent for Routine data linkage in Neonatal follow-up (ACORN): protocol for a 2×2 factorial randomised trial by Jane E Harding, Barry Milne, Jenny Rogers, Greg Gamble, Jane Marie Alsweiler, Christopher McKinlay, Gavin Brown, Aakash Bajirao Rajay, Caroline Anne Crowther, Nike Franke, Trecia Wouldes

“…Dissemination will be via peer-reviewed publications, scientific meetings, educational sessions and public fora.Trial registration number ACTRN12621000571875 (Australian New Zealand Clinical Trials Registry).…”
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Dynamic Simulation Models of Suicide and Suicide-Related Behaviors: Systematic Review by Genevieve Gariepy, Rifat Zahan, Nathaniel D Osgood, Benjamin Yeoh, Eva Graham, Heather Orpana

“…MethodsEight databases were searched, including MEDLINE, Embase, PsycINFO, Scopus, Compendex, ACM Digital Library, IEEE Xplore, and medRxiv, from inception to July 2023. We developed a search strategy in consultation with a research librarian. …”
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Centenarian Mortality Rate During COVID-19: Protocol for a Systematic Review and Meta-Analysis by Shaima Ibrahim, Omnia Mahmoud Abdelraheem, Wafa Abu El Kheir-Mataria, Sungsoo Chun

“…Trial RegistrationPROSPERO CRD42025645150; https://www.crd.york.ac.uk/PROSPERO/view/CRD42025645150 International Registered Report Identifier (IRRID)DERR1-10.2196/74068…”
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The effects of physical activity on mental health in adolescents with attention-deficit hyperactivity disorder: a randomized controlled trial by Chang Liu, Yijian Yang, Stephen Heung-sang Wong, Andes Leung, Cindy Hui-ping Sit

“…Abstract Background Adolescents with attention-deficit hyperactivity disorder (ADHD) represent a high-risk population with an elevated likelihood of developing mental health disorders. Physical activity (PA) has emerged as a promising intervention to enhance mental health in youth. …”
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Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis by Xiao Yu, Xinri Zhang, Xuesen Su, Xiaomei Kong

“…The Pearson correlation analysis revealed that silicosis incidence was highly correlated with cumulative silica exposure (r=0.794, p&lt;0.001).Conclusion The incidence of pneumoconiosis in occupational workers was 0.093 and seven factors were found to be associated with the incidence, providing some insight into the prevention of pneumoconiosis.PROSPERO registration number CRD42022323233.…”
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Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…The aim is then to reduce this comprehensive assessment to the central aspects to be able to conduct targeted and efficient risk screening. Trial RegistrationGerman Clinical Trials Registry DRKS00028614; https://www.drks.de/search/de/trial/DRKS00028614 International Registered Report Identifier (IRRID)DERR1-10.2196/59203…”
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Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri... by Nancy M. Dale, Youssouf Djidita Hagre, Susan Shepherd, George Tomlinson, Stanley Zlotkin, Masra Ngaradoum, Mahmat Bechir, Marius Madjissem, Charles Tehoua, Christopher Parshuram

“…Abstract Background The Responses to Illness Severity Quantification (RISQ) System is a scientifically developed clinical decision support tool comprised of four parts: (1) a validated 7-item severity of illness score, (2) age-specific documentation forms, (3) context-relevant score-matched recommendations, and (4) implementation programming. …”
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Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study by Jiukang Sun, Weili Xiong, Zhang Fang, Chuanjun Song

“…Results Among the patients, 55 developed lung metastasis during the study period. …”
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