Have interventions aimed at assisting general practitioners in facilitating earlier diagnosis of type 1 diabetes in children been successful in preventing acute complications? A sy... by Jo-Anne Manski-Nankervis, Barbara Hunter, Rita McMorrow, Mary White, Chiara Beccia, Andrew Donald, Lucas de Mendonça

“…Future studies should include GPs in their design and consider the sustainability of interventions in the long term.PROSPERO registration number CRD42023412504.…”
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Online Peer Support for Long-Term Conditions: Protocol for a Feasibility Randomized Controlled Trial by Grace Lavelle, Hannah Grace Jones, Ewan Carr, Elly Aylwin-Foster, Vanessa Lawrence, Alan Simpson, Matthew Hotopf

“…Trial RegistrationClinicalTrials.gov NCT06222346; https://clinicaltrials.gov/study/NCT06222346 International Registered Report Identifier (IRRID)DERR1-10.2196/71513…”
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Elevation of Inflammatory Cytokines and Proteins after Intra-Articular Ankle Fracture: A Cross-Sectional Study of 47 Ankle Fracture Patients by That Minh Pham, Lars Henrik Frich, Kate Lykke Lambertsen, Søren Overgaard, Hagen Schmal

“…These data contribute to the current understanding of the protein regulation behind the development of PTOA and is a further step towards supplementing the current surgical treatment. …”
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The effects of neighborhood perceptions on response to a technology-assisted parenting intervention for adolescent substance use: protocol of a diversity supplement to parent SMART... by Zabin Patel-Syed, Sarah A. Helseth, Robert Rosales, Tim Janssen, Kelli Scott, Sara J. Becker

“…Abstract Background It is well established that an adolescent’s neighborhood is associated with their likelihood of developing a substance use disorder. The availability of drugs, lack of access to resources, and exposure to violence are all associated with greater substance use among young people, leading to more pronounced health inequities. …”
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Genomic subtypes of non-muscle-invasive bladder cancer: guiding immunotherapy decision-making for patients exposed to aristolochic acid by Yun Peng, Yuxuan Song, Caipeng Qin, Mengting Ding, Zixiong Huang, Fei Wang, Yuchao HuangFu, Luping Yu, Yiqing Du, Tao Xu

“…Conclusions Our findings provide novel perspectives on the genomics of NMIBC, unveiling four prominent genomic subtypes, each showing different outcomes following immunotherapy. Trial registration: No. 2019PHB268-01 (retrospectively registered on February 14, 2020).…”
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Co-Designed Mobile-Based Cognitive Training for Older Chinese Americans: Protocol for a Pilot Randomized Controlled Trial Assessing Feasibility and Acceptability by Tingzhong Xue, Aybey Amy Wei, Bei Wu, Camilla Sanders, Eleanor Schildwachter McConnell, Hanzhang Xu

“…These findings will enhance the culturally tailored delivery of cognitive training to older Chinese Americans and provide insights for broader implementation, improving their engagement in dementia research. Trial RegistrationClinicalTrials.gov NCT05355870; https://clinicaltrials.gov/study/NCT05355870 International Registered Report Identifier (IRRID)PRR1-10.2196/69303…”
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Safety planning and transdiagnostic cognitive behavioral therapy for adolescent suicide prevention in Mozambique: study protocol for the SPI/TCBT-S hybrid effectiveness/implementat... by Bradley H. Wagenaar, Alberto Muanido, Morgan Turner, Kathryn L. Lovero, Doyanne Darnell, Monisha Sharma, Katherine Anne Comtois, Isaías Ramiro, Vasco F. J. Cumbe

“…Despite this, there are few to no evidence-based youth suicide prevention packages developed for, and tested in, the African context. …”
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What proportion of people have long-term pain after total hip or knee replacement? An update of a systematic review and meta-analysis by Rachael Gooberman-Hill, Michael R Whitehouse, Hung-Yuan Cheng, Andrew David Beswick, Vikki Wylde, Wendy Bertram, Mohammad Ammar Siddiqui

“…Given the prevalence of chronic postsurgical pain, implementing existing and developing new preventive and management strategies is crucial for optimal patient outcomes.PROSPERO registration number CRD42023475498.…”
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Continuing education for the prevention of mild cognitive impairment and Alzheimer’s-type dementia: a systematic review and overview of systematic reviews by Nina Matyas, Filiz Keser Aschenberger, Gernot Wagner, Stefanie Auer, Christoph Gisinger, Monika Kil, Irma Klerings

“…Two authors independently assessed inclusion and exclusion at the abstract and full-text level, rated the risk of bias, and determined the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation. We resolved all discrepancies by consensus. …”
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Knee morphology and patella malalignment in neglected developmental dysplasia of the hip: a systematic review and meta-analysis by Daofeng Wang, Jianzhong Sun, Yang Liu, Zhengjie Tang, Hui Zhang

“…Level of evidence III, systematic review. Registration This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42025640292).…”
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New synthetic resorbable mesh for open ventral hernia repair: the multicentre, single-arm, prospective study of Transorb self-gripping resorbable mesh in subjects undergoing open r... by Yohann Renard, Frederik Berrevoet, J. Scott Scott Roth, Bruce Ramshaw, G Passot, Katie Bayliss, Marion Blanc, Charles Cain, Matthew Goldblatt

“…The publication plan includes dissemination of the 12-month, 24-month, 36-month, 48-month and 60 month study results.Trial registration number The RECOVER study has been registered at clinicaltrials.gov (NCT06449378).…”
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Improving continuity of patient care across sectors: study protocol of the process evaluation of a quasi-experimental multi-centre study regarding an admission and discharge model... by Joachim Szecsenyi, Cornelia Straßner, Michel Wensing, Johanna Forstner, Aline Kunz, Lorenz Uhlmann, Stephanie Kuemmel

“…Results will be disseminated through a final report to the funding agency, articles in peer-reviewed journals and conferences.Trial registration number http://www.drks.de/DRKS00015183.Trial status The study protocol on hand is the protocol V.1.1 from 18 June 2018. …”
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Association Between Hormonal Factors and Risk of Lung and Upper Aerodigestive Tract Cancer in French Women: The E3N Prospective Cohort Study by Yawo E. Klu, Hélène Amazouz, Marianne Canonico, Pascal Guénel, Marina Kvaskoff, Gianluca Severi, Loredana Radoi, Aviane Auguste

“…Concerning individual factors, shorter menstrual cycles (≤ 24 days) were associated with a higher risk of developing female lung cancer even among never smokers (HR = 1.75, 95% CI = 1.01–3.01). …”
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Comparative association between NAFLD and MAFLD with cardiovascular events and mortality: Evidence from observational studies. by Taoli Fu, Jitao Ling, Huilei Zhao, Kaixin Lin, You Deng, Miao Zhang, Xinrui Qi, Peng Yu, Weichun Lin, Xiao Liu

“…The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology.<h4>Results</h4>Eleven cohort studies with 11,995,994 patients were included. …”
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Bridging tradition and innovation: a constitution-guided framework for personalized blood pressure management in acute ischemic stroke by Xuran Zhang, Xuran Zhang, Kegang Cao, Li Zhou, Jinxian Liu, Yufeng Ding

“…A constitution-guided framework for BP management was developed through evidence synthesis.ResultsFifty-four studies were included in the study, with the majority being of moderate-to-high quality. …”
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Outcomes of a pilot microrandomized trial of just-in-time adaptive intervention messages nudging weight-related behaviors in young adults by Carmina G Valle, Brooke T Nezami, Nisha Gottfredson O’Shea, Karen E Hatley, Deborah F Tate

“…Further research should explore how to increase and maintain engagement in mobile behavioral interventions. Trial registration Precision Public Health: Enhancing Connections to Develop Just-in-Time Adaptive Intervention Strategies (Nudge); https://clinicaltrials.gov/study/NCT03836391 ; ClinicalTrials.gov ID: NCT03836391…”
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Effectiveness of interventions designed to increase safe medicine disposal: a systematic review and meta-analysis of randomised trials by Amy Soo-Bin Ma, Andrew J. McLachlan, Christina Abdel Shaheed, Danijela Gnjidic, Jonathan Penm, Toni Riley, Stephanie Mathieson

“…Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess the quality of evidence. …”
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The burden of nosocomial superinfections in a retrospective cohort study of critically ill COVID-19 patients by Anne Kathrin Lösslein, Paulina Ines Staus, Cynthia Beisert Carneiro, Martin Wolkewitz, Georg Häcker

“…We observed an increased risk of death for patients who developed a superinfection, with Enterobacterales being the predominant agent. …”
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Using a rule‐based system to define error in the emergency department by Kiersten L. Gurley, Jonathan L. Burstein, Richard E. Wolfe, Shamai A. Grossman

“…In cases where a rule was broken and therefore an error was scored, the following 5 major themes emerged: (1) not acquiring necessary information (eg, not completing a relevant physical exam), N = 33 (31%); (2) not acting on data that were acquired (eg, abnormal vital signs or labs), N = 25 (23%); (3) knowledge gaps by clinicians (eg, not knowing to reduce a hernia), N = 16 (15%); (4) communication gaps (eg, discharge instructions), N = 17 (16%); and (5) systems issues (eg, improper patient registration), N = 17 (16%). Conclusion The development of consensus‐based rules may result in a more standardized and practical definition of error in emergency medicine to be used as a QA tool and a basis for research. …”
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Metabolic adverse events associated with systemic corticosteroid therapy—a systematic review and meta-analysis by Szilard Nemes, Veronica Phillips, Spoorthy Kulkarni, Hannah Durham, Luke Glover, Osaid Ather, Leslie Cousens, Parmis Blomgran, Philip Ambery

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