Facilitators, barriers, and guidance to successful implementation of multidisciplinary transitional care interventions: A qualitative systematic review using the consolidated frame... by Romain Collet, Juul van Grootel, Marike van der Leeden, Marike van der Schaaf, Johanna van Dongen, Suzanne Wiertsema, Edwin Geleijn, Mel Major, Raymond Ostelo

“…Further research should identify effective implementation strategies, considering the pre-, post-discharge, and general factors identified. Registration: The protocol was registered in PROSPERO (CRD42023421423). …”
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HS-10375, a selective EGFR C797S tyrosine kinase inhibitor, in advanced non–small cell lung cancer by Jianhua Zhan, Jinhui Xue, Lin Wu, Zhiye Zhang, Qiming Wang, Yuxiang Ma, Yan Huang, Yunpeng Yang, Yuanyuan Zhao, Wenfeng Fang, Yang Zhang, Qianwen Liu, Wen Xu, Yan Yang, Zhenming Chen, Baili Song, Danni Sun, Xia Sun, Peng Gao, Hongyun Zhao, Li Zhang

“…Abstract Background The C797S mutation is one of the most common mechanisms of acquired resistance to third generation EGFR TKIs, yet no approved therapies have been available to target it. Here we developed a novel selective EGFR C797S inhibitor, HS-10375, and report the results of pre-clinical research and the first-in-human phase 1 trial. …”
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Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data by Qunying Fang, Zonghui Qiao, Lei Luo, Shun Bai, Min Chen, Xiangjun Zhang, Lu Zong, Xian-hong Tong, Li-min Wu

“…Summary answer A model was developed to predict RIF. The model showed high calibration in external validation, helped to identify risk factors for RIF, and improved the efficacy of ART therapy. …”
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Optimizing a Personalized Health Approach for Virtually Treating High-Risk Caregivers of Children With Neurogenetic Conditions (Project WellCAST): Protocol for a Randomized Control... by Bridgette Kelleher, Kaleb Emerson, Lyndsey N Graham, Veronika Vozka, Anne Wheeler, William Fadel, Daniel Foti, Isha Metzger, Mandy Rispoli, Wendy Machalicek, Laurie McLay, Sean Lane, Wei Siong Neo, Allie Carter, Lisa Brown, Jennifer Brown, Laura Lee McIntyre, Elizabeth Salwitz, Gloria Dietz, Riley Naughton, Katlyn Peek, Nicole Hollins, Emma Woodford

“…A subset of caregivers will participate as waitlist controls before engaging in support programs. We developed and optimized a personalized health decision tree algorithm that matches caregivers to telehealth support programs. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…The views of stakeholders (academics, practitioners, people with lived experiences, carers) were captured to supplement systematic searches of the literature, develop theories, support the interpretation of results and co-develop recommendations. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…Study registration This study is registered as PROSPERO CRD42023487512. …”
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Co-designing and testing the learn together guidance to support patient and family involvement in patient safety investigations: a mixed-methods study by Jane O’Hara, Lauren Ramsey, Siobhan McHugh, Joseph Langley, Justin Waring, Ruth Simms-Ellis, Gemma Louch, Jenni Murray, Carl Macrae, John Baker, Rebecca Lawton, Daisy Halligan, Olivia Rogerson, Penny Phillips, Debra Hazeldine, Sarah Seddon, Joanne Hughes, Rebecca Partridge, Katherine Ludwin, Laura Sheard

“…Stage 2B synthesised previous data to develop common principles and programme theory. Stage 3 involved a 6-month co-design phase with a ‘co-design community’ of > 50 stakeholders. …”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…The programme theory developed consisted of 33 CMOCs and involved 6 partial programme theories. …”
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Advancing the implementation of quality-assured oncological exercise therapy in Germany: protocol for the IMPLEMENT project by Mirko Brandes, Anika Berling-Ernst, Hansjoerg Baurecht, Wiebke Jensen, Miriam Götte, Anne Herrmann, Daniela Fuhr, Heike Schmidt, Antonia Lucas, Bernardine Madl, Simon Elmers, Thorsten Schmidt, Christine Welker, Andre Golla, Annalena Wehner, Dominik Morlok, Jana Rueter, Janina Meuer, Melanie Reitz, Jane Kersten, Rebecca Zimmer, Yvonne Gadczikowske, Renee Stark, Kathrin Hegenberg, Michael Laxy, Martin Halle, Patrick Jahn, Carsten Bokemeyer, Sebastian Theurich, Hajo Zeeb, Michael Leitzmann, Freerk T. Baumann, on behalf of the IMPLEMENT consortium

“…Based on these findings, a set of implementation strategies (IPS) will be developed, implemented, and evaluated to facilitate the delivery of qOET for cancer patients. …”
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Optimisation of the deployment of automated external defibrillators in public places in England by Terry P Brown, Lazaros Andronis, Asmaa El-Banna, Benjamin KH Leung, Theodoros Arvanitis, Charles Deakin, Aloysius N Siriwardena, John Long, Gareth Clegg, Steven Brooks, Timothy CY Chan, Steve Irving, Louise Walker, Craig Mortimer, Sandra Igbodo, Gavin D Perkins

“…Conclusions We have developed a data-driven framework to support decisions about public-access automated external defibrillator locations, using optimisation and statistical models. …”
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Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO) by Raphaël Leman, François Cherifi, Marianne Leheurteur, Pierrick Theret, Camille Pasquesoone, Mathilde Saint-Ghislain, Lucie Bresson, Christophe Denoyelle, Nicolas Vigneron, Laurent Poulain, Raphaël Delepee, Benoit Berby, Julie Dremaux, Aurélie Dumont, Cécile Blanc-Fournier, Corinne Jeanne, Mélanie Briand, Nathalie Rousseau, Louis-Ferdinand Pepin, Elodie Deruche, Fabienne Dumont, Alexandra Leconte, Justine Lequesne, Bénédicte Clarisse, Florence Joly, Laurent Castera, Roman Rouzier

“…To fulfil these challenges, our laboratory has recently developed a HRD test named GIScar (Genomic Instability Scar). …”
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Prevalence of targetable genomic alterations among a diverse population participating in the ASCO TAPUR Study by Pam K. Mangat, M. Kelsey Kirkwood, Dominique C. Hinshaw, Elizabeth Garrett-Mayer, Richard L. Schilsky

“…We assessed 978 gene alterations or other biomarkers across sex, age, race, ethnicity, BMI category, smoking status, Eastern Cooperative Oncology Group performance status, and cancer type in 3448 registrants. We report a higher prevalence of genomic targets of FDA-approved therapies for various cancers, including PDGRFA in Hispanic versus non-Hispanic registrants and JAK2 in Asian versus White registrants. …”
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What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…Study registration This study is registered as Researchregistry.com: researchregistry4762. …”
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The use of “Acellbia” – a biosimilar of rituximab in systemic sclerosis by L. P. Ananyeva, L. A. Garzanova, O. V. Desinova, R. U. Shayakhmetova, M. N. Starovoytova, O. A. Koneva, O. B. Ovsyannikova, S. I. Glukhova, E. L. Nasonov

“…One patient developed calf vein thrombosis and lung cancer was diagnosed in one case.Conclusion. …”
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Numerical simulations in astrophysics:Supernovae explosions, magnetorotational model and neutrino emission by G. S. Bisnovatyi-Kogan

“…The first one is based on development of convective instability, and more effective heating of the outer layers by a neutrino flux.…”
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GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing by Ao Huang, De-Zhen Guo, Zhi-Xi Su, Yun-Shi Zhong, Liang Liu, Zhi-Guo Xiong, Dong-Li He, Bin Yan, Quan-Lin Li, Zhen Feng, Wen-Quan Wang, Pin-Xiang Lu, Meng-Jiang He, Zhi-Peng Qi, Qi Guo, Jian-Wen Cheng, Shi-Yu Zhang, Wei Guo, Qing Li, Guo-Yong Lin, Hui-Chuan Sun, Shuang-Jian Qiu, Qi-Ye He, Jia Fan, Ajay Goel, Rui Liu, Gang Jin, Xin-Rong Yang, Jian Zhou

“…To address this clinical need, we developed GutSeer, a blood-based assay combining DNA methylation and fragmentomics for multi-GI cancer detection. …”
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Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective coho... by Stefanie Aeschbacher, David Conen, Diederick E Grobbee, Raphael Twerenbold, Thomas Lung, Theo Rispens, Jakob Kjellberg, Lorenz Risch, Martin Risch, Marianna Mitratza, Harald Renz, Spiros Denaxas, Billy Franks, Diederick Grobbee, Martina Rothenbühler, Janneke Wijgert, Santiago Montes, Richard Dobson, Hans Reitsma, Christian Simon, Titia Leurink, Charisma Hehakaya, Patricia Bruijning, Kirsten Grossmann, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B Brakenhoff, George S Downward, Ariel Dowling, Maureen Cronin, Brianna M Goodale, Brianna Goodale, Ornella Weideli, Regien Stokman, Hans Van Dijk, Eric Houtman, Jon Bouwman, Kay Hage, Lotte Smets, Marcel van Willigen, Maui Chodura, Niki de Vink, Tessa Heikamp, Timo Brakenhoff, Wendy van Scherpenzeel, Wout Aarts, Alison Kuchta, Antonella Chiucchiuini, Steve Emby, Annemarijn Douwes, George Downward, Nathalie Vigot, Pieter Stolk, Duco Veen, Daniel Oberski, Amos Folarin, Pablo Fernandez Medina, Eskild Fredslund

“…Our proposed RNN algorithm identified 68% of COVID-19 positive participants 2 days prior to SO and will be further trained and validated in a randomised, single-blinded, two-period, two-sequence crossover trial.Trial registration numberISRCTN51255782; Pre-results.…”
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Patterns of Postablation Recurrence and Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation by Sitong Li, Jingrui Zhang, Song Zuo, Jue Wang, Yiwei Lai, Mingxiao Li, Zejun Yang, Zixu Zhao, Manlin Zhao, Lan Ren, Zhen Wang, Chao Jiang, Liu He, Xueyuan Guo, Xiaoxia Liu, Ribo Tang, Ning Zhou, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma

“…Conclusions Postablation PersAF recurrence was associated with significantly higher risks of cardiovascular death and thromboembolism, compared with paroxysmal AF recurrence and nonrecurrence, indicating the prognostic importance of recurrence patterns. Registration URL: www.chictr.org.cn/; unique identifier: ChiCTR‐OCH‐13003729.…”
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Physician group practice in China's healthcare reform: a national survey on physicians' perspectives and implementation challenges by Rui Fan, Qing Meng, Long Zhang, Chao Liu, Li Han, Meng Liu, Leiyu Shi

“…Data analysis included descriptive statistics and variance analyses to explore correlations between physicians’ characteristics and their perspectives.ResultsKey facilitators for PG development included “New career direction outside the existing system” (75.1%) and “Improved income levels” (74.4%). …”
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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder: a high-risk study in the Chinese population by Jing Wang, Tao Li, Yun Kwok Wing, Jihui Zhang, Jie Chen, Bin Zhang, Weidong Song, Chao Jiang, Jiyang Pan, Kun Zhang, Yaping Liu, Ngan Yin Chan, Hongliang Feng, Lulu Yang, Binbin Lei, Qunfeng Wang, Jessie Chi Ching Tsang, Joey W.Y. Chan, Kathleen Ries Merikangas

“…The findings of the specific age-related and stage-related developmental patterns of psychopathologies and circadian dysfunction in children and adolescent offspring of parents with bipolar disorder paved the way to develop specific and early clinical intervention and prevention strategies.Trial registration number NCT03656302.…”
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