Procalcitonin-guided initiation of antibiotics in AECOPD inpatients: study protocol for a multicenter randomised controlled trial by Bin Cao, Xiaoying Gu, Jinxiang Wang, Lixue Huang, Weili Sheng, Yeming Wang

“…If the results of the study are positive, PCT-guided antibiotic therapy is likely to change the guidelines for antibiotic recommendations for patients with AECOPD.Trial registration number ClinicalTrials.gov: NCT04682899.…”
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Understanding anhedonia in major depressive disorder in Japan: epidemiology and unmet needs from patients’ and physicians’ perspectives by Mami Kasahara-Kiritani, Tadafumi Kato, Akihide Wakamatsu, Thomas Webb, Keira Herr, Lawrence Vandervoort, Nan Li

“…Patients with MDD-ANH perceived “reduce psychological anxiety”, “control depressed mood”, and “improve sleep quality” as more important treatment goals, compared to physicians’ importance to avoid suicidal thoughts, restore normal social function, and regain interest in hobbies. …”
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Deprescribing anticholinergics to preserve brain health: reducing the risk of dementia through deprescribing (R2D2): study protocol for a randomized clinical trial by Noll L. Campbell, Richard J. Holden, Sujuan Gao, Frederick W. Unverzagt, Kathleen A. Lane, Allie Carter, Addison B. Harrington, Sneha Manoharan, Neha Manoharan, Danielle L. Rosenthal, Christopher Pitts, Kathryn Pelkey, Emily Papineau, David M. Lauck, Noha Keshk, Khalid Alamer, Hussein Khalil, Malaz A. Boustani

“…The primary outcome of the study is a composite measure of cognition that includes domains assessing executive cognitive function, language, and memory. Secondary outcomes include patient-reported measures of pain intensity, depression, anxiety, sleep disturbance, and health-related quality of life. …”
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FORMATION OF NATIONAL CERTIFICATION SYSTEM OF ORGANIC AGRICULTURAL by Oleksii SHKURATOV, Viktor KYPORENKO, Tetyana KUSHNIRUK

“…This, on the one hand, requires strict control over the activities of private certification bodies, but on the other, it will allow to avoid state monopolism and bureaucracy. A structural-functional organic certification scheme in Ukraine has been proposed, which includes three main levels: global, state, and enterprise level, and is also based on a combined certification system, in which state and private certification bodies operate under equal conditions with the involvement of control from the state accreditation body. …”
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Perencanaan Strategis Sistem Informasi dengan Metode WARD & PEPPARD Studi Kasus Dinas Kependudukan dan Pencatatan Sipil Kabupaten Boyolali by Setiawan Tri Wibowo, Hanna Prillysca Chernovita

“…This strategic planning is urgently needed by the Boyolali District Administration for Civil Service to avoid investment or procurement of IS / IT that is inconsistent with its main purpose and function as a community service office. …”
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The SmartNTx-study: a prospective, randomized controlled trial to investigate additional interventional telemedical management versus standard aftercare in kidney transplant recipi... by Mario Schiffer, Lars Pape, Julia K. Wolff, Julia K. Wolff, Raoul Gertges, Vanessa Visconti, Karen Reichert, Anja Pfau, Anne Dieterle, Katja Sauerstein, Andreas Kribben, Kristina Boss, Sinem Karaterzi, Felix Nensa, Philipp Winneckens, Mario Cypko, Mario Cypko, Wiebke Duettmann, Bianca Zukunft, Eva Schrezenmeier, Marcel G. Naik, Fabian Halleck, Roland Roller, Sebastian Möller, Sebastian Möller, Oliver Amft, Oliver Amft, Klemens Budde

“…In the interventional arm, the iBox score will be used to better detect patients at risk for early graft failure and drug-drug interactions will be regularly checked with certified software.DiscussionThe study aims to prolong patient and graft survival through additional telemedical services in order to reduce avoidable hospitalizations, improve treatment of co-morbidities, and improve adherence through patient empowerment, which should result in lower health care costs, and better quality of life of patients after kidney transplantation.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT05897047.…”
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Diagnostics of optic disk drusen in children by A. G. Shchuko, D. U. Samsonov, S. I. Zhukova, T. N. Iureva

“…No changes perineural space allowed excluding stagnation and avoiding the need for complex and invasive methods. …”
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Cost-effectiveness of prehabilitation prior to elective surgery compared to usual preoperative care: protocol for a systematic review of economic evaluations by Tanja Rombey, Helene Eckhardt, Wilm Quentin

“…Introduction Preoperative functional capacity is an important predictor of postoperative outcomes. …”
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The Effects of Compensatory Scanning Training on Mobility in Patients with Homonymous Visual Field Defects: A Randomized Controlled Trial. by Gera A de Haan, Bart J M Melis-Dankers, Wiebo H Brouwer, Oliver Tucha, Joost Heutink

“…The results suggest that different types of compensatory scanning strategies are appropriate for different types of activities.<h4>Trial registration</h4>ISRCTN Registry ISRCTN16833414.…”
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Vision Restoration through transorbital electrical stimulation in Optic Neuropathy in patients with significant optic atrophy due to primary open-angle glaucoma—a randomised, contr... by Katrin Lorenz, Alexander Radbruch, Hans Hoerauf, Philip Enders, Karl Mercieca, Christian van Oterendorp, Marc Brockmann, Anna Beck, Thomas Asendorf, Bettina Wabbels, Michael Schittkowski, Verena Prokosch, Johanna Pohlner, Carsten Grohmann, Lena Kröger, Jens Haueisen, Alexander Hunold, Maria Bernhard, Peter Dechent, Mathias Bähr, Andrea Antal

“…The disease is characterised by the loss of retinal ganglion cells associated with a progressive optic neuropathy, resulting in an impairment of visual functions, for example, visual field loss. Nowadays, the only modifiable risk factor is the increase in intraocular pressure, and its treatment is to lower this pressure by medication, laser treatment or surgery to avoid disease progression. …”
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GERD-associated laryngeal granuloma: a series of clinical observations. Case report by Svetlana V. Starostina, Olga V. Tashchyan, Marina G. Mnatsakanyan, Konstantin A. Nazarov, Liana S. Karapetyan, Polina A. Loskutova, Irina V. Kuprina

“…Diagnosis of laryngopharyngeal reflux includes analysis of the patient's life history, registration of complaints using questionnaires, assessment of the clinical and functional state of the larynx using visual analog scales of reflux signs, the use of instrumental methods and laboratory tests. …”
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“It’s like going through life at a mediocre level”: a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease by Brenda Agyeiwaa Poku, Karl Michael Atkin, John David Grainger, Iyamide Thomas, Rachael Oshinbolu, Abubakar Mohammed, Edith Kyewalyanga, Susan Kirk

“…To meet social expectations and avoid stigma, CYP described constantly pushing themselves to conceal their fatigue, exacerbating their difficulties with SCD. …”
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Use of Wearable Transdermal Alcohol Sensors for Monitoring Alcohol Consumption After Detoxification With Contingency Management: Pilot Randomized Feasibility Trial by Eileen Brobbin, Colin Drummond, Stephen Parkin, Paolo Deluca

“…Only 1 of the 29 participants (3%) admitted to turning the TAS off to avoid monitoring. There were some issues with the TAS not functioning properly and not being able to be cleaned. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Total number of major adverse cardiovascular events. Lung function (NB, during the COVID-19 pandemic, lung function could not be assessed in participants). …”
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Community Specialist Teams for Older Persons (CST-OP) at risk of, or living with frailty in Ireland: a prospective cohort study of a new model of integrated care for community dwel... by Christina Hayes, Aoife Whiston, Christine Fitzgerald, Collette Devlin, Brian Condon, Molly Manning, Aoife Leahy, Katie Robinson, Rose Galvin

“…Community-based CGA may also mitigate against potentially avoidable ED presentations and hospitalisations. Use of the Clinical Frailty Scale is recommended to predict the risk of functional decline, increased rates of mortality, NH admission, hospitalisation or ED presentation at 30- and 180-days among community-dwelling older adults. …”
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Clinical and cost evaluation of intensive support team (IST) models for adults with intellectual disabilities who display challenging behaviour: a comparative cohort study protocol by Angela Hassiotis, Rebecca Jones, Brynmor Lloyd-Evans, Renee Romeo, Nicola Morant, Ken Courtenay, Ian Hall, Athanasia Kouroupa, Vicky Crossey, Laurence Taggart, Peter Langdon, Victoria Ratti, Vincent Kirchner

“…Intensive support teams (ISTs) have been recommended to provide high-quality responsive care aimed at avoiding unnecessary admissions and reducing lengthy inpatient stays in England. …”
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A systematic review of behaviour change interventions to improve maternal health outcomes in sub-Saharan Africa. by Francis G Muriithi, Aduragbemi Banke-Thomas, Gillian Forbes, Ruth W Gakuo, Eleanor Thomas, Ioannis D Gallos, Adam Devall, Arri Coomarasamy, Fabiana Lorencatto

“…The rate of decline in the global burden of avoidable maternal deaths has stagnated and remains an issue of concern in many sub-Saharan Africa countries. …”
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Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial by Maria Antònia Fiol-deRoque, José María Valderas, María Jesús Serrano-Ripoll, Montserrat Gens-Barbarà, Francisco Martín-Luján, Encarna Sánchez-Freire, Juan José Montaño, Sofía Mira-Martínez, Guadalupe Pastor-Moreno, Rocío Zamanillo-Campos, Pau Riera-Serra, Ignacio Ricci-Cabello

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Efficacy of an Intelligent and Integrated Older Adult Care Model on Quality of Life Among Home-Dwelling Older Adults: Randomized Controlled Trial by Rongrong Guo, Jiwen Zhang, Fangyu Yang, Ying Wu

“…Secondary end points included functional status at the 3-month follow-up and percent changes in health self-management ability, social support, and confidence in avoiding falling from baseline to the 3-month follow-up. …”
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Use of Digital Health Technologies for Dementia Care: Bibliometric Analysis and Report by Hebatullah Abdulazeem, Israel Júnior Borges do Nascimento, Ishanka Weerasekara, Amin Sharifan, Victor Grandi Bianco, Ciara Cunningham, Indunil Kularathne, Genevieve Deeken, Jerome de Barros, Brijesh Sathian, Lasse Østengaard, Frederique Lamontagne-Godwin, Joost van Hoof, Ledia Lazeri, Cassie Redlich, Hannah R Marston, Ryan Alistair Dos Santos, Natasha Azzopardi-Muscat, Yongjie Yon, David Novillo-Ortiz

“… BackgroundDementia is a syndrome that compromises neurocognitive functions of the individual and that is affecting 55 million individuals globally, as well as global health care systems, national economic systems, and family members. …”
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