Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…Main outcome measures Diagnostic accuracy, protocol development, health economic modelling and value-of-information analysis. …”
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Current EpidemiologicaL Situation on Tularemia in the Northwestern Federal District of Russia by T. N. Demidova, V. P. Popov, D. S. Orlov, T. V. Mikhaylova, I. S. Meshcheryakova

“…In Russia every year are registred 100 or more cases of tularemia, with about 70% of them in the Central, Northwest and Siberian federal districts. …”
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Cheese Analogues, an Alternative to Dietary Restrictions and Choices: The Current Scenario and Future by Ingrid Leal, Paulo Correia, Marina Lima, Bruna Machado, Carolina de Souza

“…This study aimed to map technological trends, formulation strategies, and major challenges in the development of plant-based cheese analogues through a systematic review of the scientific literature and patents. …”
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Пізній протестантизм в Україні в процесі пострадянських внутрішньо-інституційних суспільних трансформацій... by Ольга СПИС

“…It is specified that on the way of institutionalization formations during the transition period from controlled, "clandestine" and the semi-clandestine activity in conditions of opened democratic development Ukrainian protesters have faced a number of problems, which can be divided in three groups. …”
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Methodological Principles for Adapting of Performance Indexes of Classical Libraries for a Comprehensive Assessment of Electronic Library Systems in Vocational Education by Svetlana Ol. Potapova, Nikolai Dm. Ambrosenko, Olga A. Lysak

“…Metrics such as the number of registrations, the number of visits and requests, the number of bookings, bounce statistics, and search queries are becoming more detailed thanks to digital technologies. …”
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Reactivity of cardiorespiratory system in bronchial asthma patients according to the tests with respiratory maneuvers performance by O. P. Romanchuk, V. I. Velychko, Ya. I. Bazhora

“…The use of respiratory maneuvers performance tests allowed revealing the characteristic regulatory features of bronchial asthma development and course, so it can be proposed for wide practical implementation in the diagnosis and monitoring of bronchial asthma course.…”
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Clinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs by Oliver Wiseman, Daron Smith, Kath Starr, Lorna Aucott, Rodolfo Hernández, Ruth Thomas, Steven MacLennan, Charles Terry Clark, Graeme MacLennan, Dawn McRae, Victoria Bell, Seonaidh Cotton, Zara Gall, Ben Turney, Samuel McClinton

“…What effect does miniaturisation of keyhole surgery have on postoperative pain, length of stay, complications, stone-free rates and costs? Trial registration This trial is registered as ISRCTN98970319. …”
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A Training Program to Support Patient Engagement in Primary Health Care Research: Co-Design, Implementation, and Evaluation Study by Amanda L Terry, Lorraine Bayliss, Leslie Meredith, Eugene Law, Rob Van Hoorn, Sandra Regan

“…Second, building on the results of the needs assessment, the development and implementation of the program followed a series of iterative steps, including user testing of the program’s content and format. …”
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COVIDTrach: a prospective cohort study of mechanically ventilated patients with COVID-19 undergoing tracheostomy in the UK by A Thompson, S Wilkinson, N Kumar, G Wong, J Smith, F Franco, P Smith, A Wilson, S Ghosh, S Shepherd, A Kumar, R Brown, D Williams, M Griffiths, J Sen, M Roberts, A McGrath, D Kumar, A Walker, A Gupta, N Sharma, P Shah, M Kumar, H Jones, P Paul, I Gonzalez, A Shah, V Srinivasan, M Kelly, P Surda, K Valchanov, S Saha, R Bentley, C Hall, J Ng, C Pearce, R Harris, H Wilson, N Amin, J Phillips, D Park, C Jennings, L Wren, B McGrath, D Walker, J Ahmed, S Menon, N Jain, R Mistry, E Jackson, W Rutherford, E France, S Mahalingam, C Hogan, A Burns, T Exall, J Rodrigues, C Xie, M Rouhani, E Paramasivam, A WILLIAMSON, K STEELE, D Dawson, S Linton, M Cameron, S Biswas, S Hodges, J Collier, J Collins, S Bennett, T Ali, N Bhatti, S Suresh, J Williamson, G Ambler, C Cook, D Baker, J Bates, J Blair, P Mukherjee, A Howard, B Cosway, M Anwar, S Fang, S Meghji, H Griffiths, M Keil, F GREEN, K Hussain, A Schache, C Lockie, S Winter, J Westwood, A Hormis, P Ward, C Walker, G Sandhu, T Davies, A Lloyd, L Linhartova, C SPENCER, A Courtney, L Bates, T Martín, T Tatla, L Ritchie, P Gill, S Shannon, A Arora, R Pinto, H Turner, J Whittaker, E Warner, L Leach, A Menon, J Higginson, G Warner, A Balfour, F Cooper, A Li, S Berry, R Gohil, M Celinski, J McEwan, E Riley, S Webster, I Ahmad, M Idle, K Jolly, S Burrows, S Parmar, B Morris, A Arya, S Mustafa, E Tam, D Chakravarty, M De, A Daudia, B Tehan, R Temple, J Broad, P Andrews, D Pennell, C Smart, R D’Souza, P Praveen, DJ Lin, M Osborne, A Coombs, T Hunt, M Singer, C Smyth, R Saha, G Walton, P Bishop, U Sheikh, R O'Brien, R Bhandari, A Rovira, S Sanyal, E Yeung, A Tse, N Lawrence, P Stimpson, H Saeed, K Fan, M Ashcroft, T Jacob, J Hadley, K Goodwin, Z Abdi, D Nair, B Hill, D Whitmore, N Macartney, P Sykes, N Mercer, R Sykes, S Siddiq, Nick JI Hamilton, AGM Schilder, MM George, GM Jama, J Goulder, C Schilling, S Laha, MA Birchall, NS Tolley, P Nankivell, O Breik, P Pracy, J Osher, C Huppa, P Stenhouse, F Ryba, EK Bhargava, D Ranford, A Takhar, C Tornari, M Verkerk, C Al-Yaghchi, M Jaafar, N Cereceda-Monteoliva, A Holroyd, K Ghufoor, H O'Mahony, H Drewery, A Mulcahy, T Magos, I Balasundaram, M Heliotis, A Loizidou, D York, R Exley, KA Solanki, P Kirticumar, A Shirazian, Y Bhatt, R Natt, N Banga, K Dhadwal, I Ekpemi, R Roplekar-Bance, N Glibbery, K Karamali, T Munroe-Gray, P Sethukumar, R Vasanthan, H Lee-Six, B Misztal, S Millington, M Musalia, A Cardozo, M Dunbobbin, S Shahidi, M Chachlani, J Fussey, M Misurati, S Ashok, H Aboulgheit, S Khwaja, R Anmolsingh, B Al-Dulaimy, E Omakobia, T Browning, L Lignos, P Twose, J Heyman, D Kathwadia, T Hwara, O Judd, W Parker, TP Davis, T Stubington, H Koumoullis, E Willcocks, L Skelly, G Dempsey, K Liatsikos, B Borgatta, A Glossop, V Politidis, D Dhariwal, A Kara, G Tattersall, W Udall, P Kirkland, J Staufenberg, H Buglass, NW Wahid, A Amlani, P Deutsch, K Markham, O Barker, A Easthope, S Glaze, D Bondin, D Thorley, K Kapoor, S Sirajuddin, F van Damme, O Mattoo, E Kershaw, S Dewhurst, S Blakeley, C Chivers, L Lindsey, R Glore, H Cunniffe, D Moult, D Zolger, J Bakmanidis, S Kandiah, A Pericleous, R Sheikh, U Nagalotimath, E El-Tabal, S Ghaffar, M Dallison, E Leakey, O Sanders, A Gomati, L Moir, CB Groba, C Davies-Husband, N Seymour, R Lovett, J Lunn, A Armson, K Hilliard, S Ladan, P Tsirevelou, V Ratnam, A Muddaiah, J Coakes, R Borg, A Tsagkovits, O Mulla, N Stobbs, D Pratap, Z Ghani, J Rocke, S Snape, A Hassaan, S Beckett, R Siau, C Lamont, C Blore, D Zakai, R Moorthy, P Bothma, A Syndercombe, N Keates, M Junaid, T Antonio, A Vijendren, V Venkatachalam, M Lechner, D Chandrasekharan, J Whiteside, S Dennis, A Eldahshan, H Paw, M Colomo-Gonzalez, N Mani, B Ranganathan, N Amiruddin, A Sladkowski, AK Abou-Foul, S Kishwan, P Naredla, A Al-Ajami, S Okhovat, E Carey, N Vallabh, A. Alatsatianos, R Townsley

“…Six reports were received of operators testing positive for SARS-CoV-2 within 2 weeks of the procedure.Conclusions Tracheostomy appears to be safe in mechanically ventilated patients with COVID-19 and to operators performing the procedure and we identified clinical parameters that are predictive of mortality.Trial registration number The study is registered with ClinicalTrials.Gov (NCT04572438).…”
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Factors Associated with Participation, Active Refusals and Reasons for Not Taking Part in a Mortality Followback Survey Evaluating End-of-Life Care. by Natalia Calanzani, Irene J Higginson, Jonathan Koffman, Barbara Gomes

“…Study design improvements may guide future questionnaire development and help develop strategies to increase response rates.…”
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PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagn... by Raman R Gangakhedkar, Ravindra Mohan Pandey, Rakesh Kumar, Randeep Guleria, Manjula Singh, Soumya Swaminathan, George D’Souza, Rashmi Rodrigues, Anand Krishnan, Sanghamitra Pati, Sudipta Mohakud, Anant Mohan, Ramesh Kumar, Prasanta Raghab Mohapatra, Parul Kodan, Rohit Sarin, Baijayantimala Mishra, Geeta Yadav, Deepak Gupta, Anuj Bhatnagar, Sriram Selvaraju, Ritu Gupta, Sandeep Patil, Sourin Bhuniya, Sanjay Mehendale, Samiran Panda, Subrata Kumar Palo, Debasish Hota, Sangeeta Sharma, Srikanth Tripathy, Kiran Katoch, Sindhu Joshi, Somashekar Narasimhaiah, Sangeeta Bhaskar, Rajni Rani, Abdul Mabood Khan, Urvashi B Singh, D K Mitra, Neelam Roy, Amitva Sen Gupta, Vikram Vohra, Neeta Singla, Vijaya Valluri Ansari, Chitra Iravatham, Shilpa Rakh, D K Prudhula, Chala Devi, N Rupa, K Sailaja, Sheela Godbole, Seema Sahay, Suchit Kamble, Megha Mamulwar, Arati Kishor Mane, Ashwini Vinod Shete, Abhijit Vasantrao Kadam, Vineet Chadha, S Uma Shankar, C Ravichandra, S K Tripathy, Dasarathi Das, Tahziba Hussain, B Dwibedi, P R Mohapatra, S C B Cuttack, M R Pattnaik, Sabita Mohapatra, Banu Rekha, Mohan Natarajan, P K Bhavani, D Bella Devaleenal, Syed Hisar, S Devarajulu Reddy, Paul Kumaran, Makhesh Kumar, Poorna Ganga Devi, Sunny Omkar Singh, Devi Pratyush, Vidushi Gupta, Parvathi

“…In this endeavour, we have developed a protocol for a multisite, double-blind, placebo-controlled clinical trial in India that aims to evaluate the efficacy and safety of two TB vaccines; namely, VPM1002 and Immuvac (M.w) (Mycobacterium Indicus Pranii) (MIP) among healthy household contacts (HHCs) of sputum smear-positive pulmonary TB (PTB) patients.Methods and analysis In the three-arm randomised double-blind placebo-controlled trial study protocol, a total of 12 000 HHCs (aged 6−99 years) of sputum smear-positive PTB patients will be randomised to receive either of the two vaccine candidates VPM1002 and MIP or placebo. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…The study findings support progression to impact research by development of tools to optimise assessment methods, educational elements of interpreting results and quality of service delivery. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…The study findings support progression to impact research by development of tools to optimise assessment methods, educational elements of interpreting results and quality of service delivery. …”
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Industry (UAPASTF) Response to Pesticide Regulators’ “State of the Knowledge” Review of Drone Use for Pesticide Application: Best Practices for Safe and Effective Application of Pe... by Hector Portillo, Roberto Barbosa, Matt Beckwith, Tyler Gullen, Rebecca Haynie, Sarah Hovinga, Banugopan Kesavaraju, Edward Lang, Pamela Livingston, Neill Newton, Mark Oostlander, Greg Watson, Rajeev Sinha

“…The Organization of Economic Cooperation and Development Working Party on Pesticides (OECD WPP) Drone/UAV Subgroup published a “state of the knowledge” report on pesticide application using unmanned aerial vehicles (UAV) in 2021. …”
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Comparison of baseline patient characteristics in phase 1 and phase 2/3 clinical trials for anticancer treatments by Maria Lucia Iacovino, Simone Talucci, Laura Arenare, Andrea Caglio, Andrea Canciello, Flavio Salerno, Sergio Facchini, Adriano Gravina, Clorinda Schettino, Maria Carmela Piccirillo, Pier Paolo Olimpieri, Massimo Di Maio, Francesco Perrone

“…Therefore, patient selection in phase 1 trials appears crucial, considering its potential impact in later development phases.…”
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Evaluating the population impact of hepatitis C direct acting antiviral treatment as prevention for people who inject drugs (EPIToPe) – a natural experiment (protocol) by Jeremy Horwood, Andrew Radley, John F Dillon, Peter Vickerman, Rory N Gunson, Mary Ramsay, Chris Metcalfe, William Hollingworth, Hannah Fraser, Helen Harris, Ellen Heinsbroek, Lawrie Elliott, Paul Flowers, Sema Mandal, Matthew Hickman, David Goldberg, Natasha Martin, Emma Hamilton, Daniela De Angelis, Graham Foster, Peter Donnan, Ann Eriksen, Samreen Ijaz, David Liddell, Lewis J Z Beer, Kate Drysdale, Rachel Glass, Lesley Graham, Ross Harris, Vivian Hope, Sarah Karen Inglis, Hamish Innes, Athene Lane, Jade Meadows, Andrew McAuley, Stephanie Migchelsen, Alex Murray, Gareth Myring, Norah E Palmateer, Anne Presanis, Pantelis Samartsidis, Ruth Simmons, Katy Sinka, Gabriele Vojt, Zoe Ward, David Whiteley, Alan Yeung, Sharon J Hutchinson

“…Through the qualitative data we will systematically explore key mechanisms of TasP real world implementation from provider and patient perspectives to develop a manual for scaling up HCV treatment in other settings. …”
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Evaluating axillary lymph node metastasis risks in breast cancer patients via Semi-ALNP: a multicenter studyResearch in context by Limeng Qu, Jinfeng Zhu, Xilong Mei, Zixi Yi, Na Luo, Songlin Yuan, Xuan Liu, Mingwen Liu, Haiqing Xie, Xiongqiang Hu, Liangrui Pan, Qingchun Liang, Yanhui Li, Qiongyan Zou, Qin Zhou, Danhua Zhang, Meirong Zhou, Lei Pei, Ke Qian, Qian Long, Qitong Chen, Xi Chen, Jennifer K. Plichta, Qingyao Shang, Meishuo Ouyang, Jiachi Xu, Wenjun Yi

“…Seven ML algorithms developed semisupervised multiclassifiers on the basis of the predicted probabilities for 4191 ALNs. …”
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Efficacy and safety of Xiao’er Fengre Qing oral liquid versus Oseltamivir in treating pediatric influenza (wind-heat invading the defense syndrome): a multicenter, randomized, non-... by Shengxuan Guo, Xinmin Li, Yuejie Zheng, Chengliang Zhong, Lei Xiong, Xi Ming, Ying Ding, Yongbin Yan, Baoqing Zhang, Peng Zhou, Zhou Fu, Jun Wang, Xuefeng Wang, Junhong Wang, Jinghua Yang, Yanxia Liu, Jianxin Cai, Lihua Ning, Xiaohong Liu, Hang Zhu, Linlin Gai, Pingding Liu, Dahong Sun, Taizhong Wang, Xiaojiao Li, Xinhua Tian, Junguang Zhang, Wenda Guan, Yupin Li, Xueming Li, Junfeng Liu, Nanyue Kuang, Ling Lu, Tongxun Gao, Haodong Liang, Kunling Shen, Rong Ma

“…BackgroundXiao’er Fengre Qing Oral Liquid (XFQOL) is developed based on the classical traditional Chinese medicinal formula Yinqiao Powder. …”
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Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT by CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson

“…People who had received active treatment were 65% less likely to develop ulcer bleeding in the first 2.5 years compared to those who had received placebos. …”
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Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…The model employed a lifetime horizon and was developed from the perspective of the National Health Service. …”
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