What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…We sent patients a questionnaire asking about their experiences of developing symptoms, seeking medical help and getting diagnosed. …”
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Baseline characteristics of patients with acute ischaemic stroke included in the randomised controlled Find-AF 2 trial by Katrin Wasser, Tobias Uhe, Wolf-Rüdiger Schäbitz, Martin Köhrmann, Martin Dichgans, Johannes Brachmann, Ulrich Laufs, Götz Gelbrich, David Petroff, Christiane Prettin, Dominik Michalski, Johann Pelz, Andrea Kraft, Thorleif Etgen, Hassan Soda, Florian Bethke, Peter D. Schellinger, Katharina Althaus, Gerhard F. Hamann, Martin Grond, Bernd Kallmünzer, Martina Petersen, Lars-Peder Pallesen, Michael Ertl, Philipp Zickler, Sven Poli, Karl Georg Haeusler, Thorsten Steiner, Paul Sparenberg, Pawel Kermer, Anna Kopczak, Lars Kellert, Martin Nückel, Jan Liman, Peter Arthur Ringleb, Meinhard Mende, Marcus Wagner, Deborah Bochert, Marlena Schnieder, Imke Amanzada, Sonja Gröschel, Marianne Hahn, Timo Uphaus, Klaus Gröschel, Rolf Wachter, on behalf of the Find-AF 2 study group

“…The objective of this analysis is to present baseline characteristics of the overall Find-AF 2 study population and stratified by low or high risk for developing AF. Methods The Find-AF 2 trial included acute ischaemic stroke patients ≥ 60 years of age within 30 days of ischaemic stroke of any cause. …”
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GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing by Ao Huang, De-Zhen Guo, Zhi-Xi Su, Yun-Shi Zhong, Liang Liu, Zhi-Guo Xiong, Dong-Li He, Bin Yan, Quan-Lin Li, Zhen Feng, Wen-Quan Wang, Pin-Xiang Lu, Meng-Jiang He, Zhi-Peng Qi, Qi Guo, Jian-Wen Cheng, Shi-Yu Zhang, Wei Guo, Qing Li, Guo-Yong Lin, Hui-Chuan Sun, Shuang-Jian Qiu, Qi-Ye He, Jia Fan, Ajay Goel, Rui Liu, Gang Jin, Xin-Rong Yang, Jian Zhou

“…To address this clinical need, we developed GutSeer, a blood-based assay combining DNA methylation and fragmentomics for multi-GI cancer detection. …”
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Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective coho... by Stefanie Aeschbacher, David Conen, Diederick E Grobbee, Raphael Twerenbold, Thomas Lung, Theo Rispens, Jakob Kjellberg, Lorenz Risch, Martin Risch, Marianna Mitratza, Harald Renz, Spiros Denaxas, Billy Franks, Diederick Grobbee, Martina Rothenbühler, Janneke Wijgert, Santiago Montes, Richard Dobson, Hans Reitsma, Christian Simon, Titia Leurink, Charisma Hehakaya, Patricia Bruijning, Kirsten Grossmann, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Daniel Leibovitz, Vladimir Kovacevic, Andjela Markovic, Paul Klaver, Timo B Brakenhoff, George S Downward, Ariel Dowling, Maureen Cronin, Brianna M Goodale, Brianna Goodale, Ornella Weideli, Regien Stokman, Hans Van Dijk, Eric Houtman, Jon Bouwman, Kay Hage, Lotte Smets, Marcel van Willigen, Maui Chodura, Niki de Vink, Tessa Heikamp, Timo Brakenhoff, Wendy van Scherpenzeel, Wout Aarts, Alison Kuchta, Antonella Chiucchiuini, Steve Emby, Annemarijn Douwes, George Downward, Nathalie Vigot, Pieter Stolk, Duco Veen, Daniel Oberski, Amos Folarin, Pablo Fernandez Medina, Eskild Fredslund

“…Based on a random split, the test set included 30% of participants and 70% were selected for the training set. The developed long short-term memory (LSTM) based recurrent neural network (RNN) algorithm had a recall (sensitivity) of 0.73 in the training set and 0.68 in the testing set when detecting COVID-19 up to 2 days prior to SO.Conclusion Wearable sensor technology can enable COVID-19 detection during the presymptomatic period. …”
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Patterns of Postablation Recurrence and Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation by Sitong Li, Jingrui Zhang, Song Zuo, Jue Wang, Yiwei Lai, Mingxiao Li, Zejun Yang, Zixu Zhao, Manlin Zhao, Lan Ren, Zhen Wang, Chao Jiang, Liu He, Xueyuan Guo, Xiaoxia Liu, Ribo Tang, Ning Zhou, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma

“…Conclusions Postablation PersAF recurrence was associated with significantly higher risks of cardiovascular death and thromboembolism, compared with paroxysmal AF recurrence and nonrecurrence, indicating the prognostic importance of recurrence patterns. Registration URL: www.chictr.org.cn/; unique identifier: ChiCTR‐OCH‐13003729.…”
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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder: a high-risk study in the Chinese population by Jing Wang, Tao Li, Yun Kwok Wing, Jihui Zhang, Jie Chen, Bin Zhang, Weidong Song, Chao Jiang, Jiyang Pan, Kun Zhang, Yaping Liu, Ngan Yin Chan, Hongliang Feng, Lulu Yang, Binbin Lei, Qunfeng Wang, Jessie Chi Ching Tsang, Joey W.Y. Chan, Kathleen Ries Merikangas

“…The findings of the specific age-related and stage-related developmental patterns of psychopathologies and circadian dysfunction in children and adolescent offspring of parents with bipolar disorder paved the way to develop specific and early clinical intervention and prevention strategies.Trial registration number NCT03656302.…”
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Global HPV vaccination programs and coverage rates: a systematic reviewResearch in context by Jingjing Han, Li Zhang, Yuqing Chen, Yuelun Zhang, Le Wang, Ruyu Cai, Minge Li, Yuxin Dai, Le Dang, Hongda Chen, Lan Zhu

“…Strategies to effectively enhance HPV vaccination coverage must be identified, developed, and implemented to address this gap. Funding: CAMS Innovation Fund for Medical Sciences (2021-I2M-1–004, 2023-I2M-3-019); National High Level Hospital Clinical Research Funding (2022-PUMCH-D-003); Supported by Sanming Project of Medicine in Shenzhen (SZSM202311011).…”
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Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations by Alejandro Álvarez‐Bustos, Helio José Coelho‐Junior, Riccardo Calvani, Leocadio Rodriguez‐Mañas, Matteo Tosato, Matteo Cesari, Antonio Cherubini, Alfonso J. Cruz‐Jentoft, Pálmi V. Jónsson, Fabrizia Lattanzio, Marcello Maggio, Regina Roller‐Wirnsberger, Ingrid Rýznarová, Annemie M. W. J. Schols, Cornel C. Sieber, Alan J. Sinclair, Anna Skalska, Timo Strandberg, Achille Tchalla, Eva Topinková, Bruno Vellas, Stephan vonHaehling, Francesco Landi, Emanuele Marzetti, for the SPRINTT consortium

“…Methods This is a secondary analysis of an evaluator blinded, randomised controlled trial, developed in 16 clinical sites across 11 European countries, from January 2016 to 31 October 2019. …”
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Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…Nevertheless, PGP provides opportunities for the paramedic profession to develop and evolve. Study registration This study is registered as ISRCTN56909665 https://doi.org/10.1186/ISRCTN56909665. …”
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A peer-support lifestyle intervention for preventing type 2 diabetes in India: A cluster-randomized controlled trial of the Kerala Diabetes Prevention Program. by Kavumpurathu R Thankappan, Thirunavukkarasu Sathish, Robyn J Tapp, Jonathan E Shaw, Mojtaba Lotfaliany, Rory Wolfe, Pilvikki Absetz, Elezebeth Mathews, Zahra Aziz, Emily D Williams, Edwin B Fisher, Paul Z Zimmet, Ajay Mahal, Sajitha Balachandran, Fabrizio D'Esposito, Priyanka Sajeev, Emma Thomas, Brian Oldenburg

“…After a median follow-up of 24 months, diabetes developed in 17.1% (79/463) of control participants and 14.9% (68/456) of intervention participants (relative risk [RR] 0.88, 95% CI 0.66-1.16, p = 0.36). …”
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Effectiveness of Kushal Maa, a group-based mhealth interactive education and social support intervention for maternal and neonatal health outcomes: study protocol for a multisite r... by Praveen Kumar, Lakshmi Gopalakrishnan, Nadia Diamond-Smith, Azaz Khan, Abhishek Singh, Rashmi Bagga, Alison M El Ayadi, Anant Bhan, Alka Ahuja, Pushpendra Singh, Mona Duggal, Jasmeet Kaur, Deepak Tugnawat, Tracy Lin, Sujata Saunik, Garima Singh Verma, Shailendrakumar Gujarathi, Dinesh Chandke, Shashi Kant Dhir, Supriya Dhakne-Palwe, Mrunal Patil, Sonam Kumar, Nitin Vasaikar, Laura Weil

“…To overcome these barriers and reduce women’s postpartum isolation, our international team of maternal and infant health clinicians and researchers developed and pilot-tested a culturally-tailored mobile interactive education and support group intervention, Kushal Maa (‘informed-mother’), confirming feasibility and acceptability and preliminary effectiveness. …”
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Characterization and utilization of an international neurofibromatosis web-based, patient-entered registry: An observational study. by Mindell Seidlin, Robert Holzman, Pamela Knight, Bruce Korf, Vanessa Rangel Miller, David Viskochil, Annette Bakker, Children’s Tumor Foundation

“…Statistical analyses were performed on data from a cohort of 4680 registrants (the number of registrants as of October 9, 2015) who met diagnostic criteria for one of the 3 NF conditions. …”
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PECTIN THERAPY IS A METHOD OF PREVENTION OF REPRODUCTIVE LOSSES ASSOCIATED WITH INTRAPLACENTARY ACCUMULATION OF RADIONUCLIDES by А. Живецька- Денисова, І. Воробйова, Н. Скрипченко, Л. Лозова, О. Шамаєва, Н. Рудакова, С. Стрижак

“…Conclusions. It is impossible to develop optimal measures for the treatment and prevention of miscarriage with universal effectiveness due to the multifactorial nature of pathology. …”
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Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experie... by Brett D. Thombs, Claire Adams, Elsa-Lynn Nassar, Marie-Eve Carrier, Meira Golberg, Kanika Bharthi, Amanda Wurz, Annabelle South, Linda Kwakkenbos, Sabrina Hoa, Danielle B. Rice, Geneviève Guillot, Amanda Lawrie-Jones, Maureen Sauvé, Susan J. Bartlett, Catherine Fortune, Amy Gietzen, Karen Gottesman, Marie Hudson, Laura K. Hummers, Vanessa L. Malcarne, Maureen D. Mayes, Michelle Richard, James Stempel, Robyn K. Wojeck, Kathleen Blagrave, Jill T. Boruff, Vanessa Cook, Nicole Culos-Reed, Ole Fröbert, Katie Gillies, Vera Granikov, Lars G. Hemkens, Elizabeth Yakes Jimenez, Agnes Kocher, Catarina Leite, Mathew A. W. T. Lim, Nancy Maltez, John Michalski, Tracy Mieszczak, Mwidimi Ndosi, Janet Pope, François Rannou, Ken Rozee, Sharon E. Straus, Matthew R. Sydes, Lehana Thabane, John Varga, Tami Yap, Merrick Zwarenstein, Luc Mouthon, Andrea Benedetti, SPIN Investigators

“…In each RCT, people with SSc and researchers will select a recent SSc research study to disseminate. Tools will be developed by experienced tool developers and people with SSc. …”
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Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoO... by Neal J Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook, James A Berkley, Bethou Adhisivam, Ramesh Agarwal, Nawshad Uddin Ahmed, Manica Balasegaram, Daynia Ballot, Adrie Bekker, Eitan Naaman Berezin, Davide Bilardi, Suppawat Boonkasidecha, Cristina G Carvalheiro, Neema Chami, Suman Chaurasia, Sara Chiurchiu, Viviane Rinaldi Favarin Colas, Simon Cousens, Tim R Cressey, Ana Carolina Dantas de Assis, Tran Minh Dien, Yijun Ding, Nguyen Trong Dung, Han Dong, Angela Dramowski, Madhusudhan Ds, Ajay Dudeja, Jinxing Feng, Youri Glupczynski, Srishti Goel, Herman Goossens, Doan Thi Huong Hao, Mahmudul Islam Khan, Tatiana Munera Huertas, Mohammad Shahidul Islam, Daniel Jarovsky, Nathalie Khavessian, Meera Khorana, Angeliki Kontou, Tomislav Kostyanev, Premsak Laoyookhon, Sorasak Lochindarat, Mattias Larsson, Maia De Luca, Surbhi Malhotra-Kumar, Nivedita Mondal, Nitu Mundhra, Philippa Musoke, Marisa M Mussi-Pinhata, Ruchi Nanavati, Firdose Nakwa, Sushma Nangia, Jolly Nankunda, Alessandra Nardone, Borna Nyaoke, Christina W Obiero, Maxensia Owor, Wang Ping, Kanchana Preedisripipat, Shamim Qazi, Lifeng Qi, Tanusha Ramdin, Amy Riddell, Lorenza Romani, Praewpan Roysuwan, Robin Saggers, Emmanuel Roilides, Samir K Saha, Kosmas Sarafidis, Valerie Tusubira, Reenu Thomas, Sithembiso Velaphi, Tuba Vilken, Xiaojiao Wang, Yajuan Wang, Yonghong Yang, Liu Zunjie, Sally Ellis, Julia A Bielicki, A Sarah Walker, Paul T Heath, Mike Sharland

“…We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future clinical trial design.…”
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A mixed methods study protocol for CONFIVAC, an intervention to enhance paediatric nurses' and paediatricians' skills to promote vaccination and vaccine confidence by Elisabet Henderson, Sara Valmayor, Victoria Porthé, Alba Asensio, Xavier Bruna, Usue Elizondo-Alzola, Anna Ramirez-Morros, Gemma Ricós, Josep Vidal-Alaball, M. Isabel Pasarín, Cristina Rius, Elena Roel, Elia Díez

“…Paediatric healthcare workers (PHCWs) are key in promoting vaccination but often feel unprepared to manage VH effectively. We developed CONFIVAC, an intervention designed to strengthen the knowledge, self-efficacy, and skills of PHCWs in improving childhood vaccination, addressing VH, and fostering a culture of immunization within primary care. …”
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Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol by Stuart B Hooper, Peter G Davis, Anup C Katheria, Venkataseshan Sundaram, Lisa Askie, Martin Kluckow, Shigeharu Hosono, Eugene Dempsey, Walid El-Naggar, William Tarnow-Mordi, Heike Rabe, Ronny Knol, Lelia Duley, Thomas Debray, Amir Kugelman, Kellie Murphy, Anna Lene Seidler, Kylie E Hunter, Michael Meyer, Catalina De Paco Matallana, John Kattwinkel, Judith Mercer, Justin Josephsen, Karen Fairchild, Ola Andersson, Vikram Datta, Graeme Polglase, Angie Barba, John Simes, Ava Grace Tan-Koay, Anu George, Anu Sachdeva, Arjan Te Pas, Ashish K C, Bimlesh Kumar, Carl Backes, Chamnan Tanprasertkul, Chayatat Ruangkit, G Ram Mohan, Gillian Gyte, Guillermo Carroli, Heidi Al-Wassia, Hytham Atia, Islam Nour, Jiangqin Liu, John Bauer, Kristy Robledo, Lakhbir Dhaliwal, Laura Perretta, Lin Ling, Manoj Varanattu, Maria Goya, Musa Silahli, Neelam Kler, Neil Finer, Omar Kamlin, Peter Giannone, Pharuhad Pongmee, Prisana Panichkul, Sandeep Kadam, Sangkae Chamnanvanakij, Shiraz Badurdeen, Simone Pratesi, Thomas Ranjit, Victor Lago Leal, Waldemar Carlo

“…Results will be relevant to clinicians, guideline developers and policy-makers, and will be disseminated via publications, presentations and media releases.Registration number Australian New Zealand Clinical Trials Registry (ANZCTR) (ACTRN12619001305112) and International Prospective Register of Systematic Reviews (PROSPERO, CRD42019136640).…”
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Cancer in English prisons: a mixed-methods study of diagnosis, treatment, care costs and patient and staff experiences by Elizabeth A Davies, Margreet Lüchtenborg, Rachael Maree Hunter, Renske Visser, Jennie Huynh, Ross Pow, Emma Plugge, Rachel M Taylor, Jo Armes

“…The four priorities developed and agreed at the Policy Lab event were giving clinical teams a better understanding of the prison system, co-ordinating and promoting national cancer screening programmes, developing ‘health champions’ in prison and raising health literacy and awareness of cancer symptoms among people in prison. …”
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Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT by F D Richard Hobbs, Richard McManus, Clare Taylor, Nicholas Jones, Joy Rahman, Jane Wolstenholme, Louise Jones, Jennifer Hirst, Sam Mort, Ly-Mee Yu

“…People with chronic kidney disease are at an increased risk of developing cardiovascular disease (heart disease and stroke), including heart failure and sudden cardiac death. …”
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Strengthening open disclosure in maternity services in the English NHS: the DISCERN realist evaluation study by Mary Adams, Natalie Sanford, Charlotte Bevan, Maria Booker, Julie Hartley, Alexander Heazell, Elsa Montgomery, Maureen Treadwell, Jane Sandall

“…Programme theories were developed with our PAG for testing during later SPs. …”
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