Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study... by Jose Viña, Chiara Milanese, Federico Schena, Anne McArdle, Malcolm J Jackson, Gabriele Di Sante, Cinzia Antognelli, Anna Pedrinolla, Masoud Isanejad, Desirée Bartolini, Consuelo Borras, Valentina Cavedon, Anna Migni, Cristina Mas-Bargues, Claudia Baschirotto, Roberto Modena, Alessandra Pistilli, Mario Rende, Anna Maria Stabile, Nicola Vincenzo Telesa, Sara Tortorella, Kay Hemmings, Eivind Wang, Massimo Venturelli, Francesco Galli

“…In the run-in phase, participants will be stabilised on a protein-rich diet (0.9–1.0 g protein/kg ideal body weight/day) and physical exercise programme (high-intensity interval training specifically developed for these subjects). Subsequently, they will be randomised into three groups (1:1:1). …”
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Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol by Nicola White, James D Chalmers, Salman Siddiqui, Paul H Lee, Cyrus Daneshvar, James Raftery, Charles Roberts, Philip Mitchelmore, Kerensa Thorne, Stefan J Marciniak, Tom Wilkinson, Angelica Cazaly, Gareth Griffiths, Neil J Greening, Anna Freeman, Alexander Allen, Andrew Cook, Karl J Staples, Tommaso Morelli, Jacqueline Nuttall, James Myerson, Olivia Cox, Emma Chamberlain, Tristan William Clark, Martha Purcell, Pedro Rodrigues, Matthew Pavitt, Michael G Crooks, Emma Tilt, Emma Knox, Monica Gil, Max Ellis, Ingrid Seath, Sandy Aitken, Barbara Costa, Sarah Dudley

“…The recent COVID-19 pandemic has underscored the urgent need for a deeper understanding of RVIs to improve patient outcomes and develop effective treatment strategies. The Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal Study is an observational study which addresses this need by investigating the heterogeneity of RVIs in hospitalised adults, aiming to identify clinical and biological predictors of adverse outcomes. …”
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Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analys... by Claudia Izquierdo Rodríguez, Cristina Cadenas-Sanchez, José L. Santos, Jonatan R. Ruiz, María Medrano, Vicente Martínez-Vizcaíno, Michael I. Goran, Idoia Labayen

“…Longitudinal studies are necessary to understand the temporal dynamics of these associations and to determine the long-term impact of intrapancreatic fat deposition on the risk of developing type 2 diabetes and cardiovascular diseases. …”
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Facilitators, barriers, and guidance to successful implementation of multidisciplinary transitional care interventions: A qualitative systematic review using the consolidated frame... by Romain Collet, Juul van Grootel, Marike van der Leeden, Marike van der Schaaf, Johanna van Dongen, Suzanne Wiertsema, Edwin Geleijn, Mel Major, Raymond Ostelo

“…Objective: To provide an overview of facilitators and barriers to implementing multidisciplinary transitional care interventions, which could be considered before developing implementation strategies. Design: A qualitative systematic review using the Consolidated Framework for Implementation Research. …”
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Glycaemic control in labour with diabetes: GILD, a scoping study by Nia Wyn Jones, Eleanor J Mitchell, Kate F Walker, Susan Ayers, Lucy Bradshaw, Georgina Constantinou, Tasso Gazis, Shalini Ojha, Phoebe Pallotti, Stavros Petrou, Rachel Plachcinski, Michael Rimmer, Liz Schroeder, Jim G Thornton, Natalie Wakefield

“…Most have gestational diabetes, which develops during pregnancy and disappears after birth, the rest have diabetes before pregnancy. …”
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The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies – Part II: Less researched... by Ken Karipidis, Dan Baaken, Tom Loney, Maria Blettner, Rohan Mate, Chris Brzozek, Mark Elwood, Clement Narh, Nicola Orsini, Martin Röösli, Marilia Silva Paulo, Susanna Lagorio

“…Then, the studies were classified into three tiers according to their overall potential for bias (low, moderate and high) in selected, predefined and relevant bias domains.Data synthesis: We synthesized the study results using random effects restricted maximum likelihood (REML) models.Evidence assessment: Confidence in evidence was assessed according to the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Results: We included 26 articles, which were published between 1988 and 2019, with participants from 10 countries, reporting on 143 different E-O pairs, including 65 different types of neoplasms. …”
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Deep phenotyping of patients with MASLD upon high-intensity interval training by Veera Houttu, Ulrika Boulund, Marian Troelstra, Susanne Csader, Daniela Stols-Gonçalves, Anne Linde Mak, Anne-Marieke van Dijk, Julia Bouts, Maaike Winkelmeijer, Xanthe Verdoes, Sandra van den Berg-Faay, Donne Lek, Ted Ronteltap, Ferdinand de Haan, Harald Jorstad, Ville Männistö, Kai Savonen, Heikki Pentikäinen, Kati Hanhineva, Ambrin Farizah Babu, Gianni Panagiotou, Otto van Delden, Joanne Verheij, Michial Doukas, Aart Nederveen, Ursula Schwab, Aldo Grefhorst, Max Nieuwdorp, Adriaan Georgius Holleboom

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HS-10375, a selective EGFR C797S tyrosine kinase inhibitor, in advanced non–small cell lung cancer by Jianhua Zhan, Jinhui Xue, Lin Wu, Zhiye Zhang, Qiming Wang, Yuxiang Ma, Yan Huang, Yunpeng Yang, Yuanyuan Zhao, Wenfeng Fang, Yang Zhang, Qianwen Liu, Wen Xu, Yan Yang, Zhenming Chen, Baili Song, Danni Sun, Xia Sun, Peng Gao, Hongyun Zhao, Li Zhang

“…Abstract Background The C797S mutation is one of the most common mechanisms of acquired resistance to third generation EGFR TKIs, yet no approved therapies have been available to target it. Here we developed a novel selective EGFR C797S inhibitor, HS-10375, and report the results of pre-clinical research and the first-in-human phase 1 trial. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…Methods for evaluation of impact also require further development to allow better understanding and comparison of different approaches. …”
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Rapid tests to inform triage and antibiotic prescribing decisions for adults presenting with suspected acute respiratory infection: a rapid evidence synthesis of clinical effective... by Katie Scandrett, Jill Colquitt, Rachel Court, Fiona Whiter, Bethany Shinkins, Yemisi Takwoingi, Emma Loveman, Daniel Todkill, Paramjit Gill, Daniel Lasserson, Lena Al-Khudairy, Amy Grove, Yen-Fu Chen

“…Assessment of certainty of evidence The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to evaluate the certainty of evidence for the key outcomes of 7- or 28-day mortality, escalation of care and hospital admission. …”
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Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data by Qunying Fang, Zonghui Qiao, Lei Luo, Shun Bai, Min Chen, Xiangjun Zhang, Lu Zong, Xian-hong Tong, Li-min Wu

“…Summary answer A model was developed to predict RIF. The model showed high calibration in external validation, helped to identify risk factors for RIF, and improved the efficacy of ART therapy. …”
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Optimizing a Personalized Health Approach for Virtually Treating High-Risk Caregivers of Children With Neurogenetic Conditions (Project WellCAST): Protocol for a Randomized Control... by Bridgette Kelleher, Kaleb Emerson, Lyndsey N Graham, Veronika Vozka, Anne Wheeler, William Fadel, Daniel Foti, Isha Metzger, Mandy Rispoli, Wendy Machalicek, Laurie McLay, Sean Lane, Wei Siong Neo, Allie Carter, Lisa Brown, Jennifer Brown, Laura Lee McIntyre, Elizabeth Salwitz, Gloria Dietz, Riley Naughton, Katlyn Peek, Nicole Hollins, Emma Woodford

“…A subset of caregivers will participate as waitlist controls before engaging in support programs. We developed and optimized a personalized health decision tree algorithm that matches caregivers to telehealth support programs. …”
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Advancing the implementation of quality-assured oncological exercise therapy in Germany: protocol for the IMPLEMENT project by Mirko Brandes, Anika Berling-Ernst, Hansjoerg Baurecht, Wiebke Jensen, Miriam Götte, Anne Herrmann, Daniela Fuhr, Heike Schmidt, Antonia Lucas, Bernardine Madl, Simon Elmers, Thorsten Schmidt, Christine Welker, Andre Golla, Annalena Wehner, Dominik Morlok, Jana Rueter, Janina Meuer, Melanie Reitz, Jane Kersten, Rebecca Zimmer, Yvonne Gadczikowske, Renee Stark, Kathrin Hegenberg, Michael Laxy, Martin Halle, Patrick Jahn, Carsten Bokemeyer, Sebastian Theurich, Hajo Zeeb, Michael Leitzmann, Freerk T. Baumann, on behalf of the IMPLEMENT consortium

“…Based on these findings, a set of implementation strategies (IPS) will be developed, implemented, and evaluated to facilitate the delivery of qOET for cancer patients. …”
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Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO) by Raphaël Leman, François Cherifi, Marianne Leheurteur, Pierrick Theret, Camille Pasquesoone, Mathilde Saint-Ghislain, Lucie Bresson, Christophe Denoyelle, Nicolas Vigneron, Laurent Poulain, Raphaël Delepee, Benoit Berby, Julie Dremaux, Aurélie Dumont, Cécile Blanc-Fournier, Corinne Jeanne, Mélanie Briand, Nathalie Rousseau, Louis-Ferdinand Pepin, Elodie Deruche, Fabienne Dumont, Alexandra Leconte, Justine Lequesne, Bénédicte Clarisse, Florence Joly, Laurent Castera, Roman Rouzier

“…To fulfil these challenges, our laboratory has recently developed a HRD test named GIScar (Genomic Instability Scar). …”
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Optimisation of the deployment of automated external defibrillators in public places in England by Terry P Brown, Lazaros Andronis, Asmaa El-Banna, Benjamin KH Leung, Theodoros Arvanitis, Charles Deakin, Aloysius N Siriwardena, John Long, Gareth Clegg, Steven Brooks, Timothy CY Chan, Steve Irving, Louise Walker, Craig Mortimer, Sandra Igbodo, Gavin D Perkins

“…A de novo decision-analytic model was developed for the cost-effectiveness analysis and used as a vehicle for assessing the costs and benefits (in terms of quality-adjusted life-years) of deployment strategies. …”
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Prevalence of targetable genomic alterations among a diverse population participating in the ASCO TAPUR Study by Pam K. Mangat, M. Kelsey Kirkwood, Dominique C. Hinshaw, Elizabeth Garrett-Mayer, Richard L. Schilsky

“…We assessed 978 gene alterations or other biomarkers across sex, age, race, ethnicity, BMI category, smoking status, Eastern Cooperative Oncology Group performance status, and cancer type in 3448 registrants. We report a higher prevalence of genomic targets of FDA-approved therapies for various cancers, including PDGRFA in Hispanic versus non-Hispanic registrants and JAK2 in Asian versus White registrants. …”
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A data management system for precision medicine. by John J L Jacobs, Inés Beekers, Inge Verkouter, Levi B Richards, Alexandra Vegelien, Lizan D Bloemsma, Vera A M C Bongaerts, Jacqueline Cloos, Frederik Erkens, Patrycja Gradowska, Simon Hort, Michael Hudecek, Manel Juan, Anke H Maitland-van der Zee, Sergio Navarro-Velázquez, Lok Lam Ngai, Qasim A Rafiq, Carmen Sanges, Jesse Tettero, Hendrikus J A van Os, Rimke C Vos, Yolanda de Wit, Steven van Dijk

“…LogiqSuite is used for multi-centre research study data registrations and monitoring, data analytics in interdisciplinary consortia, design of new machine learning / artificial intelligence (AI) algorithms, development of new or updated prediction models, integration of care with advanced therapy production, and real-world data monitoring in using CDS tools. …”
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Numerical simulations in astrophysics:Supernovae explosions, magnetorotational model and neutrino emission by G. S. Bisnovatyi-Kogan

“…The first one is based on development of convective instability, and more effective heating of the outer layers by a neutrino flux.…”
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Physician group practice in China's healthcare reform: a national survey on physicians' perspectives and implementation challenges by Rui Fan, Qing Meng, Long Zhang, Chao Liu, Li Han, Meng Liu, Leiyu Shi

“…Data analysis included descriptive statistics and variance analyses to explore correlations between physicians’ characteristics and their perspectives.ResultsKey facilitators for PG development included “New career direction outside the existing system” (75.1%) and “Improved income levels” (74.4%). …”
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The use of “Acellbia” – a biosimilar of rituximab in systemic sclerosis by L. P. Ananyeva, L. A. Garzanova, O. V. Desinova, R. U. Shayakhmetova, M. N. Starovoytova, O. A. Koneva, O. B. Ovsyannikova, S. I. Glukhova, E. L. Nasonov

“…One patient developed calf vein thrombosis and lung cancer was diagnosed in one case.Conclusion. …”
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