Reference equations for pulmonary function testing in healthy Chinese children aged 4–18 years by Jinhong Wu, Hao Zhang, Yufen Wu, Qiaoling Zhang, Ming Li, Fuli Dai, Changfu Xu, Yongsheng Shi, Ning Wang, ChunMei Jia, Sha Liu, Yuehua Zhang, Zhongping Zhang, Aihong Liu, Fei Wang, Li Liu, Qiang Chen, Jinrong Wang, Yuling Han, Yuxin Song, Yong Feng, Yun Sun, Huaping Rao, Lili zhong, Quanhua Liu, Liya Wan, Zhen Long, Xiaoyan Dong, Yanli Zhang, Wenhui Jiang, Minghong Ji, Jianfeng Huang, Zhiwei Pan, Dongjun Ma, Suping Tang

“…New prediction equations were developed using multiple linear regression models with age, height, and weight as predictors. …”
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Clinical predictors of flare and drug-free remission in rheumatoid arthritis: preliminary results from the prospective BIO-FLARE experimental medicine study by Iain B McInnes, Stefan Siebert, Arthur Pratt, Andrew Filer, Karim Raza, Wan-Fai Ng, Christopher D Buckley, Dawn Teare, Andrew Melville, Amy Anderson, Andrew McGucken, Bernard Dyke, Catharien M U Hilkens, John Isaacs, Kenneth F Baker, Mohadeseh Shojaei Shahrokhabadi, Shaun Hiu, Theophile Bigirumurame, Carl Goodyear, Fiona Rayner, Sean Kerrigan, Jonathan Prichard

“…Here, we present the clinical outcomes and predictors of drug-free remission and flare, and develop a prediction model to estimate flare risk.Design, setting and participants BIO-FLARE was a multicentre, prospective, single-arm, open-label experimental medicine study conducted across seven National Health Service Trusts in the UK. …”
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Study design and procedures for a hybrid effectiveness-implementation incomplete stepped-wedge cluster-randomized trial to evaluate a differentiated point-of-care HIV diagnosis and... by Michael E. Herce, Caitlin Cassidy, Alexandra Munson, Jessie K. Edwards, Sarah E. Rutstein, Mitch Matoga, Chimwemwe Kumwenda, Katherine R. Simon, Joep J. van Oosterhout, Carrie M. Cox, Funny Kamanga, Wiza Kumwenda, Sam Phiri, Ethel Rambiki, Agness Thawani, Jacqueline Huwa, Bridget Malewezi, Tisu Mvalo, Agatha Bula, Lameck Chinula, Irving Hoffman, Madeleine A. Squibb, Rose K. Nyirenda, Friday Saidi, Mina C. Hosseinipour, Maganizo B. Chagomerana

“…To reach PBFW living with HIV and their infants who miss critical HIV services and who are at higher risk for adverse HIV outcomes, including vertical transmission, we developed the “Point-of-care Active Case finding & Management” or “PAC-Man” model. …”
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Exploring the acceptability, appropriateness, feasibility and satisfaction of an implementation strategy for out-of-HOspital administration of the Long-Acting combination of cabote... by Jordi Puig, Vicenç Falcó, Cristina Miranda, Francis Ruiz, Julián Olalla, Àngel Rivero, Patricia Álvarez-Lopez, Eugenia Negredo, Diana Hernández-Sánchez, Javier Jusmet, Miguel Ángel Cuerda Palomo, Ana Belén Flores de la Cruz, José Manuel Pavón, Nadia Llavero, David Campany, Vicente Faus, Claudia Broto-Cortés, Lucía Bailón, Dámaris Aguilar, David Rovira

“…If the outcome is deemed positive, we will also develop and propose policy guidelines for the integration of the administration of CAB+RPV LA in alternative outpatient facilities into the standard of care in the HIV care pathway.Trial registration number NCT06185452/EUCT number: 2023-503963-41-00.…”
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Evaluating an intervention to promote access to mental healthcare for low language proficient migrants and refugees across Europe (MentalHealth4All): study protocol for a pretest–p... by Fang Wang, Mike Mösko, Demi Krystallidou, Yuhui Chen, Liza G G van Lent, Saskia Hanft-Robert, Ilaria Galasso, Barbara Schouten, Antoon Cox, Sona Hodakova, Chiara Rao, Koen Kerremans, Raquel Lázaro Gutiérrez, Özlem Temizöz, Dalia Mankauskienė, Łucja Biel, Emilio Di Maria, Julia van Weert, Melanie de Looper, Gian Hernandez, Gaukhar Orkashbayeva, Tobias Kleineidam, Angeliki Tsoukaneli, Mehmet Uygun, Ily Hollebeke, Beatrice Bünsch, Leon Köchel, Mia Mengtong Li, Mara Morelli, Stefania Muzi, Cecilia Serena Pace, Carlotta Gualco, Nijolė Maskaliūnienė, Katarzyna Czarnocka-Gołębiewska, Urszula Okulska-Łukawska, Argnieszka Biernacka, Aleksandra Kalata-Zawłocka, Agnieszka Słopień, Natalia Pytlińska, Monika Šavelová, Andrej Birčák, Daniela Müglová, Carmen Valero Garcés, Carmen Pena Díaz, Elena Alcalde Peñalver, Cristina Álvaro Aranda, Silvia Damianova Radeva, Sabine Braun, Jaleh Delfani, Graham Hieke, Elena Davitti, Constantin Orasan, Lieven Buysse

“…As part of the MentalHealth4All project, a digital multilingual communication and information platform was developed to promote access to mental healthcare for LLP migrants and refugees across Europe. …”
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Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-m... by Luiza Grycuk, Dina Monssen, Molly R. Davies, Helen Sharpe, Karina L. Allen, Vibhore Prasad, Rachel Potterton, Priya Popat, Victoria A. Mountford, Sheryllin McNeil, Vanessa Lawrence, Nina Grant, Kimberley A. Goldsmith, Danielle Glennon, Sarah Byford, Amy Brown, Ulrike Schmidt

“…An important focus of early intervention is shortening the time between a person first developing symptoms and starting treatment (duration of untreated eating disorder; DUED). …”
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Clinical course, causes of worsening, and outcomes of severe ischemic stroke: A prospective multicenter cohort study by Simiao Wu, Yanan Wang, Ruozhen Yuan, Meng Liu, Xing Hua, Linrui Huang, Fuqiang Guo, Dongdong Yang, Zuoxiao Li, Bihua Wu, Chun Wang, Jingfeng Duan, Tianjin Ling, Hao Zhang, Shihong Zhang, Bo Wu, Cairong Zhu, Craig S. Anderson, Ming Liu, Ting Gao

“…Reperfusion reduced the risk of clinical worsening and improved functional outcomes. Registration:. ClinicalTrials.gov, NCT03222024.…”
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Public health engagement in alcohol licensing in England and Scotland: the ExILEnS mixed-method, natural experiment evaluation by Niamh Fitzgerald, Matt Egan, Rachel O’Donnell, James Nicholls, Laura Mahon, Frank de Vocht, Cheryl McQuire, Colin Angus, Richard Purves, Madeleine Henney, Andrea Mohan, Nason Maani, Niamh Shortt, Linda Bauld

“…Using structured interviews (n = 66), documentation analysis, and expert consultation, we developed and applied the Public Health Engagement In Alcohol Licensing (PHIAL) measure to quantify six-monthly activity levels from 2012 to 2019. …”
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Nationwide implementation of the international multidisciplinary best-practice for locally advanced pancreatic cancer (PREOPANC-4): study protocol by T. F. Stoop, L. W. F. Seelen, F. R. van ’t Land, A. C. van der Hout, J. C. M. Scheepens, M. Ali, A. M. Stiggelbout, B. M. van der Kolk, B. A. Bonsing, D. J. Lips, D. J. A. de Groot, E. van Veldhuisen, E. D. Kerver, E. R. Manusama, F. Daams, G. Kazemier, G. A. Cirkel, G. van Tienhoven, G. A. Patijn, H. N. Lelieveld-Rier, I. H. de Hingh, I. E. G. van Hellemond, J. H. Wijsman, J. I. Erdmann, J. S. D. Mieog, J. de Vos-Geelen, J. W. B. de Groot, K. R. D. Lutchman, L. J. Mekenkamp, L. W. Kranenburg, L. P. M. Beuk, M. W. Nijkamp, M. den Dulk, M. B. Polée, M. Y. V. Homs, M. L. Wumkes, M. W. J. Stommel, O. R. Busch, R. F. de Wilde, R. T. Theijse, S. A. C. Luelmo, S. Festen, T. L. Bollen, U. P. Neumann, V. E. de Meijer, W. A. Draaisma, B. Groot Koerkamp, I. Q. Molenaar, C. L. Wolfgang, M. Del Chiaro, M. G. H. Katz, T. Hackert, J. A. C. Rietjens, J. W. Wilmink, H. C. van Santvoort, C. H. J. van Eijck, M. G. Besselink, for the Dutch Pancreatic Cancer Group

“…In qualitative interviews, treatment preferences, values, and experiences of LAPC patients, their relatives, and healthcare professionals will be assessed for the development of shared decision-making supportive tools. …”
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Culture-sensitive lifestyle intervention tailored to non-Western migrant older adults improves physical performance: A randomized controlled trial by Esmée J.M. Biersteker, Jantine van den Helder, Nannette van der Spek, Mieke Holwerda, Hinke Kruizenga, Peter J.M. Weijs, Michael Tieland

“…The aim of this study was to assess the effects of a newly developed culture-sensitive lifestyle intervention on physical performance in non-Western Surinamese older adults. …”
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Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial [version 1; peer review: 1 approved, 2 approved with reservatio... by Angela McBride, Huynh Thi Le Duyen, Nguyen Thanh Phong, Truong Ngoc Trung, Sophie Yacoub, Ronald Geskus, Tran Bang Huyen, Evelyne Kestelyn, Dang Trong Thuan, Nguyen Thi My Linh, Tran Thi Dong Vien, Nguyen Thi Cam Huong, Phan Vinh Tho, Nguyen Minh Nguyet, Vo Thi My Hoa, Nguyen Lam Vuong, Phan Tu Qui, Dong Thi Hoai Tam, James Watson, Huynh Trung Trieu

“…This trial will assess the safety and efficacy of anakinra in patients with severe dengue or at high risk of developing life-threatening dengue disease. Registration ClinicalTrials.gov (NCT05611710).…”
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Dendritic cells pulsed with multifunctional Wilms’ tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in... by Machi Suka, Hiroyuki Yanagisawa, Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Shin Kan, Tuuse Bito, Takeyuki Misawa, Zensho Ito, Kan Uchiyama, Shintaro Tsukinaga, Toshifumi Ohkusa, Haruo Sugiyama

“…Background We aimed to develop a chemoimmunotherapy regimen consisting of a novel Wilms’ tumor 1 (WT1) peptide-pulsed dendritic cell (WT1-DC) vaccine and multiagent chemotherapy and to investigate the safety, clinical outcomes, and WT1-specific immune responses of patients with unresectable advanced pancreatic ductal adenocarcinoma (UR-PDAC) who received this treatment.Methods Patients with UR-PDAC with stage III disease (locally advanced (LA-PDAC; n=6)), stage IV disease (metastatic (M-PDAC; n=3)), or recurrent disease after surgery (n=1) were enrolled in this phase I study. …”
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Efficacy of a Personalized Mobile Health Intervention (BedTime) to Increase Sleep Duration Among Short-Sleeping Patients With Type 2 Diabetes: Protocol for a Pilot Randomized Contr... by Yuki Ban, Kayo Waki, Ryohei Nakada, Akihiro Isogawa, Kengo Miyoshi, Hironori Waki, Shunsuke Kato, Hideaki Sawaki, Takashi Murata, Yushi Hirota, Shuichiro Saito, Seiji Nishikage, Atsuhito Tone, Mayumi Seno, Masao Toyoda, Shinichi Kajino, Kazuki Yokota, Yuya Tsurutani, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe

“…The sleep extension intervention, BedTime, is developed using the Theory of Planned Behavior (TPB) and focuses on TPB’s constructs of perceived and actual behavioral control (ABC). …”
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Fertility, time to pregnancy, and pregnancy outcomes among women with recurrent miscarriages in the UK: a prospective observational longitudinal studyResearch in context by Constandina Koki, Rebecca Shields, Rebecca Sweetman, James Boyle, Omar Khan, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis, Adam J. Devall, Nigel John Burroughs, Siobhan Quenby

“…Methods: We used real-world data from a UK longitudinal study of 1201 couples attending National Health Service (NHS) miscarriage clinics, with a history of previous miscarriages, comprising medical and obstetric history, results of investigations and pregnancy and neonatal outcome. We developed, parametrised, and validated predictive models for the probability that the next pregnancy is viable and for the time to next pregnancy. …”
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Mitochondrial DNA Polymorphisms of Peripheral Blood Mononuclear Cells Associated with Sustained Ventricular Tachycardia in Patients with Cardioverter-Defibrillator Implantation Ind... by Tariel Atabekov, Viacheslav Korepanov, Sergey Krivolapov, Mikhail Khlynin, Sergey Afanasiev, Maria Golubenko, Roman Batalov, Sergey Popov

“…Based on our data, we developed a risk model for SVT. …”
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Arm Based on LEg blood pressures (ABLE-BP): can systolic ankle blood pressure measurements predict systolic arm blood pressure? An individual participant data meta-analysis from th... by Una Martin, Luigi Ferrucci, James White, Fiona C Warren, Kate Boddy, Matthew Allison, Raimund Erbel, Victor Aboyans, Jan Westerink, James Peter Sheppard, Sinead T J McDonagh, Leon Farmer, Helen Shore, Phil Williams, Philip S Lewis, Michael Criqui, Carlos Lahoz, Maëlenn Guerchet, Mary McDermott, Mark Espeland, Marie Dahl, Angela Shore, Rafel Ramos Blanes, Christopher Elles Clark, Jackie Price, A Jayne Fordham

“…Objectives To determine associations between arm and ankle systolic blood pressures (SBPs), develop and validate a multivariable model predicting arm SBP from ankle SBP, and investigate associations between ankle SBP, cardiovascular disease and mortality.Design Ankle-arm SBP differences were examined in two-stage individual participant data (IPD) meta-analyses using multivariable hierarchical linear regression models. …”
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Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease by Wen Hu, Ziyu Liu, Weinan Yu, Surong Wen, Xiaoqing Wang, Xing Qi, Hairong Hao, Yanwen Lu, Jing Li, Shayan Li, Hongwen Zhou

“…The incidences of CVD and non-alcoholic fatty liver disease (NAFLD) in subjects with rs1440581 CC genotype were higher than in those with TT genotype; the incidence of CVD in subjects with rs7678928 TT genotype was higher than in those with CC (p < .05) genotype.Conclusions Allele C of PPM1K rs1440581 was associated with elevated serum Val, total BCAAs and CVD risks. rs1440581 CC genotype may be a better marker than baseline serum BCAAs in predicting the risk for CVD.Trial registration Diabetes Prevention Programme in Huai’an of Huai’an Second People's Hospital, ChiCTR-TRC-14005029.KEY MESSAGEAllele C of PPM1K rs1440581 was relevant to elevated serum Val and total BCAAs.PPM1K rs1440581 CC and rs7678928 TT genotypes were associated with CVD risk.PPM1K rs1440581 CC genotype carriers were more likely to have liver injury and develop NAFLD.…”
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Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and ma... by Leanne J Robinson, Rahel Wampfler, Inoni Betuela, Stephan Karl, Michael T White, Connie S N Li Wai Suen, Natalie E Hofmann, Benson Kinboro, Andreea Waltmann, Jessica Brewster, Lina Lorry, Nandao Tarongka, Lornah Samol, Mariabeth Silkey, Quique Bassat, Peter M Siba, Louis Schofield, Ingrid Felger, Ivo Mueller

“…A basic stochastic transmission model was developed to estimate the potential effect of mass drug administration (MDA) for the prevention of recurrent P. vivax infections. …”
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High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study. by Lynn T Matthews, Esther C Atukunda, Moran Owembabazi, Kato Paul Kalyebera, Christina Psaros, Pooja Chitneni, Craig W Hendrix, Mark A Marzinke, Peter L Anderson, Oluwaseyi O Isehunwa, Kathleen E Hurwitz, Kara Bennett, Winnie Muyindike, David R Bangsberg, Jessica E Haberer, Jeanne M Marrazzo, Mwebesa Bosco Bwana

“…Pre-exposure prophylaxis (PrEP) reduces HIV acquisition for women and, therefore, infants. We developed the Healthy Families-PrEP intervention to support PrEP use as part of HIV prevention during periconception and pregnancy periods. …”
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Metabolomic Profiling of the Blood of Patients with Chronic Consciousness Disorders by A. A. Orlova, E. A. Kondrat'eva, Ya. A. Dubrovskii, N. V. Dryagina, E. V. Verbitskaya, S. A. Kondratev, A. A. Kostareva, A. N. Kondratev

“…The main variants of chronic consciousness disorder (CCD) developing in adverse coma outcome are vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimal consciousness state (MCS).   …”
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