The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial by Cale A. Jacobs, Morgan H. Jones, Jamie E. Collins, Lily M. Waddell, Xiaojuan Li, Carl S. Winalski, Brian Pietrosimone, Virginia Byers Kraus, Miguel Otero, Elizabeth Wellsandt, Laura C. Schmitt, Kurt P. Spindler, Donald D. Anderson, Scott A. Rodeo, Robert A. Magnussen, Brian R. Wolf, Joe M. Hart, Austin V. Stone, Caitlin E. Conley, Yvonne M. Golightly, Gregory D. Myer, Lynn Snyder-Mackler, Martin K. Lotz, Jason S. Kim, Michelle M. McLeod, Janet L. Huebner, Caroline Lisee, Faith Selzer, Jeffrey N. Katz, Kyna Long, Kelly C. Frier, Daniel J. Betensky, David T. Felson, Elena Losina

“…Results: Our multidisciplinary team developed the methods and statistical analysis plan for a placebo controlled, randomized clinical trial to determine whether metformin alters pain and early osteoarthritic changes after ACLR. …”
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Prevalence of post-acute sequelae of SARS-CoV-2 infection in people living with HIV: a systematic review with meta-analysisResearch in context by Dimitra V. Pouliopoulou, Nicole Billias, Joy C. MacDermid, Erin Miller, Kelly K. O'Brien, Kieran L. Quinn, Monali S. Malvankar-Mehta, Tiago V. Pereira, Angela M. Cheung, Fahad Razak, Saverio Stranges, Pavlos Bobos

“…Summary: Background: Given the chronic immune activation and inflammatory milieu associated with Long COVID and HIV, we assessed the prevalence of Long COVID in adults living with HIV; and investigated whether adults living with HIV were associated with increased chance of developing Long COVID compared to adults living without HIV Methods: In this systematic review and meta-analysis, we searched Medline, EMBASE, CINHAL, PubMed and CENTRAL from inception until June 14th, 2024, for observational studies that measured the prevalence of Long COVID in adults living with HIV and the odds of developing Long COVID following a SARS-CoV-2 infection in people living with HIV compared to people living without HIV. …”
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Concordance and agreement between different activity scores in polymyalgia rheumatica by Bruno Fautrel, Eric Toussirot, Renaud Felten, Emmanuel Nowak, Christophe Richez, Jacques-Eric Gottenberg, Isabelle Chary-Valckenaere, Alain Saraux, Aleth Perdriger, Emanuelle Dernis, Thierry Marhadour, Marie-Elise Truchetet, Divi Cornec, Valérie Devauchelle-Pensec, Daniel Wendling, Guillaume Direz, Anne Lohse, Laurent Chiche, PASCAL HILLIQUIN, Guillermo Carvajal Alegria, Dewi Guellec, Justine D'Agostino, Aghiles Souki, Catherine Le Henaff, Benjamin Dervieux

“…Objective The C reactive protein polymyalgia rheumatica activity score (CRP-PMR-AS) is a composite index that includes CRP levels and was developed specifically for PMR. As treatments such as interleukin-6 antagonists can normalise CRP levels, the erythrocyte sedimentation rate (ESR) of PMR-AS, the clinical (clin)-PMR-AS and the imputed-CRP (imp-CRP)-PMR-AS have been developed to avoid such bias. …”
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Refining and optimising a behavioural intervention to support endocrine therapy adherence (ROSETA) in UK women with breast cancer: protocol for a pilot fractional factorial trial by Samuel G Smith, David P French, Galina Velikova, Amanda Farrin, Robbie Foy, Nikki Rousseau, Daniel Howdon, Jane Clark, Michelle Collinson, Christopher D Graham, Rebecca Walwyn, Emma McNaught, Ellen Mason, Sophie M C Green, Rachel Ellison, Louise H Hall, Hollie Wilkes, Erin Raine, Jacqueline Buxton, Sally J L Moore, Catherine Parbutt

“…There are multiple barriers to AET adherence, including medication side-effects, beliefs about medication, memory and psychological distress. We developed four intervention components, each targeting a different barrier. …”
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Prognostic Significance of Nutritional Scores in Patients With Heart Failure: Insights From the PARAGON‐HF Trial by Henri Lu, Brian L. Claggett, Masatoshi Minamisawa, John W. Ostrominski, Alberto Foà, Maria A. Pabón, Arzu Kalayci, Muthiah Vaduganathan, Maja Cikes, Amil M. Shah, Akshay S. Desai, John J. V. McMurray, Pardeep S. Jhund, Milton Packer, Martin Lefkowitz, Jean L. Rouleau, Michael R. Zile, Faiez Zannad, Sheila M. Hegde, Scott D. Solomon, Hicham Skali

“…Among the remaining 3675 patients, 1405 (38.2%) developed at least 1 abnormal score over a median follow‐up of 2.9 years. …”
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Psychotherapies for adults with complex presentations of PTSD: a clinical guideline and five systematic reviews with meta-analyses by Ole Jakob Storebø, Sophie Juul, Stephen Fitzgerald Austin, Maria Quistgaard, Julie Perrine Schaug, Lise Møller, Nina Reinholt, Dyveke Bové Illum, Frida Lau Græbe, Line Bang Mikkelsen, Nina Nørrelykke Paulsen, Adrian Maria Tremel Porsing, Oliver Rumle Hovmand, Mie Sedoc Jørgensen, Ida-Marie Terese Pereira Arendt, Magnus Tang Kristensen, Sidsel Christine Buskbjerg Døssing, Bent Rosenbaum, Nicole Gremaud Rosenberg, Sidse Marie Arnfred

“…Objective To develop a clinician-guided, research-based guideline for adult outpatient psychotherapy for complex presentations of post-traumatic stress disorder (PTSD).Methods We used state-of-the-art methods to develop clinical guideline recommendations and conduct systematic reviews with meta-analyses for five research questions: (Q1) When treating adults with PTSD, should trauma-focused psychotherapy include exposure? …”
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Multidisciplinary Delphi consensus on challenges and key factors for an optimal care model in chronic kidney disease by José Luis Górriz, Roberto Alcázar Arroyo, Patricia Arribas, Sara Artola, Sergio Cinza-Sanjurjo, Rafael de la Espriella, Javier Escalada, Lisardo García-Matarín, Luis Martínez, Juan Carlos Julián, José Pablo Miramontes-González, Félix Rubial, Mercedes Salgueira, María José Soler, José Luis Trillo

“…Results: 38 key factors were identified for an optimal CKD patient care model, organised into four challenges: (1) Development of CKD management models and increased visibility of the disease, (2) Prevention, optimisation of screening, early diagnosis and registration of CKD at all levels of care, (3) Comprehensive, multidisciplinary and coordinated monitoring, ensuring therapeutic optimisation and continuity of care, and (4) Reinforcement of CKD training for health care professionals and patients. 35 key factors were assessed by the panel as adequate and clearly necessary, and of these, 14 were considered highly imperative. …”
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HIV risk perception, trust and PrEP adherence among participants in an HIV prevention trial: a qualitative longitudinal study, South Africa by Giuseppe Pantaleo, Glenda Gray, Pontiano Kaleebu, Said Aboud, David Dunn, Merlin Robb, Janet Seeley, Sheena McCormack, Julie Fox, Jim Rooney, Tom Miller, Agricola Joachim, Ilesh Jani, Mary Amondi, Peter Hughes, Sarah Joseph, Eugene Ruzagira, Vincent Basajja, Jonathan Weber, Cherry Kingsley, Eligius Lyamuya, Lucas Maganga, Doreen Pamba, Edna Viegas, Charlotta Nilsson, Arne Kroidl, Angela Crook, Anne Gumbe, Phindile Khanyile, Jennifer Serwanga, Carter Lee, Kundai Chinyenze, Song Ding, Muhammad Bakari, Neetha Morar, Ayoub Kakande, Tumaini Nagu, Henry Bern, Sylvia Kusemererwa, Patricia Munseri, Lwitiho Sudi, Jorge Ribeiro, Igor Capitine, Diana Faini, Edna Nhacule, Kubashni Woeber, Yolanda Manganhe, Abisai Kisinda, Wiston William, Rujeko Samanthia Chimukuche, Londiwe Shandu, Silindile Zulu, Nishanta Singh, Zakir Gaffoor, Rachel Kawuma, Thandiwe Sithole, Samantha Siva, Eldinah Hwengwere, Rujeko Samanthia Chidawanyika, Nteboheleng Mahapa, Isabel Remane, Odete Bule, Patricia Ramgi, Raquel Chissumba, Eduardo Namalango, Carmelia Massingue, Emmanuel Kapesa, Elizabeth Danstan, Marco Missanga, Amani Kway, Lilian Njovu, Revocatus Kunambi, Frank Msafiri, Edith Tarimo, Deus Buma, Freddie Mukasa Kibengo, Christian Hansen Holmes, Sheila Kansiime, Sylvia Masawi, Tobias Vudriko, Shamim Nabukenya, Gertrude Mutonyi, Rita Nakiboneka, Susan Mugaba, Aminata Sy, Liz Brodnicki, Claire Wenden, Jacqueline Musau, Mabela Matsoso, Paramesh Chetty, Gustavo Doncel, Allison Matthews

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Bufei huoxue capsules in the management of convalescent COVID‐19 infection: study protocol for a multicenter, double‐blind, and randomized controlled trial by Yuqin Chen, Wenjun He, Wenju Lu, Yue Xing, Jianling Bai, Hao Yu, Jiawei Zhou, Jingyi Liang, Jiyuan Chen, Chi Hou, Bihua Zhong, Ting Wang, Huazhuo Feng, Xu Chen, Tao Wang, Kai Yang, Nuofu Zhang, Nanshan Zhong, Chunli Liu, Jian Wang

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School-level prediction and management of myopia in children and adolescents by Shengsong Xu, Linling Li, Yingting Zhu, Zhenbang Ruan, Yiwen Qu, Zhuandi Zhou, Yin Hu, Zhidong Li, Fei Hou, Xiaohua Zhuo, Yunxia Leng, Xuelin Huang, Yamei Lu, Zhirong Wang, Shuifeng Deng, Yehong Zhuo, Guoming Zhang, Min Fu, Xiao Yang

“…Finally, user-friendly software was developed, which makes this model accessible for school use. …”
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Swarm learning network for privacy-preserving and collaborative deep learning assisted diagnosis of fracture: a multi-center diagnostic study by Yi Xie, Yi Xie, Xinmeng Wang, Huiwen Yang, Huiwen Yang, Jiayao Zhang, Honglin Wang, Zineng Yan, Jiaming Yang, Zhiyuan Yan, Zhiwei Hao, Pengran Liu, Yijie Kuang, Zhewei Ye, Zhewei Ye

“…However, no prior studies have specifically developed distributed learning models for fracture recognition due to challenges in multi-institutional data harmonization. …”
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Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

“…Background Despite apparently curative treatment, many patients with colorectal cancer develop subsequent metastatic disease. Current prognostic models are criticised because they are based on standard staging and omit novel biomarkers. …”
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Clinical evaluation of adults undergoing elective surgery utilizing intraoperative incisional wound irrigation (CLEAN Wound): protocol for a randomised controlled trial by Nick Daneman, Dean A Fergusson, David Gomez, Ahmed Kayssi, Erin Lillie, Stephanie A Mason, Jad Abou Khalil, Avery B Nathens, Megan Delisle, Kelly Vogt, David E Smith, John C Marshall, George Tomlinson, Grace Ma, Sameer S Apte, Sean Bennett, Andrew J Smith, Paul Jack Karanicolas, Rachel Roke, Melanie Tsang, Pablo E. Serrano, Karim Shiraz Ladha, Erin Kennedy, Yidi Jiang, Jonah Shiroky, Sudarshani Puran, Brian Pinchuk, Tyler Lamb, Kenneth Leslie, Dorotea Mutabdzic, Shahnoor M Ullah, Jessica Holland, Michael Calderone, Judith Herriott, Ed Voltan, Barbara Sloan, Hala Muaddi, C. David Mazer, Mary-Anne Aarts

“…Introduction In moderate to high-risk surgical procedures, 15–25% of patients develop a postoperative surgical site infection. Intraoperative incisional wound irrigation has the potential to reduce surgical site infections, and additional randomised controlled trials are required to provide evidence of effectiveness.Methods and analysis This protocol describes a pragmatic, adaptive, participant and adjudicator-blinded trial at 13 sites in Canada in up to 2500 participants. …”
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Robust COVID-19 Vaccine Responses Despite Filarial Co-Infection: Insights from a Lymphatic Filariasis Cohort in Ghana by Julia Meyer, Jennifer Nadal, Linda Batsa Debrah, Alexander Yaw Debrah, Jubin Osei-Mensah, Derrick Adu Mensah, Patricia Jebett Korir, Janina M. Kuehlwein, Ute Klarmann-Schulz, Achim Hoerauf, Tomabu Adjobimey

“…All vaccinated participants received the COVID-19 vaccine ChAdOx1-S (also known as Vaxzevria) developed by the University of Oxford and AstraZenca. …”
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Lymphatic mapping Of Oropharyngeal Cancer (LOOC): protocol for a phase II surgical imaging trial to evaluate contralateral drainage and occult metastasis in oropharyngeal cancer by David Walker, Gareth Ambler, Chris Brew-Graves, Jason Fleming, Vinidh Paleri, Richard Shaw, Mark McGurk, Enyi Ofo, Clare Schilling, Karl Payne, Simon Wan, Alex Weller, Gopinath Gnanasegaran, Mandeep Bajwa

“…An imaging substudy (n=20) aims to develop a secondary imaging protocol in the event of <94% sensitivity of intraoperative fhSPECT. …”
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Exploring the association of erythrocytic NO-ferroheme, a surrogate marker of endothelial function with perioperative cardiovascular events in low/intermediate risk patients underg... by Hasnae Boughaleb, Jerome Linden, Arvind Soni, Nathalie Fabian, Irina Lobysheva, Virginie Montiel, Mona Momeni, Marie-Agnès Docquier, Annie Robert, Nancy Van Overstraeten, Jean-Luc Balligand

“…Among the 1,066 patients kept for the final analysis, 23 subjects developed a peri-operative CVE up to 30 days after surgery (p-30d CVE). …”
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A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership by Elizabeth M. Norman, Mildred Ortu Kowalski, Roxanne Sabatini, Carol S. Jones, Wendy Silverstein

“…Effective leadership and the camaraderie that developed among the nurses and other staff sustained them during this time. …”
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Modeling of the"thin" structure probability discrepancy distribution in the indications of ADS-B and SSR. Uncompensated latency by I. V. Alipov, V. L. Kuznetsov

“…The article analyzes the stable features of discrepancy distribution (histograms) probability obtained in the "Air Navigation Research and Development Institute" branch of GosNII GA by analyzing the observations of aircraft operations in Moscow region. …”
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Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses by Ruiqi Ma, Qian Cheng, Jing Yao, Zhiyu Peng, Mingxu Yan, Jie Lu, Jingjing Liao, Lejin Tian, Wenjun Shu, Yunqiu Zhang, Jinghan Wang, Pengfei Jiang, Weiyi Xia, Xiaofeng Li, Lu Gan, Yue Zhao, Jiang Zhu, Bing Qin, Qin Jiang, Xiawei Wang, Xintong Lin, Haifeng Chen, Weifang Zhu, Dehui Xiang, Baoqing Nie, Jingtao Wang, Jie Guo, Kang Xue, Hongguang Cui, Jinwei Cheng, Xiangjia Zhu, Jiaxu Hong, Fei Shi, Rui Zhang, Xinjian Chen, Chen Zhao

“…Abstract Chatbot-based multimodal AI holds promise for collecting medical histories and diagnosing ophthalmic diseases using textual and imaging data. This study developed and evaluated the ChatGPT-powered Intelligent Ophthalmic Multimodal Interactive Diagnostic System (IOMIDS) to enable patient self-diagnosis and self-triage. …”
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Novel uses of healthcare technology for individuals with mild to moderate hip or knee osteoarthritis: The technology, exercise and activity prescription for enhanced mobility (TEAM... by Jane Thornton, Kristen I. Barton, Laura Churchill, Jenna M. Schulz, Dianne Bryant, Ashley Ambrose, Harvi F. Hart, Daryl Stephenson, Guangyong Zou, Susana Correa, Steven J. MacDonald, Ryan Degen, Merrick Zwarenstein, Alan Getgood

“…Objectives: Patient education, physical activity, and exercise are recommended as first-line treatments for mild to moderate hip and knee osteoarthritis (OA). We developed two novel healthcare interventions: an electronic medical record-embedded physical activity prescription tool (PARx) for physicians, and a free, online educational platform (Joint Management (JM)) with exercise programming and optional telerehabilitation with a physiotherapist for patients. …”
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