Modulating verticality representation and uprightness by virtual reality: rationale and protocol for a within-person randomised intervention associating a basic study in healthy in... by Dominic Perennou, Eugénie Lhommée, Aurélien Hugues, Stéphanie Dehem, Celine Piscicelli, Remi Gimat, Shenhao Dai, Adélaïde Marquer

“…After hemisphere stroke, lateropulsion is caused by an impaired internal representation of verticality, for which developing rehabilitation techniques has become a priority. …”
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Acute High Dose Melatonin for Encephalopathy of the Newborn (ACUMEN) Study: a protocol for a multicentre phase 1 safety trial of melatonin to augment therapeutic hypothermia for mo... by Neil Marlow, Adrienne Foran, Deirdre M Murray, Eleanor J Molloy, James P Boardman, Atul Malhotra, Geraldine Boylan, Subhabrata Mitra, Nicola J Robertson, Karel Allegaert, Suzanne L Miller, Anne Smits, Frances Cowan, Joseph F Standing, Giles Kendall, Rodney W Hunt, Hakim-Moulay Dehbi, Julie-Clare Becher, Linda De Vries, Divyen Shah, Alyson MacNeil, Anvi Wadke, Raymand Pang, Yusuf Jaami, Pamela Tranter, Ajit K Mahaveer, Kathryn A Martinello, Balamurugan Palanisami, Brian Walsh

“…Pharmacokinetic (PK) data suggest it is necessary to reach melatonin levels of 15–30 mg/L within 6–8 hours of hypoxia-ischaemia for brain protection. We developed a novel Good Manufacturing Practice (GMP) grade melatonin in ethanol 50 mg/mL solution for intravenous use. …”
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The Effectiveness of Digital Animation–Based Multistage Education for Patients With Atrial Fibrillation Catheter Ablation: Randomized Clinical Trial by Xiaoyu Shi, Yijun Wang, Yuhong Wang, Jun Wang, Chen Peng, Siyi Cheng, Lingpeng Song, Rui Li, Fuding Guo, Zeyan Li, Shoupeng Duan, Xiaomeng Yang, Liping Zhou, Hong Jiang, Lilei Yu

“…ObjectiveThis study aimed to develop a novel digital animation-based multistage education system and evaluate its quality-of-life benefits for patients with AFCA. …”
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Lessons Learned About the Education Needs of Kidney Transplant Recipients: A Mixed-Method Study by Michelle L. Gabriel, Lucy Chen, Sharon Lee, Jenny Accettura, Emily E. Campbell, Melanie Dissanayake, Teresa J. Valenzano-Hacker, Michelle Nash, Lindita Rapi, Niki Dacouris, Weiqiu Yuan, Tiffany Thai

“…Patients revealed that their support system helps to develop self-reliance and support their transition after transplant to allow them to recover and manage challenges after transplant. …”
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Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis. by Elaine W Butterly, Peter Hanlon, Anoop S V Shah, Laurie J Hannigan, Emma McIntosh, Jim Lewsey, Sarah H Wild, Bruce Guthrie, Frances S Mair, David M Kent, Sofia Dias, Nicky J Welton, David A McAllister

“…Therefore, clinicians and guideline developers are uncertain about the applicability of trial findings to people with multimorbidity. …”
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Effectiveness of an Innovative Mobile-Based Perioperative Care Program for Women Undergoing Breast Cancer Surgery (iCareBreast): Randomized Controlled Trial by Yan Pang, Honggu He, Ruey-Pyng Ng, Nicole Kim Luan Lee, Me Me Win Htein, Xiao-Xin Zhao, Ying-Hong Li, Elizabeth Jiahui Chan, Lixia Zhu, Guang Yu Liu, Minna Pikkarainen, Swee-Ho Lim

“…ObjectiveThis study aimed to develop and evaluate the effectiveness of an innovative, mobile-based, perioperative care program for women undergoing breast cancer surgery (iCareBreast). …”
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Information Mode–Dependent Success Rates of Obtaining German Medical Informatics Initiative–Compliant Broad Consent in the Emergency Department: Single-Center Prospective Observati... by Felix Patricius Hans, Jan Kleinekort, Melanie Boerries, Alexandra Nieters, Gerhard Kindle, Micha Rautenberg, Laura Bühler, Gerda Weiser, Michael Clemens Röttger, Carolin Neufischer, Matthias Kühn, Julius Wehrle, Anna Slagman, Antje Fischer-Rosinsky, Larissa Eienbröker, Frank Hanses, Gisbert Wilhelm Teepe, Hans-Jörg Busch, Leo Benning

“… BackgroundThe broad consent (BC) developed by the German Medical Informatics Initiative is a pivotal national strategy for obtaining patient consent to use routinely collected data from electronic health records, insurance companies, contact information, and biomaterials for research. …”
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Effect of Probiotic Supplementation on Maternal Depression, Anxiety and Attachment in Gestational Diabetes by Improving Mediterranean Diet Quality: A Randomized Controlled Trial by Fatma Bengü Kuyulu Bozdoğan, Seray Kabaran, Aybala Tazeoğlu

“…Evidence shows that women with gestational diabetes (GDM) are at higher risk of developing depression during pregnancy. Despite extensive research carried out by the probiotic industry in recent years, there is a lack of consensus on the available evidence on how best to use probiotics in mental health. …”
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Accuracy of a 2-minute eye-tracking assessment to differentiate young children with and without autism by Kristelle Hudry, Lacey Chetcuti, Diana Weiting Tan, Alena Clark, Alexandra Aulich, Catherine A. Bent, Cherie C. Green, Jodie Smith, Kathryn Fordyce, Masaru Ninomiya, Atsushi Saito, Shuji Hakoshima, Andrew J. O. Whitehouse

“…Industry employees who developed the final Algorithm were non-blinded to child group, and considered only gaze fixation durations. …”
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A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial by Jessica Booth, Kathryn A Birnie, Kelsey Chomistek, Maria Santana, Jennifer N Stinson, Babatope O Adebiyi, Julia Brooks, Jaime Guzman, Robin Hellweg, Lily SH Lim, Dax Rumsey, Brian M Feldman, Jamie Tagseth, Jennifer Wilson, Heinrike Schmeling

“… BackgroundNeeds assessments in patients with juvenile idiopathic arthritis (JIA) have revealed a need for disease information, self-management skills, and peer support. We previously developed and tested the acceptability of an in-person and videoconference-based self-management program (SMP) to address these needs. …”
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Regional Blood Flow Spectral Parameters as Predictors of Epidural-Related Maternal Fever: A Prospective Observational Study by Fei Shuai, Junxiang Jia, Peng Lin, Yicong Liao, Yuemei Xie

“…Thirteen participants (17.8%) in the study developed ERMF. PSV was significantly higher in the febrile group than the non-febrile group at 10 min after ELA (p < 0.05). …”
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A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protoc... by Amy A Herrold, Alexandra L Aaronson, Dulal Bhaumik, Timothy Durazzo, Sherri L Livengood, Alma Ramic, Patrick Riordan, Neil Jordan, Todd Parrish, Trudy Mallinson, Ibuola O Kale, Andrea Billups, Kelly Krese, Sandra Kletzel, Noah S Philip, Theresa L Bender Pape

“…A 6-year research plan timeline was developed, including cost and no-cost extensions due to the COVID-19 pandemic. …”
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Effect of propofol combined with remimazolam besylate on blood pressure during general anesthesia induction in patients undergoing gynecological laparoscopic surgery: single-centre... by Xinmin Zhao, Haigen Xu, Shuping Wang, Yuanyuan Chen, Shuyu Yue

“…A total of 30 patients in the three groups developed hypotension after anesthesia induction, among which the incidence of PIH induced in group P was 31.6% (18/57), the incidence of PIH induced in group PR was 14.3% (8/56), and the incidence of PIH induced group R 7.1% (4/56), and there was a statistical difference in the incidence of PIH between the three groups (χ2 = 12.24, p = 0.0022). …”
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Experiences Receiving and Delivering Virtual Health Care For Women: Qualitative Evidence Synthesis by Karen M Goldstein, Sharron Rushton, Allison A Lewinski, Abigail Shapiro, Tiera Lanford-Davey, Jessica N Coleman, Neetu Chawla, Dhara B Patel, Katherine Van Loon, Megan Shepherd-Banigan, Catherine Sims, Sarah Cantrell, Susan Alton Dailey, Jennifer M Gierisch

“…Our eligibility criteria were developed using the Sample, Phenomenon of Interest, Design, Evaluation, Research type tool to identify qualitative studies addressing synchronous virtual care for women. …”
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Implementing a structured model for osteoarthritis care in primary healthcare: A stepped-wedge cluster-randomised trial. by Nina Østerås, Tuva Moseng, Leti van Bodegom-Vos, Krysia Dziedzic, Ibrahim Mdala, Bård Natvig, Jan Harald Røtterud, Unni-Berit Schjervheim, Thea Vliet Vlieland, Øyvor Andreassen, Jorun Nystuen Hansen, Kåre Birger Hagen

“…<h4>Background</h4>To improve quality of care for patients with hip and knee osteoarthritis (OA), a structured model for integrated OA care was developed based on international recommendations. The objective of this study was to assess the effectiveness of this model in primary care.…”
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Coronary Computed Tomographic Angiography to Optimize the Diagnostic Yield of Invasive Angiography for Low-Risk Patients Screened With Artificial Intelligence: Protocol for the Car... by Jeremy Petch, Juan Pablo Tabja Bortesi, Tej Sheth, Madhu Natarajan, Natalia Pinilla-Echeverri, Shuang Di, Shrikant I Bangdiwala, Karen Mosleh, Omar Ibrahim, Kevin R Bainey, Julian Dobranowski, Maria P Becerra, Katie Sonier, Jon-David Schwalm

“…The AI-based decision support tool was developed using referral information from over 37,000 patients and uses a light gradient boosting machine model to predict the probability of obstructive CAD based on 42 clinically relevant predictors, including patient referral information, demographic characteristics, risk factors, and medical history. …”
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Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese by Chang Lu, Dongmei Cheng, Yunqiu Xie, Minghong Shang, Rongzhen Chen, Yongqiang Zhu, Jian Gong, Huan Zhou

“…FHND9041 is a new irreversible EGFR T790M mutation-selective small molecule kinase inhibitor, a third-generation EGFR inhibitor developed by Nanjing Chuangte Pharmaceutical Technology Co., Ltd. …”
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Clinical signs of possible serious infection and associated mortality among young infants presenting at first-level health facilities. by Yasir Bin Nisar, Antoinette Tshefu, Adrien Lokangaka Longombe, Fabian Esamai, Irene Marete, Adejumoke Idowu Ayede, Ebunoluwa A Adejuyigbe, Robinson D Wammanda, Shamim Ahmad Qazi, Rajiv Bahl

“…New treatment strategies that consider differential mortality risks for the place of treatment and duration of inpatient treatment could be developed and evaluated based on these findings.<h4>Clinical trial registration</h4>This trial was registered with the Australian New Zealand Clinical Trials Registry under ID ACTRN 12610000286044.…”
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An Interdisciplinary Ecosystem for the Prevention of Cardiotoxicity in Older Patients With Breast Cancer: Protocol for a Prospective and Multicentric Study by Gaia Giulia Angela Sacco, Ketti Mazzocco, Anastasia Constantinidou, Andri Papakonstantinou, Davide Mauri, Grigorios Kalliatakis, Manolis Tsiknakis, Domen Ribnikar, Dorothea Tsekoura, Valantis Aidarinis, Kalliopi Keramida, Panagiotis Oikonomopoulos, Athos Antoniades, Cameron Brown, Federica Rizzi, Anca Bucur, Elsa Pacella, Georgia Karanasiou, Daniela Cardinale, Carlo Cipolla, Elisabetta Munzone, Dimitrios Fotiadis, Giuseppe Curigliano, Gabriella Pravettoni

“…Due to age-related factors and the presence of comorbidities, these patients are particularly vulnerable to developing cardiac toxicity associated with cancer treatments, which may lead to suboptimal interventions and undertreatment, resulting in poorer health outcomes, quality of life (QoL) deterioration, and increased health care costs. …”
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Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies by Kelsey Fehr, Kelsey Fehr, Andrew Mertens, Chi-Hung Shu, Trenton Dailey-Chwalibóg, Trenton Dailey-Chwalibóg, Liat Shenhav, Liat Shenhav, Liat Shenhav, Lindsay H. Allen, Lindsay H. Allen, Megan R. Beggs, Megan R. Beggs, Lars Bode, Lars Bode, Rishma Chooniedass, Mark D. DeBoer, Lishi Deng, Camilo Espinosa, Camilo Espinosa, Camilo Espinosa, Daniela Hampel, Daniela Hampel, April Jahual, April Jahual, Fyezah Jehan, Mohit Jain, Patrick Kolsteren, Puja Kawle, Kim A. Lagerborg, Melissa B. Manus, Melissa B. Manus, Melissa B. Manus, Samson Mataraso, Samson Mataraso, Samson Mataraso, Joann M. McDermid, Ameer Muhammad, Payam Peymani, Payam Peymani, Martin Pham, Martin Pham, Setareh Shahab-Ferdows, Yasir Shafiq, Yasir Shafiq, Yasir Shafiq, Vishak Subramoney, Daniel Sunko, Daniel Sunko, Laeticia Celine Toe, Laeticia Celine Toe, Stuart E. Turvey, Lei Xue, Natalie Rodriguez, Natalie Rodriguez, Alan Hubbard, Nima Aghaeepour, Nima Aghaeepour, Nima Aghaeepour, Meghan B. Azad, Meghan B. Azad

“…IntroductionHuman milk (HM) contains a multitude of nutritive and nonnutritive bioactive compounds that support infant growth, immunity and development, yet its complex composition remains poorly understood. …”
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