Predicting Disease Progression in Inoperable Localized NSCLC Patients Using ctDNA Machine Learning Model by Yuqi Wu, Canjun Li, Yin Yang, Tao Zhang, Jianyang Wang, Wanxiangfu Tang, Ningyou Li, Hua Bao, Xin Wang, Nan Bi

“…Conclusion In conclusion, we developed a cfDNA neomer profiling assay for predicting disease progression in inoperable NSCLC patients. …”
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Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD): An RCT of Memory Bias Modification Training vs. Cognitive Control Training vs. Atte... by N. Ikani, A. Tyborowska, N. Kohn, N. Günther, G J. Siegle, A. H. Schene, J. A. S. Vorstman, C. J. Harmer, M. J. Kas, J. N. Vrijsen, H. G. Ruhé

“…Methods Here we describe the protocol for the Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD) study, aiming to investigate different forms of cognitive training programs administered via smartphones, in order to develop a second-generation recurrence prevention program. …”
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Pharmacy Integrated Transitions (PIT) trial: a protocol for a pragmatic cluster-randomised crossover trial by Elizabeth Austin, Catherine Kim, Elizabeth J Austin, Giana H Davidson, Bryan A Comstock, Sarah E Monsell, Bryan Comstock, Mariam N Hantouli, Jocelyn Chaing, Arzu Ahmed Dervish, Nick J Gionet, Shalynn Howard, Nathalia Jimenez, Miriam Liberman, Edwin G Lindo, Zachary A Marcum, Thuan D Ong, Elina Serrano, Katherine Simons, Lydia S Sun, Oleg Zaslavsky

“…Current protocols often fail to ensure effective medication management and communication between hospital and SNF teams. Developed with input from multiple interest holders, the Pharmacy Integrated Transitions (PIT) programme enhances these transitions by improving medication safety and communication. …”
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Leg Muscle Volume, Intramuscular Fat and Force Generation: Insights From a Computer‐Vision Model and Fat‐Water MRI by Andrew C. Smith, Javier Muñoz Laguna, Eddo O. Wesselink, Zachary E. Scott, Hazel Jenkins, Wesley A. Thornton, Marie Wasielewski, Jordan Connor, Scott Delp, Akshay S. Chaudhari, Todd B. Parrish, Sean Mackey, James M. Elliott, Kenneth A. Weber II

“…Decreases in lower limb muscle volume and increased intramuscular fat (IMF) are common findings in people with impaired mobility. We developed an automated method to extract markers of leg muscle health, muscle volume and IMF, from MRI. …”
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A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…To address this, we developed a mechanism-based anti-aggression psychotherapy (MAAP) for the group setting that specifically targets the biobehavioral mechanisms underlying outward-directed aggression in BPD. …”
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Effects of Physical Exercise on Executive Function in Schizophrenia: Systematic Review and Meta-Analysis by Nuria Pérez-Romero, Christian Campos-Jara, Caterina Pesce, Sergio Araya Sierralta, Enrique Cerda-Vega, Rodrigo Ramirez-Campillo, Rodrigo Campos-Jara, Cristian Martínez-Salazar, Cristián Arellano-Roco, Victoria Hernández-Cifuentes, Falonn Contreras-Osorio

“…Understanding the impact of physical exercise on these cognitive domains is essential for developing effective interventions. The aim of this review is to assess the effect of physical exercise on executive functions in adults diagnosed with schizophrenia spectrum disorders. …”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…The current study: (1) developed a TES tailored for Primary Care patients with depression and/or anxiety, and (2) conducted a pilot randomized controlled trial to assess the efficacy of the TES compared to a digital psychoeducation control app. …”
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Protocol for #iBeatCRC: a community-based intervention to increase early-onset colorectal cancer awareness using a sequential explanatory mixed-methods approach by Mary A De Vera, Charles R Rogers, Tiana N Rogers, Fares Qeadan, Margaret A Handley, Karen Curtin, Ellen Brooks, Ethan Petersen, Phuong Gallagher, Curt Pesmen, Wenora Johnson, Candace Henley, Walter Hickman, Elaine Newcomb, Kevin M Korous

“…Final intervention-specific data will be available on reasonable request from the corresponding author.Trial registration number NCT04715074.…”
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Cost-effectiveness analysis of proactive home visits compared with site-based community health worker care on antenatal care outcomes in Mali: a cluster-randomised trial by Osondu Ogbuoji, Caroline Whidden, Emily Treleaven, Youssouf Keita, Kassoum Kayentao, Ari Johnson, Jenny X Liu, Minahil Shahid, Mohamed Berthé, Armand Zimmerman, David Charles Boettiger, Coumba Traoré, Mahamadou Sogoba, Saibou Doumbia, Amadou Beydi Cissé

“…However, despite the success of CHW programmes in various countries, WHO has called for additional research to develop evidence-based models that optimise CHW service delivery and that can be replicated across geographies.Methods The ProCCM Trial was a cluster-randomised controlled trial to compare proactive home visits by CHWs (intervention, 69 village clusters) to the provision of CHW care at community fixed sites only (control, 68 village clusters) in the Bankass health district in Central Mali. …”
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Human papillomavirus vaccine uptake and its determinants among women in Africa: an umbrella review by Berihun Agegn Mengistie, Amlaku Nigusie Yirsaw, Gebeyehu Lakew, Gebrehiwot Berie Mekonnen, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Gemeda Wakgari Kitil, Wubet Tazeb Wondie, Alemken Eyayu Abuhay, Eyob Getachew

“…Although HPV vaccination is the most effective form of primary prevention against cervical cancer, the accessibility and uptake of the HPV vaccine remain low in developing nations, particularly in Africa. Therefore, this umbrella review aimed to determine the pooled prevalence of human papillomavirus vaccine uptake and its determinant factors in Africa.MethodsThe protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under reference number CRD42024560032. …”
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Maximising Embedded Pharmacists in AGed CAre Medication Advisory Committees (MEGA-MAC): protocol for implementing Australia’s new guiding principles for medication management in re... by Amanda J. Cross, Brooke Blakeley, Kate Laver, Terry P. Haines, Sarah N. Hilmer, Atish Manek, Alexandra Bennett, Angelita Martini, Lyntara Quirke, Mary Ann Kulh, Sara L. Whittaker, Dayna R. Cenin, Anthony Hobbs, Joanne Money, Karina Rieniets, Kris Salisbury, Alene Sze Jing Yong, J. Simon Bell

“…The intervention will involve knowledge broker dyads (pharmacist plus a MAC representative [e.g. nurse]) developing, implementing and evaluating RACF-specific local action plans to implement the Guiding Principles in up to 15 RACFs. …”
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Advancing access to substance use prevention for foster youth through digital innovation: an open trial of fostrspace with court appointed special advocate programs by Marina Tolou-Shams, Johanna B. Folk, Margareth V. Del Cid, Jannet Lara Salas, Alison Czopp, Juan Carlos Gonzalez, Tylia Lundberg, Erin Michelle Turner Kerrison, Martha Shumway, Ann Wrixon, Robert Salgado, Jill Duerr Berrick

“…A concurrent 6-session ECHO® substance use prevention telementoring curriculum was co-developed as a FostrSpace implementation strategy with a 6-member CASA Advisory Board. …”
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GRACE: protocol for a UK, secondary care, multicentre, assessor-blinded randomised controlled trial with a non-inferiority comparison to evaluate graduated compression stockings as... by John Norrie, Rebecca Lawton, Jonathan L Rees, Joseph Shalhoub, Beverley J Hunt, Zaed Hamady, Maria Kyrgiou, Tom Pinkney, Andrew D Beggs, Tamara Everington, Linda Williams, Simon Toh, Francine Heatley, Alun Davies, Matthew Machin, Nick Watkin, Sasha Smith, Sara Jasionowska, Alexander Liddle, Layla Bolton Saghdaoui

“…Patients undergoing surgery are at increased risk of developing VTE within hospital admission and 90 days after hospital discharge are collectively known as hospital-acquired thrombosis (HAT). …”
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Automatic failure mode evaluation using non-linear phase contrast correction to improve flow measurement accuracy in cardiovascular magnetic resonance phase contrast imaging by Ana Beatriz Solana, Savine C.S. Minderhoud, Piotr A. Wielopolski, Juan Antonio Hernandez-Tamames, Ricardo P.J. Budde, Willem A. Helbing, Martin A. Janich, Alexander Hirsch

“…Here, we validate a recently developed non-linear phase contrast correction (nPCcor) algorithm that includes automatic failure mode classification in a large single-vendor multi-scanner retrospective study. …”
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Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed... by Heather K. O’Grady, Kathy Smith, Sandra Dalziel, Barbara Dolanjski, Gyan Sandhu, Marlene Santos, Jackie Bosch, Lyn S. Turkstra, Srinivas Murthy, John C. Marshall, Michelle E. Kho, for the Canadian Critical Care Trials Group

“…Integration: Results from Phase 1 were used to develop a final consent infographic. Phase 2: Sixty-three patients were eligible for REMAP-CAP during the study period; 21 were eligible (33%) for the SWAT. …”
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Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial by Céline Fernandez, Marion Cremoni, Laurent Bailly, Kevin Zorzi, Vesna Brglez, Barbara Seitz-Polski, Maxime Teisseyre, Alexandre Destere, Sylvain Benito

“…Underdosing of rituximab is associated with treatment failure. We have previously developed a machine learning algorithm to predict the risk of underdosing. …”
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Understanding the potential factors affecting carers’ mental health during end-of-life home care: a meta synthesis of the research literature by Gunn Grande, Tracey Shield, Kerin Bayliss, Christine Rowland, Jackie Flynn, Penny Bee, Alexander Hodkinson, Maria Panagioti, Morag Farquhar, Danielle Harris, and Alison Wearden

“…Understanding what factors may affect carers’ mental health is important in developing strategies to maintain mental health, through identifying carers at risk who may need added monitoring and support or developing interventions to change modifiable factors. …”
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Evaluating a mobile-based short virtual course on family planning for frontline health workers in India by Farhad Ali, Gelsey Bennett, S. Vijay Paulraj, Sanjay Kumar Paswan, Vir Narayan, Adam Wills

“…The method for this descriptive study is divided into two broad categories: (i) course development, promotion, and rollout processes, and (ii) course evaluation. …”
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Nab-paclitaxel plus cisplatin versus gemcitabine plus cisplatin as first-line treatment in advanced biliary tract cancer: results of a multicentre, randomised, phase II trial by Xiao Yang, Yu-Hong Dai, Hui Peng, Ming-Sheng Zhang, Qiang Fu, Shun-Fang Liu, Li Sun, Yan-Mei Zou, Hai-Sheng Xu, Ping Qiu, Hong Qiu, Qiao Huang, Heng-hui Cheng, Liang Zhuang

“…Methods Patients with unresectable advanced-stage tumors, or those who have developed recurrence or metastasis following initial radical surgery, between January 2021 and November 2022 were included. …”
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Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental... by Kaeley M. Simpson, Robert J. W. McHardy, J. Grace Zhou, Sydney Levasseur-Puhach, Cynthia M. Côté, Millie Braun, Fiona Clement, Anna L. MacKinnon, Nathan Nickel, Tracie O. Afifi, Gerald F. Giesbrecht, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Terry P. Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M. Hensel, James M. Bolton, Jo Ann M. Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E. Roos

“…In response, we developed the Building Emotional Awareness and Mental Health (BEAM) program, an innovative mobile health (mHealth) solution for parents of young children. …”
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