Evaluating the Effectiveness of a Roblox Video Game (Super U Story) in Improving Body Image Among Children and Adolescents in the United States: Randomized Controlled Trial by Nicole Paraskeva, Sharon Haywood, Jason Anquandah, Paul White, Mahira Budhraja, Phillippa C Diedrichs, Heidi Williamson

“… BackgroundBody dissatisfaction is a global public health issue negatively impacting young people’s mental and physical well-being, underscoring an urgent need to develop early interventions. Emerging evidence suggests that microinterventions are acceptable and effective in delivering mental health interventions. …”
Get full text

Culturally Adapted Guided Internet-Based Cognitive Behavioral Therapy for Hong Kong People With Depressive Symptoms: Randomized Controlled Trial by Jia-Yan Pan, Jonas Rafi

“…MethodsAn 11-week guided iCBT program, “Confront and Navigate Depression Online” (CANDO), consisting of 8 online modules, was developed and implemented for Hong Kong residents. …”
Get full text

Adjuvant dendritic cell-based immunotherapy in melanoma: insights into immune cell dynamics and clinical evidence from a phase II trial by Jenny Bulgarelli, Claudia Piccinini, Emanuela Scarpi, Giorgia Gentili, Laura Renzi, Silvia Carloni, Francesco Limarzi, Elena Pancisi, Anna Maria Granato, Massimiliano Petrini, Francesco De Rosa, Massimo Guidoboni, Dalila Fanelli, Maria Maddalena Tumedei, Marcella Tazzari, Stefano Baravelli, Ilaria Bronico, Pietro Cortesi, Sara Pignatta, Laura Capelli, Valentina Ancarani, Giovanni Foschi, Livia Turci, Francesca Tauceri, Massimo Framarini, Laura Ridolfi

“…Trial registration ClinicalTrials.gov NCT02718391; EudraCT no. 2014-005123-27.…”
Get full text

Risk factors for contrast-induced acute kidney injury (CI-AKI): protocol for systematic review and meta-analysis by Yan Liang, Yong Liu, Ning Tan, Jiyan Chen, Xingcheng Liang, Shaojun Xin, Jin Liu, Guoli Sun, Shiqun Chen, Xiaolin Cen, Yibo He, Feier Song, Yuying Hu, Yingling Zhou, Zhujun Chen

“…We will perform a systematic review and meta-analysis to assess the important risk factors for developing CI-AKI, including those new, modifiable factors, which are considered controversial. …”
Get full text

A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers by Vanessa Meier-Stephenson, Michael T. Hawkes, Catherine Burton, Ainslie Calcutt, Chris Davis, Jessica Dooley, Michael Good, Michael Houghton, Eloise Keeffe, Kelly Kim, Ailin Lepletier, Conar O’Neil, Ijeoma Ogbuehi, Victoria Ozberk, Manisha Pandey, Simone Reynolds, Avi Seth, William Stokes, Alena Tse-Chang, Ben Tyrrell, D. Lorne Tyrrell, Gregory J. Tyrrell, Maryna Yaskina

Get full text

Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta... by Leiling Liu, Zhiqi Li, Wenrui Ye, Pu Peng, Yurong Wang, Luqing Wan, Jiangnan Li, Mei Zhang, Yihua Wang, Runqi Liu, Danyan Xu, Jingjing Zhang

“…The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system was used to assess the certainty of evidence for each pooled analysis. …”
Get full text

Antibiotic prescribing practices according to the AWaRe classification among children under 5 of age attending public primary care centres in four West African countries: a cross-s... by Valéry Ridde, S Shepherd, Valériane Leroy, L Barry, M Bah, A Maïga, S Diallo, G Noel, T Sidibé, V Ridde, F Bah, Désiré Kargougou, A Baldé, D Diarra, D Zongo, F Lamontagne, M Traoré, A Ouedraogo, A Ouattara, V Leroy, R Becquet, L Catala, Ibrahima Sory Diallo, S Sani, Emelyne Gres, Cédric Besnier, Abdoul Aziz Diakité, Zineb Zair, Solange Ouédraogo Yugbaré, Gildas Boris Hedible, Abdoul Guaniyi Sawadogo, Jacques Séraphin Kolié, Bertrand Meda, Sandrine Busière, Franck Lamontagne, S Yugbaré Ouédraogo, VM Sanon Zombré, M Sama Cherif, I S Diallo, D F Kaba, A A Diakité, A Sidibé, H Abarry Souleymane, F Tidjani IssaganaDikouma, H Agbeci, D L Dahourou, S Desmonde, E Gres, G B Hedible, L Peters Bokol, J Tavarez, Z Zair, S Louart, A Cousien, V Briand, V Journot, S Lenaud, C N’Chot, B Seri, C Yao, G Anago, D Badiane, M Kinda, D Neboua, P S Dia, N di Mauro, K Nyoka, W Taokreo, OB Coulidiati Lompo, M Vignon, P Aba, N Diallo, M Ngaradoum, S Léno, A T Sow, A Soumah, B Baldé, K C Millimouno, M Haba, M Soumah, M Guilavogui, M N Sylla, S F Dounfangadouno, T I Bah, C Gnongoue, S Gaye, JPY Guilavogui, A O Touré, J S Kolié, A S Savadogo, F Sangala, T Konare, A Coulibaly, A Keita, H Traoré, I Sangaré, I Koné, S Diarra, V Opoue, F K Keita, M Dougabka, B Dembélé, M S Doumbia, G D Kargougou, S Keita, S Bouille, S Calmettes, K H Harouna, B Moutari, I Issaka, S O Assoumane, S Dioiri, M Sidi, K Sani Alio, S Amina, R Agbokou, M G Hamidou, S M Sani, A Mahamane, Aboubacar Abdou, B Ousmane, I Kabirou, I Mahaman, I Mamoudou, M Baguido, R Abdoul, A Sahabi, F Seini, Z Hamani, L-Y B Meda, Mactar Niome, X Toviho, I Sanouna, P Kouam, S Busière, F Triclin, A Hema, M Bayala, L Tapsoba, J B Yaro, S Sougue, R Bakyono, A G Sawadogo, Y A Lompo, B Malgoubri, F Douamba, G Sore, L Wangraoua, S Yamponi, S I Bayala, S Tiegna, S Kam, S Yoda, M Karantao, D F Barry, O Sanou, N Nacoulma, N Semde, I Ouattara, F Wango, Z Gneissien, H Congo, Y Diarra, B Ouattara, F Diabate, O Goita, S Gana, S Sylla, D Coulibaly, N Sakho, K Kadio, J Yougbaré, S Tougouma, A Dicko, Z Nanema, I Balima, S E Coulibaly, H Baldé, E Duparc Haba, Y Sangare, B Traore, A E Dagobi, S Salifou, B Gana MoustaphaChétima, I H Abdou

Get full text

Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study by Wenjun Wu, Shengsheng Yao, Daming Liu, Yuan Luo, Yihan Sun, Ting Ruan, Mengyou Liu, Li Shi, Chang Liu, Mingming Xiao, Qi Zhang, Zhengshuai Liu, Xingai Ju, Jiahao Wang, Xiang Fei, Li Lu, Yang Gao, Ying Zhang, Liying Gong, Xuanyu Chen, Wanli Zheng, Xiali Niu, Xiao Yang, Huimei Cao, Shijie Chang, Jianchun Cui, Zuoxin Ma

“…A machine learning model, CCH-NET, was developed using a random forest classifier after feature selection with Least Absolute Shrinkage and Selection Operator (LASSO) regression. …”
Get full text

Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis by Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid

“…Our realist analysis developed and refined 6 overarching context–mechanism–outcome configurations and 30 sub context–mechanism–outcome configurations. …”
Get full text

Statistical analysis plan for the 24-week randomised trial of hypoglycaemia prevention, awareness of symptoms, and treatment: HypoPAST by Sharmala Thuraisingam, Jennifer A. Halliday, Uffe Søholm, Elizabeth Holmes-Truscott, Christel Hendrieckx, Timothy C. Skinner, Vincent L. Versace, Jane Speight

“…The analysis methods were developed by statisticians, with input from trial investigators. …”
Get full text

Study protocol for the COMET study: a cluster-randomised, prospective, parallel-group, superiority trial to compare the effectiveness of a collaborative and stepped care model vers... by Hans-Helmut König, Olaf von dem Knesebeck, Karl Wegscheider, Martin Härter, Jörg Dirmaier, Bernd Löwe, Bernd Schulte, Daniela Heddaeus, Christian Brettschneider, Anne Daubmann, Thomas Grochtdreis, Kerstin Maehder, Sarah Porzelt, Moritz Rosenkranz, Ingo Schäfer, Martin Scherer, Angelika Weigel, Silke Werner, Thomas Zimmermann

“…The intervention is a newly developed collaborative and stepped care model in which patients will be treated using treatment options of various intensities within an integrated network of outpatient general practitioners, psychiatrists, psychotherapists and inpatient institutions. …”
Get full text

Quasiexperimental intervention study protocol to optimise the use of new antibiotics in Spain: the NEW_SAFE project by Jesús Rodríguez-Baño, Zaira R Palacios-Baena, Clara M Rosso-Fernández, Pilar Retamar, Lucia Valiente de Santis, Natalia Maldonado, Irene Borreguero, Carmen Herrero-Rodríguez, Salvador López-Cárdenas, Franciso J Martínez-Marcos, Andrés Martín-Aspas, Patricia Jiménez-Aguilar, Juan J Castón, Guillermo Ojeda-Burgos, M Pilar Aznarte-Padial, Julia Praena-Segovia, Juan E Corzo-Delgado, M Ángeles Esteban-Moreno

“…Second, a quasiexperimental intervention study will be developed with an interrupted time-series analysis (2020–2021). …”
Get full text

TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis by Sofia Charneca, Ana Hernando, Inês Almada-Correia, Joaquim Polido-Pereira, Adriana Vieira, Joana Sousa, Ana Santos Almeida, Carla Motta, Gonçalo Barreto, Kari K. Eklund, Ana Alonso-Pérez, Rodolfo Gómez, Francesco Cicci, Daniele Mauro, Salomé S. Pinho, João Eurico Fonseca, Patrícia Costa-Reis, Catarina Sousa Guerreiro

“…The 12-week nutritional intervention includes a personalised dietary plan following the MedDiet + pattern, along with educational resources, food basket deliveries, and clinical culinary workshops, all developed and monitored weekly by registered dietitians. …”
Get full text

How do technological innovation and urbanization drive economic growth in Tanzania and transform societies? Exploring the potential channels by Mwoya Byaro, Anicet Rwezaula

Get full text

Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mecha... by Joanne R Chalmers, Sanja Kezic, Zarif K Jabbar-Lopez, Nikeeta Gurung, Danielle Greenblatt, Annette Briley, Kim Suzanne Thomas, Tony Frost, John E A Common, Heidi H Kong, Julie A Segre, Simon Danby, Michael J Cork, Janet L Peacock, Carsten Flohr

“…Participants are newborn babies (n=80) living in a hard water (>250 mg/L calcium carbonate) area at risk of developing atopic eczema because of a family history of atopy. …”
Get full text

Reducing medicine-induced deterioration and adverse reactions (ReMInDAR) trial: study protocol for a randomised controlled trial in residential aged-care facilities assessing frail... by Nicole L Pratt, Lisa M Kalisch Ellett, Elizabeth Ellen Roughead, Renly Lim, Megan Corlis, Gaynor Parfitt, Debra Rowett, Luke Bereznicki, Ai Choo Kang, Tracy Merlin, Stacey Torode, Joseph Whitehouse, Andre Q Andrade, Rebecca Bilton, Justin Cousins, Lan Kelly, Camille Schubert, Mackenzie Williams

“…A copy of the final report will be provided to the Australian Government Department of Health.Trial registration number Australian and New Zealand Trials Registry ACTRN12618000766213.…”
Get full text

Identification of influenza urban transmission patterns by geographical, epidemiological and whole genome sequencing data: protocol for an observational study by Andreas Buser, Sarah Tschudin-Sutter, Adrian Egli, Claudia Saalfrank, Nina Goldman, Myrta Brunner, Yvonne Hollenstein, Thomas Vogel, Noémie Augustin, Daniel Wüthrich, Helena M.B. Seth-Smith, Elisa Roth, Mohammedyaseen Syedbasha, Nicola F. Mueller, Dominik Vogt, Jan Bauer, Nadezhda Amar-Sliwa, Dominik M. Meinel, Olivier Dubuis, Michael Naegele, Christian H. Nickel, Andreas Zeller, Nicole Ritz, Manuel Battegay, Tanja Stadler, Rita Schneider-Sliwa

“…It is planned to present the results at conferences and publish the data in scientific journals.Trial registration number NCT03010007.…”
Get full text

Tools to improve discharge equity: Protocol for the pilot TIDE trial by Kirsten Austad, Cecilia Thai, Alegna Zavatti, Nhi Nguyen, Diana Bautista-Hurtado, Patrick Kenney, Noelia Lugo, Joo H. Lee, Howard Lanney, Ziming Xuan, Erika G. Cordova-Ramos, Mari-Lynn Drainoni, Brian Jack

“…Outcomes include patient recall of primary diagnosis and overall understanding of discharge instructions using a newly developed 24-point score, patient experience, implementation measures (acceptability, feasibility, and appropriateness), and clinical effectiveness (including hospital reutilization). …”
Get full text

Transcutaneous auricular vagal nerve stimulation for consciousness recovery in patients with prolonged disorders of consciousness (TAVREC): study protocol for a multicenter, triple... by Jan D Reinhardt, Jin Liu, Ting Luo, Xiao Lu, Zhen-Yu Liu, Long-yun Zhou, Li-jun Peng, Ya-feng Liu, Shu-wei Wang, Yue Qiu, Si-jing Chen, Ming-ming Feng, Shan-shan Wu, Hui-juan Wu, Jiang-ping Ge

“…Findings will be disseminated in a peer-reviewed journal and presented at relevant conferences.Trial registration number ChiCTR2300073950.…”
Get full text

Carer perspectives on overweight, obesity and dental caries in early childhood: findings from a systematic qualitative review by Heilok Cheng, Heilok Cheng, Heilok Cheng, Rebecca Chen, Rebecca Chen, Rebecca Chen, Bradley Christian, Bradley Christian, Jessica Appleton, Jessica Appleton, Jessica Appleton, Amit Arora, Amit Arora, Amit Arora, Amit Arora, Amit Arora, Elizabeth Denney-Wilson, Elizabeth Denney-Wilson, Elizabeth Denney-Wilson

“…Understanding these beliefs towards children's teeth and weight can address parents’ priorities and develop prevention messages. This qualitative systematic review (PROSPERO registration #CRD42022348783) aimed to identify parent or carer perspectives on obesity and ECC in children aged ≤6 years.MethodsDatabase searching of CINAHL, Medline and EMBASE, with hand searching, was undertaken. …”
Get full text