Design, development and randomised controlled trial protocol of a smartphone-delivered version of ‘SOLAR’ for emergency service workers to manage stress and trauma by Meaghan O'Donnell, Olivia Metcalf, Kari Gibson, Julia Fredrickson, Laura Finlayson-Short, Tracey Varker

“…Methods and analyses First, focus groups and codesign activities with mental health professionals and emergency service workers will be conducted to develop and test the prototype smartphone version of SOLAR (ie, SOLAR-m). …”
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Pan-cancer predictive survival model development and evaluation using electronic health record and genetic data across 10 cancer types by Jurgita Gammall, Alvina G. Lai

“…The aim of this study is to develop and evaluate prognostic cancer survival models across ten common cancer types based on a large patient sample. …”
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Inclusive, supportive and dignified maternity care (SDMC)-Development and feasibility assessment of an intervention package for public health systems: A study protocol. by Bilal Iqbal Avan, Waqas Hameed, Bushra Khan, Muhammad Asim, Sarah Saleem, Sameen Siddiqi

“…<h4>Methods</h4>Guided by human-centred design approach, the implementation of this study will be divided into two phases: development of intervention, and implementing and testing feasibility. …”
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Intervention Development for Tailored Education for Aging and Cognitive Health (TEACH) for Dementia Prevention in Midlife Adults: Protocol for a Randomized Controlled Trial by Laura E Korthauer, Rochelle K Rosen, Geoffrey Tremont, Jennifer D Davis

“…ObjectiveIn keeping with stage I of the National Institutes of Health (NIH) Stage Model for Behavioral Intervention Development, this study will use mixed methods to (1) develop an enhanced health education intervention, including an explanatory method for communicating information about dementia risk and personal health beliefs, and (2) conduct a pilot randomized controlled trial (n=20 per intervention arm) over 8 weeks to assess the feasibility of delivering the enhanced intervention versus basic health education alone. …”
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Development of hypertensive complications in oocyte donation pregnancy: protocol for a systematic review and individual participant data meta-analysis (DONOR IPD) by Saskia le Cessie, Marie-Louise van der Hoorn, Jan van Lith, Eileen Lashley, Kim van Bentem

“…Various covariates among women pregnant by OD, however, also contribute to an increased risk for developing hypertensive complications. Therefore, we will conduct the DONation of Oocytes in Reproduction individual participant data (DONOR IPD) meta-analysis to determine the risk for the development of hypertensive complications in OD pregnancy, in comparison to autologous oocyte pregnancy (non-donor IVF/intracytoplasmic sperm injection (ICSI) and NC pregnancy). …”
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Determinants of inappropriate antibiotic prescription in primary care in developed countries with general practitioners as gatekeepers: a systematic review and construction of a fr... by Mattijs E Numans, Frederike L Büchner, Martijn Sijbom, Nicholas H Saadah, Mark G J de Boer

“…Objectives This study aimed to identify determinants of inappropriate antibiotic prescription in primary care in developed countries and to construct a framework with the determinants to help understand which actions can best be targeted to counteract development of antimicrobial resistance (AMR).Design A systematic review of peer-reviewed studies reporting determinants of inappropriate antibiotic prescription published through 9 September 2021 in PubMed, Embase, Web of Science and the Cochrane Library was performed.Setting All studies focusing on primary care in developed countries where general practitioners (GPs) act as gatekeepers for referral to medical specialists and hospital care were included.Results Seventeen studies fulfilled the inclusion criteria and were used for the analysis which identified 45 determinants of inappropriate antibiotic prescription. …”
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Addressing Underutilization of Antenatal Care in Sagar City: A Call to Action by Shefali Jain

“…Aligning these efforts with the Sustainable Development Goals (SDGs) related to maternal health can help bridge existing gaps and improve maternal health outcomes in Sagar.   …”
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Health outcomes, healthcare use and development in children born into or growing up in single-parent households: a systematic review study protocol by Pia Hardelid, Jenny Woodman, Katie Harron, Alice Armitage, Elizabeth Ingram, Irina Lut

“…This is consistent for key health and development outcomes including physical health, psychological well-being and educational attainment. …”
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Development of the DONOR prediction model on the risk of hypertensive complications in oocyte donation pregnancy: study protocol for a multicentre cohort study in the Netherlands by Saskia le Cessie, Géraldine C M Lafeber, Vera H W Van der Endt, Yvonne Louwers, Marie-Louise P van der Hoorn, Eileen E L O Lashley

“…Following data collection, a multivariate logistic regression model will be developed for the binary outcome hypertensive complication ‘yes’ and ‘no’. …”
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Development of a core outcome set for studies on prevention and management of pregnancy-associated venous thromboembolism (COSPVenTE): a study protocol by Rohan D’Souza, Alexandria King, Lizabeth Teshler, Nadine Shehata, Ann K Malinowski

“…Introduction Pregnancy and post partum are times of heightened risk for the development of venous thromboembolism (VTE), which in turn is one of the leading causes of maternal mortality and long-term morbidity. …”
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Development and acceptance of a new adherence monitoring package to identify non-adherent patients with polypharmacy in primary care: a feasibility study by Andreas Zeller, Samuel Allemann, Isabelle Arnet, Fine Dietrich

“…Practical tools to assess adherence to polypharmacy in primary care are missing.Aims We aimed to develop an Adherence Monitoring Package (AMoPac) for general practitioners (GPs) to identify patient non-adherence. …”
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Implementation research to develop an optimized delivery model for effective implementation of evidence-based interventions to reduce stillbirth in India: A study protocol. by Gadapani Barsha Pathak, Reema Mukherjee, Vani Kandpal, Abhishek Agarwal, Prem Mony, Maryann Washington, Sarmila Mazumder, N K Arora

“…The primary outcome is the development of a scalable, sustainable model of intervention package and delivery strategies to reduce stillbirths. …”
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Development and testing of a videogame intervention for symptom management among 8–18 years old children with cancer: a study protocol by Rubina Barolia, Zehra Fadoo, Sehrish Sajjad, Raisa B Gul, Saleem Sayani, Ahmed N Abbasi

“…Moreover, their preferences for the development of the videogame were also elicited. Based on the findings from relevant literature and the interviews, we developed the videogame in collaboration with clinical and digital experts in the study’s second phase. …”
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Value of General Movements Assessment in Predicting Neuromotor Development Outcomes in Neonates with Neonatal Respiratory Distress Syndrome: A Prospective Cohort Study by Hainan Wang, Chun Su, Ming Zhang, Peng Liu, Wei Chen

“…Conclusions: GMA has a favorable predictive value for neuromotor development outcomes in children with NRDS. Clinical Trial Registration: ChiCTR2200061223.…”
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Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“…ObjectiveThis study aimed to develop and validate a machine learning–based model to predict MAKE30 in hospitalized older patients with AKI. …”
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iKids study protocol: a longitudinal study to understand the impact of interactive electronic devices on the development and health of young children in England by Jenny Retzler, Daniel Jones, John J Reilly, John Stephenson, Stuart Fairclough, Christine Smith, Amy Hughes, Tony Okely, Liane Beretta De Azevedo, João Paulo de Aguiar Greca, Colette Marr

“…Introduction There is evidence of both positive and negative impacts of interactive electronic devices (IEDs), such as tablets and smartphones, on young children’s development and health outcomes. Consultations with early years practitioners, parents and policy makers recognise IEDs as a valuable resource for early-year learning. …”
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The effect of acute branched-chain amino acids ingestion on rate of force development in different time intervals: a controlled crossover study by Xi-Nuan Zhang, Long-Ji Li, Yan-Hao Tu, Li-Feng Zhang, Hua-Yu Shang, Meng Liu, Ming-Da Li

“…However, their impact on the rate of force development (RFD), an indicator of explosive muscle strength, has not yet been validated. …”
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Development and feasibility of a conceptual model for planning individualised physical exercise training (IPET) for older adults: a cross-sectional study by Karen Søgaard, Lars Holm, Sanel Teljigovic, Louise Fleng Sandal, Tina Dalager, Nina Odgaard Nielsen, Gisela Sjøgaard, Mette Bahn Ejvang

“…Thus, this is the first effort to explicitly conceptualise the planning of individualised physical exercise training (IPET) for older adults in an outpatient setting and investigate individual exercise preferences.Design The concept of IPET was developed by researchers, exercise physiologists and health professionals from a real-life outpatient setting using an iterative approach. …”
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Development of an Online Scenario-Based Tool to Enable Research Participation and Public Engagement in Cystic Fibrosis Newborn Screening: Mixed Methods Study by Louise Moody, Samantha Clarke, Matt Compton, Rachael Hughson-Gill, Felicity Boardman, Corinna Clark, Pru Holder, James R Bonham, Jane Chudleigh

“…MethodsAround 4 development workshops with policymakers, parents, and other stakeholders informed the design of an interactive activity, including the structure, content, and questions posed. …”
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Protocol for developing a core outcome set for medicines safety at transitions of care: a systematic review, qualitative study and Delphi consensus by Fiona Boland, Patrick Redmond, Tamasine C Grimes, Carmel Hughes, Mariam Molokhia, Ibidun Fakoya, Lise M Bjerre, C Alice Oborne, Ryan Jayesinghe

“…A core outcome set (COS) is a list of outcomes which should be measured and reported in studies in order to avoid heterogeneity between trials, measure outcomes relevant to stakeholders and ensure all trials report usable information. This study aims to develop a COS for medicines safety at transitions of care, through updating an existing systematic review and evaluating the perspectives of patients, carers and healthcare professionals.Methods This study is registered with the Core Outcome Measures in Effective Trials (COMET) initiative and the project will be conducted following the COS-STAR (Core Outcome Set-Standards for Reporting) guidelines for the design and reporting of COSs. …”
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