Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. by Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra J M Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline W J Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks

“…We sought to expand etiological understanding and develop a diagnostic tool for NAFLD using machine learning.…”
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A randomized trial to evaluate the impact of breast density notification on anxiety, breast cancer worry, and perceived risk among Latinas at a federally qualified health center by Karthik Ghosh, Sarah M. Jenkins, Jennifer L. Ridgeway, Jessica D. Austin, Bijan J. Borah, Bhavika Patel, Deborah J. Rhodes, Aaron D. Norman, Edna P. Ramos, Matt Jewett, Crystal R. Gonzalez, Valentina Hernandez, Davinder Singh, Celine M. Vachon, Vera J. Suman

“…BC worry was reported to be sometimes/ often/ almost all the time among 41.3% of participants. 25.4% reported a perceived lifetime risk of developing BC of > 10%, compared with 6.6% with Gail model estimated lifetime risk score of > 10%. …”
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The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study by Liwei Lyu, Yong Fan, Josef Korbinian Vogt, Marc Clos-Garcia, Amelie Bonnefond, Helle Krogh Pedersen, Avirup Dutta, Robert Koivula, Sapna Sharma, Kristine Højgaard Allin, Caroline Brorsson, Henna Cederberg, Elizaveta Chabanova, Federico De Masi, Emmanouil Dermitzakis, Petra J. Elders, Marieke T. Blom, Monika Hollander, Rebeca Eriksen, Ian Forgie, Gary Frost, Giuseppe N. Giordano, Harald Grallert, Mark Haid, Tue Haldor Hansen, Bernd Jablonka, Tarja Kokkola, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Petra B. Musholt, Imre Pavo, Cornelia Prehn, Martin Ridderstråle, Hartmut Ruetten, Leen M.‘t Hart, Jochen M. Schwenk, Evelina Stankevic, Henrik S. Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Ana Viñuela, Mark Walker, Torben Hansen, Allan Linneberg, Henrik Bjørn Nielsen, Søren Brunak, Mark I. McCarthy, Philippe Froguel, Jerzy Adamski, Paul W. Franks, Marku Laakso, Joline W. J. Beulens, Ewan Pearson, Oluf Pedersen

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Assessing Patient-Reported Satisfaction With Care and Documentation Time in Primary Care Through AI-Driven Automatic Clinical Note Generation: Protocol for a Proof-of-Concept Study by Josep Vidal-Alaball, Carlos Alonso, Daniel Hugo Heinisch, Alberto Castaño, Encarna Sánchez-Freire, María Luisa Benito Serrano, Carla Ferrer Pascual, Ignacio Menacho, Ruthy Acosta-Rojas, Odda Cardona Gubert, Rosa Farrés Creus, Joan Armengol Alegre, Carles Martínez Querol, Marina Moreno-Martinez, Mercè Gonfaus Font, Silvia Narejos, Anna Gomez-Fernandez

“… BackgroundRelisten is an artificial intelligence (AI)–based software developed by Recog Analytics that improves patient care by facilitating more natural interactions between health care professionals and patients. …”
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Implementation and Evaluation of a Best Practice Advisory to Reduce Inequities in Technology Use for People With Type 1 Diabetes: Protocol for a Mixed Methods, Nonrandomized Contro... by Nestoras Mathioudakis, Risa Wolf, Abha Choudhary, Georgia Davis, Mary Pat Gallagher, Meenal Gupta, Manmohan Kamboj, Nicole Rioles, Emma Ospelt, Susan Thapa, Ruth S Weinstock, Trevon Wright, Osagie Ebekozien

“…ObjectiveThis study aims to develop and evaluate a best practice advisory (BPA) within the electronic medical record (EMR) to reduce racial and ethnic disparities in ADT use. …”
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Integration and evaluation of implementation strategies to improve guideline-concordant bladder cancer surveillance: a prospective observational study by Lisa Zubkoff, A. Aziz Ould Ismail, Laura Jensen, David A. Haggstrom, Soham Kale, Muta M. Issa, Jeffrey J. Tosoian, Mohummad Minhaj Siddiqui, Kennedi Bloomquist, Elisabeth R. Kimball, Susan Zickmund, Florian R. Schroeck

“…Abstract Background Despite guideline recommendations, our prior work revealed more than half of low-risk bladder cancer patients within the Department of Veterans Affairs (VA) undergo too many surveillance procedures and about a third of high-risk patients do not undergo enough procedures. Thus, we developed and integrated implementation strategies to improve risk-aligned bladder cancer surveillance for the VA. …”
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Association of temporal MASLD with type 2 diabetes, cardiovascular disease and mortality by Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park, on Behalf of Fatty LiverResearch Group of the Korean Diabetes Association

“…Results In 4,397,808 individuals without T2DM, 229,475 (5.2%) developed T2DM during a median follow-up period of 7.3 years. …”
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Combined effect of skeletal muscle mass loss and elevated insulin resistance on heart failure risk in older adults: a community-based longitudinal cohort study by Weike Liu, Hua Zhang, Xin Wang, Huajing Song, Yanli Yao, Zhendong Liu, Juan Wang, Yuqi Guo

“…Results In the prospective analysis, 1087 individuals developed HF. Restricted cubic splines analysis showed L-shaped associations between ASMI and eGDR and HF risk. …”
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Nurses’ perceptions regarding the establishment of clinical education and training units in public hospitals in the North-West Province: a qualitative study by Mmapule Motshabi Maria Mosete, Isaac Ontchebile Mokgaola, Leepile Alfred Sehularo, Miriam Mmamphamo Moagi

“…In South Africa, Clinical Education and Training Unit was developed to reconstruct and revitalise nursing education and training. …”
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Effectiveness of Interventions to Improve Digital Health Literacy in Forced Migrant Populations: Mixed Methods Systematic Review by Achille Roghemrazangba Yameogo, Carole Délétroz, Maxime Sasseville, Samira Amil, Sié Mathieu Aymar Romaric Da, James Plaisimond, Frédéric Bergeron, Sofia Tadlaoui, Patrick Bodenmann, Marie-Pierre Gagnon

“…Going forward, these stakeholders need to develop innovative initiatives that rely on holistic approaches and are based on the specific needs of forced migrants to improve equity and health outcomes. …”
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Future Patient—Telerehabilitation of Patients With Atrial Fibrillation: Protocol for a Multicenter, Mixed Methods, Randomized Controlled Trial by Birthe Dinesen, Andi Eie Albertsen, Elisabet Dortea Ragnvaldsdóttir Joensen, Helle Spindler, Katja Møller Jensen, Kristian Kidholm, Lars Frost, Lars Dittman, Mathushan Gunasegaram, Søren Paaske Johnsen, Mads Rovsing Jochumsen, Dorthe Svenstrup

“…Due to increased AF prevalence, telerehabilitation has been developed to enhance patient engagement, health care accessibility, and compliance through digital technologies. …”
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Immune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome by David Ribes, Nihal Martis, Jehane Fadlallah, Ygal Benhamou, Veronique Le Guern, Virginie Rieu, Gabriel Choukroun, Raïda Bouzid, Agnès Veyradier, Paul Coppo, Bérangère S Joly, Júlia Weisinger, François Provôt, Pascale Poullin, Yahsou Delmas, Sylvain Chantepie, Manon Marie, Ranta Dana

“…Among patients with ANAs without other clinical features of SLE, 33 (8%) were diagnosed with SLE 27 months (IQR: 7–65 months) following iTTP diagnosis; 32 additional patients (7%) developed another systemic autoimmune disease. No patient from the idiopathic iTTP group developed clinical SLE during follow-up.Conclusion Patients with iTTP are prone to develop autoimmune features, and patients with SLE-iTTP have distinct clinical features and outcome. …”
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Protocol of the Tailored Evidence-based Enhancements in Mental Health-Gamified and Individualized Follow-Up Treatment for Suicide (TEEM-GIFTS): a Multiphase Optimization Strategy (... by Bo Peng, Jinghua Li, Fengsu Hou, Huiming Liu, Guanjie Chen, Yuanhan Bai, Yingli Zhang, Donghui Wu, Tiantian Fu, LuYao Hu

“…Following the MOST framework, we will develop the gamified mHealth app (Tailored Evidence-based Enhancements in Mental Health (TEEM)) with four intervention components in the selection phase. …”
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Radiomic Feature Characteristics of Ovine Pulmonary Adenocarcinoma by David Collie, Ziyuan Chang, James Meehan, Steven H. Wright, Chris Cousens, Jo Moore, Helen Todd, Jennifer Savage, Helen Brown, Calum D. Gray, Tom J. MacGillivray, David J. Griffiths, Chad E. Eckert, Nicole Storer, Mark Gray

“…OPA lung tumour RF characteristics are distinct from those of other lung tissues of similar density and evolve as the tumour develops. Such characteristics suggest that radiomic analysis offers potential for the early detection and management of JSRV-related lung tumours. …”
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Longitudinal graphics of patient-reported physical function in patients treated for hematologic malignancies by Gita Thanarajasingam, Vishal Bhatnagar, Brie N. Noble, Ting-Yu Chen, Mallorie H. Fiero, Ron Hoffman, Molly Jeffery, Gina L. Mazza, John Mascarenhas, Ruben Mesa, Meena Murugappan, Joseph Ross, Surbhi Sidana, Rahma Warsame, Paul G. Kluetz, Amylou C. Dueck

“…The objectives of this study were to develop analytic methods and visualizations of patient-reported PF in patients with cancer. …”
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OptimisAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies (ADAPT study): a protocol for a prospective diagnostic accuracy study of multimodality testing in patients... by Frank F Smithuis, Anneke J van der Kooi, Joost Raaphorst, Ivo N van Schaik, Marianne de Visser, Paul A Baars, Patrick M M Bossuyt, Eleonora Aronica, Johannes H T M Koelman, Camiel Verhamme, Hannah A W Walter, Renske G Kamperman, Wouter V Potters, Ester M M van Leeuwen

“…The results will be distributed through conference presentations and peer-reviewed publications.Trial registration number Netherlands trial register; NL8764.…”
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Vagus nerve stimulation therapy for treatment-resistant PTSD by Mark B. Powers, Seth A. Hays, David Rosenfield, Amy L. Porter, Holle Gallaway, Greg Chauvette, Jasper A.J. Smits, Anne Marie Warren, Megan Douglas, Richard Naftalis, Jane G. Wigginton, M Foreman, Michael P. Kilgard, Robert L. Rennaker

“…Background: Posttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. …”
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Diagnosis of Sarcopenia Using Convolutional Neural Network Models Based on Muscle Ultrasound Images: Prospective Multicenter Study by Zi-Tong Chen, Xiao-Long Li, Feng-Shan Jin, Yi-Lei Shi, Lei Zhang, Hao-Hao Yin, Yu-Li Zhu, Xin-Yi Tang, Xi-Yuan Lin, Bei-Lei Lu, Qun Wang, Li-Ping Sun, Xiao-Xiang Zhu, Li Qiu, Hui-Xiong Xu, Le-Hang Guo

“…Three monomodal models based on each data type were developed in the training cohort. The data type with the best diagnostic performance was selected to develop the bimodal and multimodal model by adding another one or two data types. …”
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Efficacy, Safety, and Cost-effectiveness of Zinc Oxide Nanoparticles in Whitfield’s Spirit Solution for Treating Superficial Fungal Foot Infections: A Randomized Controlled Trial by Charussri Leeyaphan, Primana Punnakitikashem, Bordeesuda Suiwongsa, Phojana Komesmuneeborirak, Piriyaporn Chongtrakool, Nattanichcha Kulthanachairojana, Pichaya Limphoka, Thrit Hutachoke, Phuwakorn Saengthong-aram, Pantaree Kobkurkul, Supisara Wongdama, Bawonpak Pongkittilar, Lalita Matthapan, Chatisa Panyawong, Waranyoo Prasong, Akkarapong Plengpanich, Natsuda Kunwong, Kamonlatth Rodponthukwaji, Sumanas Bunyaratavej

“…Abstract Introduction A novel antifungal formulation combining zinc oxide nanoparticles and Whitfield’s spirit solution (ZnO-WFs) was developed to enhance the treatment of superficial fungal foot infections. …”
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Coronary artery calcium and cardiovascular risk factors analysis after radiotherapy for breast cancer (the CLARIFIER: a gender-based preventive medicine study) by Daniela Trabattoni, Maria Cristina Leonardi, Maria Elisabetta Mancini, Barbara A. Jereczek-Fossa, Barbara A. Jereczek-Fossa, Federica Cattani, Giulia Santagostino Baldi, Alice Bonomi, Arianna Galotta, Saima Mushtaq, Saima Mushtaq, Andrea Annoni, Davide Alio, Maria Giulia Vincini, Cristiana Iuliana Fodor, Ludovico La Grutta, Piero Montorsi, Piero Montorsi, Gianluca Pontone, Gianluca Pontone

“…Coronary artery calcium (CAC) is an independent risk factor for cardiac events.AimThe aim of this prospective, joint-institution, study was to analyze the relationship between cardiovascular risk factors (CVRF) known before breast cancer diagnosis and treatment, and the risk of developing coronary events in women undergoing adjuvant breast radiotherapy by measuring CAC.MethodsWomen (n = 92) diagnosed with early-stage breast cancer between 2010 and 2016 were enrolled and underwent cardiologic clinical assessment and coronary CT-scan for CAC score analysis, at least 5 years after RT.ResultsData obtained from 91/92 patients, showed a 36.2% incidence of pathologic Agatston CAC score, independent of the irradiated breast side. …”
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