Novel Smartphone App and Supportive Accountability for the Treatment of Childhood Disruptive Behavior Problems: Protocol for a Randomized Controlled Trial by Oliver Lindhiem, Claire S Tomlinson, David J Kolko, Jennifer S Silk, Danella Hafeman, Meredith Wallace, I Made Agus Setiawan, Bambang Parmanto

“… BackgroundAlthough evidence-based treatments have been developed for childhood behavior problems, many families encounter barriers to treatment access and completion (eg, local availability of services, transportation, cost, and perceived stigma). …”
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Reliability of the electronic patient reported outcome measures for assessing xerostomia, dysphagia and quality of life in Spanish patients with head and neck cancer: a randomised... by Mario Lozano-Lozano, Maria Lopez-Garzon, Paula Cuadrado-Guerrero, Paula Postigo-Martin, Carolina Fernández-Lao, Isabel Tovar-Martín, Noelia Galiano-Castillo

“…Conclusion The newly developed ePROMs embedded into LAXER application have showed high level of reliability that supports their implementation in clinical practice, offering a convenient and efficient alternative to paper-based questionnaires. …”
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Effect of the Yon PD App on the Management of Self-Care in People With Parkinson Disease: Randomized Controlled Trial by JuHee Lee, Subin Yoo, Yielin Kim, Eunyoung Kim, Hyeran Park, Young H Sohn, Yun Joong Kim, Seok Jong Chung, Kyoungwon Baik, Kiyeon Kim, Jee-Hye Yoo

“…In our previous study, we developed a mobile app (Yon PD app) to monitor nonmotor symptoms of PD. …”
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A Prospective Study on Yoga for Anterior Knee Pain in Adolescents by Stephanie Price, MD, Robert Martin, MD, Chand Shah, MPAS/PA-C/RYT 200, Matthew Ellington, MD

“…Methods: A certified yoga instructor developed 2 separate videos for study participants to perform 3 to 4 times per week for a total of 8 weeks. …”
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Evaluation of Free-Living Motor Symptoms in Patients With Parkinson Disease Through Smartwatches: Protocol for Defining Digital Biomarkers by Carlos Polvorinos-Fernández, Luis Sigcha, María Centeno-Cerrato, Guillermo de Arcas, Miriam Grande, Mayca Marín, Isabel Pareés, Juan Carlos Martínez-Castrillo, Ignacio Pavón

“…In addition, the study seeks to develop analytical techniques capable of tracking PD symptoms in real-life scenarios, both in everyday settings and clinical environments. …”
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Wearable Devices for Supporting Chronic Disease Self-Management: Scoping Review by Marie-Pierre Gagnon, Steven Ouellet, Eugène Attisso, Wilfried Supper, Samira Amil, Caroline Rhéaume, Jean-Sébastien Paquette, Christian Chabot, Marie-Claude Laferrière, Maxime Sasseville

“…We excluded studies with participants with only a predisposition to develop a chronic disease, hospitalized patients, patients with acute diseases, patients with active cancer, and cancer survivors. …”
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Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma by Zhixin Sun, Jacqueline M. Godbe, Alexander Zheleznyak, Brad Manion, Junhao Hu, Julie L. Prior, Kathleen Duncan, Ulugbek S. Kamilov, Monica Shokeen

“…However, manual quantification in longitudinal small animal PET/CT is limited by annotator bias, signal artifacts from urinary/fecal excretion, and voxel misalignment due to non-rigid registration. To address these challenges and improve characterization of tumor biology, we developed a semi-automated PET/CT quantification pipeline targeting defined regions of interest (ROIs) within the bone marrow-rich mouse skeleton, achieving sub-organ spatial resolution, including in anatomically complex sites such as the pelvis. …”
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Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young... by Sarah T Roberts, Alexandra M Minnis, Sue Napierala, Elizabeth T Montgomery, Lina Digolo, Mackenzie L Cottrell, Erica N Browne, Jacqueline Ndirangu, Joyce Boke, Kawango Agot

“…ConclusionsThe study builds directly on our promising formative and pilot research to develop the evidence base for this youth-designed, multilevel HIV prevention intervention. …”
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Enhancing protection against vector-borne diseases in forcibly displaced communities: evaluating the efficacy of spatial repellents for cutaneous leishmaniasis control in North-Eas... by Richard Allan, Ramona Scherrer, Ozge Erisoz Kasap, Laura Paris, Thomas Scott, Hendrik Sauskojus, Olivia Wetherill, Sara Estecha-Querol, Zaid Alkhalaf, Mehmet Karakus, Ayda Yilmaz, Bülent Alten, Louisa A. Messenger

“…A small, lightweight, portable transfluthrin-based spatial repellent (Mosquito Shield™) has been developed which may circumvent some of these logistical issues and provide improved protection from vector-borne diseases in harsh environments. …”
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Effect of cervical cancer education and provider recommendation for screening on screening rates: A systematic review and meta-analysis. by Jonah Musa, Chad J Achenbach, Linda C O'Dwyer, Charlesnika T Evans, Megan McHugh, Lifang Hou, Melissa A Simon, Robert L Murphy, Neil Jordan

“…The protocol registration number is CRD42016045605 available at: http://www.crd.york.ac.uk/prospero/display_record.asp?…”
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The clinical effectiveness and safety of low/moderate-intensity statins & ezetimibe combination therapy vs. high-intensity statin monotherapy: a systematic review and meta-analysis by Pishoy Sydhom, Bakr Al-Quraishi, Mohamad El-Shawaf, Mohamed T. Osman, Nourhan Naji, Nouran Awwad, Nahla Shehata, Mostafa Osama, Heba Sergany, Kerollos F. Maurice, Ahmed Sayed

“…Abstract Background Despite widespread use of high-intensity statin monotherapy, achieving target LDL-C levels and reducing cardiovascular events in patients with or at high risk of developing ASCVD remains challenging. Our study measured the effects of low/moderate-intensity statins and ezetimibe combination therapy compared to high-dose statin monotherapy on major adverse cardiovascular events (MACEs) and coronary atherosclerotic plaque reduction. …”
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A 360° Approach to Personalize Lifestyle Treatment in Primary Care for People With Type 2 Diabetes: Feasibility Study by Zeena Harakeh, Iris de Hoogh, Anne-Margreeth Krijger-Dijkema, Susanne Berbée, Gino Kalkman, Pepijn van Empelen, Wilma Otten

“…To address this, we developed the web-based 360-degree (360°) diagnostic tool, which assesses 4 key domains: “body” (physical health parameters), “thinking and feeling” (eg, mental health and stress), “behavior” (lifestyle factors), and “environment” (eg, work and housing conditions). …”
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A WeChat-Based Decision Aid Intervention to Promote Informed Decision-Making for Family Members Regarding the Genetic Testing of Patients With Colorectal Cancer: Randomized Control... by Huanhuan Li, Yanjie Zhao, Wei Li, Wenxia Wang, Shengze Zhi, Yifan Wu, Qiqing Zhong, Rui Wang, Jiao Sun

“…However, the current DA tool requires optimization and further evaluation—for example, by leveraging more advanced technology than WeChat to develop a simpler and more intelligent DA system. …”
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Online Group–Based Dual-Task Training to Improve Cognitive Function of Community-Dwelling Older Adults: Randomized Controlled Feasibility Study by Pui Hing Chau, Denise Shuk Ting Cheung, Jojo Yan Yan Kwok, Wai Chi Chan, Doris Sau Fung Yu

“…The intervention group underwent 60-minute online dual-task training sessions twice a week for 12 weeks, incorporating cognitive components (upper limb and finger movement, arithmetic operation, and verbal fluency) and physical components (chair-based exercises) developed through a co-design approach. The attention control group received online health talks. …”
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Enrollment and Retention Outcomes from the Veterans Health Administration for a Remote Digital Health Study: Multisite Observational Study by Jaclyn A Pagliaro, Lauren K Wash, Ka Ly, Jenny Mathew, Alison Leibowitz, Ryan Cabrera, Jolie B Wormwood, Varsha G Vimalananda

“…Device and survey data were combined with VA clinical and utilization data to develop a predictive algorithm for clinical decompensation. …”
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Patient-Related Metadata Reported in Sequencing Studies of SARS-CoV-2: Protocol for a Scoping Review and Bibliometric Analysis by Karen O'Connor, Davy Weissenbacher, Amir Elyaderani, Ebbing Lautenbach, Matthew Scotch, Graciela Gonzalez-Hernandez

“…Our classification model has been developed and we have classified publications in LitCovid published through February 2023. …”
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Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study by Guangyu Lu, Zhixia Su, Xiaoping Yu, Yuhang He, Taining Sha, Kai Yan, Hong Guo, Yujian Tao, Liting Liao, Yanyan Zhang, Guotao Lu, Weijuan Gong

“…We applied five machine learning (ML) algorithms to develop predictive models which were evaluated using area under the curve (AUC), sensitivity, specificity, and other relevant metrics. …”
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Pilot study to test the feasibility of a trial design and complex intervention on PRIoritising MUltimedication in Multimorbidity in general practices (PRIMUMpilot) by Rafael Perera, Marjan Van Den Akker, Ferdinand M Gerlach, Jose M Valderas, Martin Beyer, Christiane Muth, Lorenz Uhlmann, Corina Güthlin, Antje Erler, Sebastian Harder, Justine Rochon, Birgit Fullerton, André Knottnerus, Walter E Haefeli

“…Objective To improve medication appropriateness and adherence in elderly patients with multimorbidity, we developed a complex intervention involving general practitioners (GPs) and their healthcare assistants (HCA). …”
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Employing artificial intelligence for optimising antibiotic dosages in sepsis on intensive care unit: a study protocol for a prospective observational study (KI.SEP) by Tim Rahmel, Michael Adamzik, Hartmuth Nowak, Lars Bergmann, Björn Koos, Martin Eisenacher, Barbara Sitek, Britta Marko, Lars Palmowski, Andrea Witowski, Katharina Rump, Julia Bandow, Patrick Günther

“…We will use the collected data to develop multifaceted ML-based algorithms aimed at optimising antibiotic dosing in sepsis. …”
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Flow cytometric lyophilised reagent tube assay for peripheral blood neutrophil myeloperoxidase expression to rule out myelodysplastic neoplasms at a university hospital: a diagnost... by Sophie Park, José Labarère, Arnaud Seigneurin, Lysiane Molina, Raymond Merle, Tatiana Raskovalova, Laura Scheffen, Marie-Christine Jacob, Simon Chevalier, Sylvie Tondeur, Bénédicte Bulabois, Mathieu Meunier, Gautier Szymanski, Christine Lefebvre, Charlotte Planta, Nicolas Gonnet, Frédéric Garban, Radu Chiriac, Claire Paradis

“…The median intra-individual robust coefficient of variation (RCV) for myeloperoxidase expression was 30.9% using the BD Lyotube Stain 468 and 31.2% using the laboratory-developed liquid reagent assay, with an intraclass correlation coefficient of 0.94 (95% CI 0.91 to 0.96). …”
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