Evaluation of a two-way SMS messaging strategy to reduce neonatal mortality: rationale, design and methods of the Mobile WACh NEO randomised controlled trial in Kenya by John Kinuthia, Jennifer A Unger, Lusi Osborn, Barbra A Richardson, Manasi Kumar, Keshet Ronen, Esther M Choo, Dalton C Wamalwa, Brenda Wandika, Jenna I Udren, Peninah Kithao, Anna B Hedstrom, Millicent Masinde

“…Findings will be published in peer-reviewed journals and international conferences.Trial registration number NCT04598165…”
Get full text

Comparing the efficacy of topical interventions for pain management in oral lichen planus: a time-stratified bayesian network analysis of randomized controlled trials by Yuanmei Zhang, Chenhao Mao, Juanfang Zhu, Wenli Yang, Yanli Wang, Weiwei Yu, Jing Wang, Na Li, Jia Guo, Qi Zhang, Yi Zhou, Mengdong Peng, Yining Wang

“…Abstract Background The evaluation of short-term pain relief provided by newly developed drugs for the treatment of oral lichen planus is currently limited. …”
Get full text

Efficiency and effectiveness of intensive multidisciplinary follow-up of patients with stroke/TIA or myocardial infarction compared to usual monitoring: protocol of a pragmatic ran... by Yannick Béjot, Marc Bardou, Mathieu Boulin, Yves Cottin, Maurice Giroud, Anne-Laure Soilly, Gauthier Duloquin, Thibaut Pommier, Gabriel Laurent, Lucie Vadot, Héloïse Adam

“…In these patients, implementing secondary prevention is a critical challenge and new strategies need to be developed to close the gap between clinical practice and evidence-based recommendations. …”
Get full text

Polyacrylic acid-polyvinylpyrrolidone complex for achieving hemostasis after hemodialysis: study protocol for an open-label crossover randomized controlled trial (PAA-PVP study) by Ryohei Terashima, Mototsugu Tanaka, Atsushi Hashimoto, Daiki Omori, Takahiro Tanaka, Haruna Miyazawa, Masahiro Ishizawa, Yoshihiko Tomita, Tomoko Ito, Yoshiyuki Koyama, Kokichi Saito, Suguru Yamamoto, Shin Goto, Ichiei Narita

“…Abstract Background Achieving rapid and secure hemostasis of the vascular access point is important for patients undergoing maintenance hemodialysis (HD). We developed a polyacrylic acid-polyvinylpyrrolidone (PAA-PVP) complex that absorbs moisture such as blood or sterilizing solution, forms a hydrogel, and adheres to the body’s surface, thereby exerting a powerful hemostatic effect. …”
Get full text

‘Do they care?’: a qualitative examination of patient perspectives on primary care clinician communication related to opioids in the USA by Leif I Solberg, Katrina M Romagnoli, Anthony W Olson, Andrei Bucaloiu, Clayton I Allen, Lorraine D Tusing, Hillary A Henzler-Buckingham, Christina M Gregor, Laura A Freitag, Stephanie A Hooker, Rebecca C Rossom, Eric A Wright, Irina V Haller

“…Objectives This substudy’s objectives were to (1) examine the transferability of a four archetype framework (simplified pattern of prototypical features) for patients at high risk for opioid use disorder (OUD) developed from a previous study with a similar population; (2) explore how patient preferences for terminology can inform clinician communication strategies for patients with OUD across archetypes and (3) explore how patient perceptions of opioid risks can inform clinician communication strategies across patient archetypes.Design This qualitative study collected data via semistructured phone interviews with patients about views on opioid-related discussions with primary care clinicians. …”
Get full text

Risk prediction models for dental caries in children and adolescents: a systematic review and meta-analysis by Peng Zhang, Kang Li, Xijia Wang, Huifei Lu, Dandan Luo, Dunhui Yang, Shuqi Qiu, Haotao Zeng, Xianhai Zeng

“…The search focused on caries prediction models in children and adolescents.Eligibility criteria Eligible studies included observational research (cohort, case–control and cross-sectional designs) that developed risk prediction models for dental caries in children and adolescents aged ≤18 years. …”
Get full text

Efficacy and safety of a novel CD19, CD22 dual-targeted fully human loop bi-CAR-T for the treatment of relapsed/refractory B cell non-Hodgkin lymphoma by Hanyu Wang, Gaoxiang Wang, Tongjuan Li, Peiling Zhang, Zekai Mao, Hui Luo, Xiaojian Zhu, Dengju Li, Jianfeng Zhou, Xiaoxi Zhou, Liang Huang

“…Methods In this study, we developed a fully human, bivalent loop bi-CAR-T targeting both CD19 and CD22 (CT120). …”
Get full text

Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational... by Steve Connor, Gabriella Wojewodka, Jean-Pierre Jeannon, Anthony Kong, Rhonda Henley-Smith, Teresa Guerrero-Urbano, Jessica Davis, Ifigenia Vasiliadou, Christiana Cattaneo, Phoebe Yuen Ka Chan, Harry Gregson-Williams, Lisette Collins, Anna Pasto, Rami Mustapha, Tony Ng

“…Introduction Organoids have been successfully used in several areas of cancer research and large living biobanks of patient-derived organoids (PDOs) have been developed from various malignancies. The characteristics of the original tumour tissue such as mutation signatures, phenotype and genetic diversity are well preserved in organoids, thus showing promising results for the use of this model in translational research. …”
Get full text

Creation and validation of a roadside rescue skills scale for training pre-hospital medical teams: the RoadRes-Q scale by Killien Lavabre, Nicolas Marjanovic, Denis Oriot, Mathilde Chenu, Adrien Gransagne, Michel Gentilleau, Anthony Moreau, Paul Contal, Olivier Mimoz, Bertrand Drugeon, Road Rescue Study Group

“…Methods We used a two-round Delphi method to develop the RoadRes-Q scale. A panel of 9 international roadside rescue experts, including 7 firefighters and 2 engineers in road rescue equipment, agreed to participate. …”
Get full text

Effectiveness of non-technical skills training in intensive care units: a systematic review by Isac Davidson Santiago Fernandes Pimenta, Ádala Nayana de Sousa Mata, Isaac Newton Machado Bezerra, Rícia Medeiros Palmeira de Araújo, Jorge Lucas Alves Santana, Helaine Carneiro Capucho, Adriana Catarina de Souza-Oliveira, Paloma Echevarría-Pérez, Daniel Guillén-Martínez, Grasiela Piuvezam

“…Risk of bias and quality assessments were performed using Cochrane Risk of Bias 2, Risk of Bias in Non- randomized Studies of Interventions and Quality Assessment Tool developed by the National Heart, Lung, and Blood Institute. …”
Get full text

Treatment options for women with heavy menstrual bleeding: a protocol for comprehensive systematic review, network meta-analyses and health economic assessment by Rachael M Hunter, Ewelina Rogozinska, Claire L Vale, Khalid Saeed Khan, David J Fisher, Bassel H Al Wattar, Davor Jurkovic, Ngawai Moss, Jayne F Tierney, Ekaterina Bordea, Niccola Hutchinson-Pascal, Lily Nicholson

“…We will report primarily on changes in menstrual blood loss (using Pictorial blood loss assessment chart scores or the Alkaline-Haematin method), quality-of-life measures, safety in addition to other important clinical outcomes.We will develop a health economic model to evaluate the cost-effectiveness of available treatments within a healthcare perspective using data inputs from the planned meta-analyses. …”
Get full text

Incidence and risk factors of post-transplant diabetes mellitus among kidney transplant recipients: a retrospective study from a tertiary center in Saudi Arabia by Mutlaq Alotaibi, Najlaa Almalki, Manal E. Alotaibi, Majed Alosaimi, Monther Alazwari, Mohamed Hussein, Faisal Alhomayani, Abdulmajeed Alotaibi, Ameerah Bajaber, Fahad Bhutto, Abdulmajeed Algethami, Bassem A. Almalki

“…Results Of 228 kidney transplant recipients (64% males, mean age 47.2 ± 14.6 years), 54 (23.7%) developed PTDM. PTDM patients were significantly older (53.1 ± 12.9 vs. 45.4 ± 14.6 years, p < 0.001) and had higher BMI (27.0 ± 4.7 vs. 25.2 ± 5.4 kg/m², p = 0.023). …”
Get full text

Patient satisfaction with radio-frequency identification (RFID) tag localization compared with wire localization for nonpalpable breast lesions: the RFID trial by Raphaël Pete, Céleste Pinard, Fanny Sirodot, Ioana Molnar, Margot Dressaire, Angeline Ginzac, Catherine Abrial, Xavier Durando, Marielle Tekath

“…Several wire-free techniques have been developed to overcome these drawbacks; one technique is localisation by Radiofrequency Identification (RFID). …”
Get full text

Pulmonary uptake value (PUV): a new quantification method for lung PET/CT imaging by Pierre-Yves Le Roux, Romain Le Pennec, Vincent Bourbonne, Frédérique Blanc-Béguin, Mathieu Pavoine, Kevin Kerleguer, Maëlle Mauguen, Olivier Pradier, Pierre-Yves Salaun, François Lucia, David Bourhis

“…Abstract Background A current limitation to the use of lung PET/CT is the absence of a tool that reliably and reproducibly quantifies the intensity of tracer uptake. We aim to develop a quantitative approach for lung perfusion PET/CT imaging. …”
Get full text

Smart Technology Facilitated Patient-Centered Venous Thromboembolism Management (the SmaVTE Study): Protocol for a Randomized Controlled Trial by Zhi-Geng Jin, Zhe-Qi Zhang, Bin-Bin Liu, Hao Wang, Ying Yang, Li-Na Ren, Hui Zhang, Wei Ji, Zhen-Guo Zhai, Yu-Tao Guo

“…To address this, we have developed a smart technique–assisted patient-centered care mobile health app for managing VTE (mVTEA), which integrates psychological frameworks to improve patient outcomes in VTE management. …”
Get full text

Outdoor Exercise Facility–Based Integrative Mobile Health Intervention to Support Physical Activity, Mental Well-Being, and Exercise Self-Efficacy Among Older Adults With Prefrailt... by Janet Lok Chun Lee, Arnold Y L Wong, Peter H F Ng, S N Fu, Kenneth N K Fong, Andy S K Cheng, Karen Nga Kwan Lee, Rui Sun, Hao Yi Zhang, Rong Xiao

“…To assess the acceptability of the intervention, individual semistructured interviews were conducted with, and a self-developed questionnaire was administered to, 14 participants from the intervention group. …”
Get full text

The EmpaTeach intervention for reducing physical violence from teachers to students in Nyarugusu Refugee Camp: A cluster-randomised controlled trial. by Camilla Fabbri, Katherine Rodrigues, Baptiste Leurent, Elizabeth Allen, Mary Qiu, Martin Zuakulu, Dennis Nombo, Michael Kaemingk, Alexandra De Filippo, Gerard Torrats-Espinosa, Elizabeth Shayo, Vivien Barongo, Giulia Greco, Wietse Tol, Karen M Devries

“…Further research is needed to develop and test interventions to prevent teacher violence in humanitarian settings.…”
Get full text

Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217 by Branislav Kovacech, Nicholas C. Cullen, Petr Novak, Jozef Hanes, Eva Kontsekova, Stanislav Katina, Vojtech Parrak, Michal Fresser, Jeroen Vanbrabant, Howard H. Feldman, Bengt Winblad, Erik Stoops, Eugeen Vanmechelen, Norbert Zilka

“…Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt disease progression. …”
Get full text

The Effectiveness of a Chatbot Single-Session Intervention for People on Waitlists for Eating Disorder Treatment: Randomized Controlled Trial by Gemma Sharp, Bronwyn Dwyer, Alisha Randhawa, Isabella McGrath, Hao Hu

“…Single-session interventions (SSIs) can provide short-term support to people on waitlists for eating disorder treatment; however, it is not always possible to access SSIs. We co-designed and developed a rule-based chatbot called ED ESSI (Eating Disorder Electronic Single-Session Intervention), which delivered an SSI and demonstrated its acceptability and feasibility. …”
Get full text

Evaluasi Kualitas Layanan E-Government Pada Aplikasi Pendaftaran Seleksi Calon Aparatur Sipil Negara Menggunakan Model E-GovQual Berdasarkan Perspektif Pengguna by Puja Putri Abdullah, Rina Rahmawati, Dana Indra Sensuse, Sofian Lusa, Assaf Arief, Prasetyo Adi

“…The recommendation that we provide is that BKN as the responsible institution for developing SSCASN must prioritize all indicators in the Efficiency and Reliability variabels because they get the highest score and have the most influence on the quality of SSCASN services. …”
Get full text