Psychological Barriers to the Use of Opioid Analgesics for Treating Pain in Patients With Advanced Recurrent Cancer: A Multicenter Cohort Study by Takehiko Tsuno, Takashi Kawaguchi, Ryota Yanaizumi, Junichi Kondo, Keiko Kojima, Takashi Igarashi, Masaki Inoue, Tomofumi Miura, Akime Miyasato, Kanako Azuma, Hiroshi Hamada, Tomoya Saeki, Hironori Mawatari, Hiroyuki Ogura, Akira Kotani, Takuhiro Yamaguchi, Hideki Hakamata

“…Clinical Trial Registration Number UMIN000042443.…”
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Barriers and facilitators impacting the implementation of digital interventions targeted at mental health and musculoskeletal disorders in the workplace: a scoping review protocol by Mallorie Leduc, Andrea Sinesi, Margaret Kenneally, Margaret Maxwell, Birgit Greiner, Birgit Aust, Carolina Piña, Andreas Czaplicki, Evelien Coppens, Alex Burdorf, Ricardo Gusmão, Daniel Guinart, Johanna Cresswell-Smith, Gentiana Qirjako, Naim Fanaj, Eleftherios Giovanis, Ainslie O’Connor, Eva Zsak, Pedro Lobo, Arlinda Cerga Pashoja, Victoria Ross, Ella Arensman, Eve Griffin, the PROSPERH Consortium

“…Discussion The findings from this review will provide practical recommendations relevant to researchers and practitioners developing or implementing digital interventions in the workplace targeting mental health conditions and MSDs. …”
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Protocol for a mixed-methods feasibility study for the surviving opioid overdose with naloxone education and resuscitation (SOONER) randomised control trial by Peter Jüni, Carol Strike, Rita Shahin, Kevin Thorpe, Douglas Campbell, Aaron Orkin, Shaun Hopkins, Michelle Klaiman, Janet A Parsons, Kate Sellen, Geoffrey Milos, Amy Wright, Mercy Charles, Ruby Sniderman, Leigh Chapman, Nick Goso, Richard Hunt, Vicky Stergiopoulos, Daniel Werb

“…Introduction The surviving opioid overdose with naloxone education and resuscitation (SOONER) project uses co-design and trial methods to develop and evaluate a point-of-care overdose education and naloxone distribution (OEND) tool. …”
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Theory-based chatbot for promoting colorectal cancer screening in a community setting in Hong Kong: study protocol of a randomised controlled trial by Samuel Yeung Shan Wong, Dong Dong, Yue Hu, Thomas Yuen Tung Lam, Xixin Wu, Wai Man Lau, Zixin Johnson Wang, Raymond Shing Yan Tang, Phoenix Kit Han Mo, Mei Ling Helen Meng, Joseph Jao You Sung

“…The intervention group will deliver Chinese culturally tailored education texts and videos developed based on the Health Belief Model and the Trans-Theoretical Model. …”
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Compassion Fatigue and Burnout Among Health Care Professionals: Protocol for a Scoping Review by Christian Guilherme Capobianco dos Santos, Martins Fideles dos Santos Neto, Stela Regina Pedroso Vilela Torres de Carvalho, Márcia Regina Furlani, Cíntia Canato Martins, Emerson Roberto Santos, João Daniel Souza Menezes, Matheus Querino da Silva, Loiane Letícia Santos, Thaysa Castro Molina, Natalia Almeida de Arnaldo Silva Rodriguez Castro, Helena Cristóvão., Randolfo Santos Júnior, Vânia MS Brienze, Alba Regina de Abreu Lima, Patricia da Fucuta, Denise Vaz-Oliani, Neide Aparecida Domingos, Maria Cristina Miyazaki, Gerardo Araújo Filho, Júlio César André

“…The review is expected to be completed by December 2025, and the search strategy has been developed and pilot-tested. ConclusionsOur findings will help identify gaps in the literature with respect to compassion fatigue and burnout prevention strategies for health care professionals. …”
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Adjusting Early Warning Score by clinical assessment: a study protocol for a Danish cluster-randomised, multicentre study of an Individual Early Warning Score (I-EWS) by Lars Simon Rasmussen, Kasper Karmark Iversen, Theis Lange, Gitte Bunkenborg, Pernille B Nielsen, Martin Schultz, Caroline Sophie Langkjaer, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Michael Dan Arvig, Christian Sahlholt Meyhoff, Morten Bestle, Bibi Hølge-Hazelton, Anne Lippert, Ove Andersen

“…Individual Early Warning Score (I-EWS) is a newly developed TTS with an aggregated score based on vital signs that can be adjusted according to the clinical assessment of the patient. …”
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Interventions to improve the quality of cataract services: protocol for a global scoping review by Nathan Congdon, João M Furtado, Matthew J Burton, Jacqueline Ramke, Stephen Gichuhi, Helen Burn, Iris Gordon, William H Dean, John Buchan, Ada Aghaji, Miho Yoshizaki, Ana P Marques

“…We will publish our findings in an open-access peer-reviewed journal and develop an accessible summary of the results for website posting. …”
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Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME) by Archya Dasgupta, Saranga Sawant, Abhishek Chatterjee, Vikram Gota, Arpita Sahu, Amitkumar Choudhari, Kajari Bhattacharya, Ameya Puranik, Indraja Dev, Aliasgar Moiyadi, Prakash Shetty, Vikas Singh, Nandini Menon, Sridhar Epari, Ayushi Sahay, Aekta Shah, Nazia Bano, Farnaz Shaikh, Aabha Jirage, Tejpal Gupta

“…Adults (> 18 years) with a histological diagnosis of diffuse glioma developing radionecrosis will be eligible for the study. …”
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Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhan... by Toshi A Furukawa, Pim Cuijpers, Tatsuo Akechi, Masaru Horikoshi, Yan Luo, Hisashi Noma, Takeo Nakayama, Helen Christensen, Naoki Kondo, Norito Kawakami, Aran Tajika, Ronald C Kessler, Shingo Fukuma, Masatsugu Sakata, Rie Toyomoto, James M S Wason

“…In addition, there has been no platform for iCBT that can accommodate ongoing evolution of internet technologies.Methods and analysis Based on our decade-long experiences in developing smartphone CBT apps and examining them in randomised controlled trials, we have developed the Resilience Training App Version 2. …”
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Establishing best practices in cancer online support groups: protocol for a realist review by Geoff Wong, Holly Witteman, Henry Potts, Andrea C Tricco, Olga Perski, Marina Englesakis, Jacqueline L Bender, Charlene Soobiah, Mary Jane Esplen, Richard Wassersug, Stephanie Babinski, Alaina B Cyr, Colleen Young, Victoria Forster, Janet Papadakos, Colleen Fox, Alison Gothard-Huang

“…We will follow Pawson’s five steps and existing quality standards to develop a program theory that explains how cancer online support groups work, for whom and in what circumstances. …”
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Efficacy of recombinant thrombomodulin for poor prognostic cases of acute exacerbation in idiopathic interstitial pneumonia: secondary analysis of the SETUP trial by Yoshikazu Inoue, Satoshi Marumo, Toru Arai, Hiroshi Kida, Yoshitaka Ogata, Hiroto Matsuoka, Iwao Gohma, Suguru Yamamoto, Masahide Mori, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira

“…A multivariate Cox proportional hazard regression analysis with stepwise selection was performed to reveal the prognostic factors of AE-IIP.Results We developed a prognostic scoring system using two significant prognostic factors, higher FDP/d-dimer at AE and prednisolone therapy before AE, with 3 and 2 points assigned for each parameter, respectively. …”
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Simulation-based infection prevention and control training for medical and healthcare students: a systematic review by Akira Yoshikawa, Hiroyuki Ohtsuka, Keiichiro Aoki, Naonori Tashiro, Shusuke Togo, Kazuki Komaba, Satoshi Nogawa, Miwa Osawa, Megumi Enokida

“…The characteristics of simulation-based educational strategies included confidence in skill performance, decision-making and problem-solving skills, emotional aspects related to infectious diseases (such as fear, empathy, self-reflection, and integration of complex information), and student satisfaction.ConclusionThis systematic review suggests that simulation-based education is effective in developing students’ skills and attitudes, while traditional lecture-based methods are more suited for reinforcing students’ knowledge. …”
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Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Based on the results of this trial, a patient-tailored treatment strategy can be developed for obstructive colon cancer. Registration This study is registered on ClinicalTrials.gov Identifier: NCT04889820, registered on May 17, 2021 in clinicaltrials.gov; Protocol ID: XC21MIDI0004.…”
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Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced... by John Marshall, Ruth Wood, Denise Howel, Emma Clark, Rakesh Heer, John Staffurth, Miranda Morton, Shriya Sharma, Holly Fisher, Jenn Walker, Helen Hancock, Rebecca Maier, Ian Pedley, Rob Jones

“…Introduction Prostate cancer is the most common male cancer with one in four developing non-curable metastatic disease. Initial treatment responses to hormonal therapies are transient and further management options lie between (1) further hormone therapy or (2) a non-hormonal approach involving additional chemotherapy or molecular radiotherapy (radium-223). …”
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Patient-Centered Risk Prediction, Prevention, and Intervention Platform (TIMELY) to Support the Continuum of Care in Coronary Artery Disease Using eHealth and Artificial Intelligen... by Mirela Habibovic, Emma Douma, Hendrik Schäfer, Manuela Sestayo-Fernandez, Tom Roovers, Xin Sun, Henrik Schmidt, Mona Kotewitsch, Jos Widdershoven, David Cantarero-Prieto, Frank Mooren, Carlos Pena-Gil, José Rámon González Juanatey, Martin Schmidt, Hagen Malberg, Vassilis Tsakanikas, Dimitrios Fotiadis, Dimitris Gatsios, Jos Bosch, Willem Johan Kop, Boris Schmitz

“…ObjectiveThe TIMELY project aims to develop and evaluate a personalized, artificial intelligence–driven eHealth platform and app to support sustainable behavior change during phase-3 CR, subsequently reducing cardiac risk scores. …”
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Survey and analysis of the prevalence of tobacco use among patients with severe mental illness at a tertiary specialized psychiatric medical center in China by Hai-Bo Zheng, Hai-Bo Zheng, Chang-Qing Yu, Qiu-Ming Ji, Bing Liu, Yuan-Yuan Liu, Hai-Ying Chen, Yu-Lin Cao, Ji-Fen Gong, Ting Chen

“…Furthermore, there were significant differences in nicotine dependence levels across different psychiatric diagnoses, with patients diagnosed with schizophrenia and bipolar disorder exhibiting higher levels of nicotine dependence compared to those with paranoid disorder who showed lower levels.ConclusionsThe study elucidates the complex nature and critical determinants of tobacco use patterns among individuals with severe mental illness, providing a solid scientific foundation for developing targeted intervention strategies.China Clinical Trial Registry registration numberChiCTR2400088459…”
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FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

“…WP1: A Prospective UK Multicentre Study, WP2A: a Qualitative Study Exploring Parents’ and Clinicians’ Views and WP3: a Consensus Development to Determine Feasibility of a Trial. Eligible pregnancies will be recruited to WP1 and WP2, which will run concurrently. …”
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High recent PrEP adherence with point‐of‐care urine tenofovir testing and adherence counselling among young African women: results from the INSIGHT cohort by Brenda Gati Mirembe, Deborah Donnell, Meighan Krows, Zinhle Zwane, Elizabeth Bukusi, Ravindre Panchia, Cheryl Louw, Noluthando Mwelase, Pearl Selepe, Melissa Senne, Logashvari Naidoo, Rachel Chihana, Margaret Kasaro, Harriet Nuwagaba‐Biribonwoha, Philip Kotze, Katherine Gill, Pippa MacDonald, Alastair vanHeerden, Shannon Bosman, Manjeetha Jaggernath, Phillip du Preez, Amy Ward, Remco P. H. Peters, Sinead Delany‐Moretlwe, Sue Peacock, Rachel Johnson, Jason Caucutt, Susan Morrison, Guohong Wang, Monica Gandhi, Jennifer Velloza, Renee Heffron, Connie Celum, the INSIGHT Study Team

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Clinical value of early assessment of hyperfibrinolysis by rotational thromboelastometry during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter pros... by Marije Tahitu, Paul I. Ramler, Ada Gillissen, Camila Caram‐Deelder, Dacia D. C. A. Henriquez, Moniek P. M. deMaat, Johannes J. Duvekot, Jeroen Eikenboom, Kitty W. M. Bloemenkamp, Thomas van denAkker, Johanna G. van derBom

“…Four (1%) women had thromboelastometric evidence of hyperfibrinolysis, of whom two developed severe postpartum hemorrhage. The AUC for enzymatic fibrinolysis index more than 15% for progression to severe postpartum hemorrhage was 0.47 (95% CI 0.40–0.54). …”
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Clinical features and predictive nomogram for fatigue sequelae in non-severe patients infected with SARS-CoV-2 Omicron variant in Shanghai, China by Xiao-Lei Shen, Yu-Han Jiang, Shen-Jie Li, Xin-Yi Xie, Yu Cheng, Li Wu, Jun Shen, Wei Chen, Jian-Ren Liu

“…Objective: To collect and analyze the long-term effects of non-severe COVID-19 infection patients and to develop a model for the prediction of fatigue symptoms. …”
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