Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial by Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

“… BackgroundPsychotherapy is central to the treatment of mental disorders, highlighting the importance of medical students and residents developing competencies in this area. Chinese medical residents have expressed a strong need for psychotherapy training, yet they are generally dissatisfied with the current offerings. …”
Get full text

A protocol using mixed methods for the impact analysis of the implementation of the EMPOWER project: an eHealth intervention to promote mental health and well-being in European wor... by Tom Chen, Sue Lukersmith, Luis Salvador-Carulla, Cindy E Woods, Carlota de Miquel

“…The aim of this paper is to describe the rationale and methods that will be used to conduct a maxi impact analysis of the processes undertaken to develop and implement the EMPOWER platform in European workplaces using the Global Impact Analytics Framework (GIAF) methodology.Methods and analysis We will undertake a mixed-methods analysis of the impact of the process of implementation in the two phases of implementation (initiation and maturity—the early implementation phase). …”
Get full text

Using an anti-racist research framework to design studies of oral human papillomavirus and oropharyngeal cancer in San Francisco: rationale and protocol for the Health Equity and O... by Alessandro Villa, Alexandra L Hernandez, Elena O Lingas, William Juarez, Joel Palefsky

“…Introduction The goal of our research programme is to develop culturally appropriate patient-specific interventions for primary and secondary prevention of human papillomavirus (HPV)-related oropharyngeal cancer (OPC) among people living with HIV (PLWH); PLWH are at a higher risk for OPC than the general population and, as with many cancers, there are disparities in OPC health outcomes by race and ethnicity. …”
Get full text

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial. by Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

“…<h4>Methods and findings</h4>To establish preclinical proof of concept, we developed two independent rat models of cirrhosis that were characterized by progressive reduction in renal blood flow and glomerular filtration rate and showed evidence of renal endothelial dysfunction. …”
Get full text

Novel longitudinal Multiple Overall Toxicity (MOTox) score to quantify adverse events experienced by patients during chemotherapy treatment: a retrospective analysis of the MRC BO0... by Jakob Anninga, Hans Gelderblom, Marta Fiocco, Marta Spreafico, Francesca Ieva, Francesca Arlati, Federico Capello, Federico Fatone, Filippo Fedeli, Gianmarco Genalti

“…Conventional regimen may be preferred to dose-intense in terms of AEs at cycles 2–3 (p&lt;0.05).Conclusions The novel longitudinal method developed can be applied to any cancer studies with CTCAE-graded toxicity data. …”
Get full text

Assessing the Cultural Fit of a Digital Sleep Intervention for Refugees in Germany: Qualitative Study by Maja Blomenkamp, Andrea Kiesel, Harald Baumeister, Dirk Lehr, Josef Unterrainer, Lasse B Sander, Kerstin Spanhel

“…Sleep-e, a digital sleep intervention originally developed for German teachers, has been culturally adapted for refugees in Germany mainly coming from African and Middle East countries. …”
Get full text

The benefit of inhibitory control training for insomnia with short sleep duration phenotype: a pilot randomized trial by Haobo Zhang, Zhangwei Lv, Hanfei Chen, Zijie Tang, Xu Lei

“…These findings provide new insights for developing precise intervention strategies in ID. Trial registration The study was prospectively registered on May 30, 2024, in Chinese Clinical Trials registry (ChiCTR2400085063).…”
Get full text

Incidence and predictors of pulmonary aspergillosis in patients with lung cancer: a systematic review and meta-analysis by Geling Teng, Feng Jin, Hua Zhang, Min Zhang

“…Future research should focus on validating these findings in prospective studies and exploring the underlying biological mechanisms to develop more effective preventive and treatment strategies.Systematic review registrationThis study was registered in the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY) platform (number: INPLASY2024100066).…”
Get full text

Validation of the Nociception Level Index for the Detection of Nociception and Pain in Critically Ill Adults: Protocol for an Observational Study by Céline Gélinas, Shiva Shahiri T, Han Ting Wang, Maria Cecilia Gallani, Walid Oulehri, Denny Laporta, Philippe Richebé

“…The Nociception Level (NOL) index is a multiparameter technology initially developed for the monitoring of nociception and related pain in anesthetized patients, and its use in the ICU is new. …”
Get full text

eHealth versus face-to-face support for remission of type 2 diabetes by calorie restriction (eHealth DIabetes remission Trial): study protocol for a non-inferiority parallel group... by Lars Lindholm, Per Liv, Julia Otten, Anna Winkvist, Andreas Stomby, Youssef Chninou, Anna Tellström, Claudia Schien

“…However, this intervention involves support through face-to-face meetings every 2 to 4 weeks over a 2-year period, which is not feasible in routine care with limited resources. Therefore, we have developed an eHealth programme to help patients achieve diabetes remission through calorie restriction in a cost-effective manner. …”
Get full text

Causes and prognosis of neovascular glaucoma after pars plana vitrectomy in patients with diabetic retinopathy by Xiaolu Cao, Peipei Jia, Xiulian Qiao, Beibei Gao, Fuyin wang

“…Results Among the total 225 eyes, 15 (6.7%) eyes developed NVG 1–12 months after surgery, including 11 cases within 6 months. …”
Get full text

Impacts of mandatory clinical ethics consultation on resource utilization and ethical conflicts in critically ill patients: a comparison between medical and surgical intensive care... by Yen-Ko Lin, Chao-Wen Chen, Yung-Sung Yeh, Chia-Ju Lin, Yu-Wen Huang, Yu-Chih Lin, Chau-Chyun Sheu

“…Trial registration The ClinicalTrials.gov Identifier is NCT04926610.…”
Get full text

Bedside counseling on complementary medicine as a new model in pediatric cancer care—protocol of the SiKOM multicenter prospective cohort study by Lara Nowak, Daniela Reis, Rebecca Büttner, Melanie Schwermer, Jennifer Bals, David D. Martin, David D. Martin, Thomas Ostermann, Alfred Längler, Alfred Längler, Heidemarie Haller, Tycho Zuzak, Tycho Zuzak

“…By integrating these findings, we aim to develop a replicable approach to complementary medicine counseling that addresses the unique needs of pediatric cancer patients, their families, and medical professionals.DiscussionPrevious initiatives have primarily focused on training individual physicians within each center to address complementary medicine. …”
Get full text

A Self-Adaptive Serious Game to Improve Motor Learning Among Older Adults in Immersive Virtual Reality: Short-Term Longitudinal Pre-Post Study on Retention and Transfer by Gauthier Everard, Louise Declerck, Thierry Lejeune, Martin Gareth Edwards, Justine Bogacki, Cléo Reiprich, Kelly Delvigne, Nicolas Legrain, Charles Sebiyo Batcho

“… BackgroundDespite their potential, the use of serious games within immersive virtual reality (iVR) for enhancing motor skills in older adults remains relatively unexplored. In this study, we developed a self-adaptive serious game in iVR called REAsmash-iVR. …”
Get full text

Effectiveness of virtual reality technology in rehabilitation after anterior cruciate ligament reconstruction: A systematic review and meta-analysis. by Yunchuan Li, Junjie Peng, Jintao Cao, Yang Ou, Jiaming Wu, Weisha Ma, Feng'e Qian, Xiaoqian Li

“…<h4>Background</h4>Anterior cruciate ligament reconstruction (ACLR) can be fully recovered with effective rehabilitation, which also lowers the risk of developing osteoarthritis in the knee. Virtual reality technology (VRT) has been used for rehabilitation after ACLR. …”
Get full text

Trusted health system implementation strategies to increase vaccination (TRUE SYNERGI): a stepped-wedge cluster randomized trial to reduce HPV-related cancers by Daisy Y. Morales-Campos, Prajakta Adsul, Yuanyuan Liang, Erin Donovan, Leticia R. Moczygemba, Jessica A. Kahn

“…We will conduct baseline assessments at each practice, which will provide data to assist the practice facilitator in engaging with the providers and leadership to develop a tailored implementation plan for each practice. …”
Get full text

The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis by Fateme Salemi, Sara Jambarsang, Amir Kheirkhah, Amin Salehi-Abargouei, Zahra Ahmadnia, Haniye Ali hosseini, Marzieh Lotfi, Saad Amer

“…However, further research is needed to develop models assessing the combined impact of AMH and AFC on ovarian response prediction. …”
Get full text

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse by Noah Robinson, Francisco N Ramos, Steven D Hollon, Gloria T Han, Iony D Ezawa

“…Cognitive behavioral immersion (CBI)—a cognitive behavioral skills training intervention delivered by peer coaches in the metaverse—has been developed to address these barriers. CBI can be used through a virtual reality headset or via flat-screen devices such as phones, tablets, or computers. …”
Get full text

Assessing Sedation Depth with PSI in Elderly ERCP Patients: A Prospective Cohort Study by Huang L, Liu LL, Lu YD, Zhuang MY, Dou W, Liu H, Ji FH, Peng K

“…Five patients (8.8%) experienced PSI < 25 for at least 10 min, and three of them (5.3%) showed EEG burst suppression. No patients developed desaturation or intra-procedural awareness. …”
Get full text

Gaming-Based Tele-Exercise Program to Improve Physical Function in Frail Older Adults: Feasibility Randomized Controlled Trial by Lakshmi Kannan, Upasana Sahu, Savitha Subramaniam, Neha Mehta, Tanjeev Kaur, Susan Hughes, Tanvi Bhatt

“…This contributes to accelerated aging processes, leading to adverse health outcomes and reduced quality of life. We have developed and piloted the design, usability, safety, and feasibility of a gaming-based cognitive-motor (CogXergaming) tele-exercise protocol in prefrail older adults. …”
Get full text