Blended palliative and survivorship care intervention (POISE) for patients with metastatic oncogene-driven non-small cell lung cancer: study protocol for a pilot randomised control... by Jennifer S Temel, Joseph A Greer, Vicki Jackson, Dustin J Rabideau, Heather A Richard, Roshni Sarathy, Jill Feldman, Leslie Cartagena, Heather Patel, Lecia V Sequist, Elyse Park, Laura A Petrillo

“…These advanced cancer survivors face new challenges related to living with uncertainty and desire more support to maximize their health and quality of life. Therefore, we developed a population-specific, blended palliative and survivorship care intervention to address the supportive care needs of patients recently diagnosed with advanced lung cancer and who are receiving targeted therapy for NSCLC with EGFR, ALK, ROS1 or RET driver mutations.Methods and analysis This study is a single-site, non-blinded pilot randomised controlled trial of an intervention for patients with metastatic oncogene-driven NSCLC, Patient-centred, Optimal Integration of Survivorship and palliative carE (POISE) versus usual care. …”
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Exercise-Induced Excessive Blood Pressure Elevation Is Associated with Cardiac Dysfunction in Male Patients with Essential Hypertension by Binfeng Xia, Pengyu Cao, Li Zhang, Huihui Huang, Rongyu Li, Xia Yin

“…The study was registered with the Chinese Clinical Trials Register, registration number: ChiCTR2100053140.…”
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Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Tri... by Agricola Joachim, Agricola Joachim, Asli Bauer, Sarah Joseph, Christof Geldmacher, Patricia J Munseri, Said Aboud, Marco Missanga, Philipp Mann, Britta Wahren, Guido Ferrari, Victoria R Polonis, Merlin L Robb, Jonathan Weber, Roger Tatoud, Leonard Maboko, Michael Hoelscher, Eligius F Lyamuya, Gunnel Biberfeld, Eric Sandström, Arne Kroidl, Muhammad Bakari, Charlotta Nilsson, Sheena McCormack

“…Two weeks after the second HIV-MVA vaccination 34 (97%) of the 35 previously vaccinated developed Env-specific binding antibodies, and 79% and 84% displayed IFN-γ ELISpot responses to Gag and Env, respectively. …”
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Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial by Emmeline Montane, Nabila Brihmat, Camille Cormier, Claire Thalamas, Vanessa Rousseau, Gerard Tap, Xavier De Boissezon, Evelyne Castel-Lacanal, Philippe Marque

“… BackgroundIndividuals with poststroke hemiplegia often develop spasticity, which increases disability. Antispastic treatments such as baclofen and botulinum toxin are commonly prescribed in poststroke recovery. …”
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Delayed muscle fatigue during electrical stimulation of the proximal nerve using asymmetric random high-frequency carrier pulse cluster by Rui Yuan, Yang Zheng, Henry Shin, Guanghua Xu, Shengnuo Fan, Zhanhong Du

“…Finger force, high-density electromyographic (EMG) signals of the flexor muscles and the pain score were recorded. In addition, we developed a finite element model of the upper arm and a motor fiber model to simulate motor axon activation of the peripheral nerve induced by the two electrical stimulation modes. …”
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Three decades of progress: evolution of outcomes and prognostic indicators in biliary atresia management by Senol Emre, Yalim Benibol, Ali Ekber Hakalmaz, Buse Karakurt, Ayse Kalyoncu Ucar, Nuray Kepil, Ömer Faruk Beşer, Sebuh Kuruğoğlu, Osman Faruk Senyuz

“…Patients were stratified by preoperative ALBI (originally developed for HCC but applied here for its objective assessment of liver function), preoperative and postoperative APRI, and METAVIR scores. …”
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Long-term outcomes of an educational intervention to reduce antibiotic prescribing for childhood upper respiratory tract infections in rural China: Follow-up of a cluster-randomise... by Xiaolin Wei, Zhitong Zhang, Joseph P Hicks, John D Walley, Rebecca King, James N Newell, Jia Yin, Jun Zeng, Yan Guo, Mei Lin, Ross E G Upshur, Qiang Sun

“…To reduce prescribing of antibiotics in Chinese primary care to children with upper respiratory tract infections (URTIs), we developed an intervention comprising clinical guidelines, monthly prescribing review meetings, doctor-patient communication skills training, and education materials for caregivers. …”
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Clinically directed initiation versus routine use of amoxicillin-clavulanate and the risk of local complications among patients with haemotoxic snakebite envenomation treated at a... by Tamilarasu Kadhiravan, Chanaveerappa Bammigatti, Akinchan Bhardwaj, Aditya Gautam, Malayil B Indu, Paramasivam Sabitha, Surendran Deepanjali, Bettadpura Shamanna Suryanarayana

“…Russell’s viper was the most common (21 (32%)) biting snake species identified; 52 (79%) patients had evidence of haemotoxic envenomation at baseline, and 24 (36%) patients developed AKI. There were 10 clinical failures—six in the clinically directed initiation arm and four in the routine use arm. …”
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Safety and therapeutic potential of allogeneic adipose-derived stem cell spray transplantation in ischemic cardiomyopathy: a phase I clinical trial by Takuji Kawamura, Daisuke Yoshioka, Ai Kawamura, Yusuke Misumi, Takura Taguchi, Daisuke Mori, Shunsuke Saito, Takashi Yamauchi, Hiroki Hata, Shigeru Miyagawa

“…One patient in the ADSC group developed pleural effusion that was resolved with drainage. …”
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Evaluation Methods, Indicators, and Outcomes in Learning Health Systems: Protocol for a Jurisdictional Scan by Shelley Vanderhout, Marissa Bird, Antonia Giannarakos, Balpreet Panesar, Carly Whitmore

“…ConclusionsThis research will characterize the current landscape of LHS evaluation approaches and provide a foundation for developing consistent and scalable metrics of LHS growth, maturity, and success. …”
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Population pharmacokinetics and pharmacodynamics of two dosing regimens of antenatal corticosteroids: protocol for a prospective nested study in a randomised controlled trial by Adejumoke Idowu Ayede, Olufemi T Oladapo, Rekha Bharti, Nitya Wadhwa, Tina Lavin, Nicole Minckas, Ebunoluwa A Adejuyigbe, Shivaprasad S Goudar, William Jusko, Shuchita Gupta, Ayesha De Costa, Adesina Olubukola Adeponle, Ramana Moorthy Aripaka, Francis Olubanji Awoniyi, Nurudeen Ola Bello, Anjali Dabral, Zubair Hasan, Dennis Anthony Isah, Ranjit P Kangle, Wojciech Krzyzanski, Olatunji Okikiola Lawal, Elijah-David Ukpahiu-Ojo Ogwu, Kabir Olatunde Oyeniyi, Amaresh P Patil, Yeshita V Pujar, Subramanian Ramachandran, Sunil Ranga, Ezekiel Onoja Ray, Suresh Sivasankaran, Manjunath S Somannavar, Jyotsna Suri

“…The study results will be published in a peer-reviewed journal and presented at scientific conferences.Trial registration number ISRCTN11434567.…”
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Mobile Health–Based Motivational Interviewing to Promote SARS-CoV-2 Vaccination in Rural Adults: Protocol for a Pilot Randomized Controlled Trial by Ashlea Braun, Sarah Corcoran, Khue Tu Doan, Cameron Jernigan, Cate Moriasi, Michael Businelle, Thanh Bui

“…ObjectiveThis study aims to develop and evaluate the feasibility, acceptability, and preliminary efficacy of our mHealth-based MI intervention to diminish SARS-CoV-2 vaccine hesitancy (MOTIVACC). …”
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Are there differences in efficacy and safety between local and imported direct-acting antiviral agents for hepatitis C in China? by Zhitao Wang, Youbing Ran, Yihan Fu, Jing Sun, Yuanli Liu

“…It is critical for local DAA developers to generate more evidence with expanded patient population in terms of age, treatment experience and genotype of hepatitis C virus, conducting head-to-head studies directly comparing the efficacy and safety. …”
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PHOENIX (Picking up Hidden Osteoporosis Effectively during Normal CT Imaging without additional X-rays): protocol for a randomised, multicentre feasibility study by Lee Shepstone, Jane Fleming, Stephen K Kaptoge, Emma Clark, Adam P Wagner, Kenneth E S Poole, Daniel D G Chappell, Thomas D Turmezei, Karen Willoughby

“…Up to one-third reveal undiagnosed osteoporosis or vertebral fractures. We developed an intervention, Picking up Hidden Osteoporosis Effectively during Normal CT Imaging without additional X-rays (‘PHOENIX’), to facilitate early detection and management of osteoporosis in people attending hospitals for CT scans.Methods and analysis A multicentre, randomised, pragmatic feasibility study. …”
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Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort stu... by Janine Makaronidis, Jessica Mok, Nyaladzi Balogun, Cormac G Magee, Rumana Z Omar, Alisia Carnemolla, Rachel L Batterham

“…<h4>Trials registration</h4>ClinicalTrials.gov NCT04377815.…”
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Understanding the acute care context to inform palliative care improvements: a qualitative study of hospital-based multidisciplinary clinicians by Claudia Virdun, Gursharan K. Singh, Patsy Yates, Jane L. Phillips, Alison Mudge

“…Improvements with a focus on developing clinician knowledge, skills, and confidence in palliative care need to pay attention to organisational siloes that constrain shared care, cultures of care that prioritise cure and efficiency, clinical uncertainty in the context of advanced serious illness and optimising the environment for quality palliative care.…”
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Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks by Wei S, Chen B, Guo Z, Zhang H, Li J, Hu X, Yang C, Li J, Li X, Liu Z, Xu Y, Liu S

“…The study protocol describes our interventional clinical trial aimed at developing magnetic convulsive therapy as an effective and safe treatment for SCZ. …”
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Evaluation of the Aspects of Digital Interventions That Successfully Support Weight Loss: Systematic Review With Component Network Meta-Analysis by Michael Nunns, Samantha Febrey, Rebecca Abbott, Jill Buckland, Rebecca Whear, Liz Shaw, Alison Bethel, Kate Boddy, Jo Thompson Coon, G.J. Melendez-Torres

“… BackgroundObesity is a chronic complex disease associated with increased risks of developing several serious and potentially life-threatening conditions. …”
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A mobile health intervention in caregivers of patients undergoing hematopoietic cell transplantation: a randomized controlled trial to examine health-related quality of life by Xiao Cao, Michelle Rozwadowski, Thomas M. Braun, Noelle E. Carlozzi, Afton L. Hassett, Amanda K. Johnson, Evan Shereck, David A. Hanauer, Sung Won Choi

“…To address this, we developed the Roadmap mHealth app, which incorporates resilience-building features based on positive psychology. …”
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Do coping strategies mediate the effects of childhood adversities and traumata on clinical high-risk of psychosis, depression, and social phobia? A cross-sectional study on patient... by Zhixiong Chang, Naweed Osman, Carolin Martha Doll, Theresa Katharina Lichtenstein, Marlene Rosen, Eva Meisenzahl, Hanna Kadel, Joseph Kambeitz, Kai Vogeley, Frauke Schultze-Lutter

“…A detailed understanding of the effects of CAT will in future help to develop a multi-dimensional, holistic and sex-specific approach to the treatment of patients who have experienced CAT. …”
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