Sensory processing and child appetitive traits: findings from the ROLO longitudinal birth cohort study by Anna Delahunt, Sophie Callanan, Eileen C. O’ Brien, Aisling A. Geraghty, Sharleen L. O’ Reilly, Ciara M. McDonnell, Emma Hokey, Fionnuala M. McAuliffe

“…Abstract Background Oral sensory hypersensitivity has been linked with fussy eating predominantly in non-typically developing children. We hypothesized that child ‘Oral’ (touch, smell and taste in the mouth) and ‘Social-Emotional’ (response to social expectations) sensory processing are associated with child appetitive traits in typically developing preteen children. …”
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An animal model study of simplified optical navigation system-assisted percutaneous lumbar transforaminal puncture by B. N. Wenxiu Chai, Yuqing Chen, Li Sheng, Yong Huang

“…Methods A simplified optical navigation system based on an optical tracker and 3D Slicer software was developed. Eight fresh goat lumbar spine segments were randomly divided into the navigation group and control group. …”
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Community-based palliative care needs and barriers to access among cancer patients in rural north India: a Participatory action research by Mayank Gupta, Ankita Kankaria, Liya E. Joshy, Sandeep Singh, Bhajan Lal, Subhash Choudhary, Sapna Marcus, Anju Grewal, Lajya Devi Goyal, Rakesh Kakkar

“…Conclusions The study emphasize the need for and provide a roadmap for developing context-specific and culturally appropriate CBPC services to address the identified challenges and needs. …”
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Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity by Rafael Perera, Marjan Van Den Akker, Kym I E Snell, Joerg J Meerpohl, Ferdinand M Gerlach, Daniela Küllenberg de Gaudry, Ana Isabel González-González, Jeanet Blom, Christiane Muth, Walter Emil Haefeli, Karin M A Swart, Petra Elders, Henrik Rudolf, Ulrich Thiem, Andreas Daniel Meid, Truc Sophia Dinh, Donna Bosch-Lenders, Hans J Trampisch, Benno Flaig, Ghainsom Kom

“…Objective To explore factors that potentially impact external validation performance while developing and validating a prognostic model for hospital admissions (HAs) in complex older general practice patients.Study design and setting Using individual participant data from four cluster-randomised trials conducted in the Netherlands and Germany, we used logistic regression to develop a prognostic model to predict all-cause HAs within a 6-month follow-up period. …”
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Pharmacokinetic Profiles of Lansoprazole in Patients With Morbid Obesity Post‐Roux‐en‐Y Gastric Bypass Surgery by Suthep Udomsawaengsup, Sathienrapong Chantawibul, Naranon Boonyuen, Sarunnuch Panyavorakhunchai, Pattharasai Kachornvitaya, Wasu Wisanuyothin, Pittawat Somvanapanich, Warittha Lertwatthiphong, Napatsanan Tanathitiphuwarat, Pajaree Chariyavilaskul

“…Further studies are needed to explore the clinical implications of these pharmacokinetic changes and develop optimized treatment strategies for post‐RYGB patients. …”
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Evaluation of the efficacy of angiotensin receptor–neprilysin inhibitor in patients with aortic stenosis undergoing transcatheter aortic valve implantation: protocol for a randomis... by Hideki Hanaoka, Yoshio Kobayashi, Hideki Kitahara, Takeshi Sugawara, Goro Matsumiya, Yosuke Inaba, Shogo Okita, Hiroaki Yaginuma, Hiroki Goto, Hiroaki Yamamoto, Tomoyoshi Kanda, Kaoru Matsuura

“…Introduction There are a substantial number of patients developing heart failure after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS), even though AS has been successfully treated. …”
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Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study by Carlo Volf, Anne Sofie Aggestrup, Paul Michael Petersen, Carsten Dam-Hansen, Ulla Knorr, Ema Erkocevic Petersen, Janus Engstrøm, Janus C Jakobsen, Torben Skov Hansen, Helle Østergaard Madsen, Ida Hageman, Klaus Martiny

“…The objective of this study is to investigate the antidepressant efficacy of a newly developed dynamic LED-lighting system installed in an inpatient ward.Methods and analysis In all, 150 inpatients with a major depressive episode, as part of either a major depressive disorder or as part of a bipolar disorder, will be included. …”
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Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementing the TREAT INTERACT intervention for primary school teachers an... by Ane-Marthe Solheim Skar, Ingunn Marie S. Engebretsen, Nora Braathu, Harriet Aber, Harald Bækkelund, Melf-Jakob Kühl, Marjorie Mukisa, Joyce Sserunjogi Nalugya, Norbert Skokauskas, Vilde Skylstad, Tore Wentzel-Larsen, TREAT research consortium, Juliet Ndimwibo Babirye

“…Discussion Based on the results, we will develop sustainable and scalable implementation advice on mental health promotion and draft implementation guidelines in line with current WHO guidelines. …”
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Combined chemoimmunotherapy of patients with mature B-cell non-Hodgkin lymphomas age group until 18 years: results of multicenter study NHL 2004 m with rituximab and modified B-NHL... by E. V. Samochatova, L. N. Schelikhova, M. B. Belogurova, A. V. Schamardina, E. V. Bascharova, D. V. Litvinov, N. V. Myakova, L. G. Fechina, O. P. Chlebnikova, E. V. Inuschkina, O. V. Riskal, P. Z. Schammasov, I. M. Yunusova, S. Yu. Umnova, D. M. Konovalov, A. G. Talalaev, J. V. Roumiantseva, A. A. Maschan

“…There was no case of remission death; relapse has developed only at one patient (neuroleukemia in patient with Burkitt lymphoma). 54 patients (88%) are in continuous complete remission. …”
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Middle meningeal artery (MMA) embolisation for chronic subdural haematomas: rationale and design for the STOp Recurrence of MMA Bleeding (STORMM) randomised control trial—a study p... by Granit Molliqaj, Gianmarco Bernava, Andrea Rosi, Karl Schaller, Paolo Machi, Jeremy Hofmeister, Aria Nouri, Sandrine Morel, Andrea Cardia, Abdullah Al Awadhi, Caterina Mollica, Michele Da Broi, Torstein Ragnar Meling

“…Surgery is typically performed once neurological symptoms develop. Recent studies suggest that arteries nourished by the middle meningeal artery (MMA) may be responsible for haematoma progression and that MMA embolisation is clinically useful. …”
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Comparative efficacy and complication rates after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network... by Orestis Efthimiou, Georgia Salanti, Huseyin Naci, Philip Bennett, Antonios Athanasiou, Areti Angeliki Veroniki, Ilkka Kalliala, Sarah Bowden, Maria Paraskevaidi, Pierre Martin-Hirsch, Evangelos Paraskevaidis, Maria Kyrgiou

“…We will assess the risk of bias in RCTs and observational studies using tools developed by the Cochrane Collaboration. Two authors will independently assess study eligibility, abstract the data and assess the risk of bias. …”
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Cost-effectiveness of a patient-centred approach to managing multimorbidity in primary care: a pragmatic cluster randomised controlled trial by Peter Bower, Bruce Guthrie, Stewart W Mercer, Daisy Gaunt, Sara Brookes, Joanna Thorn, Chris Salisbury, Mei-See Man, Katherine Chaplin, Bridie Fitzpatrick, Caroline Gardner, Sandra Hollinghurst, Victoria Lee

“…This study aimed to determine the cost-effectiveness of the 3D intervention, which was developed to improve the system of care.Design Economic evaluation conducted alongside a pragmatic cluster-randomised trial.Setting General practices in three centres in England and Scotland.Participants 797 adults with three or more chronic conditions were randomised to the 3D intervention, while 749 participants were randomised to receive usual care.Intervention The 3D approach: comprehensive 6-monthly general practitioner consultations, supported by medication reviews and nurse appointments.Primary and secondary outcome measures The primary economic evaluation assessed the cost per quality-adjusted life year (QALY) gained from the perspective of the National Health Service (NHS) and personal social services (PSS). …”
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Impact of increasing post-filter ionised calcium target on regional citrate anticoagulation efficacy in ICU continuous renal replacement therapy: the non-inferiority randomised con... by Mona Assefi, Jean-Michel Constantin, Elodie Baron, Noemie Clavieras, Rayan Braik, Arthur James, Florian Blanchard

“…All procedures were developed in order to assure data protection and confidentiality.Trial registration number NCT05814341.…”
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Ambulatory cancer care electronic symptom self-reporting (ACCESS) for surgical patients: a randomised controlled trial protocol by Andrea L Pusic, Daniel Stein, Cara Stabile, Larissa K Temple, Jessica S Ancker, Ethan Basch, Jeanne Carter, Magen Miranda, Peter D Stetson, Andrew Vickers, Brett A Simon

“…Findings will be relevant in designing future coordinated care models targeting improved healthcare quality and patient experience.Trial registration number NCT03178045…”
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Evaluation of a 1-hour troponin algorithm for diagnosing myocardial infarction in high-risk patients admitted to a chest pain unit: the prospective FAST-MI cohort study by Michael Amann, Felix Gaiser, Sandra Iris Schwenk, Faridun Rahimi, Roland Schmitz, Kambis Mashayekhi, Miroslaw Ferenc, Franz-Josef Neumann, Christian Marc Valina, Willibald Hochholzer

“…This algorithm recommend by current guidelines was previously developed in cohorts with a prevalence of MI of less than 20%.Design Prospective cohort study from November 2015 until December 2016.Setting Dedicated chest pain unit of a single referral centre.Participants Consecutive patients with suspected MI were screened. …”
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Evaluation of the effects of pre-exposure treatment with hydroxychloroquine on the risk of COVID-19 infection and on the efficacy of anti-COVID-19 vaccination during lupus or Gouge... by Patrice Cacoub, David Ribes, Laurent Alric, Dominique Chauveau, Grégory Pugnet, Laurent Sailler, Estibaliz Lazaro, Martin Michaud, Marion Migueres, Mathieu Vautier, Kim Ly, Anne Laure Fauchais, Emilie Berard, Morgane Mourguet, Clara Brusq, Stephanie Faure, Pascal Lebray, Jean François Viallard, Carle Paul, Arnaud Constatin, Adeline Ruysen Wittrand, Marie Irles Depe

“…Moreover, non-exposure to HCQ treatment (combined or not with IS) was associated with decreased risk of COVID-19 infection and of developing a symptomatic or severe infection. HCQ and IS do not influence the vaccine response. …”
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MIKROBE: a feasibility study for a randomised controlled trial of one-stage or two-stage surgery for prosthetic knee infection by Rohini Terry, Sarah Dean, Patrick Hourigan, Hugh Ben Waterson, Vikki Wylde, Natalie Carpenter, Bethany Whale, Roy J. Powell, Polly Tarrant, Antonieta Medina-Lara, Abtin Alvand, Andrew D. Toms

“…After surgery, about 1% of patients develop a deep infection, known as a prosthetic joint infection. …”
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A weather-forecast driven early warning system for wheat blast disease: User-centered design, validation, and scaling in Bangladesh and Brazil by Timothy J. Krupnik, José Mauricio Cunha Fernandes, Felipe Vargas, Emerson Medeiros Del Ponte, Khaled Hossain, Mustafa Kamal, Mutasim Billah, Md. Harun-Or-Rashid, Sk. Ghulam Hussain, Pawan Kumar Singh, Krishna Kanta Roy, Carlos Augusto Pizolotto, Md. Shah Kamal Khan, Willingthon Pavan, Golam Faruq

“…Collaboration between agricultural research, meteorological and extension organizations in developing and supplying weather forecasts, disease management advisories, and early warning systems—along with presenting hindcast validation results to stakeholders—led to the formal endorsement of the EWS in both countries. …”
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Evaluating an evidence-based iSupport for Dementia programme in routine care services: study protocol for a hybrid type II trial by Jing Wang, Shahid Ullah, Ying Yu, Rujun Hu, Lily Dongxia Xiao, Xiaoying Pan, Ada Cheng, Candy Xie, Kam Chiu, Dingxin Xu, Angela Rong Yang Zhang

“…Introduction Disparities in supporting carers of people with dementia exist in carer populations. The WHO developed an evidence-based iSupport for Dementia programme to address the disparities. …”
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Design of the OverCool study: Lung-conservative liquid ventilation for the induction of Ultra-Rapid Cooling after Cardiac Arrest (OverCool) by Renaud Tissier, Fabio Silvio Taccone, Lionel Lamhaut, Eric Vicaut, Fabrice Paublant, Jean-Damien Ricard, Alain Mercat, Alain Cariou

“…A new medical device system, Vent2Cool, was developed for clinical use in the Intensive Care Unit to achieve ultra-rapid therapeutic hypothermia by total liquid ventilation to patients. …”
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