Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS): study protocol for a nationwide prospective cohort study by Marc G Besselink, Marja A Boermeester, Frank P Vleggaar, Paul Fockens, Marco J Bruno, Hjalmar C van Santvoort, Jeanin E van Hooft, Menno A Brink, Jan-Werner Poley, Robert C Verdonk, Hendrik M van Dullemen, Liesbeth M Kager, Devica S Umans, Hester C Timmerhuis, Nora D Hallensleben, Stefan A Bouwense, Marie-Paule GF Anten, Abha Bhalla, Rina A Bijlsma, Lieke Hol, Wouter L Curvers, Brechje C van Eijck, G Willemien Erkelens, Erwin J M van Geenen, Wouter L Hazen, Chantal V Hoge, Akin Inderson, Sjoerd D Kuiken, Lars E Perk, Rutger Quispel, Tessa EH Römkens, Adriaan CITL Tan, Annemieke Y Thijssen, Niels G Venneman, Annet MCJ Voorburg, Roy LJ van Wanrooij, Ben J Witteman

Get full text

Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a phase II, open-label,... by Jesús Rodríguez-Baño, Antonio Luque-Pineda, Julian Torre-Cisneros, M Ángeles Esteban-Moreno, Rafael León López, Sheila Cárcel Fernández, Laura Limia Pérez, Alberto Romero Palacios, María Concepción Fernández-Roldán, Eduardo Aguilar Alonso, Inés Pérez Camacho, Nicolás Merchante, Julián Olalla, Marta Santos

“…Introduction About 25% of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) associated with a high release of pro-inflammatory cytokines such as interleukin-6 (IL-6). …”
Get full text

Protocol of the follow-up of patients with transthyretin amyloid cardiomyopathy by multimodality imaging (FAITH) study: a prospective observational study in patients with ATTR-CM u... by Bettina Heidecker, Jeanette Schulz-Menger, Ingolf Sack, Carsten Schwenke, Jan Gröschel, Gina Barzen, Jasmin Zernikow, Edyta Blaszczyk, Katrin Hahn, Helena F Pernice, Elena Romero Dorta, Phillip van Dijck, Sebastian Spethmann

“…The final statistical analysis will be based on developing a multiparametric score for the prediction of treatment response. …”
Get full text

Effect of spironolactone on cardiovascular morbidity and mortality in patients with hypertension and glucose metabolism disorders (ESCAM): a study protocol for a pragmatic randomis... by Nanfang Li, Lin Wang, Qin Luo, Jing Hong, Yuanyuan Li, Mengyue Lin, Mulalibieke Heizhati, Jina Yili, Xiaoguang Yao, Qing Zhu

“…Introduction Hypertension combined with diabetes and hypokalemia is more likely to develop hyperaldosteronism and is at higher risk of cardiovascular events. …”
Get full text

Design of a Cost-Effective Ultrasound Force Sensor and Force Control System for Robotic Extra-Body Ultrasound Imaging by Yixuan Zheng, Hongyuan Ning, Eason Rangarajan, Aban Merali, Adam Geale, Lukas Lindenroth, Zhouyang Xu, Weizhao Wang, Philipp Kruse, Steven Morris, Liang Ye, Xinyi Fu, Kawal Rhode, Richard James Housden

“…To address these challenges, we developed a cost-effective, lightweight, 3D-printed force sensor and a hybrid position–force control strategy tailored for robotic ultrasound scanning. …”
Get full text

RadBone: bone toxicity following pelvic radiotherapy – a prospective randomised controlled feasibility study evaluating a musculoskeletal health package in women with gynaecologica... by Janelle Yorke, Sarah O’Connell, Sally Taylor, Karen Johnson, Robert G Bristow, Martin Eden, Kate Haslett, John Moore, Rohit Kochhar, Victoria Chatzimavridou Grigoriadou, Lisa H Barraclough, Ivona Baricevic-Jones, Zoe Merchant, Thomas Westwood, Anthony David Whetton, Claire E Higham

“…Introduction Patients receiving radiotherapy are at risk of developing radiotherapy-related insufficiency fractures, which are associated with increased morbidity and pose a significant burden to patients’ quality of life and to the health system. …”
Get full text

Transcriptional signatures of human peripheral blood mononuclear cells can identify the risk of tuberculosis progression from latent infection among individuals with silicosis by Qiao-ling Ruan, Qing-luan Yang, Yi-xin Gao, Jing Wu, Si-ran Lin, Jing-Yu Zhou, Ling-yun Shao, Sen Wang, Qian-qian Liu, Yan Gao, Ning Jiang, Wen-hong Zhang

“…The prospective signatures of TB risk between the two participants who developed active TB (progressors) and four matched individuals who remained healthy (non-progressors) were compared using differential expression analysis, Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis, and Weighted Gene Co-expression Network Analysis. …”
Get full text

Transmural collaborative care model for cardiovascular risk management and medication review in patients using antipsychotics in primary care (TACTIC): A study protocol of an incom... by Kirsti M. Jakobs, Karlijn J. van den Brule-Barnhoorn, Jan van Lieshout, Joost G.E. Janzing, Wiepke Cahn, Wietske Kievit, Steven Teerenstra, Maria van den Muijsenbergh, Marion C.J. Biermans, Erik W.M.A. Bischoff

“…However, primary care currently lacks adequate monitoring of AAP usage, its effects, and the associated cardiovascular risk. We have developed TACTIC, a transmural collaborative care model for patients using AAPs prescribed by the general practitioner (GP) to address the issues of potential overtreatment with AAPs and undertreatment for cardiovascular risk. …”
Get full text

Unraveling the role of gut microbiome in predicting adverse events in neoadjuvant therapy for rectal cancer by Jingxin Ma, Shengbo Sun, Xin Cheng, Cong Meng, Hanzheng Zhao, Wentao Fu, Yan Gao, Liyan Ma, Zhengyang Yang, Hongwei Yao, Jianrong Su

“…Some patients may develop adverse events during neoadjuvant chemoradiotherapy combined with immunotherapy, influencing response rates. …”
Get full text

Crohn’s disease therapeutic dietary intervention (CD-TDI): study protocol for a randomised controlled trial by Subrata Ghosh, Levinus A Dieleman, Christopher Ma, Ian Lewis, Herman W Barkema, Humberto Jijon, Kathy D McCoy, Georgios V Gkoutos, Maitreyi Raman, Lorian M Taylor, Jeff K Vallance, Derek M McKay, David M Mutch, Deanna Gibson, Marcus Rauch

“…We aim to explore the efficacy of the CD therapeutic dietary intervention (CD-TDI), a novel dietary approach developed from best practices and current evidence, to induce clinical and biomarker remission in adult patients with active CD.Methods and analysis This study is a 13-week, multicentre, randomised controlled trial in patients with mild-to-moderate active CD at baseline. …”
Get full text

The Australian Traumatic Brain Injury Initiative: Review and Recommendations for Outcome Measures for Use With Adults and Children After Moderate-to-Severe Traumatic Brain Injury by Jennie L. Ponsford, Amelia J. Hicks, Matthew K. Bagg, Ruby Phyland, Sarah Carrier, Amelia C. James, Natasha A. Lannin, Nick Rushworth, Terence J. O'Brien, Peter A. Cameron, D. Jamie Cooper, Regina Hill, Belinda J Gabbe, Melinda Fitzgerald

“…The aim of this article was to report on the implementation and findings of an evidence-based consensus approach to develop AUS-TBI recommendations for outcome measures following adult and pediatric moderate-to-severe TBI. …”
Get full text

What factors are associated with informal carers’ psychological morbidity during end-of-life home care? A systematic review and thematic synthesis of observational quantitative stu... by Tracey Shield, Kerin Bayliss, Alexander Hodkinson, Maria Panagioti, Alison Wearden, Jackie Flynn, Christine Rowland, Penny Bee, Morag Farquhar, Danielle Harris, Gunn Grande

“…Understanding what factors may affect carers’ mental health is important in developing strategies to maintain their psychological well-being during caregiving. …”
Get full text

Evaluating a brief imagery-based intervention for adolescent depression: study protocol for a Phase IIB randomised control trial (INDIGO) in secondary schools by Victoria Pile, Rose Tinch-Taylor, Ben Carter, Jessica Richardson, Lisa De Rijk, Mary Leamy, Simon E. Blackwell, Richard Meiser-Stedman, Barnaby D. Dunn, Sarah Byford, Emily A. Holmes, Cathy Creswell, Patrick Smith

“…Schools have been identified as a promising setting to enhance access to interventions and offer support earlier. We have co-developed a novel intervention, IMAGINE, that targets key cognitive mechanisms implicated in depression across the lifespan. …”
Get full text

Evaluation of a telehealth service to support breast cancer prevention medication uptake: a protocol of a mixed methods study by Tim Spelman, Stephanie Best, Christobel Saunders, Paul A James, Sarah Latham, Louise A Keogh, Sarah Mason, Katrina Louise West, Wanda Cui, Sabine Deij, Sandy Minck, Catherine Poliness, Greg Wheeler, Kelly Anne Phillips

“…The Preventing Cancer with Medications (PCMed) Telehealth Service was therefore developed to provide this specialist support and to bridge the evidence–implementation gap. …”
Get full text

Structured home-based exercise programme and concentric versus eccentric-based stair training programme for pain and function in knee osteoarthritis: a two-phase, double-blinded, r... by Feroz Kabir, Sharmila Jahan, Ehsanur Rahman, Kazi Md Azman Hossain, Kazi Md Amran Hossain, Ambika Kormoker, Md Zahirul Islam, Md Kabir Hossain, Jannatul Ferdous Rikti, Abid Hasan Khan, Sharna Yesmin Suraiya, Md Zahid Hossain

“…The findings will be published in peer-reviewed journals and disseminated at international conferences.Trial registration number CTRI/2025/03/081574.…”
Get full text

Prehospital triage of patients with suspected stroke symptoms (PRESTO): protocol of a prospective observational study by Hester F Lingsma, Aad van der Lugt, Diederik W J Dippel, Vicky Chalos, Esmee Venema, Martijne H C Duvekot, Anouk D Rozeman, Walid Moudrous, Frederique H Vermeij, Marileen Biekart, Henk Kerkhoff, Bob Roozenbeek, Cees L Alblas, Laus Jjm Mulder, Bruno JM van Moll, Lisette Maasland, Roeland PJ van Eijkelenburg, Frits GJ Weijschede, Bianca Buijck, Amber Hoek, Jeanette Bakker, Erick Oskam, Rezan Demir, Mandy MA van der Zon, Egon D Zwets, Mirjam Woudenberg, Anja Noordam-reijm, Timo Bevelander, Eveline JA Wiegers

“…Several prehospital stroke scales were developed to identify patients that are likely to have an LVO, which could allow for direct transportation of EVT eligible patients to an endovascular-capable centre without delaying IVT for the other patients. …”
Get full text

Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol by Daniel Oros, Jon Schoorlemmer, Cristina Paules, Jesús Gonzalez, Marta Fabre, Sara Ruiz-Martínez, Lina Youssef, Natalia Abadía-Cuchí, Marcos Clavero-Adell, Ana Medel-Martinez, Ariadna Ayerza-Casas, Juan Lerma-Irureta, Pilar Maestro-Quibus, Jesús Rodriguez-Calvo, Diego Lerma

“…More than half of women with SPL deliver a premature baby which is a known risk factor for developing cardiovascular and metabolic disorders in childhood and later in adult life. …”
Get full text

Protocol for the implementation evaluation of an integrated paediatric and primary care model: Strengthening Care for Children (SC4C) by Yvonne Zurynski, Susan Woolfenden, Peter D Hibbert, Harriet Hiscock, Raghu Lingam, Karen Wheeler, Michael Hodgins, Jade Burley, Rachel Pelly, Jane Le, Sonia Khano, Tammy Meyers Morris, Stephanie Germano

“…The purpose of this manuscript is to describe the pragmatic methods that will be used to capture implementation evaluation process and outcome data within this trial.Methods and analysis Our implementation evaluation will use a mixed methods design, with data collected in the intervention arm of the SC4C trial guided by a logic model developed using the Consolidated Framework for Implementation Research (CFIR) and Proctor and colleague’s taxonomy of implementation outcomes. …”
Get full text

Implementation of a diagnostic decision aid for people with memory complaints and their general practitioners: a protocol of a before and after pilot trial by Marcel Olde Rikkert, Marieke Perry, Marjolein de Vugt, Rudolf W H M Ponds, Ron Handels, Job Metsemakers, Trudy van der Weijden, Frans R Verhey, Iris Linden, Claire Wolfs, Carmen Dirksen

“…This study was funded by the public funded Dutch Research Institute for Care and Medical Sciences (ZonMw).Trial registration number NCT04531956.…”
Get full text

Predicting postoperative pulmonary infection in elderly patients undergoing major surgery: a study based on logistic regression and machine learning models by Jie Liu, Xia Li, Yanting Wang, Zhenzhen Xu, Yong Lv, Yuyao He, Lu Chen, Yiqi Feng, Guoyang Liu, Yunxiao Bai, Wanli Xie, Qingping Wu

“…Results Of the 9481 older adults in our study, 951 developed POI. Among the different algorithms, LR performed the best with an AUC of 0.80, whereas the decision tree performed the worst with an AUC of 0.75. …”
Get full text