Summary of discussions from the 2022 OECD CRP-sponsored conference on innovating microbial pesticide testing by Magdalini Sachana, Patience Browne, Domenico Deserio, Emily Hopwood, Eric Liégeois, Geoff Sinclair

“…Mammalian (human health) and non-target organism hazard testing are required to support registrations of microbial pesticides; however, developers and regulators of microbial pesticides face both new and old challenges for testing. …”
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The Basilar Artery Collateral Simplified Score: a Novel Collateral Circulation Score Associated With Outcomes in Patients With Basilar Artery Occlusion: Results From the ATTENTION... by Cong Luo, Rui Li, Chunrong Tao, Ming Cai, Lang Chen, Peng Hao, Xinfeng Liu, Wei Hu

“…Background The aim of the current study was to develop a simplified collateral score for basilar artery occlusion and assess its impact on the relationship between procedure time and outcomes. …”
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Evaluating the impact of a champion on implementation of the Back Skills Training (BeST) programme in Canada: a mixed methods feasibility study protocol by Amanda Hall, Sarah Lamb, Charlotte Albury, Shabnam Asghari, Bethan Copsey, Andrea Pike, Holly Etchegary, Zara Hansen, Esther Williamson, Helen Richmond, Krystal Bursey, Vernon Curran

“…A minimum champion training package has been developed based on known barriers in the literature. …”
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Tuberculosis-associated respiratory impairment and disability in children, adolescents and adults: protocol for a systematic review and individual participant data meta-analysis by Andrea Benedetti, Dick Menzies, Kamila Romanowski, Faiz Ahmad Khan, Mayara Lisboa Bastos, Silvia S. Chiang, James C. Johnston, Alexandre Petiquan, Sierra A. Land, Marieke M. van der Zalm, Jonathon R. Campbell

“…Increasing evidence indicates that a significant proportion of pulmonary TB survivors develop TB-associated respiratory impairment and disability—commonly referred to as post-TB lung disease—marked by impaired respiratory function, persistent symptoms and activity limitations. …”
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Antithrombotic management of patients with acute coronary syndrome and atrial fibrillation undergoing coronary stenting: a prospective, observational, nationwide study by Leonardo Bolognese, Pasquale Caldarola, Andrea Rubboli, Leonardo De Luca, Lucio Gonzini, Stefano Urbinati, Adriano Murrone, Fortunato Scotto di Uccio, Fabio Ferrari, Fabiana Lucà, Donata Lucci, Domenico Gabrielli, Andrea Di Lenarda, Michele Massimo Gulizia

“…At multivariable analysis, a major bleeding event (OR: 5.40; 95% CI: 2.42 to 12.05; p<0.0001) and malignancy (OR: 5.11; 95% CI: 1.77 to 14.78; p=0.003) resulted the most important independent predictors of DAT prescription.Conclusions In this contemporary registry of patients with ACS with AF treated with coronary stents, TAT still resulted as the antithrombotic strategy of choice, DAT was reserved for high bleeding risk and DAPT was mainly prescribed in those developing AF during hospitalisation.Trial registration number NCT03656523.…”
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Protocol for a hybrid effectiveness-implementation clinical trial evaluating video-assisted electronic consent vs standard consent for patients initiating and continuing haemodialy... by Helen Healy, Ann Bonner, Rebecca B Saunderson, Martin Wolley, Chenlei Kelly Li, Pedro Henrique Franca Gois, Marina Wainstein, Matthew J Damasiewicz, Vera Y Miao, Kirsten Hepburn, Clyson Mutatiri, Bobby Chacko

“…The aims of this study are to (1) develop a digital information interface to better equip patients in the decision-making process to undergo HD; (2) evaluate the effectiveness of the co-designed digital information interface to improve patient outcomes; and (3) evaluate an implementation strategy.Methods and analysis First, a co-design process involving consumers and clinicians to develop audio-visual content for an innovative digital platform. …”
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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. …”
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Smartphone intervention for pregnancy smoking cessation with peer support: the study protocol of the SmokeFree Together 2.0 (SFT 2.0) randomised controlled trial by Ken Resnicow, Kristie Foley, Daniel Muresan, Oana M Blaga, Marina D Dascal, Alexandra Onișor, Teodora Frățilă, Andreea Morar, Dan Mihu, Cristian I Iuhas, Gabriela Caracostea, Cristian I Meghea

“…Building on these findings, we developed an innovative smartphone application (app) that combines the power of social support with artificial intelligence. …”
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Uptake and use of a minimum data set (MDS) for older people living and dying in care homes in England: a realist review protocol by Claire Goodman, Julienne Meyer, Karen Spilsbury, Barbara Hanratty, Lisa Irvine, Sarah Kelly, Massirfufulay Kpehe Musa, Gizdem Akdur, Adam Gordon, Guy Peryer, Anne Killett, Jennifer Burton, Sue Fortescue, Ann-Marie Towers

“…The aim of this realist review is to develop a theory-driven understanding of how care home staff implement and use MDS to plan and deliver care of individual residents.Methods and analysis A realist review will be conducted in three research stages.Stage 1 will scope the literature and develop candidate programme theories of what ensures effective uptake and sustained implementation of an MDS.Stage2 will test and refine these theories through further iterative searches of the evidence from the literature to establish how effective uptake of an MDS can be achieved.Stage 3 will consult with relevant stakeholders to test or refine the programme theory (theories) of how an MDS works at the resident level of care for different stakeholders and in what circumstances. …”
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Improving transitions in care for children and youth with mental health concerns: implementation and evaluation of an emergency department mental health clinical pathway by Alexandra Tucci, Paula Cloutier, Christine Polihronis, Allison Kennedy, Roger Zemek, Clare Gray, Sarah Reid, Kathleen Pajer, William Gardner, Nicholas Barrowman, Mario Cappelli, Mona Jabbour

“…Methods We implemented the pathway at four ED sites from 2018 to 2019 using the Theoretical Domains Framework to develop a tailored strategy at each site. We conducted chart reviews retrospectively in 2017–2018 (pre-implementation) and prospectively in 2019–2020 (post-implementation). …”
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Effectiveness of HAPA-based multidomain fall risk management for older adults with declining intrinsic capacity in nursing homes: protocol of a randomised controlled trial by Jing Yang, Qinghua Zhang, Mei Cheng, Siyi Shang, Shengguang Cheng, Lingxia Qi, Tongtong Liu, Yuhan Yang, Xinuo Yao, Danyan Lu, Xiaoyu Cheng

“…In the first part, a fall risk management intervention pathway and programme will be developed with the theoretical and IC framework, which will be refined via the Delphi method. …”
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Protocol for the challenge non-typhoidal Salmonella (CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection mo... by Melita A Gordon, Christopher Smith, Xinxue Liu, Andrew J Pollard, Emma Smith, Graham S Cooke, Robert K M Choy, Anna Rydlova, Robert Varro, Jay C D Hinton, Christopher Chiu, Malick M Gibani

“…The primary objective is to determine the minimum infectious dose (colony-forming unit) required for 60%–75% of participants to develop clinical or microbiological features of systemic salmonellosis. …”
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Towards a prescribing monitoring system for medication safety evaluation within electronic health records: a scoping review by Camilo Scherkl, Theresa Dierkes, Michael Metzner, David Czock, Hanna M. Seidling, Walter E. Haefeli, Andreas D. Meid

“…As a further aside, we use hyperkalaemia as an example to discuss the framework for developing Prescribing Monitoring in an electronic health record (EHR). …”
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Biologging intelligent Platform (BiP): an integrated and standardized platform for sharing, visualizing, and analyzing biologging data by Katsufumi Sato, Shinichi Watanabe, Takuji Noda, Takuya Koizumi, Ken Yoda, Yuuki Y. Watanabe, Kentaro Q. Sakamoto, Teijiro Isokawa, Makoto A. Yoshida, Kagari Aoki, Akinori Takahashi, Takashi Iwata, Hideaki Nishizawa, Takuya Maekawa, Ryo Kawabe, Yutaka Watanuki

“…In light of social and academic requirements, we developed "Biologging intelligent Platform (BiP)", which adheres to internationally recognized standards for sensor data and metadata storage. …”
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CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy by Clare Taylor, Carl H June, Joseph A Fraietta, Boris Engels, Gabriela Plesa, Marco Ruella, Stephan A Grupp, Hongyan Liu, Colleen Callahan, Shannon L Maude, Regina M Myers, Caroline Diorio, Yimei Li, Vanessa Gonzalez, Julie K Jadlowsky, Amanda M DiNofia, Gerald Wertheim, Donald L Siegel, Emma Iannone, Laura Shinehouse, Jennifer L Brogdon, Elizabeth O Hexner, Diane Baniewicz, Richard Aplenc, Allison Barz Leahy, Susan E McClory, Susan R Rheingold, Lisa Wray, Noelle V Frey

“…In vivo cellular kinetic data revealed robust CART22-65s proliferation by quantitative PCR peaking at a median of 20 days postinfusion, with the cells persisting out to month 42 in one patient who achieved a long-term remission with CART22-65s alone.Conclusions The favorable safety profile and high remission rates in exceedingly refractory B-ALL support the continued development of CART22-65s but also highlight the need to use the product in combination with HCT or other novel strategies.Trial registration numbers NCT02650414 and NCT03620058.…”
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Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, imple... by Shelly Karuna, Fatima Laher, Sufia Dadabhai, Pei‐Chun Yu, Doug Grove, Catherine Orrell, Joseph Makhema, Mina C. Hosseinipour, Carrie‐Anne Mathew, William Brumskine, Nyaradzo Mgodi, Philip Andrew, Lucio Gama, Carissa Karg, Gail Broder, Kagisho Baepanye, Jonathan Lucas, Michele Andrasik, Simbarashe Takuva, Manuel Villaran, Azwidihwi Takalani, Randall Tressler, Lydia Soto‐Torres, Amanda S. Woodward Davis, Ames Dhai, Ian M. Sanne, Myron S. Cohen, Lawrence Corey, Glenda Gray, Allan C. deCamp, Katharine J. Bar

“…Clinical Trial Registration NCT04860323…”
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Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) tri... by Hina Raheel, Sheela Sinharoy, Anaité Diaz-Artiga, Sarada S. Garg, Ajay Pillarisetti, Kalpana Balakrishnan, Marilu Chiang, Amy Lovvorn, Miles Kirby, Usha Ramakrishnan, Shirin Jabbarzadeh, Alexie Mukeshimana, Michael Johnson, John P. McCracken, Luke P. Naeher, Ghislaine Rosa, Jiantong Wang, Joshua Rosenthal, William Checkley, Thomas F. Clasen, Jennifer L. Peel, Lisa M. Thompson

“…Background: Air pollution may impair child growth and cognitive development, with potential markers including birth length and head circumference. …”
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Comparison of intravascular imaging, physiological assessment and angiography for coronary revascularization in acute coronary syndrome: a systematic review and network meta-analys... by Xuan-Yan Liu, Bin-Hua Ye, Xian-Dan Wu, Yue Lin, Xian Lin, Yan-Yan Li, Jing-Chao Sun

“…Each PCI strategy was ranked as per the risk ratio (RR) at the 95% confidence interval (95% CI) for developing MACE.ResultsTwenty-eight RCTs with 18,221 patients were identified. …”
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Telenursing Health Education and Lifestyle Modification Among Patients With Diabetes in Bangladesh: Protocol for a Pilot Study With a Quasi-experimental Pre- and Postintervention D... by Michiko Moriyama, K A T M Ehsanul Huq, Lucy Mondol, Akhi Roy Mita, Niru Shamsun Nahar

“…ObjectiveThe objective of this study is to apply the self-management telenursing program and telenursing system developed by the researchers to Bangladesh and to evaluate its feasibility and efficacy (improved diabetes control in participants). …”
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A digitally enabled home-based wound care program using the PEDALs model: a mixed-methods study protocol by Lili Chen, Lili Chen, Xuefang Zhuo, Xuefang Zhuo, Hong Cai, Hong Cai, Penghua Zeng, Penghua Zeng, Hongyu Chen, Gang Chen

“…In Phase IV, the DE-HBWC intervention protocol will be developed and followed by a randomized controlled trial of the DE-HBWC intervention program. …”
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