Intermittent hypoxia index: a new indicator for assessing the degree of intermittent hypoxia in obstructive sleep apnea by Kui Xie, Xiaoqing Tang, Jiacheng Zhou, Xiang Liu, Yunyun Zhang, Xiaochuan Cui

“…The IHI was calculated using the NLAS (Certificate of Registration Number for Computer Software Copyright of the People’s Republic of China: 12208933), and its threshold was defined. …”
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Chronic kidney disease in adults with sickle cell trait: a systematic review and meta-analysis by Yagahira E. Castro-Sesquen, Gelida Barboza Justiniano, Diego J. Aparcana-Granda, Andres R. Aquino, Pierre Luckens Adelson, Ronald D. Mondragón, John Kwagyan, Vimal K. Derebail, Mehdi Nouraie, Santosh L. Saraf, Marina Jerebtsova

“…SCT increases the risk of developing CKD and ESRD. PROSPERO registration: CRD42021275274.…”
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Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol for a multicentre, randomised, controll... by Yan Zhang, Jing Zhang, Jin Jin, Hongchun Zhang, Demin Li, Yue Jing, Tianhong Cui, Xiang Lei, Qijian Cheng, Erran Li

“…Although there are many therapies being developed to alleviate symptoms and reduce mortality, a few studies have supported which treatment method is the best. …”
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Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial by Mark J Peters, Daniel Francis McAuley, Margaret Murray, Karla Hemming, Lyvonne N Tume, Mike Clarke, Bronagh Blackwood, Ashley Agus, Joanne Jordan, Roisin Boyle, Duncan Macrae, Clíona McDowell, Lisa McIlmurray, Kevin P Morris, Roger Parslow

“…Delay at any stage can prolong the duration of mechanical ventilation. We developed a multicomponent intervention targeted at helping clinicians to safely expedite this process and minimise the harms associated with unnecessary mechanical ventilation.Methods and analysis This is a 20-month cluster randomised stepped wedge clinical and cost-effectiveness trial with an internal pilot and a process evaluation. …”
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Segmentation of Leukoaraiosis on Noncontrast Head CT Using CT‐MRI Paired Data Without Human Annotation by Wi‐Sun Ryu, Jae W. Song, Jae‐Sung Lim, Ju Hyung Lee, Leonard Sunwoo, Dongmin Kim, Dong‐Eog Kim, Hee‐Joon Bae, Myungjae Lee, Beom Joon Kim

“…ABSTRACT Objective Evaluating leukoaraiosis (LA) on CT is challenging due to its low contrast and similarity to parenchymal gliosis. We developed and validated a deep learning algorithm for LA segmentation using CT‐MRIFLAIR paired data from a multicenter Korean registry and tested it in a US dataset. …”
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Instruments for measuring fatigue in patients with brain tumours: protocol for a COSMIN-­based systematic review by Yan Luo, Rui Wang, Zhou Zhou, Liwei Wang, Shuyi Wang, Zefeng Xiao, Zhouning Li, Shuji Li, Tuanbiao Nie, Wenjing Hong

“…Many measures have been developed to assess this condition, but there have been no systematic reviews evaluating the metrological properties of these tools, and it is difficult to determine the measures with optimal properties and the conditions under which they should be applied. …”
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Effects and mechanisms of a home-based action observation and motor imagery intervention on cognitive function and depression in spinal cord injury: a pilot randomized controlled t... by Yule Hu, Yan Li, Ran Tao, Chun Liang Hsu, Ashley Craig, Ashley Craig, Chor Yin Lam, Turhan Kahraman, Angela Yee Man Leung

“…The home-based Action Observation and Motor Imagery (AOMI), a form of neurorehabilitation, was developed grounded in theoretical foundations and practical evidence, rendering it especially suitable for adults with SCI. …”
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Technology readiness among UK-based cognitively unaffected older adults during the COVID-19 pandemic: potential implications for decentralised alzheimer’s disease prevention trials... by S. Taylor, L. Dunn, C. Udeh-Momoh, K. Abbott, P. Giannakopoulou, L. Middleton, O. Robinson, J. Kalsi, D. Kafetsouli, J. Ford

“…This study aimed to assess technology readiness among older adults at risk of developing dementia, with the goal of informing the design and delivery of technology-based approaches in AD prevention research. …”
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The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT by Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo

“…Background Long-term surviving liver transplant recipients can spontaneously develop operational tolerance, which allows them to completely discontinue their immunosuppression, but we lack validated tools to predict the likelihood of rejection following immunosuppression withdrawal. …”
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Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile by Yan Ma, Xingdong Chen, Jie Wei, Li Guo, Jian Huang, Li Xie, Lei Chen, Ping Lu, Wei Sun, Wei Shi, Feng Ding, Liping Zhang, Yue Zhang, Linlin Zhang, Rui Song, Yi Huang, Jun Shen, Hong Xu, Zhigang Chen, Qian Shen, Ying Ma, Yiwen Zhang, Hongxia Li, Yihui Zhai, Biao Xu, Xian Zhou, Jun Sun, Bing Wu, Rui Su, Xiaoyan Yu, Jianhong Zhu, Yihong Huang, Ling Gong, Nana Wu, Jingjing Sun, Tianyi Liu, He Yuan, Yiwen Shen, Jiaojiao Liu, Xia Han, Juanjuan Wu, Yinghua Sun, Suxiang Xu, Qinyi Zhang, Na Xie, Jianfeng Ji, Weizhi Mo, Yuanxin Liu, Xinghua Shi, Wanshan Qiu, Jiapeng Mi, Juhua Yan, Minghui Zhu, Pei Feng, Wenqian Sheng, Mingqin Tai, Chunqin Zhou, Qian Jin, Chengyu Gu, Xiujuan Huang, Qinfang Qian, Yixin Cao, Haochen Shen, Ziwen Xue, Yucui Ma, Juan Tian, Yingdan Zhang, Weiyuan Zhuang, Kaiqun Yang, Xiaohui Shen, Yanwei Gu, Beibei Shi, Chenhong Pan, Hongmei Zhou, Xiuchen Zhang, Meihua Tang, Kaixuan Gu, Hongping Liu, Yuanxian Li

“…We aim to develop multimodal risk prediction models by integrating genomics and artificial intelligence algorithms. …”
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Design and validation of an energy level diary for fatigue management in patients with post-COVID syndrome by Maryam Balke, Maryam Balke, René Garbsch, René Garbsch, Jessica Cormann, Pantea Pape, Frank C. Mooren, Frank C. Mooren, Boris Schmitz, Boris Schmitz

“…Cognitive and motor fatigue are common clinical manifestations, limiting patients’ occupational, educational, and social activities severely.ObjectiveThis study aimed to develop a diary to keep record of daily changes in energy levels of patients with PCS to adapt their rehabilitation program.Material and methodsWe conducted a prospective observational study at two German rehabilitation centers in a codesign approach with repeated feedback loops. …”
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Knowledge translation strategies for policy and action focused on sexual, reproductive, maternal, newborn, child and adolescent health and well-being: a rapid scoping review by Etienne V Langlois, Leah Boulos, Lori Wozney, Janet A Curran, Helen Wong, Zulfiqar Bhutta, Robin Urquhart, Hwayeon Danielle Shin, Allyson J Gallant, Julia Kontak

“…Objective The aim of this study was to identify knowledge translation (KT) strategies aimed at improving sexual, reproductive, maternal, newborn, child and adolescent health (SRMNCAH) and well-being.Design Rapid scoping review.Search strategy A comprehensive and peer-reviewed search strategy was developed and applied to four electronic databases: MEDLINE ALL, Embase, CINAHL and Web of Science. …”
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Application of indocyanine green–human serum albumin complex in fluorescence image-guided laparoscopic anatomical liver resection: study protocol for a randomized controlled trial... by Qingyun Xie, Fengwei Gao, Xiaoyun Ran, Xin Zhao, Manyu Yang, Kangyi Jiang, Tianyang Mao, Jiayin Yang, Kun Li, Hong Wu

“…To address these issues, we developed a novel ICG–human serum albumin (ICG-HSA) complex to enhance fluorescence visualization during laparoscopic anatomical liver resection. …”
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It’s safe to move! A protocol for a randomised controlled trial investigating the effect of a video designed to increase people’s confidence becoming more active despite back pain... by Ian A Harris, Adrian C Traeger, James H McAuley, Siobhan M Schabrun, Benedict Martin Wand, Aidan Cashin, Christopher Michael Williams, Edel O'Hagan, Sean O'Neill

“…People over 18 years of age and fluent in English will be recruited via social media advertising. We developed a social media-based public health campaign to support recommendations for managing low back pain. …”
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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

“…Study results will be disseminated through conferences and peer-reviewed scientific journals.Trial registration number NCT06293235.…”
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Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and networ... by Orestis Efthimiou, Georgia Salanti, Huseyin Naci, Philip Bennett, Antonios Athanasiou, Areti Angeliki Veroniki, Ilkka Kalliala, Sarah Bowden, Maria Paraskevaidi, Pierre Martin-Hirsch, Evangelos Paraskevaidis, Maria Kyrgiou

“…We will assess the risk of bias in RCTs and cohort studies using tools developed by the Cochrane collaboration. Two investigators will independently assess the eligibility, abstract the data and assess the risk of bias of the identified studies. …”
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Evaluation of lung homogeneity in neonates and small infants during general anaesthesia using electrical impedance tomography: a prospective observational study by Vanessa Marchesini, Sebastian Corlette, Suzette Sheppard, Andrew Davidson, David Tingay

“…These results suggest the need to better understand the impact of general anaesthesia on the developing lung. Clinical trial registration: Australian New Zealand Clinical Trials Registry (ACTRN 12616000818437, 22 June 2016).…”
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Advance care planning for vulnerable older adults within an Accountable Care Organization: study protocol for the IMPACT randomised controlled trial by Jennifer Gabbard, NM Pajewski, Kathryn E Callahan, Ajay Dharod, Kristie Foley, Keren Ferris, Adam Moses, Carl Grey, Jeff Williamson

“…The electronic health record was used to develop an automatic prescreening system for eligible patients (n=765) and participants were randomised in a 1:1 ratio to either the nurse navigator-led ACP pathway or usual care. …”
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Enhancing Aboriginal and Torres Strait Islander research trial leadership and participation: insights from the initial stages of the Australian Fans in Training Project in the Nort... by Eleanor Quested, Bryce Brickley, James A Smith, Toby Pavey, Andrew Maiorana, Matthew David McDonald, Jason Bonson, Lee Wharton, Joshua Danvers, John Ah Mat, Patrick Stephensen, Evelyn Bennett

“…A culturally diverse community advisory group was established, which codesigned engagement standards tailored to community needs and preferences.Strengths and limitations While the codesigned standards supported Aboriginal and Torres Strait Islander trial leadership and participation during the trial, the extensive consultation needed to build cross-cultural relationships and develop the standards meant they were finalised only after trial recruitment had ceased. …”
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Feasibility study of an experimental social space-oriented rehabilitation concept for people with intellectual and/or multiple disabilities: a study protocol by Kathrin Förster, Judith Gartmann, Andrea Boekel, Thilo Busche, Christoph Egen

“…In line with this, the German Federal Participation Act has further developed the relevant disability policy at the national level. …”
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