Association between ultra-short-term heart rate variability and atrial fibrillation in heart failure population: a protocol for a prospective observational cohort study by Ping Zhang, Xiaodi Tang, Rong He

“…Introduction Patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with mildly reduced ejection fraction (HFmrEF) are at high risk for developing atrial fibrillation (AF) due to significantly impaired cardiac pump function, heightened sympathetic nervous system activity and the frequent coexistence of cardiovascular comorbidities such as hypertension and coronary artery disease. …”
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Association of vaginal oestradiol and the rate of breast cancer in Denmark: registry based, case-control study, nested in a nationwide cohort by Christian Torp-Pedersen, Lina Steinrud Mørch, Nelsan Pourhadi, Amani Meaidi, Ellen Christine Løkkegaard

“…Exclusions were a history of cancer, mastectomy, use of systemic hormone treatment, use of the levonorgestrel releasing intrauterine system, or use of vaginal oestrogen treatments other than oestradiol tablets. To each woman who developed breast cancer during follow-up (18 997), five women in the control group (94 985) were incidence density matched by birth year.Main outcome measure The main outcome was pathology confirmed breast cancer diagnosis.Results 2782 (14.6%) women with breast cancer (cases) and 14 999 (15.8%) women with no breast cancer diagnosis (controls) had been exposed to vaginal oestradiol tablets with 234 cases and 1232 controls having been in treatment for at least four years at a high intensity (>50 micrograms per week). …”
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External validation of risk prediction models for post-stroke mortality in Berlin by Jessica L Rohmann, Tobias Kurth, Heinrich J Audebert, Marco Piccininni, Lukas Reitzle

“…Although numerous models have been developed, external validation studies determining the models’ transportability beyond the original settings are lacking. …”
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Government Digital Transformation and the utilization of Basic Public Health Services by China’s migrant population by Haowen Jia

“…To gauge BPHS utilization among migrants, two indicators were developed: the establishment of health records and registration with family doctors. …”
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Effectiveness of intelligent robotic-assisted training system combined with repetitive facilitative exercise on upper limb motor function after stroke: a randomized controlled tria... by Jing-Zhi Zhang, Jun Chen, Xiao-Long Liu, Lin-Bo Yan, Si-Mao Xu

“…Neuromuscular facilitation manipulation is a common series of therapies for stroke clinical practice, and the Repetitive facilitative exercise (RFE) developed based on it has been widely applied. This study aims to investigate the effectiveness of IRAT combined with RFE on upper limb motor function in stroke patients. …”
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Automatic setting optimization for robotic upper-extremity rehabilitation in patients with stroke using ReoGo-J: a cross-sectional clinical trial by Takashi Takebayashi, Yuki Uchiyama, Kazuhisa Domen

“…Abstract Stroke-induced upper-extremity paralysis affects a substantial portion of the population, necessitating effective rehabilitation strategies. This study aimed to develop an automated program, incorporating the item response theory, for rehabilitation in patients with post-stroke upper-extremity paralysis, focusing on the ReoGo-J device, and to identify suitable robot parameters for robotic rehabilitation. …”
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Torque visuomotor feedback training versus standard eccentric exercise for the management of patellar tendinopathy: protocol for a randomised controlled trial by David Evans, Francesco Negro, Michail Arvanitidis, Eduardo Martinez-Valdes, Ragul Selvamoorthy, Patricio Pincheira

“…The results of this study will be disseminated in peer-reviewed journals and at international conferences.Trial registration number ISRCTN15821610.…”
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Impact of tumor necrosis factor-alpha gene variant in pediatric nephrotic syndrome: a meta-analysis by Yogalakshmi Venkatachalapathy, Praveenkumar Kochuthakidiyel Suresh, Thendral Hepsibha Balraj, Vettriselvi Venkatesan, Sangeetha Geminiganesan, Indira Bhagam, C. D. Mohana Priya

“…The TNFα 308 G/A polymorphism was identified as being associated with the risk of developing childhood NS. Registration: Registered in PROSPERO with ID: CRD420251083425.…”
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Safety and immunogenicity of a new formulation of a pentavalent DTwP-HepB-Hib vaccine in healthy Indian infants-A randomized study. by Naveena Aloysia D'Cor, Prashanth Siddaiah, Satyajit Mohapatra, Sangappa Malappa Dhaded, Padmavathi I V, Sonali Kar, Tripathi V N, Prasad Muley, Jugesh Chhatwal, Badri Narayan Patnaik, Emmanuel Vidor, Annick Moureau, Dhaval M Patel, Venkata Jayanth Midde, Sathish Reddy Jagga, Satyanarayana Peesapati, Fernando Noriega

“…The new formulation was developed using well-characterized hepatitis B and pertussis whole cell vaccine components.…”
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Essential Coaching for Every Mother Tanzania (ECEM-TZ): Protocol for a Type 1 Hybrid Effectiveness-Implementation Randomized Controlled Trial by Justine Dol, Lilian Teddy Mselle, Marsha Campbell-Yeo, Columba Mbekenga, Thecla Kohi, Douglas McMillan, Cindy-Lee Dennis, Gail Tomblin Murphy, Megan Aston

“…MethodsECEM-TZ consists of standardized text messages from birth to 6 weeks post partum that provide evidence-based information on caring for their newborn and recognizing danger signs. Messages were developed and then reviewed by Tanzanian mothers and nurse midwives before implementation. …”
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Parental involvement in infection prevention and control in low- and middle-income country neonatal units: a scoping review protocol by Felicity Fitzgerald, Rudo Chingono, Hannah Blencowe, Sarah Moxon, Gwendoline Chimhini, Lydia Davidson, Chikomborero Kitikiti

“…This scoping review aims to provide an overview of parental involvement in infection prevention and control in low- and middle-income setting neonatal units.Methods and analysis This protocol was developed in line with the Joanna Briggs Institute recommendations. …”
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Do school-based smoking preventive interventions have unintended effects? Post hoc analysis of the Focus cluster randomised controlled trial by Susan Andersen, Lau C Thygesen, Charlotta Pisinger, Simone G Kjeld, Dina Danielsen, Marie P Jensen, Rikke F Krølner

“…This study focused solely on students who smoked at baseline (N=491).Interventions The intervention was developed systematically based on theory and a thoroughly mixed-methods needs assessment. …”
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Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, rando... by Sanjita Brito-Mutunayagam, David O Hamilton, Elena Mitsi, Carla Solórzano, Grace Li, Bruno Rocha De Macedo, Filora Elterish, Xinxue Liu, Kiarash Tanha, Rachel White, Angela Hyder-Wright, Bhumika Patel, Britta C Urban, Conor Whelan, Hanane Trari Belhadef, Hannah Robinson, Emma Plested, Amber Thompson, Maria Lahuerta, Isis Kanevsky, Kena Swanson, Negar Aliabadi, Julie Catusse, Christian Theilacker, Bradford D Gessner, Natalie I Mazur, Christopher Chiu, Andrea M Collins, Ben Morton, Maheshi N Ramasamy, Daniela M Ferreira

“…This knowledge could help inform pneumococcal and RSV vaccination strategies, particularly for groups at risk of developing severe pneumococcal and RSV disease.<h4>Trial registration</h4>The study is registered on ISRCTN (The UKs Clinical Study Registry). …”
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The effect of educational intervention based on the mobile application on women’s knowledge, attitude, and practice on microplastics and health: study protocol for a randomized con... by Zahra Seifi, Fatemeh Zarei, Fazlollah Ahmadi

“…In the first phase, a questionnaire assessing women’s knowledge, attitudes, and practices (KAP) regarding microplastics will be developed and validated. In phase two, educational content for the mobile application “PlastiWise” will be created based on behavior change constructs. …”
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Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial. by Jake Dunning, Foday Sahr, Amanda Rojek, Fiona Gannon, Gail Carson, Baimba Idriss, Thomas Massaquoi, Regina Gandi, Sebatu Joseph, Hassan K Osman, Timothy J G Brooks, Andrew J H Simpson, Ian Goodfellow, Lucy Thorne, Armando Arias, Laura Merson, Lyndsey Castle, Rebecca Howell-Jones, Raul Pardinaz-Solis, Benjamin Hope-Gill, Mauricio Ferri, Jennifer Grove, Mark Kowalski, Kasia Stepniewska, Trudie Lang, John Whitehead, Piero Olliaro, Mohammed Samai, Peter W Horby, RAPIDE-TKM trial team

“…<h4>Background</h4>TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated.…”
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Exercise interventions in patients with multiple myeloma: a scoping review by Jiayao Li, Yi Peng, Di Zhan, Ying Zhang, Shanshan Yu

“…This conclusion holds clinical relevance, as it not only addresses patients’ concerns regarding exercise safety but also provides evidence-based guidance for healthcare professionals in developing personalized exercise plans tailored to patients at different treatment stages. …”
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The effect of implementing parenteral nutrition guideline on growth and clinical outcomes in preterm infants: a comparative study by Majid Mahallei, Lida Gorbani, Mohammad Bagher Hoseini, Elnaz Shaseb, Bahareh Mehramuz, Khatereh Rezazadeh

“…Abstract Background To improve the nutritional management of premature infants in neonatal intensive care units (NICUs), we developed and implemented a standardized parenteral nutrition (PN) protocol aimed at optimizing early macronutrient delivery. …”
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Association between avoidant/restrictive food intake disorder risk, dietary attitudes and behaviors among Chinese patients with inflammatory bowel disease: a cross-sectional study by Wenjing Tu, Yiting Li, Tingting Yin, Sumin Zhang, Ping Zhang, Guihua Xu

“…Abstract Background Restrictive eating behaviors are common among patients with inflammatory bowel disease (IBD), which may may develop nutritional and/or quality of life impairments into avoidant/restrictive food intake disorder (ARFID). …”
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Data-driven decision-making for district health management: a cluster-randomised study in 24 districts of Ethiopia by Joanna Schellenberg, Tanya Marchant, Lars Åke Persson, Bilal Iqbal Avan, Mehret Dubale, Girum Taye

“…Here, we describe implementation including process evaluation at district level in Ethiopia, and evaluation through a cluster-randomised trial.Methods We supported district health teams in 4-month cycles of data-driven decision-making by: (a) defining problems using a health system framework; (b) reviewing data; (c) considering possible solutions; (d) value-based prioritising; and (e) a consultative process to develop, commit to and follow up on action plans. 12 districts were randomly selected from 24 in the North Shewa zone of Ethiopia between October 2020 and June 2022. …”
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Cost-effectiveness analysis of ixekizumab versus secukinumab in patients with psoriatic arthritis and concomitant moderate-to-severe psoriasis in Spain by Susanne Hartz, Christophe Sapin, Bernd Schweikert, Chiara Malmberg, Mercedes Núñez, Tatiana Dilla

“…Objective To conduct a cost-effectiveness analysis from the perspective of the Spanish National Health System (NHS) comparing ixekizumab versus secukinumab.Design A Markov model with a lifetime horizon and monthly cycles was developed based on the York model. Four health states were included: a biological disease-modifying antirheumatic drug (bDMARD) induction period of 12 or 16 weeks, maintenance therapy, best supportive care (BSC) and death. …”
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