Safety and immunogenicity of freeze-dried human rabies vaccines: A phase 3 clinical trial of Zagreb and Essen regimes by Jia Li, Zhiang Wu, Xiaohong Wu, Yunpeng Wang, Leitai Shi, Danhua Zhao, Haiyan Liang, Zhaojun Mo, Shouchun Cao

“…This phase III clinical trial aimed to assess the safety and immunogenicity of candidate freeze-dried rabies vaccines developed for human use by Shandong Yeedo Biotechnology (Registration No.: CTR20182016, http://www.chinadrugtrials.org.cn/index.html). …”
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Exploring the burden of paediatric acute otitis media with discharge in the UK: a qualitative study by Rachel Isba, Darren M Ashcroft, Alastair D Hay, Elliot Heward, Iain A Bruce, Judith Lunn, John Molloy, Jaya R Nichani, James Birkenshaw-Dempsey

“…Evidence-based management guidelines should be developed once high-quality evidence is available.Trial registration number ISCTRN43760.…”
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A multicentre randomised feasibility STUdy evaluating the impact of a prognostic model for Management of BLunt chest wall trauma patients: STUMBL Trial by Ceri Battle, Richard Body, Hayley A Hutchings, Fiona Elizabeth Lecky, Timothy Driscoll, James Gagg, Claire O’Neill, Sam Groves, Sally Jones, Zoe Abbott, Phillip A Evans

“…Objective A new prognostic model has been developed and externally validated, the aim of which is to assist in the management of the blunt chest wall trauma patient in the emergency department (ED). …”
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Predicting adherence to therapy in rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis: a large cross-sectional study by Philip J Mease, Joachim Sieper, Josef S Smolen, Dafna Gladman, H Patrick McNeil, Maja Hojnik, Pascal Nurwakagari, John Weinman

“…Objective This analysis explored the association of treatment adherence with beliefs about medication, patient demographic and disease characteristics and medication types in rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondylitis (AS) to develop adherence prediction models.Methods The population was a subset from ALIGN, a multicountry, cross-sectional, self-administered survey study in adult patients (n=7328) with six immune-mediated inflammatory diseases who were routinely receiving systemic therapy. …”
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Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a te... by Harro Seelaar, John C Van Swieten, Elise G P Dopper, Itamar Ronen, Chloé Najac, Fieke A M Prinse, Louise van der Weerd, Lydiane Hirschler

“…We aim to include 25 patients with probable FTLD-tau, 25 with probable FTLD-TDP and 50 healthy individuals with 50% risk to develop FTLD. We will use several MRI techniques, including magnetic resonance spectroscopy, diffusion weighted spectroscopy and quantitative susceptibility mapping. …”
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The role of microglia in neuropathic pain: A systematic review of animal experiments by Junyi Long, Guihua Tian, Ke He, Youxiang Su, Ziyao Wang, Liangqing Huang, Youmei Yao, Xinyi Li, Yi Lin

“…Background: Neuropathic pain develops from lesions or diseases that affect the peripheral or central somatosensory nervous system. …”
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Paediatric liver transplantation—improving health care through needs assessment, screening and interventions: protocol for a mixed-methods study by Elke Lainka, Laura Inhestern, Lene Marie Johannsen, Angela Buchholz, Jana Winzig, Sanna Higgen, Bianca Hegen, Stefanie Kraft, Jun Oh

“…In study arm 2, a distress screening will be developed based on a literature search and n=10–20 interviews with families and HCPs. …”
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Innovative administration of long-acting injectables for HIV treatment enhancement at home (INVITE-HOME): implementation science study protocol by Parya Saberi, Mallory O Johnson, Starley B Shade, Orlando Harris, Erin Moore, Beth Bourdeau, Greg Rebchook, Jesse O’Shea, Kate Buchacz, Michelle Palomares, Alicia T Bolton, Jonathan Van Nuys

“…First, INVITE-Home will design and develop an innovative, theory-based layperson injector training to improve acceptability and uptake of LAI-ART in home-based settings, grounded in qualitative evaluation of training barriers and needs of PWH, layperson injectors and clinicians to develop the training. …”
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Sodium-glucose co-transporter-2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes: systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Thomas Agoritsas, Haoming Tian, Sheyu Li, Chang Xu, Ping Fu, Qingyang Shi, Xiaoxi Zeng, Per Olav Vandvik, Xinyu Zou, Yunhe Mao, Qinbo Yang, Xianghang Luo, Belen Ponte

“…Certainty of evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach.Results Evidence from 13 randomised controlled trials (29 614 patients) informed treatment effect estimates. …”
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Integrando Facebook en el Modelo de Educación Deportiva: Una experiencia práctica (Integrating Facebook in Sport Education: A practical experience) by Javier Bernabé Martín, Francisco Javier Fernández-Río

“…In this experience, Facebook was used as an environment to develop the characteristics of the sports education model (season, affiliation, formal competition, systematic registration, festive atmosphere and final celebration) in the area of Physical Education, using the resources of the social network. …”
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Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial by Marwa Khalil, Omar Hamadah, Maher Saifo

“…In contrast, all patients in Group 1 developed oral mucositis, ranging from mild erythema to ulceration greater than 3 cm². …”
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Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. by Samuel Dunyo, Giorgio Sirugo, Sanie Sesay, Cyrille Bisseye, Fanta Njie, Majidah Adiamoh, Davis Nwakanma, Mathurin Diatta, Ramatoulie Janha, Fatou Sisay Joof, Beth Temple, Paul Snell, David Conway, Robert Walton, Yin Bun Cheung, Paul Milligan

“…<h4>Background</h4>Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients. …”
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Medical Marijuana Documentation Practices in Patient Electronic Health Records: Retrospective Observational Study Using Smart Data Elements and a Review of Medical Records by Donielle Beiler, Aanya Chopra, Christina M Gregor, Lorraine D Tusing, Apoorva M Pradhan, Katrina M Romagnoli, Chadd K Kraus, Brian J Piper, Eric A Wright, Vanessa Troiani

“…MethodsWe developed a protocol for reviewing medical records for extracting MMJ-related information. …”
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Nurses’ Knowledge and Skills After Use of an Augmented Reality App for Advanced Cardiac Life Support Training: Randomized Controlled Trial by Wan-Na Sun, Min-Chai Hsieh, Wei-Fang Wang

“…An ACLS cart training course was developed using AR technologies in the first stage. …”
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Patient-Related Risk Factors for Periprosthetic Joint Infection after Total Joint Arthroplasty: A Systematic Review and Meta-Analysis. by Setor K Kunutsor, Michael R Whitehouse, Ashley W Blom, Andrew D Beswick, INFORM Team

“…<h4>Background</h4>Periprosthetic joint infections (PJIs) are dreaded complications of total joint arthroplasties. The risk of developing PJIs is likely to be influenced by several patient factors such as sociodemographic characteristics, body mass index (BMI), and medical and surgical histories. …”
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Leveraging infant visit PrEP screening INtegration & tasK shifting to improve post-partum HIV prevention in Malawi (LINK): a cluster-randomized trial evaluation of a postpartum HIV... by Sarah E. Rutstein, Valerie A. Lucas, Mina C. Hosseinipour, Michael E. Herce, Jessie Edwards, Caitlin Cassidy, Jimmy Villiera, Funny Kamanga, Maganizo Chagomerana, Joep J. van Oosterhout, Elijah Chikuse, Ethel Rambiki, Agness Thawani, Bridget Malewezi, Lazola Makhupula, Clement Udedi, Patrick Mbulaje, Mitch Matoga, Wiza Kumwenda, Tisungane Mvalo, Agatha Bula, Lovemore Nkhalamba, Innocent Mofolo, Lameck Chinula, Virginia Thonyiwa, Owen Kumwenda, Mike Nenani Chisema, Irving F. Hoffman, William C. Miller, Vivian F. Go, Brian Pence, Madeleine A. Squibb, Friday Saidi

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A phase I, open-label, multicentre, first-in-human study to evaluate safety, pharmacokinetics and efficacy of AMG 404, a PD-1 inhibitor, in patients with advanced solid tumours by Yasutoshi Kuboki, Hendrik-Tobias Arkenau, Vivek Subbiah, Timothy Price, Gerald Falchook, Hans Prenen, Rafal Dziadziuszko, Hansen Wong, Iwona Lugowska, Daniel Tan, Weibing Shi, Ryota Shibaki, Min Hee Hong, Sant P Chawla, Jose G Monzon, Mun Hui, Caio Max Rocha Lima, Kejia Wang, Antreas Hindoyan, Mira Kistler

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Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial by Simon Valayer, Marie Alexandre, Mélanie Prague, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Brian Greenwood, Bailah Leigh, Marie Poupelin, Christine Schwimmer, Samba O. Sow, Irina Maljkovic Berry, Jens H. Kuhn, Daniela Fusco, Natasha Dubois Cauwelaert, Deborah Watson-Jones, Rodolphe Thiébaut, Yves Lévy, Yazdan Yazdanpanah, Laura Richert, Edouard Lhomme

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Design and Construction of an Automatic Discharge and Sediment Load Monitoring Equipment by Hasan rezaei moghadam, Vahedberdi Sheikh, Maryam Azarakhshi, Mohsen Hosseinalizadeh, Jahangir Mohamadi

“…With ongoing trends in socioeconomic development, climate change, increasing pressure on natural resources and watersheds, and, consequently, an increase in floods and sediment yield, there will be a greater need for more accurate information about sediment and runoff processes in the near future. …”
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Effectiveness of stress management and relaxation interventions for management of hypertension and prehypertension: systematic review and network meta-analysis by Deborah M Caldwell, Sarah Dawson, Rachel Johnson, Jelena Savović, Alyson Huntley, Christopher E Clark, Russell J Bowater, Julian PT Higgins, Katie E Webster, Monika Halicka, Thomas Parkhouse, Dara Stanescu, Athitya Vel Punniyakotty

“…The certainty of the evidence was assessed with CINeMA (Confidence in Network Meta-Analysis) and GRADE (Grading of Recommendations Assessment, Development, and Evaluation).Results 182 studies were included (166 for hypertension and 16 for prehypertension). …”
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