Different artificial neural networks for predicting burnout risk in Italian anesthesiologists by Marco Cascella, Alessandro Simonini, Sergio Coluccia, Elena Giovanna Bignami, Gilberto Fiore, Emiliano Petrucci, Alessandro Vergallo, Giacomo Sollecchia, Franco Marinangeli, Roberto Pedone, Alessandro Vittori

“…Machine learning, particularly neural networks, can offer effective data-driven approaches to identifying BO risk more accurately. This study aims to develop and evaluate different artificial dense neural network (DNN)-based models to predict BO based on occupational, psychological, and behavioral factors. …”
Get full text

Randomised controlled interventions on physical activity, diet or their dual approach to better public health and the links to body mass index in 10–19 years: a systematic review a... by Thomas Rosemann, Gerhard Ruedl, Clemens Drenowatz, Georg Göbel, Derrick R Tanous, Mohamad Motevalli, Joel Craddock, Markus Schauer, Werner Kirschner, Katharina C Wirnitzer

“…Introduction Health behaviour serves as a pivotal domain for the control of current health crises that primarily develop in young people and affect the global population in excess. …”
Get full text

Case Report: Summary of multiple CAR-T expansions in anti-BCMA/GPRC5D bispecific CAR-T cell therapy for multiple myeloma by Liya Wei, Xingxian Xiao, Xin Jing, Yuwei Zheng, Xiaoyan Sun, Wei Bai, Manjun Li, Min Luo, Yang Xiao, Yang Xiao

“…Although the patient experienced four episodes of CAR-T cell expansion and developed grade 3 cytokine release syndrome (CRS), the symptoms were well controlled, and the treatment demonstrated generally safe. …”
Get full text

Post-COVID pain and quality of life in COVID-19 patients: protocol for a meta-analysis and systematic review by Yongxing Xu, Jianwen Gu, Mengrong Miao, Yitian Yang, Pule Li, Mengqi Jia, Zhaoyu Wen, Mengmeng Yu, Jiaqiang Zhang

“…The risk of bias tool developed by Hoy et al will be used to assess the risk of bias of prevalence studies. …”
Get full text

Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) in Puno, Peru: rationale and study protocol for a hybrid type 2 effectiveness and implementation rand... by Lindsay J. Underhill, Kendra N. Williams, Lucy Cordova-Ascona, Karina Campos, Lisa de las Fuentes, Mark D. Huffman, Joel Gittelsohn, Kenneth B. Schechtman, Zoila Vela-Clavo, Carla Tarazona-Meza, Laura K. Beres, Parker K. Acevedo, Abigail Barker, Nishadi Rajapakse, Makeda Williams, Veronica Tonwe, Aaloke Mody, Raquel Hurtado, Juan Carlos Mendoza, Gonzalo Cuentas, Elvin H. Geng, William Checkley, Victor G. Dávila-Román, Stella M. Hartinger-Peña

“…Participants will be individually randomized (1:1) to either continue with usual care or participate in a 12-month CHW-led home-based hypertension control program consisting of blood pressure monitoring, medication adherence support, and healthy lifestyle counseling. Outcome development and reporting are guided by the Consolidated Framework for Implementation Research (CFIR), the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework, and the Proctor et al. framework. …”
Get full text

Influence of agroclimatic factors on the efficiency of multi-ovulation in cattle in the Peruvian tropics by Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Nilton Luis Murga Valderrama, Rainer Marco Lopez Lapa, José Américo Saucedo Uriarte, Deiner Jhonel Gongora Bardales, Hugo Frias Torres, Annie Yoselin Poclín Rojas, Benjamin Depaz Hizo, Ronald Will Vasquez Tarrillo, Lizeth Amparo Heredia Vilchez, Gustavo Ampuero Trigoso

“…IntroductionAgroclimatic conditions are key determinants in the development of animal production and reproduction, with specific breed differences in vulnerability to environmental stress. …”
Get full text

Benefits and harms of perioperative high fraction inspired oxygen for surgical site infection prevention: a protocol for a systematic review and meta-analysis of individual patient... by Paul Myles, Markus W Hollmann, Janet Martin, Andrew Forbes, Benedetta Allegranzi, Kate Leslie, Robert Greif, Matthew TV Chan, Christian S Meyhoff, Marcel GW Dijkgraaf, Stijn W de Jonge, Carlos Ferrando, Kane Pryor, Andrea Kurz, Daniel I Sessler, Pascal Thibon, Marja Boermeester, Rick H Hulskes, Maedeh Zokaei Nikoo, Robert P Weenink, Ozan Akca, F Javier Belda, Gabriel M Gurman, Christina M Scifres, David S McKenna, Jannicke Mellin-Olsen

“…The results will be submitted to a peer-review journal.PROSPERO registration number CRD42018090261.…”
Get full text

Assessment of ovarian dysfunction induced by environmental toxins: a systematic review by Lu An, Yali Huang, Yunkai Wang, Shuting Shen, Xuexing Luo, Xiaoyan Liang, Xiaoyan Liang, Liming Lu, Chunzhi Tang, Jinglin Lin, Jinglin Lin, Ting Su, Ting Su, Meiqi Zhan, Meiqi Zhan, Dongying Wang, Dongying Wang, Jue Wang, Jue Wang, Xin Lai, Xin Lai, Yu Li, Yu Li

“…The Newcastle-Ottawa Scale (NOS) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach were used to assess study quality.ResultsThis study ultimately included 40 cohort study reports derived from 33 distinct studies that analyzed the effects of 20 pollutant types on ovarian function. …”
Get full text

Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project by Lu Tang, Manish Arora, Wei Perng, Marcela Tamayo-Ortiz, Brisa N Sánchez, Alejandra Cantoral, John D Meeker, Dana C Dolinoy, Elizabeth F Roberts, Esperanza Angeles Martinez-Mier, Hector Lamadrid-Figueroa, Peter X K Song, Adrienne S Ettinger, Robert Wright, Lourdes Schnaas, Deborah J Watkins, Jaclyn M Goodrich, Robin C Garcia, Maritsa Solano-Gonzalez, Luis F Bautista-Arredondo, Adriana Mercado-Garcia, Howard Hu, Mauricio Hernandez-Avila, Martha Maria Tellez-Rojo, Karen E Peterson

“…Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated in the mid-1990s to explore: (1) whether enhanced mobilisation of lead from maternal bone stores during pregnancy poses a risk to fetal and subsequent offspring neurodevelopment; and (2) whether maternal calcium supplementation during pregnancy and lactation can suppress bone lead mobilisation and mitigate the adverse effects of lead exposure on offspring health and development. Through utilisation of carefully archived biospecimens to measure other prenatal exposures, banking of DNA and rigorous measurement of a diverse array of outcomes, ELEMENT has since evolved into a major resource for research on early life exposures and developmental outcomes.Participants n=1643 mother–child pairs sequentially recruited (between 1994 and 2003) during pregnancy or at delivery from maternity hospitals in Mexico City, Mexico.Findings to date Maternal bone (eg, patella, tibia) is an endogenous source for fetal lead exposure due to mobilisation of stored lead into circulation during pregnancy and lactation, leading to increased risk of miscarriage, low birth weight and smaller head circumference, and transfer of lead into breastmilk. …”
Get full text

Cohort profile: the open, prospective Community-Based chronic Care Lesotho (ComBaCaL) cohort – design, baseline chronic disease risk factors and hypertension and diabetes care casc... by Matthias Briel, Thilo Burkard, Ravi Gupta, Frédérique Chammartin, Alain Amstutz, Thabo Ishmael Lejone, Eleonora Seelig, Irene Ayakaka, Mosa Tlahali, Matumaole Bane, Makhebe Khomolishoele, Tristan Lee, Niklaus Daniel Labhardt, Felix Gerber, Giuliana Sanchez-Samaniego, Thesar Tahirsylaj, Fabian Raeber, Mamakhala Chitja, Malebona Mathulise, Thuso Kabi, Mosoetsi Mokaeane, Malehloa Maphenchane, Manthabiseng Molulela, Mota Mota, Sesale Masike, Retselisitsoe Makabateng, Mamoronts’ane Sematle, Lebohang Sao, Sejojo Phaaroe, Malitaba Litaba, Madavida Mphunyane, Dave Brian Basler, Kevin Kindler, Pauline Grimm

“…This will provide further insights into the dynamics and interactions of chronic diseases and inform the development of future nested trials on innovative community-based prevention and care interventions.Trial registration number NCT05596773.…”
Get full text

Effectiveness of a multicomponent intervention to promote physical activity during the school day: rationale and methods of the MOVESCHOOL study by Francisco J. Bandera-Campos, Francisco J. Bandera-Campos, Alberto Grao-Cruces, Alberto Grao-Cruces, Daniel Camiletti-Moirón, Daniel Camiletti-Moirón, Fátima Martín-Acosta, Fátima Martín-Acosta, Raúl Muñoz-González, María González-Pérez, María González-Pérez, Abel Ruiz-Hermosa, Abel Ruiz-Hermosa, Miguel Vaquero-Solís, Miguel Vaquero-Solís, Carmen Padilla-Moledo, Carmen Padilla-Moledo, David Sánchez-Oliva, David Sánchez-Oliva, David Sánchez-Oliva

“…In addition, this research promises to provide a transformative experience for educators, equipping them with tools to promote the holistic development of their students, enriching their academic performance and enhancing their well-being.Clinical trial registrationClinicalTrials.gov, identifier NCT06254638.…”
Get full text

Risk prediction models for breast cancer: a systematic review by Jiang Li, He Li, Jie He, Ni Li, Yadi Zheng, Zheng Wu, Maomao Cao

“…High-quality breast cancer risk prediction models assessed by PROBAST should be developed and validated, especially among Asian women.PROSPERO registration number CRD42020202570.…”
Get full text

Effectiveness and cost-effectiveness of the Assessment of Burden of Chronic Conditions (ABCC) tool in patients with COPD, asthma, diabetes mellitus type 2 and heart failure: protoc... by Bjorn Winkens, Esther A. Boudewijns, Danny Claessens, Manuela Joore, Lotte C.E.M. Keijsers, Onno C.P. van Schayck, Annerika H.M. Gidding-Slok

“…The Assessment of Burden of Chronic Conditions (ABCC) tool was developed to integrate these elements in daily healthcare practice. …”
Get full text

Predicting the use of antibiotics after initial symptomatic treatment of an uncomplicated urinary tract infection: analyses performed after a randomised controlled trial by Ibrahimu Mdala, Morten Lindbaek, Ingvild Vik, Marianne Bollestad, Gloria Cristina Cordoba, Lars Bjerrum, Thomas Neumark, Eivind Damsgaard, Anders Bærheim, Nils Grude

“…Larger data sets are needed to develop models that are more accurate.Trial registration number ClinicalTrials.gov (NCT01849926).…”
Get full text

Study protocol for the TRUSt trial: a pragmatic randomised controlled trial comparing the standard of care with a transitional pain service for patients at risk of chronic postsurg... by Markus W. Hollmann, Henning Hermanns, Jeroen Hermanides, Manouk Admiraal, Carin G.C.L. Wensing, Soe L. Meinsma, Hans C. H. Wartenberg, Martin V. H. Rutten, Vivian M. C. Ward - van der Stam

“…The results will be disseminated by open access publication in a peer-reviewed journal.Trial registration number NL9115…”
Get full text

Bilateral prophylactic mastectomy: should we preserve the pectoral fascia? Protocol of a Dutch double blinded, prospective, randomised controlled pilot study with a within-subject... by Cornelis Verhoef, Linetta B Koppert, Marloes E Clarijs, Laurentine S E van Egdom, Dalibor Vasilic, T. van Dalen, C. de Betue, J. Rothbarth, E.V.E. Madsen, L.M. Beelen, M.A.M. Mureau, E.M.L. Corten, A.J.M. Luijsterburg, M.J. Hop, H.M. Zuijdendorp, N.A.S. Posch, C.M.C.A. van Laarhoven, M. de Kraker

“…Introduction Bilateral prophylactic mastectomy (BPM) in women with a high risk of developing breast cancer has shown to provide the greatest risk reduction. …”
Get full text

Adjuvant nonavalent HPV vaccination in women treated for vulvar HSIL, a randomized placebo-controlled trial; VulVaccin study protocol by Vera J. G. M. Vaessen, Ralf L. O. van de Laar, Marta Piso-Jozwiak, Virgil A. S. H. Dalm, Elmar A. Joura, Matthias Jentschke, Heleen J. van Beekhuizen

“…Abstract Background Each year, 45,000 women worldwide develop vulvar cancer, often occurred from vulvar high-grade squamous intraepithelial lesions (vHSIL), a precancerous stage associated with high- risk human papillomavirus (HPV). …”
Get full text

Evaluation of the new antimicrobial benziothiazolinone for management of fire blight disease of pear by Jiuxiang Zhu, Ling Cai, Yixin Wang, Wenxi Jiang, Xinran Liu, Jun Wang, Yanli Tian, Baishi Hu, Youfu Zhao

“…Resistance risk analysis indicates that E. amylovora has a low risk of developing resistance to benziothiazolinone. Results from two-year field trials demonstrated that benziothiazolinone could significantly reduce the disease incidence of fire blight. …”
Get full text

Quantitative Detection of Pericardial Adhesions Using Four-Dimensional Computed Tomography: A Novel Motion-Based Analysis Framework by Tong Ren, Shuo Wang, Nan Cheng, Zekun Feng, Menglu Li, Li Zhang, Rong Wang

“…Results: Statistical analysis revealed significant differences between adhesion and non-adhesion groups (<i>p</i> < 0.01) using two newly developed metrics: peak ratio (PR) and distribution width index (DWI). …”
Get full text

Towards novel BIOmarkers to diagnose SEPsis (BIOSEP) in the emergency room: a protocol for a multicentre, prospective cohort study by Tom van der Poll, W Joost Wiersinga, Michiel Schinkel, Renee A Douma, Hazra S Moeniralam, Marleen A Slim, Evelien Reijnders, Oren Turgman, Sebastiaan C M Joosten, Hessel Peters-Sengers

“…Research results will be published in peer-reviewed journals.Trail registration number ClinicalTrials.gov, NCT06178822.…”
Get full text