Comparative efficacy of transdermal forms for alopecia therapy by U. V. Nogaeva, D. Yu. Ivkin, G. A. Plisko, E. V. Flisyuk, V. E. Kovanskov, Yu. G. Shtyrlin, K. O. Sidorov

“…Baldness causes psychological and social discomfort to patients, in connection with what an important task is to develop formulations that are more effective than the reference agents.Aim. …”
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Prognostic models for adverse pregnancy outcomes in low-income and middle-income countries: a systematic review by Diederick E Grobbee, Kerstin Klipstein-Grobusch, Kitty Bloemenkamp, Joyce L Browne, Marcus J Rijken, Tessa Heestermans, Beth Payne, Gbenga Ayodele Kayode, Ewoud Schuit

“…External validation of existing models developed in both LMIC and high-income countries instead of developing new models should be encouraged.PROSPERO registration number CRD42017058044.…”
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Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis... by Keith M Godfrey, Philip Titcombe, Sarah El-Heis, Benjamin B Albert, Elizabeth Huiwen Tham, Sheila J Barton, Timothy Kenealy, Mary Foong-Fong Chong, Heidi Nield, Yap Seng Chong, Shiao-Yng Chan, Wayne S Cutfield, NiPPeR Study Group

“…<h4>Background</h4>Maternal vitamin status preconception and during pregnancy has important consequences for pregnancy outcome and offspring development. Changes in vitamin status from preconception through early and late pregnancy and postpartum have been inferred from cross-sectional data, but longitudinal data on vitamin status from preconception throughout pregnancy and postdelivery are sparse. …”
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Gender-specific sarcopenia screening in hemodialysis: insights from lower limb strength and physiological indicators by Yujie Yang, Hualong Liao, Yang Chen, Ying Qiu, Fei Yan, Ping Fu, Jirong Yue, Yu Chen, Huaihong Yuan

“…Sarcopenia was assessed using the 2019 Asian Working Group for Sarcopenia update. A self-developed lower limb muscle strength testing device was used. …”
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Low-added sugar dietary intervention study to mitigate glucose intolerance and improve body composition in adults with cystic fibrosis: a protocol of a double-blind, randomised stu... by Priyathama Vellanki, Kirk Easley, Terryl J Hartman, Thomas R Ziegler, Puneet Sharma, Swati Zaveri, Arlene Stecenko, William R Hunt, Amy Goss, Joshua D Chandler, Tasha M Burley, Chris Driggers, Amy Ciccarella, Heather Zhou, Kristen Narlow, Tanicia Daley, Jessica Alvarez

“…Introduction People with cystic fibrosis (PwCF) are at high risk for developing cystic fibrosis (CF)-related diabetes (CFRD), which worsens morbidity and mortality. …”
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Reducing outpatient visits for FIT-positive participants of colorectal cancer screening programs with home-based digital counselling by Fleur E. Marijnissen, Elyse E. C. Rijnders, Merel M. Tielemans, Désiree van Noord, Leonieke M. M. Wolters, Jeroen M. Jansen, Ingrid Schot, Frank C. Bekkering, Agnes N. Reijm, Sophia M. van Baalen, Tingting Wang, Marijke Melles, Richard Goossens, Sohal Y. Ismail, Iris Lansdorp–Vogelaar, Pieter Jan F. de Jonge, Manon C. W. Spaander

“…While it has been evaluated as a supplement to standard care or a substitute for follow-up visits, its use for initial triaging and counselling remains unstudied. We developed a Digital Intake Tool (DIT) to facilitate the entire pre-colonoscopy counselling process for FIT-positive participants of a colorectal cancer screening program digitally, replacing the need for physicians. …”
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Comparisons of efficacy and safety of immunotherapies for Alzheimer’s disease treatment: A network meta-analysis of randomised controlled trials by Ching-Hui Su, Ying-Tzu Chang, Huan-Shu Tseng, Chan-Yen Kuo, Jin-Hua Chen, Po-Yu Chien, Yao-Jen Chang, Chin-Chuan Hung

“…Moreover, direct comparisons between newly developed and symptomatic drugs are lacking. This network meta-analysis aimed to compare the efficacy and safety of immunotherapies for AD. …”
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Effects of nutritional intervention strategies in the primary prevention of overweight and obesity in school settings: systematic review and network meta-analysis by Joerg J Meerpohl, Lukas Schwingshackl, Guido Schwarzer, Jürgen M Steinacker, Edris Nury, Blin Nagavci, Georg Hoffmann, Jakub Morze, Janine Wendt, Julia Stadelmaier, Kathrin Grummich, Claudia M Angele, Johanna Conrad, Daniela Schmid

“…The results of the network meta-analysis could be used by policy makers in developing and implementing effective, evidence based nutritional intervention strategies in the school setting.Systematic review registration PROSPERO CRD42020220451.…”
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Urolithin A supplementation to improve endothelial and cerebrovascular function in middle-aged adults with obesity: Study protocol for a double-blind placebo-controlled randomized... by Ana Clara da C. Pinaffi-Langley, Camila B. Pinto, Zsofia Szarvas, Anna Peterfi, Zalan Kaposzta, Peter Mukli, Mihaly Muranyi, Cameron D. Owens, Cheryl Adams, Ali Shahriari, Henry Kinnard, Jr., Bryan Ticer, Leah Anderson, Stefano Tarantini, Yan Daniel Zhao, Norman G. Hord, Andriy Yabluchanskiy

“…Summary: Background &amp; Aims: Obesity-related mitochondrial dysfunction initiates and exacerbates endothelial dysfunction, which in turn contributes to the development of several diseases, such as cardiovascular disease and cognitive impairment. …”
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Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis by Mari Imamura, Clare Robertson, Jemma Hudson, Daniel Whibley, Lorna Aucott, Katie Gillies, Marcus Beasley, Martin J Stevens, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole KY Tang, Gary J Macfarlane, Miriam Brazzelli

“…When possible, for studies that included PROMs originally developed in non-fibromyalgia patients, we consulted the original development study to inform our analysis. …”
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Influence of social determinants on lifestyle modification adherence in people with prediabetes: a sequential explanatory mixed-methods study protocol by Ana Carvalho-Azevedo, Ana Carvalho-Azevedo, Ana Carvalho-Azevedo, Manuela Abbate, Manuela Abbate, Manuela Abbate, Sergio Fresneda, Sergio Fresneda, Sergio Fresneda, María Arias-Fernández, María Arias-Fernández, María Arias-Fernández, Marina Torres-Carballo, Marina Torres-Carballo, Aina M. Yañez, Aina M. Yañez, Aina M. Yañez, Aina M. Yañez, Aina M. Yañez, Cristina Moreno-Mulet, Cristina Moreno-Mulet, Cristina Moreno-Mulet, Miquel Bennasar-Veny, Miquel Bennasar-Veny, Miquel Bennasar-Veny, Miquel Bennasar-Veny, Miquel Bennasar-Veny

“…Our study can guide the development of health interventions tailored to individuals with prediabetes, focusing on addressing social disparities in lifestyle modification.Patient or public contributionParticipants will contribute through semi-structured interviews and discussion groups, providing insights into their experiences on adherence to lifestyle changes.Clinical trial registrationClinicalTrials.gov, identifier NCT06488677.…”
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The Use of 360-Degree Video to Reduce Anxiety and Increase Confidence in Mental Health Nursing Students: A Mixed Methods Preliminary Study by Caroline Laker, Pamela Knight-Davidson, Andrew McVicar

“…More research is needed to explore how to develop resilient mental health nurses who face multiple workplace stressors, including interacting with distressed clients. …”
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Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial by W Michael Hooten, Darin J Erickson, Marek Chawarski, Natalie A Scholz, Jennifer F Waljee, Chad M Brummett, Molly M Jeffery

“…ConclusionsFollowing complete data analyses, it is anticipated that electronic health record systems will be leveraged to help clinicians identify at risk patients and to develop direct-to-patient educational materials to raise awareness of the risk factors for developing UPOU. …”
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Current status and prognostic factors of paediatric arterial ischaemic stroke in China: a study protocol for Chinese Paediatric Ischaemic Stroke Registry (CPISR) by Wei Li, Bin Zhu, Wen Sun, Fan Wu, Pan Zhang, Lulu Xiao, Huiping Wang, Gang Cai, Yingjie Xu, Wanqiu Zhang, Cuirong Duan, Mingyang Niu, Qiankun Li, Zhiwen Su

“…To streamline data collection, a WeChat-based programme has been developed to allow participating institutions to input standardised questionnaire data directly and upload electronic medical records. …”
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Impact of the Acti-Pair programme on physical activity in patients with prostate cancer: protocol of the Acti-Pair 2 stepped-wedge cluster randomised trial by Franck Chauvin, Aurélie Bourmaud, Emilie Presles, David Hupin, Mathieu Oriol, Nathalie Barth, Amandine Baudot, Evolene Fayolle, Maël Garros, Florence Colin, Fanny Collange

“…Motivational peer support seems to be an innovative strategy for lifestyle change. Therefore, we developed the Acti-Pair programme and demonstrated its feasibility. …”
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At the grassroots of home and community-based aged care: strategies for successful consumer engagement by Andrew Georgiou, Johanna Westbrook, Joyce Siette, Amy Nguyen, Lindsey Brett, Mikaela Jorgensen, Melissa Miao, Winifred Lee, Edwina Gow, Fleur Hourihan

“…The stakeholder forum was developed using five key principles of consumer engagement activities: purposeful, inclusive, timely, transparent and respectful. …”
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Mechanism-based modular psychotherapy versus cognitive behavioural therapy for adolescents and young adults with childhood trauma experiences: study protocol for a feasibility tria... by Till Bärnighausen, Hanna Zimmermann, Christian Schmahl, Stephanie Bauer, Beate Ditzen, Hans-Christoph Friederich, Markus W Haun, Astrid Berner-Rodoreda, Elisabeth Schramm, Svenja Taubner, Corina Aguilar-Raab, Sabine C Herpertz, Manuel Feisst, Frank Enning, Katja I Seitz, Niklas Schouler, Jan Hundertmark, Maximilian Wilhelm, Svea Franz, Christoph W Korn, Ruben Vonderlin, Eva Vonderlin, Josef Bailer, Elias Bopp, Sophia von Stockert, Laura Tabea Kristalis, Claudia Calvano

“…Findings will be communicated within the research community as well as with patients and the public by the dissemination strategies of the German Center for Mental Health.Trial registration number German Clinical Trials Register DRKS00034058.…”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…Dissemination will be via publications, conference presentations, newsletter articles, social media, talks to clinicians and consumers and meetings with health departments/managers.It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT and POWER on subclinical markers of disease.Trial registration number ACTRN12617001440314 Australian New Zealand Clinical Trials Registry.…”
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HiSNAP trial—a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 60... by Alasdair Gray, David M Wood, Jacqueline James, Keith Boath, Rajendra Raman, Matt Reed, Rachel O’Brien, Alison Grant, Sharon Tuck, Liza Keating, Craig Davidson, Christopher J Weir, Jonathan Carter, Stephen Lynch, James W Dear, Michael Eddleston, Lyle Moncur, Julia Grahamslaw, Katherine Oatey, Marianne Gillings, Lynsey Milne, Natalie Homer, Caroline Blackstock, Philippa Wright, Christopher Humphries, Alan Timmins, Laura Muir, Ruben Thanacoody, Ellise Clarke, Heather Robertson, Anna Miell, Chloe Haigh, Luisa Padovani, Karen Gray, Sandra Pirie, Christina Coventry, Amy Armstrong, Sian Irvine, Oliver Carlill, Donna Clark, Fraser Craig, Angela Crawford, Carlyn Davie, Judith Flemming, Marie-Claire Harris, Katy Letham, Malgorzata Litwin, Fiona McCurrach, Shona McDonald, Fraser McFadyen, Hazel Milligan, Victoria Minnis, Gillian Pickering, Rebecca Rielly, Emma-Beth Wilson, Lisa-Marie Butt, Kathleen Scullion, Claire Cheyne, Angela McGeough, Nikki McLaughlin, Fern Purdie, Sandee Beattie, Anna Borkowska, Katie Hamilton, Keith Jacques, Jeronimo Martin Ramirez, Vasilika Ntoko, Surinder Pandhor, Janine Ramsey, Maria Simpson

“…The study will first test the primary outcome on the HiSNAP Group 2 against Standard NAC; only if that is significant will HiSNAP Group 1 be tested against Standard NAC.Ethics and dissemination The HiSNAP trial has been approved by the East Midlands (Derby) Research Ethics Committee (reference 23/EM/0129), NHS Lothian Research and Development Department, and the MHRA. Results will be disseminated by peer-reviewed publication, conferences and linked on isrctn.com.Trial registration number ISRCTN17516192.…”
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Digital delivery of behavioural activation therapy to overcome depression and facilitate social and economic transitions of adolescents in South Africa (the DoBAt study): protocol... by Stephen Tollman, Kathleen Kahn, F Xavier Gómez-Olivé, Crick Lund, Alan Stein, Heather A O'Mahen, Eustasius Musenge, Sarah-Jayne Blakemore, Alastair van Heerden, Tholene Sodi, Bianca D Moffett, Julia R Pozuelo, Michelle Craske, Kate Orkin, Emma J Kilford, Mahreen Mahmud, Meghan Davis, Zamakhanya Makhanya, Tlangelani Baloyi, Daniel Mahlangu, Gabriele Chierchia, Sophie L Fielmann, Imraan Valodia

“…Secondary objectives are to pilot a range of cognitive, mental health, risky behaviour and socioeconomic measures; and to collect descriptive data on the feasibility of trial procedures to inform the development of a further larger trial.Ethics and dissemination This study has been approved by the University of the Witwatersrand Human Research Ethics Committee (MED20-05-011) and the Oxford Tropical Research Ethics Committee (OxTREC 34-20). …”
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