Prospective cohort for early detection of liver cancer (Pearl): a study protocol by Emma Culver, Eleanor Barnes, Michael Pavlides, Hamish Innes, Jennifer Benselin, William Irving, Kartikeya Khanna, DeLIVER Consortium

“…Approximately 75 patients are predicted to develop de novo HCC within the 3-year follow up period. …”
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Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review by Claire Goodman, Tom Dening, Neil H Chadborn, Maria Zubair, Lídia Sousa, John R F Gladman, Adam, L Gordon

“…It will be of use to teams developing, implementing or auditing CGA in care homes. …”
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Incidence and prevalence of rabies virus infections in tested humans and animals in Asia: A systematic review and meta-analysis study by Farzane Shams, Mohammad Jokar, Ehssan Djalali, Arman Abdous, Mehdi Rahnama, Vahid Rahmanian, Kaushi S.T. Kanankege, Torsten Seuberlich

“…Introduction: Rabies is a fatal neurological zoonotic disease affecting warm-blooded animals, causing nearly 60,000 human deaths annually, primarily in developing Asian and African countries (95 % of cases). …”
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Effectiveness of pharmacological treatments in Duchenne muscular dystrophy: a protocol for a systematic review and meta-analysis by Vicente Martínez-Vizcaíno, Iván Cavero-Redondo, Carlos Pascual Morena, Celia Álvarez-Bueno, Ruben Fernández Rodríguez, Estela Jiménez López, Ana Isabel Torres-Costoso

“…Findings will be disseminated to academic audiences through peer-reviewed publications, as well as to clinical audiences, patients’ associations and policy makers, and may influence guideline developers in order to improve outcomes for these patients.PROSPERO registration number CRD42018102207…”
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Accuracy of endoscopic staging and targeted biopsies for routine gastric intestinal metaplasia and gastric atrophy evaluation study protocol of a prospective, cohort study: the est... by Manon C W Spaander, Matthew Banks, Manuel Rodriguez-Justo, Marnix Jansen, Ernst J Kuipers, David Graham, Stella A V Nieuwenburg, William W Waddingham, Katharina Biermann

“…Introduction Patients with chronic atrophic gastritis (CAG) and intestinal metaplasia (IM) are at risk of developing gastric adenocarcinoma. Their diagnosis and management currently rely on histopathological guidance after random endoscopic biopsy sampling (Sydney biopsy strategy). …”
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Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys by Ghulam Nabi, Hamid Ullah, Suliman Khan, Fazal Wahab, Pengfei Duan, Rahim Ullah, Lunguang Yao, Muhammad Shahab

“…Our data suggest that sensitivity of KISS1R on GnRH neurons with reference to LH stimulation in boys develops during the later part of puberty reaching to adult level at Tanner stage V. …”
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Mortality in patients with adrenal insufficiency: a protocol for a systematic review and meta-analysis by Eva Hessman, Bright I Nwaru, Emanuele Bobbio, Daniela Esposito, Francesca Allosso, Konstantinos Dalakas, Ragnhildur Bergthorsdottir, Dimitrios Chantzichristos, Daniela Pasquali, Gudmundur Johannsson

“…Treatment strategies for AI have developed over time with reduced glucocorticoid replacement doses and improved circadian exposure regimens, but whether this has resulted in better survival is unknown. …”
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Auto-segmentation of cerebral cavernous malformations using a convolutional neural network by Chi-Jen Chou, Huai-Che Yang, Cheng-Chia Lee, Zhi-Huan Jiang, Ching-Jen Chen, Hsiu-Mei Wu, Chun-Fu Lin, I-Chun Lai, Syu-Jyun Peng

“…The Dice similarity coefficients for the segmentation of CCMs types were as follows: Zabramski Classification type I (0.743), type II (0.742), and type III (0.740). We also developed a user-friendly graphical user interface to facilitate the use of these models in clinical analysis. …”
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Is hypertension negatively associated with memory performance in women during climacteric? A systematic review by Arthur Polveiro da Silva, Laura Scatena Fávero, Adriano Bruno Corrêa, Mateus do Carmo Bardella, Luís Felipe Pengo Almeida Leite, Leonardo Santos Lopes da Silva, Márcio Fernando Tasinafo Júnior, Leonardo da Silva Gonçalves, Camila de Moraes

“…However, due to the small number of studies and the fact that most were conducted in developed countries, these results should be interpreted with caution (PROSPERO registration number: CRD42023391668).…”
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Effect of physical activity on the risk of new-onset chronic kidney disease: a systematic review and meta-analysis of cohort studies by Arman Shafiee, Fatemeh Movahed, Masoud Dehbozorgi, Sanam Mirzaei, Ali Kolahdooz, Saleheh Khorasani, Farima Safari, Saba Goodarzi, Neda Izadi

“…Abstract Objective The aim of this systematic review and meta-analysis was to investigate the association between physical activity levels and the risk of developing new-onset chronic kidney disease (CKD). Methods In accordance with PRISMA guidelines and PROSPERO registration, a detailed literature search was conducted in PubMed, Embase, Scopus, Cochrane and Web of Science databases until April 13, 2025. …”
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Identifying and measuring the severity of somatic symptom disorder using the Self-reported Somatic Symptom Scale-China (SSS-CN): a research protocol for a diagnostic study by Meng Jiang, Weituo Zhang, Xuan Su, Chuang Gao, Bingxu Chen, Zehao Feng, Jialiang Mao, Jun Pu

“…The Somatic Symptom Scale-China (SSS-CN) questionnaire has been developed to meet this urgent clinical demand. The aim of this research is to validate the self-reported SSS-CN as a timely and practical instrument that can be used to identify SSD and to assess the severity of this disorder.Methods and analysis At least 852 patients without organic disease but presenting physical discomfort will be recruited at a general hospital. …”
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Strategic Business Management and Its Role in the Formalization of Micro and Small Enterprises in Emerging Economies by Uldarico Inocencio Aguado-Riveros, Sonia Luz Barzola-Inga, Carlos Antonio Adauto-Justo, Diana Pariona-Amaya, Luis Enrique Espinoza-Quispe, Luis Alberto Poma-Lagos, Vicente González-Prida, Javier Amador Navarro-Veliz

“…This study explores the connection between business management and the formalization of micro and small businesses (MSEs) in a particular developing economy environment. The main objective is to identify the business management factors that influence the business registration and compliance processes of these enterprises. …”
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Prevalence and influencing factors of comorbidity of central obesity and hyperuricemia in adult residents of Inner Mongolia Autonomous Region in 2018: a cross-sectional survey by Lehui LI, Xingguang ZHANG, Nan ZHANG, Tao YAN, Yonggang QIAN, Huimin LIU

“…ObjectiveTo investigate the prevalence and influencing factors of the comorbidity of central obesity and hyperuricemia (HUA) among adult residents in the Inner Mongolia Autonomous Region, and to provide evidence for developing prevention and control strategies. MethodsA cross-sectional study was conducted among 5 076 permanent residents aged ≥18 years in the Inner Mongolia Autonomous Region from July to December 2018. …”
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Taste test using an edible taste film kit: a randomised controlled trial by Ji-sun Kim, Dong-Hyun Kim, Eun-ju Jeon, Byung Guk Kim, Jeongjun Yu, Hyun-Il Shin

“…Objectives We developed an edible taste film test that can be stored easily as a kit. …”
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Measurement of Maize Leaf Phenotypic Parameters Based on 3D Point Cloud by Yuchen Su, Ran Li, Miao Wang, Chen Li, Mingxiong Ou, Sumei Liu, Wenhui Hou, Yuwei Wang, Lu Liu

“…While various lidar-based methods have been developed for acquiring these parameters, existing approaches face limitations, including low automation, prolonged measurement duration, and weak environmental interference resistance. …”
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Multiple lifestyle behaviour mHealth intervention targeting Swedish college and university students: protocol for the Buddy randomised factorial trial by Hanna Henriksson, Pontus Henriksson, Marie Löf, Preben Bendtsen, Marcus Bendtsen, Katarina Åsberg, Oskar Lundgren

“…Introduction The time during which many attend college or university is an important period for developing health behaviours, with potentially major implications for future health. …”
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Technology to improve reliable access to oxygen in Western Uganda: study protocol for a phased implementation trial in neonatal and paediatric wards by Graham Moore, Hamish Graham, Rami Subhi, Sheillah Bagayana, Joseph Mugerwa, David Peake, Eleanor Nakintu, Daniel Murokora, Roger Rassool, Marc Sklar, Bryn Sobott

“…FREO2 Foundation Australia has developed an integrated oxygen system, driven by a mains-powered oxygen concentrator, with the ability to switch automatically between low-pressure oxygen storage device and cylinder oxygen in power interruptions. …”
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Study protocol for Care cOORDInatioN And sympTom managEment (COORDINATE) programme: a feasibility study by Nancy Perrin, Caleb Ferguson, Binu Koirala, Patricia Davidson, David N Hager, Sarah Badawi, Steven Frost, Lara Street, Cheryl Dennison Himmelfarb

“…The study aims to test the feasibility of the Care cOORDInatioN And sympTom managEment (COORDINATE) intervention to improve health outcomes of adults living with multimorbidity.Methods and analysis A multicomponent nurse-driven intervention was developed using experience-based co-design and human-centred design. …”
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Safety and effectiveness of modified laparoscopic transcystic biliary drainage in the treatment of choledocholithiasis: study protocol for a prospective single-arm clinical trial by Long Cui, Gang Wang, Lixin Wang, Yun Yi Zhang, Chunsheng Hou, Zhi Xu, Xiaofeng Ling, Lingfu Zhang

“…Introduction Several techniques are used for laparoscopic treatment of gallstone disease with biliary duct stone, but each approach has indications and shortcomings. We have developed a modified laparoscopic transcystic biliary drainage for the management of cholecysto-choledocholithiasis. …”
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Protecting Emergency Responders with Evidence-Based Interventions (PEREI): protocol for a randomized controlled trial for early career emergency responders, significant others, and... by Reginald D.V. Nixon, Marja Elizabeth, Daniel B. Fassnacht, Joep van Agteren, Laura C. Edney, Jennifer Wild

“…Although programs exist to minimise the risk of developing mental health problems, their efficacy to date has been limited or untested. …”
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