Assessment of secondary surgical repair versus salvage endoscopic correction for persistent (recurrent) vesicoureteral reflux in children: protocol for a systematic review and meta... by Ulugbek Nurmatov, Kobiljon Ergashev, Zafar Abdullaev, Kamron Khidoyatov, Askar Soliev, Sarvar Eshankulov, Davronbek Khaltursunov, Akmal Rakhmatullaev, Saidanvar Agzamkhodjaev

“…Introduction Developing a comprehensive understanding of the current estimates for incidence and prevalence of persistent vesicoureteral reflux (VUR) following ureteroneocystostomy or endoscopic correction is crucial. …”
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Rationale and methods for the Exercise for Type 1 Diabetes Education program: a pilot randomized controlled trial of an education program to support adults with type 1 diabetes mel... by Melanie Davies, Parth Narendran, Catherine Thompson, Nishal Bhupendra Jaicim, Robert C Andrews, Niamh Quann, Dinesh Nagi, Ian Gallen, Janet Gorton, Heather Daly

“…We aim to recruit 96 patients with T1DM at two UK hospitals.Conclusions This article outlines the protocol for a pilot RCT to develop a program of education that will support adults with T1DM to undertake safe and effective exercise. …”
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Emotional awareness and expression therapy (EAET) for chronic pain following traumatic orthopaedic injury and surgery: study protocol for a single-arm feasibility clinical trial by Renan Castillo, Stephen Wegener, Mark A Lumley, Claudia Campbell, Scott G Ravyts, Nicolette Carnahan, Fenan S Rassu, Rachel Aaron

“…Background Nearly half of individuals who sustain orthopaedic trauma develop chronic pain and experience significant levels of depression and anxiety. …”
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Phase I-IIa clinical trial to evaluate the safety, feasibility and efficacy of the use of a palate mucosa generated by tissue engineering for the treatment of children with cleft p... by Ingrid Garzón, Antonio Campos, Miguel Alaminos, Gloria Carmona, Antonio España-López, Ricardo Fernández-Valadés, Elisa Cubiles, Miguel Angel Martin-Piedra, Víctor Carriel, Fernando Campos, Adoración Martínez-Plaza, Daniel Vallejo, Esther Liceras-Liceras, Jesús Chato-Astrain, Oscar Dario García-García, David Sánchez-Porras, Paula Ávila-Fernández, Miguel Etayo-Escanilla, Blanca Quijano, Elisabet Aguilar

“…Preliminary signs of efficiency will be explored by sequentially evaluating craniomaxillofacial development, hearing impairment, speech capability and quality of life of the family. …”
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Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study by Duncan Wagstaff, John Amuasi, Sumaiya Arfin, Diptesh Aryal, Mohd Basri Mat Nor, Joseph Bonney, Arjen Dondorp, David Dongelmans, Layoni Dullawe, Fathima Fazla, Aniruddha Ghose, Eva Hanciles, Rashan Haniffa, Madiha Hashmi, Adam Hewitt Smith, Bharath Kumar, Yen Lam Minh, Ramani Moonesinghe, Luigi Pisani, Cornelius Sendagire, Mohd Shahnaz Hasan, Maryam Shamal Ghalib, Moses Siaw Frimpong, Otavio Ranzani, Menbeu Sultan, David Thomson, Swagata Tripathy, Louise Thwaites, Rabiul Alam Md. Erfan Uddin, Mohd Zulfakar Mazlan, Wangari Waweru-Siika, Abigail Beane

“…Strategies to support stakeholder-led implementation include development of local protocols, registry-enabled audit and feedback, and education. …”
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Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review by Brittany J. Johnson, Paul M. Chadwick, Samantha Pryde, Anna Lene Seidler, Kylie E. Hunter, Mason Aberoumand, Jonathan G. Williams, Hei In Lau, Sol Libesman, Jannik Aagerup, Angie Barba, Louise A. Baur, Samantha Morgillo, Lee Sanders, Sarah Taki, Kylie D. Hesketh, Karen Campbell, Alexandra Manson, Alison Hayes, Angela Webster, Charles Wood, Denise A. O’Connor, Karen Matvienko-Sikar, Kristy Robledo, Lisa Askie, Luke Wolfenden, Rachael Taylor, H. Shonna Yin, Vicki Brown, Alexander Fiks, Alison Ventura, Ata Ghaderi, Barry J. Taylor, Cathleen Stough, Christine Helle, Cristina Palacios, Eliana M. Perrin, Elizabeth Reifsnider, Finn Rasmussen, Ian M. Paul, Jennifer S. Savage, Jessica Thomson, Jinan Banna, Junilla Larsen, Kaumudi Joshipura, Ken K. Ong, Levie Karssen, Li Ming Wen, Márcia Vitolo, Margrethe Røed, Maria Bryant, Maribel Campos Rivera, Mary Jo Messito, Natalia Golova, Nina Cecilie Øverby, Rachel Gross, Rajalakshmi Lakshman, Rebecca Byrne, Russell L. Rothman, Sharleen O’Reilly, Stephanie Anzman-Frasca, Vera Verbestel, Claudio Maffeis, Kayla de la Haye, Sarah-Jeanne Salvy, Seema Mihrshahi, Janani Ramachandran, Paola Seffrin Baratto, Rebecca K. Golley, on behalf of the TOPCHILD Collaboration

“…These findings can be used to examine effectiveness of components and inform intervention development and evaluation in future trials. Trial registration PROSPERO registration no. …”
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The Impact of a Clay-Core Embankment Dam Break on the Flood Wave Characteristics by Cristina-Sorana Ionescu, Daniela-Elena Gogoașe-Nistoran, Constantin Alexandru Baciu, Andrei Cozma, Iana Motovilnic, Livioara Brașovanu

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Rehabilitation via HOMe-Based gaming exercise for the Upper limb post Stroke (RHOMBUS): a qualitative analysis of participants’ experience by Cherry Kilbride, Daniel J M Scott, Tom Butcher, Meriel Norris, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Elizabeth Cassidy

“…The findings add to the developing literature on the interface between virtual reality systems and user experience.Trial registration number ISRCTN60291412.…”
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Organizational health culture in the Korean firefighter intervention studies: a scoping review by Hanbit Jin, Hanbit Jin, Hyungsun Jun, Jisu Ha, Inae Youn, Jungtae Leem, Jungtae Leem, Jungtae Leem

“…Future research should prioritize diverse interventions addressing firefighters’ health, incorporate sensitive and ethical research designs, and work closely with experts in firefighting to develop adaptable and relevant interventions.Systematic Review Registrationhttps://osf.io/s378j/, Registration DOI: https://doi.org/10.17605/OSF.IO/7EQ8M.…”
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Feasibility of dynamic chest radiography to calculate lung volumes in adult people with cystic fibrosis: a pilot study by Matthew Shaw, Thomas Simon FitzMaurice, Paul Stephen McNamara, Dilip Nazareth, Caroline McCann, Martin Walshaw, Scott Hawkes

“…Despite the small sample size, accurate models were developed for predicting TLC, RV and FRC.Conclusion DCR is a promising new technology that can be used to estimate lung volume subdivisions. …”
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Evidence map of liver surgery: study protocol of a living systematic review by Pascal Probst, Ismail Labgaa, Gaëtan-Romain Joliat, Felix Hüttner, Sidney Heersche, Héloïse Giron, Emilie Uldry, Emmanuel Melloul

“…There is a critical unmet need to develop tools that will facilitate navigating the literature and offer easy, fast and accurate access to data with a high level of evidence. …”
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Evaluating impacts of improved flooring on enteric and parasitic infections in rural households in Kenya: study protocol for a cluster-randomised controlled trial by Elizabeth Allen, Robert Dreibelbis, Katherine E Halliday, Rachel L Pullan, Charles S Mwandawiro, Carlos Mcharo, Doris Njomo, Stella Kepha, William E Oswald, Hugo Legge, Martin Rono, Lynne Elson, Beatrice K Kakoi, Sharon Muli, Jacinta Mwongeli, Margaret M Njoroge, Victoria Ochwal, Tuva K Safari, Ulrike Filinger, James Wambua Kaluli

“…Results will be disseminated within Kenya, to the Ministries of Health and of Lands, Public Works, Housing and Urban Development, and to subnational leadership and communities. …”
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Comparison of 6 cycles of isatuximab with lenalidomide, bortezomib and dexamethasone (I-VRd) versus 3 cycles of I-VRd followed by one cycle of high-dose melphalan in newly diagnose... by Theo Leitner, Evgenii Shumilov, Christina Schwitlick, Raphael Koch, Franziska Hamm, Marion Högner, Florian Bassermann, Katja Weisel, Hermann Einsele, Martin Kortüm, Leo Rasche, Martin Görner, Kai Wegehenkel, Stefan Knop, Jan Krönke, Axel Nogai, Inke R. König, Maren Vens, Kay Horn, Nikolas von Bubnoff, Cyrus Khandanpour

“…Registration Date: 21.07.2022.…”
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Efficacy of IsaPomDex triplet therapy in double refractory multiple myeloma patients in real clinical practice in Russia by M. V. Solovev, M. V. Solovevа, L. P. Mendeleeva, T. I. Pospelova, N. V. Skvortsova, S. V. Voloshin, A. D. Garifullin, A. S. Chuprakova, T. A. Mitina, I. S. Usankin, I. V. Vasileva, N. V. Medvedeva, V. V. Ryabchikova, M. Ya. Kiseleva, G. A. Dudina, Yu. S. Gammershmidt, O. S. Kuznetsova, Yu. V. Dolgushina, G. B. Kuchma, T. N. Tsyganok, E. N. Misyurina, E. I. Zhelnova, A. V. Kopylova, M. N. Zakharova, A. V. Korobkin, G. S. Tumyan, A. A. Semenova, E. G. Kirillova, E. M. Volodicheva, V. I. Bakhtina, T. I. Olkhovik, N. R. Solovkova, M. V. Demchenkova, O. E. Ochirova, O. L. Panteleeva, V. S. Abramova

“…Discontinuation of isatuximab due to the development of adverse event was recorded in 2 cases (2 %). …”
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Implementation and effectiveness of a nurse-enabled, shared-care follow-up model for early breast cancer survivors (The IBIS-Survivorship Study): protocol for a stepped-wedge clust... by Karla Hemming, Jane Turner, Meinir Krishnasamy, Nicolas H Hart, Patsy Yates, Helen Skerman, Elizabeth Eakin, Jon Emery, Jane Mahony, Kerry Patford, Bogda Koczwara, Fiona Crawford-Williams, Caroline Kristunas, Raymond J Chan, G Bruce Mann, Mary Azer, Louisa G Collins, Jasotha Sanmugarajah, Bethany Crowe, Gillian Blanchard, Laura Healey, Rhea Liang, Paul Craft, Amy Shorthouse, Ruth McCaffery

“…The IBIS-Survivorship intervention involves a nurse-led consultation, development of a Survivorship Care Plan and case-conferencing between a breast care nurse and the patient’s primary care provider. …”
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Acceptability of the live biotherapeutic LACTIN-V (Lactobacillus crispatus CTV-05) among young women at high risk of HIV acquisition in South Africa: data from the phase 2 placebo-... by A. Hemmerling, V. Govender, K. Dong, K. Dong, K. Dong, K. Dong, M. Dong, M. Dong, Sooseela Pillay, T. Ndung’u, T. Ndung’u, T. Ndung’u, T. Ndung’u, A. Bhoola, J. Moodley, G. Casillas, L. Lagenaur, C. M. Mitchell, C. M. Mitchell, D. S. Kwon, D. S. Kwon, D. S. Kwon, C. R. Cohen

“…Determining acceptability of LBPs among African women at high risk of HIV is essential to guide product development.MethodsThe phase 2 double-blind randomized placebo-controlled trial recruited young sexually active cis-women with vaginal dysbiosis from a community-based research clinic. …”
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Predictors of treatment REsponse to inhaled corticosteroids (ICS) in Chronic Obstructive pulmonary disease: randomised controlled trials individual participant Data re-Evaluation–p... by Matthew Sperrin, John R Hurst, Michael Miligkos, Joergen Vestbo, Pradeesh Sivapalan, Mike Clarke, Lesley Stewart, Jørgen Vestbo, Dave Singh, Tim Felton, Alexander G Mathioudakis, Rebecca Fortescue, Jennifer Quint, Jonathan Marshall, Anurita Majumdar, Jan Hansel, Alice M Turner, Sinduja Manohar, Catherine Fullwood, Nawar Diar Bakerly, Mark Simmonds, Steven Barnes, Ashley Woodcock, Sebastian Bate, Jens-Ulrik Jensen, Markus Fally, Helen Ashdown, Ashley A Woodcock, Emily Howlett, John Linnell, Alan Preston, Glauco Cappellini, Dmitry Galkin, Olaf Joens

“…Our findings will be published in peer-reviewed journals and shared with the scientific and broader stakeholder communities.PROSPERO registration number CRD42024508286.…”
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Comparative effectiveness of epilepsy surgery versus additional anti-seizure medications for Lennox–Gastaut syndrome: study protocol for a multicenter, mixed-methods study by Sandi Lam, Sandi Lam, Marc Rosenman, Marc Rosenman, Tracy Dixon-Salazar, Kelly G. Knupp, Liu Lin Thio, Taylor J. Abel, Taylor J. Abel, William P. Welch, William P. Welch, Laurel Reed, Laurel Reed, Stephanie C. Randle, Stephanie C. Randle, Rebecca Garcia-Sosa, Rebecca Garcia-Sosa, Jason S. Hauptman, Carolyn C. Foster, Carolyn C. Foster, Elizabeth R. Alpern, Elizabeth R. Alpern, Lu Zhang, Lu Zhang, Nicole Villalba, Nicole Villalba, Maura Carroll, Anup D. Patel

“…The results of this study may help guide decisions regarding the treatment of LGS and development of computable phenotypes for this rare disease. …”
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CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study by Cecilia T Costiniuk, Jean-Pierre Routy, Shari Margolese, Enrico Mandarino, Joel Singer, Mohammad-Ali Jenabian, Mario Ostrowski, Jonathan B Angel, Ann Burchell, Darrell Tan, Colin Kovacs, Mark Hull, Mark Brockman, Sharon Walmsley, Aslam H Anis, Marianne Harris, Curtis Cooper, Marc-André Langlois, Iva Kulic, Judy Needham, Zabrina Brumme

“…The findings will inform the design of future COVID-19 clinical trials, dosing strategies aimed to improve immune responses and guideline development for PLWH.Trial registration number NCT04894448.…”
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Justification of Methodological Approaches to Identification Testing of Biomedical Cell Products by E. V. Melnikova, O. A. Rachinskaya, G. A. Trusov, M. D. Khorolsky, I. S. Semenova, N. V. Tereshkina, V. A. Merkulov

“…The manufacturer (developer) has to prepare a specification for each newly developed biomedical cell product (BCP) that has passed the stage of preclinical studies. …”
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