Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial [version 3; peer review: 2 approved, 1 not a... by Temitayo Shokunbi, Haleema Shakur-Still, Raoul Mansukhani, Antonio Belli, Rizwana Chaudhri, Sabariah Faizah Jamaluddin, Amy Brenner, Lauren Frimley, Rashid Jooma, Ian Roberts

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Long-Term Safety and Efficacy of Macitentan in Inoperable Chronic Thromboembolic Pulmonary Hypertension: Results from MERIT and its Open-Label Extension by Nick H. Kim, Andrea M. D’Armini, Luke S. Howard, David P. Jenkins, Zhi-Cheng Jing, Eckhard Mayer, Liliya Chamitava, Gabriela Lack, Hany Rofael, Maria Solonets, Hossein-Ardeschir Ghofrani

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Personalized neoantigen-based immunotherapy for advanced collecting duct carcinoma: case report by Wei Zhang, Xiaoping Su, Yongyi Zeng, Zhenli Li, Youshi Zheng, Yingchao Wang, Geng Chen, Liman Qiu, Kun Ke, Zhixiong Cai, Jingfeng Liu, Xiaolong Liu

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Are maternal vaccines effective and safe for mothers and infants? A systematic review and meta-analysis of randomised controlled trials by Kitty Bloemenkamp, Louis Bont, Fariba Ahmadizar, Miriam Sturkenboom, Odette de Bruin, Emily Phijffer, Nicoline van der Maas, Joanne Wildenbeest

“…Quality appraisal was performed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE).Results Six RCTs on four maternal vaccines, influenza, tetanus, diphtheria and pertussis (Tdap), pneumococcal and respiratory syncytial virus (RSV) were eligible. …”
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DIAMONDS—a diabetes self-management intervention for people with severe mental illness: protocol for an individually randomised controlled multicentre trial by Tim Doran, Najma Siddiqi, Simon Gilbody, Rowena Jacobs, Patrick Doherty, Catherine Hewitt, Laura Mandefield, Simon Walker, Ian Kellar, Sarah Alderson, David Osborn, Vicki Johnson, Judith Watson, Gregor Russell, Steve Parrott, Jan Rasmus Boehnke, Peter A Coventry, Jinshuo Li, Richard Ian Gregory Holt, Judy Wright, David Shiers, Michelle Hadjiconstantinou, Keith Double, Claire Carswell, Jennifer V E Brown, Lucy Sheehan, Grace Catherine O’Carroll, Charlie Peck, R A Ajjan, Angela Ross, Mark Dawson

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Effects of YouTube Health Videos on Mental Health Literacy in Adolescents and Teachers: Randomized Controlled Trial by Rebekka Schröder, Tim Hamer, Victoria Kruzewitz, Ellen Busch, Ralf Suhr, Lars König

“… BackgroundAdolescence is a critical period for mental health development, yet prevalences of mental health problems are high among young people. …”
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Efficacy and safety of first-line avelumab in patients with advanced non-small cell lung cancer: results from a phase Ib cohort of the JAVELIN Solid Tumor study by James L Gulley, Jaafar Bennouna, Guy Jerusalem, Janice Mehnert, Matthew Taylor, Karen Kelly, David Spigel, Marcis Bajars, Claire F Verschraegen, Edward F McClay, Nicholas Iannotti, Charles H Redfern, Franklin L Chen, John C Morris, Ding Wang, Hans Juergen Grote, Dongli Zhou, Neru Munshi

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Lay health worker-delivered and technology-based interventions for sexual and reproductive health among adolescents and young adults in low- and middle-income countries: protocol f... by David Guwatudde, Till Bärnighausen, Ina Danquah, Yemane Berhane, Wafaie Fawzi, Ali Sie, Mosa Moshabela, Shannon McMahon, Jacob Burns, Justine Bukenya, Michael Laxy, Japhet Killewo, Abbas Ismail, Shraddha Bajaria, Amani Tinkasimile, Adi Lukas Kurniawan, Sachin Shinde, Christine Neumann, Mary Mwanyika Sando, Ayoade Oduola, Adom Manu, Matthias Kern, Joy Mauti, Mashavu Yussuf, Innocent Yusufu, Benjamin Bosompim, Dorit Ann, Nolwazi Dlamini, Sarah Nabukeera, Sphindile Machanyangwa, Dagmawit Tewahido, Said Ali Vuai

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Immunobiological Methods for Monitoring Latent Tuberculosis Infection in Children and Adolescents and Analysis of Tuberculosis Infection Reactivation by M. A. Vladimirskiy, M. B. Lapenkova, A. A. Elov, V. A. Aksenova, M. A. Plekhanova, S. V. Smerdin, P. N. Rutkevich

“…Simultaneous registration of IFN-γ and IL-6 levels and mRNA expression of the PDL2, BATF2 and GBP5 genes above reference values indicates a high risk of developing active tuberculosis. …”
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A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine. by Robert B Couch, Shital M Patel, Chianti L Wade-Bowers, Diane Niño

“…<h4>Results</h4>Reactogenicity evaluations indicated the vaccinations were well tolerated. Only one subject developed a ≥4-fold serum hemagglutination-inhibition (HAI) antibody response and a final titer of ≥1:40 four weeks after dose two and only five subjects developed a neutralizing antibody rise and a final titer of ≥1:40 in tests performed at a central laboratory. …”
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Artificial Intelligence Systems for Solving Problems of Agro­Industrial Complex Digitalization and Robotization by A. L. Ronzhin, A. I. Savel'ev

“…Algorithmic software and hardware have been developed for the automation of vertical farms, closed cycle fish farming plants. …”
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Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…These post-SVR changes raise concerns that the chemopreventive benefits of HCV cure may be counterbalanced by increased risks of liver disease progression and LC development from metabolic risk factors and alcohol use. …”
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Virtual reality-delivered skills-based therapy for chronic lower back pain: from proof-of-concept to FDA authorization to clinical implementation in-home and beyond by Todd Maddox, Josh Sackman, Matthew Stoudt, Michael Chibbaro, Emily Judge, Regan Rothery, Jesse Donini, Roselani Maddox, Beth D. Darnall

“…We detail the iterative path to design, develop and validate this immersive therapeutic medical device and the process followed to obtain FDA-authorization. …”
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Modeling and optimizing deep brain stimulation to enhance gait in Parkinson’s disease: personalized treatment with neurophysiological insights by Hamid Fekri Azgomi, Kenneth H. Louie, Jessica E. Bath, Kara N. Presbrey, Jannine P. Balakid, Jacob H. Marks, Thomas A. Wozny, Nicholas B. Galifianakis, Marta San Luciano, Simon Little, Philip A. Starr, Doris D. Wang

“…ClinicalTrials.gov registration: NCT-03582891.…”
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Youth co-production for sustainable engagement and empowerment in health (YiPEE): protocol for a cluster-randomised controlled trial of an intervention for mental health promotion... by Josefien van Olmen, Pilvikki Absetz, Mark Tomlinson, Carina King, Edwin Wouters, Josefien van Olmen, G J Melendez-Torres, Jeroen De Man, Stefan Swartling Peterson, Suresh Kumar, Mariam Claeson, Monika Martens, Frances Mathews, Christina A Laurenzi, Yoona Kim, Yeukai Chideya, Maria Niemi, Vijaya Raghavan, Jill Åhs, Anu Linnansaari, Fredric Azariah, Moitreyee Sinha, Upasana Sharma, Orlaith O’Sullivan, Yoo Na Kim, Akshaya Rajesh, Samyukta Saravanan, Nivetha Vasanthan, N P Haritha, Lander Willem, Jeroen de Man, Christina Laurenzi, GJ Melendez Torres, Matt Hughsam, Maureen Gikonyo, Joyce Arita

“…Introduction Adolescence is a time of rapid physical, social and psychological development and many risk factors for mental disorders have their roots in this age period. …”
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Evaluation of non-invasive continuous physiological monitoring devices for neonates in Nairobi, Kenya: a research protocol by Amy Sarah Ginsburg, Evangelyn Nkwopara, Shuai Xu, J Mark Ansermino, William Macharia, Roseline Ochieng, Mary Waiyego, Guohai Zhou, Roman Karasik

“…Easy-to-use, non-invasive, multiparameter, continuous physiological monitoring devices could be instrumental in providing appropriate care and improving outcomes for high-risk neonates in these low-resource settings.Methods and analysis The purpose of this prospective, observational, facility-based evaluation is to provide evidence to establish whether two existing non-invasive, multiparameter, continuous physiological monitoring devices developed by device developers, EarlySense and Sibel, can accurately and reliably measure vital signs in neonates (when compared with verified reference devices). …”
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Unlocking minds: fostering critical thinking in postgraduates trainees through a foundation course - a prospective quasi-experimental study by Veena Kumari Singh, Shruti Singh, Meenakshi Tiwari, Ansarul Haq, Sarsij Sharma, Tania Moudgil

“…Methodology A structured CT module was developed based on literature review and expert opinion. …”
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Prochlorperazine maleate versus placebo for the prevention of acute mountain sickness: study protocol for a randomized controlled trial by Elan Small, Elizabeth Goldberg, Martin Musi, Brian Strickland, Ryan Paterson, Caleb Phillips, Linda E. Keyes

“…Abstract Background Acute mountain sickness (AMS) is a debilitating condition that individuals may develop on ascent to high altitude. It is characterized by headache, nausea, vomiting, dizziness, and fatigue with the potential to progress to fatal disease. …”
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Designing the Minimum Data Set for National Scorpion Sting Registry in Iran by Mehraban Shahi, Mehran Shahi, Farid Khorrami, Nasrin Davaridolatabadi

“…The present study attempted to develop a minimum data set for a national registry of scorpion stings. …”
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An overview of the treatment interventions and assessment of fear-avoidance for chronic musculoskeletal pain in adults: A scoping review protocol. by Sam Tan, Anju Jaggi, Alex Tasker, Catherine Borra, Fraje Watson

“…<h4>Introduction</h4>The Fear-Avoidance (FA) model aims to explain how an acute pain experience can develop into a persistent state. The FA model considers five core components: kinesiophobia, pain-related fear, catastrophisation, victimisation, and interpersonal social environment. …”
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