Dual knowledge‐guided two‐stage model for precise small organ segmentation in abdominal CT images by Tao Liu, Xukun Zhang, Zhongwei Yang, Minghao Han, Haopeng Kuang, Shuwei Ma, Le Wang, Xiaoying Wang, Lihua Zhang

“…Additionally, inspired by the practice of annotating images from multiple perspectives by radiologists, novel Multi‐View Fusion Convolution (MVFC) operator is developed, which can extract and adaptively fuse features from various directions of CT images to refine segmentation of small organs effectively. …”
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Early Start Denver Model effectiveness in young autistic children: a large multicentric randomised controlled trial in two European countries by Marie-Maude Geoffray, Sandrine Sonié, Mario Speranza, Bruno Falissard, Sandrine Touzet, Angelique Denis, Lucie Jurek, Marie-Joelle Oreve, Carmen Schroder, Amélie Zelmar, Sabine Manificat, Stephane Bahrami, Flavia Mengarelli, Véronique Delvenne, Sophie Carlier, Mikail Nourredine, Jay Agathe, Gallifet Natacha, Nicolas Petit, Laetitia Bouveret, Sara Linda Dochez, Pauline Auphan, Olivia Febvey-Combes

“…However, the effectiveness of ESDM across diverse cultural contexts remains under-researched.Objective To assess the effectiveness of ESDM compared with treatment as usual (TAU) on overall development in young children with autism spectrum disorder (ASD).Method This parallel, randomised controlled trial, using a modified Zelen design, was conducted in five Child and Adolescent Mental Health Services in France and Belgium. …”
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Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) trial: study protocol for a multicentre, double-blinded, placebo-controlled, phase IIa trial by Julian R Marchesi, Emma Nicholson, Benjamin H Mullish, Renuka Palanicawandar, Graham Wheeler, Francesca Kinsella, Andrew J Innes, Lauren A Roberts, Shian Anim-Burton, Lee Webber, Nicholas A Johnson, Rohma Ghani, Pakhshan Farshi, Anjum B Khan, Panagiotis Kottaridis, Pramila Krishnamurthy, Frances Davies, Jiří Pavlů

“…Secondary outcomes will include tolerability, the dynamics of gut microbiome diversity metrics and taxonomy over all time points assessed, as well as clinical outcomes (including burden of invasive infections, days of fever, admission to intensive care, development of graft-vs-host disease and mortality).Ethics and dissemination This study was approved by a UK Research Ethics Committee (REC reference: 23/NE/0105). …”
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Community-based interventions targeting multiple forms of malnutrition among adolescents in low-income and middle-income countries: protocol for a scoping review by David Guwatudde, Till Bärnighausen, Ina Danquah, Elisabetta Ferrero, Yemane Berhane, Ali Sie, Clarisse Dah, Jabulani Ncayiyana, Mosa Moshabela, Shannon McMahon, Jacob Burns, Wafaie W. Fawzi, Michael Laxy, Japhet Killewo, Deda Ogum Alangea, Bruno Sunguya, Sara Pedron, Amani Tinkasimile, Uttara Partap, Adi Lukas Kurniawan, Marijana Ranisavljev, Sachin Shinde, Sergej Ostojic, Ntombizodumo Mkwanazi, Christine Neumann, Shuyan Liu, Mary Mwanyika Sando, Ayoade Oduola, Adom Manu, Jan A.C. Hontelez, Magda Rosenmöller, Irene Brandt, Matthias Kern, Joy Mauti, Hanna Y. Berhane, Mashavu Yussuf, Innocent Yusufu, Laetitia Paumard, Millogo Ourohiré, Erick Agure, Tiwatayo Lasebikan, Marina Taonda, Sylvain Somé, Katian Napon, Moussa Ouédraogo

“…Background Adolescent malnutrition is a significant public health challenge in low-income and middle-income countries (LMICs), with long-term consequences for health and development. Community-based interventions have the potential to address multiple forms of malnutrition and improve the health outcomes of adolescents. …”
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Screening and intervention for intimate partner violence at trauma centers and emergency departments: an evidence-based systematic review from the Eastern Association for the Surge... by Hee Soo Jung, Rishi Rattan, Anna Goldenberg, Erin Chang, Stephanie Bonne, D'Andrea Joseph, Amanda L Teichman, Patrick B Murphy, Courtney Edwards, Christina Colosimo, Anna Liveris, Emily Lawson, Kathleen Fox, Jennifer J Freeman, Krista L Haines, Linda Dultz, Farheen A Qurashi, Nathan Polite, Rachel L Choron, Sandra Arabian, Andrew T Schramm, Hassan Naser A Mashbari, Randi N Smith

“…The Grading of Recommendations, Assessment, Development and Evaluations methodology was used to determine the quality of evidence. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…Two additional therapeutic arms are currently in development.Ethics and dissemination Central ethics approval was obtained from the Sydney Local Health District Ethics Review Committee, Royal Prince Alfred Hospital Zone, Sydney, Australia (Approval: 2022/ETH02230). …”
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The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating... by Navdeep Tangri, Dylan Mackay, Rebecca C Mollard, Matthew Granger, Sharon Bruce, Heather Blewett, Jared Carlberg, Todd Duhamel, Peter Eck, Patrick Faucher, Naomi C Hamm, Ehsan Khafipour, Diana McMillan, Semone Myrie, Amir Ravandi, Meghan Azad, Peter JH Jones

“…Additional information at www.TMPLR.ca.Trial registration number NCT03674957; Pre-results.…”
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Unrecognised rural–urban disparities in epidemiology of metabolic-associated fatty liver disease in the representative area of China by Qing Li, Yi Zhang, Xing Chen, Xiaoyi Li, Tingfeng Wu, Junzhao Ye, Suilin Mo, Miaosheng Ye, Wengeng Wang, Qiaocong Zheng, Ke Luo, Shouwei Tu, Daituan Che, Rulong Gong, Rong Miu, Congxiang Shao, Yanhong Sun, Bihui Zhong

“…We aimed to clarify the prevalence and risk factors in rural areas of China.Methods This cross-sectional study used the most densely populated area with highly unbalanced development differences in China (Guangdong Province) as a representative sample, and multistage stratified random sampling was performed. …”
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SMALL: open surgery versus minimally invasive vacuum-assisted excision for small screen-detected breast cancer—protocol for a phase III randomised multicentre trial by Sian Taylor-Phillips, Tracy Roberts, Nisha Sharma, Sangeetha Paramasivan, Shelley Potter, Stuart McIntosh, David Dodwell, Julia R Henderson, Hilary Stobart, Sarah Pinder, Jenna Morgan, Matthew G Wallis, Charlotte Coles, Zohal Nabi, Beatrix Elsberger, William Teh, Kenneth Elder, Jessica Foster, Claire Gaunt, Iain Lyburn, Claire Mabena, Sarah Pirrie, Elizabeth Southgate, Amruta Talwalkar, Elliot Turner, Dan Rea

“…Results will be submitted for publication in a peer-reviewed journal, presented, shared with patient partners and with relevant professional organisations to inform future guideline development for the management of screen-detected breast cancer.Trial registration number ISRCTN12240119.…”
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Evaluation of the insertion parameters and complications of the i-gel Plus airway device for maintaining patent airway during planned procedures under general anaesthesia: a protoc... by Michal Kral, Jonathan Holland, Ana M Lopez, Jan Bruthans, Pavel Michalek, Olga Klementova, Taranpreet Kaur Bhoday, Jakub Werner, Will Donaldson, Erik Lichnovsky, Tomasz Gaszyński, Tomas Henlin, Jitka Ulrichova, Martin Lukes, Jan Blaha, Lidia Gomez, Raquel Berge, Francis McAleavey, Shiva Arava, Lubica Merjava Skripecka, Sebastian Sobczyk, Tomas Tyll

“…Introduction Supraglottic airway devices represent a less invasive method of airway management than tracheal intubation during general anaesthesia. Their continued development is focused mainly on improvements in the insertion success rate and minimalisation of perioperative and postoperative complications. …”
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Evaluation of antimicrobial photodynamic therapy and minimal intervention associated with deproteinisation in permanent teeth with molar incisor hypomineralisation: study protocol... by Ana Paula Taboada Sobral, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Raquel Agnelli Mesquita Ferrari, Amanda Rafaelly Honório Mandetta, Carolina Carvalho Bortoletto, Renato Araujo Prates, Alessandro Melo Deana, Rita de Cássia Loiola Cordeiro, Lourdes Aparecida Martins dos Santos Pinto

“…Introduction Molar incisor hypomineralisation (MIH) is a qualitative defect of enamel development that occurs in the mineralisation phase. …”
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Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials by Xiao-ying Chen, Chun-li Lu, Qian-yun Wang, Xing-ru Pan, Yang-yang Zhang, Jia-le Wang, Jun-Ya Liao, Nai-chong Hu, Chen-yang Wang, Bing-jie Duan, Xue-han Liu, Xin-yan Jin, Jennifer Hunter, Jian-ping Liu

“…Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). …”
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The role of osteopathic manipulative treatment in neurological disorders: A critical review with clinical advice by Mirjam Bonanno, Francesco Cerritelli, Rocco Salvatore Calabrò

“…Background: Since more people age and live longer with chronic disease, it is important to develop complementary and adjunctive approaches to improve body homeostasis and ensure the highest possible level of well-being for people affected by neurological disorders, besides the known benefits related to neurorehabilitation. …”
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Allelopathic effect of Mountain sagebrush (Artemisia aucheri) on seedling emergency and vigor and some related traits Tall tescue (Festuca arundinaseae) by فیروزه مقیمی نژاد, رضا یاری, یاسر قاسمی آریان, علی طویلی, حسین شکیب

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Ultrasound-Guided Percutaneous Microwave Ablation for Solid Benign Thyroid Nodules: Comparison of MWA versus Control Group by Wenjun Wu, Xiaohua Gong, Qi Zhou, Xiong Chen, Xiaojun Chen

“…Hoarseness occurred in 2 cases (2.7%) and Horner syndrome in 1 case (1.3%), and 1 patient (1.3%) developed slight burn on cervical skin. Conclusions. …”
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Application of graph theory in liver research: A review by Xumei Hu, Longyu Sun, Rencheng Zheng, Xueqin Xia, Meng Liu, Weibo Chen, Xinyu Zhang, Chengyan Wang

“…Functional networks for the liver have also been developed with graph‐based methods, providing insights into the metabolic processes occurring in the liver and the functional organization of the liver. …”
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Prevalence of orthorexia nervosa: a systematic review and meta-analysis protocol by Julie A Pasco, Lana J Williams, Shae E Quirk, Tayla Eckley, Mariel Messer

“…To the authors’ knowledge, the proposed review will be the first systematic review to critically appraise the quality and quantity of evidence on this topic.Methods The protocol has been developed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. …”
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A systematic review of real-world clinical practice data in COVID-19: non-interventional studies by S. A. Mishinova, Yu. M. Gomon, A. S. Kolbin, V. V. Strizheletsky, I. G. Ivanov

“…A search strategy for the terms “COVID-19 AND real-life”, “COVID-19 AND real-data”, “COVID-19 AND real-world” was developed to extract articles published between December 1, 2020 and March 12, 2021 from the databases: PubMed/MEDLINE, the Cochrane Database of Systematic Reviews, and the ClinicalTrials.gov database.Results. …”
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Role of stratification and priming with arginine and gibberellic acid on germination character’s of Fritillaria raddeana by Sajad Alipour, Ali Tehranifar, Mahmoud Shoor, Leila Samiei, Homayoun Farahmand

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Diet therapy (The 8×5 Diet) for adults living with bile acid diarrhoea: protocol for a feasibility randomised controlled trial by Chris Todd, Lawrence Kelman, Julian RF Walters, Sorrel Burden, Michelle O’Connor, Yvonne A McKenzie

“…Eligible participants will be assigned to groups using permuted block randomisation using 1:1 allocation to receive either 8 weeks of usual care or The 8×5 Diet using one-to-one, dietitian counselling via a video-conferencing platform and developed digital resources. Randomisation, consent, recruitment, retention and acceptability will be evaluated using data from the RCT and post-trial interviews conducted with those in the intervention group. …”
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