The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial by Maria Sartori, Giuseppe Tedesco, Paolo Spinnato, Antonio Mazzotti, Antonio Mazzotti, Alessandro Gasbarrini, Alessandro Gasbarrini, Cesare Faldini, Cesare Faldini, Marco Miceli, Gianluca Giavaresi, Francesca Salamanna

“…Among these, Vertebral Bone Marrow Aspirate (vBMA) clot emerges as an innovative and promising avenue for future development. The primary challenge in using vBMA clot for SF procedures lies in the lack of high-level clinical evidence demonstrating whether its combination with bone allograft chips is superior to using bone allograft chips alone. …”
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Students’ motives for enrolling in the master of nursing program in Croatia despite degree recognition uncertainties: a cross-sectional study by Andrea Vuksa, Vesna Mijoc, Ivica Matic, Marta Civljak, Marin Cargo, Snježana Cukljek, Kata Ivanisevic, Mario Marendic, Zrinka Puharic, Natasa Skitarelic, Sanja Zoranic, Marijana Neuberg, Dijana Majstorovic, Alen Brecek, Ivana Barac, Livia Puljak

“…Among BN students, 39% intended to enrol in MN studies, citing personal and professional development as key motives. Most BN and MN students, while cognizant of the limited MN-recognized roles, were primarily motivated to enrol in MN programs to deepen knowledge (94%) and advance career opportunities. …”
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Safety and feasibility of allogeneic cord blood-derived cell therapy in preterm infants with severe brain injury (ALLO trial): a phase-1 trial protocol by Atul Malhotra, Lin Liu, Abdul Razak, Rod W Hunt, Suzanne L Miller, Graham Jenkin, Michelle Martin, Kristyn Connelly, Courtney A McDonald, Lindsay Zhou, Madison CB Paton, Cathie Hart, Ngaire J Elwood

“…Findings will be disseminated through peer-reviewed publications and conference presentations, contributing to the development of novel neuroreparative therapies for preterm brain injury.Trial registration number ACTRN12623001352695 (The Australian New Zealand Clinical Trials Registry).…”
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Integrated two-photon and optoacoustic microscopy for functional neuroimaging by Shruti Sundar, Tian Jin, Yu-Hang Liu, Zhenyue Chen, Michael Reiss, Alexey Kurnikov, Pavel Subochev, Daniel Razansky

“…To address this challenge, we developed a dual-modality system that combines optical-resolution optoacoustic microscopy with two-photon fluorescence microscopy. …”
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Plant and Animal Protein Intake and Transitions From Multimorbidity to Frailty and Mortality in Older Adults by Aitana Vázquez‐Fernández, Francisco F. Caballero, Humberto Yévenes‐Briones, Ellen A. Struijk, Ana Baylin, Teresa T. Fung, Esther Lopez‐Garcia

“…It is unknown which amount and source of protein influences the development of frailty and mortality in patients with multimorbidity. …”
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Multi-environmental traits selection and farmer's participatory assessment of mean performance and stability of orange-fleshed sweet potato genotypes in Benin by Idrissou Ahoudou, Nicodeme V. Fassinou Hotegni, Dêêdi E.O. Sogbohossou, Tania L.I. Akponikpè, Charlotte O.A. Adjé, Françoise Assogba Komlan, Ismail Moumouni-Moussa, Enoch G. Achigan-Dako

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Endovascular thrombectomy in acute stroke with a large ischemic core: A systematic review and meta-analysis of randomized controlled trials. by Chun-Hsien Lin, Meng Lee, Bruce Ovbiagele, David S Liebeskind, Borja Sanz-Cuesta, Jeffrey L Saver

“…Grading of Recommendations Assessment, Development and Evaluations (GRADE) was used to evaluate summaries of evidence for the outcomes. …”
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Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer by Makoto Ueno, Masafumi Ikeda, Do-Youn Oh, Masatoshi Kudo, Christoph Helwig, Changhoon Yoo, Hye Jin Choi, Shunsuke Kondo, Li-Tzong Chen, Motonobu Osada, Isabelle Dussault

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Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. by Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari

“…GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to assess the quality of evidence.…”
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The Effectiveness of Computerized Cognitive Training in Patients With Poststroke Cognitive Impairment: Systematic Review and Meta-Analysis by Min Gao, Lu Huang, Jiang Yi, Tianqi Zhang, Guangyao Zhu, Qi Zhang, Jiaxiao Tian, Rongxuan Zhao, Xiaoqin Duan, Zhongliang Liu

“…The risk of bias was evaluated using the Cochrane Risk of Bias tool, and the quality of evidence was appraised in accordance with the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework. Meta-analysis was conducted using RevMan 5.3 software published by The Cochrane Collaboration. …”
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Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA‐DHF, and BIOSTAT‐CHF Cohorts by Jeremy Lagrange, Mohammad Jahangiri, Guillaume Baudry, Nathalie Mercier, Luca Monzo, Zohra Lamiral, Kévin Duarte, Jozine M ter Maaten, Faiez Zannad, Adriaan A. Voors, Nicolas Girerd

“…Endothelial glycocalyx degradation's role in the development and prognosis of HFpEF remains largely unexplored. …”
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Accuracy of Large Language Models When Answering Clinical Research Questions: Systematic Review and Network Meta-Analysis by Ling Wang, Jinglin Li, Boyang Zhuang, Shasha Huang, Meilin Fang, Cunze Wang, Wen Li, Mohan Zhang, Shurong Gong

“…ObjectiveThis study uses a network meta-analysis (NMA) to assess the accuracy of LLMs when answering clinical research questions to provide high-level evidence-based evidence for its future development and application in the medical field. …”
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Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis by Peng Su, Maofu Li, Jian Xiao, Longbin Bai

“…The frequentist random-effect model for network meta-analysis was performed to summarize the evidence, and the Grading of Recommendations Assessment, Development, and Evaluation frameworks was applied to rate the certainty of evidence. …”
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Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment: Protocol for a Multicenter Cohort Study (Swiss Childhood Cancer Survivor Study FollowUp–Pulmo) by Maša Žarković, Christina Schindera, Grit Sommer, Christine Schneider, Jakob Usemann, Maria Otth, Sonja Lüer, Marc Ansari, Philipp Latzin, Claudia E Kuehni

“…The results will assist in the development of more targeted screening and risk-stratified follow-up care. …”
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Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis by Yi-An Lu, Hui-Chen Lin, Pei-Shan Tsai

“…Evidence quality was evaluated using the Grading of Recommendations Assessment, Development, and Evaluations framework. …”
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Evaluation of a complex integrated, cross-sectoral psycho-oncological care program (isPO): a mixed-methods study protocol by Christina Samel, Holger Pfaff, Stephanie Stock, Nadine Scholten, Martin Hellmich, Imke Jenniches, Clarissa Lemmen, Jan Christopher Cwik, Michael Kusch, Hildegard Labouvie, Alexander Gerlach, Anna Hagemeier, Peter Haas, Michael Hallek, Antje Dresen

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Detrimental Effect of Acute Hyperglycemia on the Outcomes of Large Ischemic Region Stroke by Kanta Tanaka, Takeshi Yoshimoto, Junpei Koge, Hiroshi Yamagami, Hirotoshi Imamura, Nobuyuki Sakai, Kazutaka Uchida, Mikiya Beppu, Yuji Matsumaru, Yasushi Matsumoto, Kazumi Kimura, Reiichi Ishikura, Manabu Inoue, Fumihiro Sakakibara, Takeshi Morimoto, Shinichi Yoshimura, Kazunori Toyoda

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Renal drug dosing practices and clinical outcomes in patients with kidney disease admitted at two referral hospitals in Northwest Ethiopia by Gebeyaw Addis Bezie, Meseret Adugna, Gizachew Tadesse Wassie

“…Therefore, we recommend a holistic approach in the care of renal patients and prompt consideration of adherence to guidelines in drug dosing. Trial registration Was not applicable because the study was not clinical trial.…”
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Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial by Akshita Gupta, Riyue Bao, F Stephen Hodi, Jaclyn Neely, Jason J Luke, Ashish Massey, Santanu Dutta, Janis Taube, George Lee, Katherine Bever, Peter Szabo, David Yao, Rachel Tam, Tim Reilly

“…These data emphasize the difficulty of integral biomarker development for I-O in translating from immunotherapy treatment-naïve biospecimens to the selection of patients in the PD-1-refractory state.Trial registration number NCT03335540.…”
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Efficacy of eHealth Interventions for Hemodialysis Patients: Systematic Review and Meta-Analysis by Xu-Hua Zhou, Hui Chen, Weiwei Yang, Li Wang, Lin Chen, Ying Zhu, Yingjun Zhang, Mei Shi, Qin Zhang

“…The quality of evidence for the outcomes was evaluated following the Grading of Recommendations, Assessment, Development, and Evaluation approach. ResultsA total of 17 randomized controlled trials involving 1728 participants were included in this meta-analysis out of 5741 articles identified in the initial database search and additional search references. …”
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