Effect of weight loss and liraglutide on neutrophil gelatinase-associated lipocalin levels among individuals with overweight and knee osteoarthritis: Exploratory analyses of a rand... by Asbjørn Seenithamby Poulsen, Zara Rebecca Stisen, Marie Skougaard, Robin Christensen, Anders Overgaard, Henrik Gudbergsen, Stine Jacobsen, Andreas Peter Balslev-Clausen, Marius Henriksen, Lars Erik Kristensen, Henning Bliddal

“…Adipose tissues may be linked to OA development through secretion of potential proinflammatory cytokines including neutrophil gelatinase-associated lipocalin (NGAL). …”
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Cluster randomised controlled trial of an online intervention to improve healthy food purchases from primary school canteens: a study protocol of the ‘click & crunch’ trial by Karen Campbell, Rachel Sutherland, Luke Wolfenden, Nicole Nathan, Sze Lin Yoong, Chris Rissel, Penny Reeves, Rebecca Wyse, Tessa Delaney, Pennie Gibbins, Kylie Ball, Kirsty Seward, Rachel Zoetemeyer, John Wiggers, Chris Oldmeadow, Kathryn Reilly

“…Introduction School canteens are the most frequently accessed take-away food outlet by Australian children. The rapid development of online lunch ordering systems for school canteens presents new opportunities to deliver novel public health nutrition interventions to school-aged children. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…The study results will be disseminated in scientific conferences and peer-reviewed indexed journals.Trial registration number ClinicalTrials.gov identifier: NCT04923841…”
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First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers by Aurélien Marabelle, Aung Naing, Funda Meric-Bernstam, Xingfeng Bao, Andrea Varga, David S Hong, Aparna Parikh, Geoffrey I Shapiro, Özlem Ataman, Larisa Reyderman, Terri A Binder, Min Ren, Mingjie Liu, Satish Dayal, Amy Y Siu, Pallavi Sachdev, Lucy Xu, Vijay Bhagawati-Prasad, Ilian Tchakov, Chean Eng Ooi

“…The 250 and 500 mg doses are proposed for further development in the combination setting.Trial registration number NCT02540291.…”
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Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial by Ville-Markus Konola, Jari Parkkari, Juhani Multanen, Riku Nikander, Timo Rantalainen, Johanna Vesanto, Satu Pekkala, Merja Kalaja, Johanna K. Ihalainen, Benjamin Waller, Matti Munukka, Harri Sievänen, Mika Nevalainen, Hannu Kautiainen, Victor Casula, Juha Paloneva, Tommi Vasankari, Arttu Peuna, Simo Saarakkala, Miika T. Nieminen, Ari Heinonen

“…Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. …”
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A practice and exploration of blended learning in medical morphology during the post-COVID-19 pandemic era by Qinlai Liu, Na Yuan, Yongan Wang, Beibei Sun, Leiying Yang, Zhaopeng Wang, Chen Fang, Wenping Sun, Baihua Luo, Yaling Liu, Xin Liu, Li Ge

“…It also has substantial promotional instructive modeling value. Clinical trial registration Not applicable.…”
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A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics. by Jorge Duconge, Alga S Ramos, Karla Claudio-Campos, Giselle Rivera-Miranda, Luis Bermúdez-Bosch, Jessicca Y Renta, Carmen L Cadilla, Iadelisse Cruz, Juan F Feliu, Cunegundo Vergara, Gualberto Ruaño

“…<h4>Aim</h4>This study is aimed at developing a novel admixture-adjusted pharmacogenomic approach to individually refine warfarin dosing in Caribbean Hispanic patients.…”
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Effects of sensory reactivity and haptic interaction on children's anthropomorphism of a haptic robot by Hikaru Nozawa, Masaharu Kato

“…Social touch is vital for developing stable attachments and social skills, and haptic robots could provide children opportunities to develop those attachments and skills. …”
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Mapping the Evidence on Compassion Skills in Applied Behavior Analysis: Protocol for Scoping Review by Daniele Nunes Longhi Aleixo, Daiton Junior Martins de Souza, Stela Regina Pedroso Vilela Torres de Carvalho, Marcia Regina Furlani, Cíntia Canato Martins, Emerson Roberto dos Santos, João Daniel de Souza Menezes, Matheus Querino da Silva, Sônia Maria Maciel Lopes, Marcos Sanches Rodrigues, Natalia Almeida de Arnaldo Silva Rodriguez Castro, Helena Landim Gonçalves Cristóvão, Josimerci Ittavo Lamana Faria, Vânia Maria Sabadoto Brienze, Alba Regina de Abreu Lima, Patrícia da Silva Fucuta, Denise Cristina Móz Vaz Oliani, Neide Aparecida Micelli Domingos, Maria Cristina Oliveira Santos Miyazaki, Gerardo Maria de Araújo Filho, Júlio César André

“…The findings may inform the development of compassion training programs and influence care policies in ABA. …”
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Do preoperative interventions affect patient satisfaction or expectation fulfilment following total hip arthroplasty? A systematic review by April-Rose Matt, Joanne L. Kemp, Andrea B. Mosler, Lucy Salmon, Diogo Almeida Gomes, Alysha De Livera, Erica Hateley, Adam L. Semciw

“…Meta-analysis was performed, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the quality of the body of evidence. …”
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Efficacy and Safety of Adding Ribavirin to Sofosbuvir-Based Direct-Acting Antivirals (DAAs) in Re-Treating Non-Genotype 1 Hepatitis C—A Systematic Review and Meta-Analysis by Shahd Hamran, Amani A. Al-Rajhi, Kawthar Jasim, Majed A. Al-Theyab, Mohamed Elahtam, Mooza K. Al-Hail, Wadha Al-Fahaidi, Yaman A. Khamis, Yara Dweidri, Abdel-Naser Elzouki, Tawanda Chivese

“…Overall, the addition of ribavirin to sofosbuvir, compared to sofosbuvir alone, did not show a benefit in achieving sustained virological response (SVR) (OR 0.91, 95% CI 0.26–3.17, I2 = 70.0%) with moderate certainty in Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence. In subgroup analysis, there was no benefit of adding ribavirin to sofosbuvir in individuals with non-genotype 1 HCV. …”
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Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review by Giulia Negro, Giulia Negro, Michele Rossi, Camillo Imbimbo, Alberto Gatti, Andrea Magi, Andrea Magi, Ildebrando Marco Appollonio, Ildebrando Marco Appollonio, Alfredo Costa, Alfredo Costa, Tino Emanuele Poloni, Tino Emanuele Poloni

“…Evidence suggests that TAUopathy and multiple proteinopathies in key brain regions, such as amygdala, are central to the development of these symptoms. In contrast, the contribution of beta-amyloid and vascular damage appears marginal in the genesis of HIDA and psychotic symptoms. …”
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Risk of conversion from mild cognitive impairment to dementia in low‐ and middle‐income countries: A systematic review and meta‐analysis by Andrea M. McGrattan, Eduwin Pakpahan, Mario Siervo, Devi Mohan, Daniel D. Reidpath, Matthew Prina, Pascale Allotey, Yueping Zhu, Chen Shulin, Jennifer Yates, Stella‐Maria Paddick, Louise Robinson, Blossom C. M. Stephan, the DePEC team

“…Being able to identify those individuals with cognitive impairment who are at highest risk of dementia in LMICs is necessary for the development of risk reduction strategies that are contextualized to these unique settings.…”
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Safety, Tolerability and Pharmacokinetics of Sodium Tungstate (OXO-001) in Healthy Female Volunteers of Childbearing Age: A Randomized, Double-Blind, Dose-Finding, and Placebo-Cont... by Agnes Arbat, Ignasi Canals, Jimena Coimbra, Pol Molina-Perelló, Marta Llorens, Rosa Torres, Josep Perello, Marta Moral-Blanch, Rosa María Antonijoan, Joaquim Calaf

“…These data are sufficient to support further clinical trials (registration number: 2016-001276-30).…”
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Long COVID in people with mental health disorders: a scoping review by Catharina Münte, Manuela Glattacker, Saskia Müller, Andrea E. Zülke, Martin Heinze, Steffi G. Riedel-Heller, Dawid Pieper, Christian Jacke, Stefanie Deckert, Anne Neumann

“…Abstract Background Long COVID, Post COVID Syndrome or PASC (post-acute sequelae of COVID-19), according to the World Health Organization (WHO), is defined as the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. …”
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Comparative Analysis of 68Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging for Gross Tumor Volu... by Hamed Bagheri, PhD, Seied Rabi Mahdavi, PhD, Parham Geramifar, PhD, Ali Neshasteh-Riz, PhD, Masoumeh Sajadi-Rad, MD, Habibollah Dadgar, PhD, Hossein Arabi, PhD, Habib Zaidi, PhD

“…The prostate-specific membrane antigen (PSMA), which is frequently overexpressed in PCa, has led to the development of 68Ga-labeled PSMA inhibitors for positron emission tomography (PET)/computed tomography (CT), showing promising results in PCa detection. …”
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BMI matters: understanding the link between weight and severe psoriasis by Huiwei Wang, Suchun Hou, Xiaojing Kang, Chen Yu, Bin Yang, Yuling Shi, Fuqiu Li, Wei Li, Jun Gu, Mingjun Lei, Youkun Lin, Gang Wang, Hongzhong Jin, Xiaoming Liu

“…Clinicaltrials.gov: ChiCTR1900024852, date of registration: 2019-07-31.…”
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In-person vs mobile app facilitated life skills education to improve the mental health of internally displaced persons in Nigeria: protocol for the RESETTLE-IDPs cluster randomized... by Ejemai Eboreime, Chisom Obi-Jeff, Rita Orji, Tunde M Ojo, Ihoghosa Iyamu, Bala I Harri, Jidda M Said, Funmilayo Oguntimehin, Abdulrahman Ibrahim, Omolayo Anjorin, Andem Effiong Etim Duke, Umar Baba Musami, Linda Liebenberg, Raquel Crider, Lydia Wagami, Asmau MC Dahiru, Jesse C. Uneke, Sanni Yaya, Vincent IO Agyapong

“…Findings will inform the development and scale-up of evidence-based, sustainable mental health interventions for IDPs in Nigeria and other humanitarian contexts. …”
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Effect of opioid-free anaesthesia on postoperative delirium in elderly patients undergoing gastrointestinal surgery: study protocol for a single-centre, prospective, randomized con... by Yuehan Du, Mengjie Liu, Xiaoling Yang, Jianbo Wu, Xiaojun Gao, Qiuyue Liu, Lina Chen, Xiaxuan Sun, Min Zhang, Yongtao Sun

“…This study aims to investigate the effects of OFA on the development of POD in elderly patients following gastrointestinal surgery. …”
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Evaluating the psychometric measurement properties of patient-reported outcome measures for uterine fibroids using the Consensus-based Standards for the selection of health Measure... by Wei Yan, Fei Liu, Ya Li, Shixuan Wang, Minli Zhang, Wenwen Wang, Suzhen Yuan, Shuhao Yang, Qing Yan, Tao Xiang

“…Objectives To systematically evaluate the psychometric measurement properties of existing patient-reported outcome measures (PROMs) for uterine fibroids using the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines and to provide recommendations for the most appropriate tools in clinical and research settings.Design Systematic review using the COSMIN guidelines and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.Data sources The Medline, CINAHL, Embase and Web of Science databases were searched for relevant studies published up to 28 February 2025. …”
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