A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial by Ryan A Mace, Makenna E Law, Joshua E Cohen, Christine S Ritchie, Olivia I Okereke, Bettina B Hoeppner, Judson A Brewer, Stephen J Bartels, Ana-Maria Vranceanu

“…We are iteratively developing and testing My Healthy Brain (MHB), the first mindfulness-based lifestyle group program targeting AD/ADRD risk factors in older adults with subjective cognitive decline. …”
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Effectiveness of clinical healthcare interventions for enhancing the work participation of patients with various health conditions: a synthesis of systematic reviews by Jan L Hoving, Astrid de Wind, Angela G E M de Boer, Annechien Beumer, Faridi S Jamaludin, Lana Kluit, Coen A M van Bennekom

“…More evidence is needed on developing tailored interventions and evaluating their cost-effectiveness.PROSPERO registration number CRD42022346552.…”
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Acceptability and adherence to a Mediterranean diet in the postnatal period to prevent type 2 diabetes in women with gestational diabetes in the UK: a protocol for a single-arm fea... by Doris Lanz, Julie Dodds, Graham Hitman, Elena Pizzo, Shakila Thangaratinam, Angeliki Bolou, Zoe Drymoussi, Francisco Jose Gonzalez Carreras, Maria del Carmen Pardo Llorente, Amy Thomas, James Heighway, Anita Sanghi, Angela Harden, Teresa Pérez, Mohammed SB Huda, Anita Mehay, Frances Austin

“…Introduction Women with gestational diabetes are at increased risk of developing type 2 diabetes later in life. In at-risk general populations, Mediterranean-style diet helps prevent type 2 diabetes. …”
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Content validation of an electronic remote toxicity management system in adult patients undergoing cancer treatment: a prospective longitudinal study on the QuestOnco application by Raffaele Longo, Christophe Goetz, Marco Campitiello, Francesca Plastino, Julie Egea, Pierre-Olivier Legros, Arpiné Ardzivian Elnar, Salma Meraihi, Elisabeth Luporsi, Véronique Noirez

“…Here, to meet the oncological-healthcare needs of our region, we developed QuestOnco, a mobile-phone ePROM application. …”
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Nurse-Delivered Telehealth in Home-Based Palliative Care: Integrative Systematic Review by Cong Ma, Yifan Fang, Hui Zhang, Ying Zheng, Ying Zhang, Wanchen Zhao, Ge Yan, Yaoxin Zeng, Yanwu Zhang, Xiaohong Ning, Zhimeng Jia, Na Guo

“…With the empowerment of telehealth technologies, nurses could establish a stronger professional identity and develop leadership in home-based palliative care. …”
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Determination of the stability of a nonsteroidal anti-inflammatory drug for dogs based on celecoxib by R. M. Sachuk, V. M. Hunchak, M. L. Kondratyuk, T. A. Velesyk

“…Further studies will be the next stage of pre-registration testing aimed at developing the section “Data reflecting the risk assessment for the environment”, which is a mandatory material of the part “Chemical, pharmaceutical and biological documentation” of the dossier for this veterinary drug. …”
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Prolonged dual hypothermic oxygenated machine preservation (DHOPE-PRO) in liver transplantation: study protocol for a stage 2, prospective, dual-arm, safety and feasibility clinica... by Aad P van den Berg, Hans Blokzijl, Marieke T de Boer, Frans van der Heide, Ruben H J de Kleine, Otto B van Leeuwen, Ton Lisman, Vincent E de Meijer, Anne Loes Van den Boom, Joost M Klaase, Peter Meyer, Robert J Porte, Frederike G I van Vilsteren, Frans J C Cuperus, Martijn P D Haring, Isabel M A Brüggenwirth, Veerle A Lantinga, Michel Rayar, Koen M E M Reyntjens, Carlijn I Buis, Suomi MG Fouraschen, Frederik JH Hoogwater, Mark Meerdink, Maarten W Nijkamp, A Michel Rayar, Ilhama F Abbasova, Meine H Fernhout, Ernesto R R Muskiet, Jaap J Vos, Miriam Zeillemaker, Bianca Lascaris, Carol C Pamplona, Adam M Thorne, Silke B Bodewes

“…In addition to graft reconditioning, DHOPE may also be used to prolong preservation time, which could facilitate logistics for allocation and transplantation globally.Methods and analysis This is a prospective, pseudo-randomised, dual-arm, IDEAL-D (Idea, Development, Exploration, Assessment, Long term study-Framework for Devices) stage 2 clinical device trial designed to determine safety and feasibility of prolonged DHOPE (DHOPE-PRO). …”
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Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol by Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group

“…Discussion INFRAGEN will contribute to exploring the complex pathophysiologic mechanisms of frailty in the context of infections in older adults through a translational approach. Trial registrations NCT06430073 (ClinicalTrials.gov); Registration date: 2024–05-28.…”
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HLA-mismatched allogeneic adoptive immune therapy in patients with severely immunosuppressed AIDS: a multicenter, open-label, controlled, phase 2a study by Tao Yang, Zhiman Xie, Zhe Xu, Bo Tu, Huan Lu, Huihuang Huang, Lei Huang, Chao Zhang, Liying Gao, Lei Jin, Ping Ma, Jun Zou, Limin Liu, Cheng Zhen, Chunbao Zhou, Sirun Meng, Yuan-Yuan Li, Jin-Wen Song, Shixiong Yang, Hui-Sheng Ai, Yanmei Jiao, Ming Shi, Ruonan Xu, Fu-Sheng Wang

“…To address this gap, we developed an HLA-mismatched allogeneic adoptive immune therapy (AAIT) specifically targeting this patient population. …”
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The first generic tirzepatide GP30931: physicochemical and biological similarity to the reference drug by I. A. Lugovik, A. V. Babina, S. S. Arutyunyan, D. О. Ermolaeva, V. B. Saparova, T. N. Kobeleva, P. G. Zaikin, A. D. Mikushina, A. S. Bukatin, I. E. Eliseev, B. Ts. Zajchik, Y. S. Keruchenko, I. S. Ohrimenko, E. V. Bocharov, A. Kh. Taldaev, V. A. Lushpa, I. E. Makarenko, R. V. Drai

“…The original drug (Mundjaro, pln: tirzepatide) is not registered in the Eurasian Economic Union (EAEU), which limits its availability to patients and leads to the need to develop a domestic generic.Aim. Conducting a physicochemical and biological characterization of the drug Sejaro® (GP30931) in comparison with the original drug Mundjaro® to establish their comparability.Materials and methods. …”
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Improving regional care in the last year of life by setting up a pragmatic evidence-based Plan–Do–Study–Act cycle: results from a cross-sectional survey by Lena Ansmann, Holger Pfaff, Ingrid Schubert, Ludwig Kuntz, Stephanie Stock, Sheila Payne, Nadine Scholten, Ute Karbach, Stefanie Hamacher, Raymond Voltz, Christian Albus, Frank Jessen, Christian Rietz, Frank Schulz-Nieswandt, Julia Strupp, Gloria Dust, Nicolas Schippel

“…Objectives To set up a pragmatic Plan–Do–Study–Act cycle by analysing patient experiences and determinants of satisfaction with care in the last year of life.Design Cross-sectional postbereavement survey.Setting Regional health services research and development structure representing all health and social care providers involved in the last year of life in Cologne, a city with 1 million inhabitants in Germany.Participants 351 bereaved relatives of adult decedents, representative for age and gender, accidental and suspicious deaths excluded.Results For the majority (89%) of patients, home was the main place of care during their last year of life. …”
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Peer-Assisted Lifestyle (PAL) intervention: a protocol of a cluster-randomised controlled trial of a health-coaching intervention delivered by veteran peers to improve obesity trea... by Stephanie L Orstad, Melanie Jay, Victoria Sweat, Sandra Wittleder, Scott E Sherman, Jeannette M Beasley, Shea Smith, Binhuan Wang, Allison Squires, Laura Wong, Yixin Fang, Paula Doebrich, Damara Gutnick, Craig Tenner

“…Repeated measures modelling based on mixed models will compare mean BM loss (primary outcome) between study arms.Ethics and dissemination The protocol has been approved by the Institutional Review Board and the Research and Development Committee at the VA NY Harbor Health Systems (#01607). …”
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PANDA study: subtyping of Parkinson’s disease – cohort study protocol by Yan Li, Rui Yang, Zihao Li, Mengfei Cai, Chentao He, Siming Rong, Ziqi Gao, Qibing Luo, Xilie Cui, Piao Zhang, Yuhu Zhang

“…The classification of PD into distinct subtypes remains a major challenge, limiting the development of precision medicine approaches. Existing subtyping methods have relied on clinical features, genetic markers or isolated biomarkers, but an integrated classification system incorporating neuroimaging and fluid biomarkers is lacking. …”
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Randomised placebo-controlled multicentre trial to evaluate the efficacy and safety of JTR-161, allogeneic human dental pulp stem cells, in patients with Acute Ischaemic stRoke (J-... by Hideo Hara, Nobuyuki Sakai, Shinichi Yoshimura, Masafumi Ihara, Satoshi Suda, Chikako Nito, Kazumi Kimura, Yuji Matsumaru, Taketo Hatano, Masaki Takao, Takeshi Yoshimoto, Masahiro Yasaka, Masafumi Morimoto, Akira Tsujino, Takeshi Inoue, Seiji Okubo, Mitsuyasu Kanai, Kenichi Morita, Yuka Terasawa, Yasuyuki Iguchi, Takao Urabe, Masataka Takeuchi, Shinichi Takahashi, Yasuhisa Akaiwa, Norihiro Ishii, Takao Kanzawa, Eiichiro Kamatsuka, Takeshi Iwanaga, Ryuzaburo Kanazawa, Norimichi Nakamura, Yutaka Honma, Tomohiko Izumidani, Shoji Arihiro, Takayuki Mizunari

“…It is currently under development as a cell-based therapy for ischaemic stroke. …”
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INTERNATIONAL COLLABORATION: STRENGTHENING ADOLESCENT HEALTH PROGRAMS THROUGH GLOBAL PARTNERSHIPS IN EMPOWERING SCHOOL HEALTH PROGRAM CADRES AND PEER TUTORS by Ivon Diah Wittiarika, Ratna Dwi Jayanti, Andriyanti, Dewi Setyowati, Riri Aprianti, Nenccy Mirasari, Mulia Dian Sumbawati, Siti Nurul Komariah, Deby Artika P, Pupus Ultraluana, Ngatwati, Yublina Rambu Mbali Idi, Nurhayati Fitria Amin, Mohamed Alif Haikal Bin Mohamed Iskandar, Fatin Nazurah Izzati Binti Hamdani, Siti Norhikmah Binti Abd. Razak

“…The long-term positive impact is expected to contribute to the achievement of the 3rd Sustainable Development Goals (SDGs), namely ensuring healthy lives and well-being for all ages by 2030. …”
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Physiological-based cord clamping versus immediate cord clamping for infants born with a congenital diaphragmatic hernia (PinC): study protocol for a multicentre, randomised contro... by Arjan B te Pas, Neysan Rafat, Thomas Schaible, Stuart B Hooper, René M H Wijnen, Kelly J Crossley, Philip L J DeKoninck, Ronny Knol, Irwin K M Reiss, Marijn J Vermeulen, Florian Kipfmueller, Berndt Urlesberger, Anne Debeer, Emily J J Horn-Oudshoorn, Suzan C M Cochius-den Otter, Calum T Roberts, Willem P de Boode

“…The current care during the perinatal stabilisation period in these infants might contribute to the development of pulmonary hypertension after birth—in particular umbilical cord clamping before lung aeration. …”
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Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised... by Nigel Garrett, Sharana Mahomed, Edmund Capparelli, Cheryl Baxter, Nonhlanhla Yende Zuma, Tanuja Gengiah, Derseree Archary, Penny Moore, Natasha Samsunder, Dan H Barouch, John Mascola, Julie Ledgerwood, Lynn Morris, Salim Abdool Karim

“…Introduction Despite extensive prevention campaigns and scale-up of antiretroviral therapy, HIV incidence among young women in southern Africa remains high. While the development of an efficacious vaccine remains a challenge, the discovery of broadly neutralising monoclonal antibodies (mAbs) has created the opportunity to explore passive immunisation as a long-acting injectable HIV prevention strategy. …”
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Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study by Long Zhang, Ying Yang, Lie Dai, Yingying Zhu, Jian-Zi Lin, Ze-Hong Yang, Qian-Hua Li, Zhi-Ming Ouyang, Hai-Jun Liu, Yao-Wei Zou, Kui-Min Yang, Li-Juan Yang, Ying-Qian Mo, Jian-Da Ma

“…Dissemination of results will occur via national and international conferences, in peer-reviewed journals, public conferences and social media.Trial registration number NCT06233929.…”
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Sex as a prognostic factor for mortality in critically ill adults with sepsis: a systematic review and meta-analysis by Alba Antequera, Alfonso Muriel, Rosa del Campo, Javier Zamora, Elena Stallings, Gerard Urrútia, Ivan Solà, Jesus Lopez-Alcalde, Manuel Ponce-Alonso, Federico Gordo, Pilar Fidalgo, Ana Verónica Halperin, Noelia Álvarez-Díaz, Olaya Madrid-Pascual, Borja Fernández Félix

“…The Grades of Recommendations, Assessment, Development and Evaluation approach was used to rate the certainty of evidence.Results From 14 304 records, 13 studies (80 520 participants) were included. …”
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Incidence and risk factors of acute kidney injury after abdominal surgery: a systematic review and meta-analysis by Jian Liu, Shi-hui Lin, Yi-si Zhao, Ren-jie Luo, Zheng-tao Zhang, Liu-yang Wang, Ke Xie, Jing Fan, Mu Zhang, Yu-sen Chai, Hong Tang, Fang Xu

“…Objective To determine the incidence of acute kidney injury (AKI) following abdominal surgery, assess its outcome associations, and identify factors associated with postoperative AKI development.Methods We performed a systematic search of PubMed, Embase, and Cochrane Database of Systematic Reviews, from January 2004, to December 2024. …”
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