Eleven internal fixations for young vertical femoral neck fractures: A protocol for systematic review and network meta-analysis. by Weiwei Shen, Yun Xue, Jie Shi, Xiaowen Deng, Zhongshu Pu, Qiuming Gao

“…Multitudinous internal fixation devices have been developed and utilized in clinical interventions. However, there has yet to be a consensus expert opinion regarding the optimal internal fixation configurations. …”
Get full text

Malignant hyperthermia (literature review) by R. R. Tukhvatullina, N. V. Matinyan

“…It was shown that malignant hyperthermia develops in susceptible individuals during or after general anesthesia with the use of trigger agents – inhaled halogen-containing anesthetics and succinylcholine. …”
Get full text

A novel ACT-based video game to support mental health through embedded learning: a mixed-methods feasibility study protocol by Darren J Edwards, Andrew H Kemp

“…Dissemination activities will involve publications in peer-reviewed journals, presentations at local and national conferences and promotion through social media.Trial registration number NCT04566042.…”
Get full text

THRIVE 2.0: A randomized-controlled trial of an obesity prevention intervention designed for infants in pediatric primary care by Tiffany M. Rybak, Sarah E. Francis, Constance A. Mara, Cynthia Zion, Avani C. Modi, Lori E. Crosby, Rachel B. Herbst, Brea A. Lauer, Bridget N. Murphy, Kasey R. Harry, Devanshi J. Patel, Mary Carol Burkhardt

“…Background: Unprecedented rates of overweight and obesity are seen in childhood with evidence suggesting that infancy may be a critical period for the development of this elevated-weight trajectory. The impact of rapid growth in infancy on later obesity may differ by social stratification factors such as race/ethnicity and family income and be mediated by infant feeding and sleeping practices. …”
Get full text

Modern Strategies in the Pharmacotherapy of Inflammatory Bowel Diseases – A Literature Review by Bartłomiej Czarnecki, Wiktor Werenkowicz, Aleksandra Boral, Dominika Kryś, Joanna Brzoza, Julia Koczur, Michał Górski, Wiktoria Pniok, Wojciech Kurkiewicz

“…Further comparative studies and the development of predictive biomarkers are essential for optimizing treatment selection and improving patient outcomes. …”
Get full text

Key performance indicators for acute intermittent kidney replacement therapy in critically ill patients: a protocol for a systematic review by Oleksa G Rewa, Sean M Bagshaw, Javier A Neyra, Matthew James, Liza Bialy, Scott Klarenbach, Xiaoming Wang, N Pannu, Fadi Hammal, Dawn Opgenorth, Janice Y Kung, Jeanna Morrissey, Kristin Robertson, Samantha L Bowker, Selvi Sinnadurai, Ashita Tolwani, Michael Heung, Teresa Mottes

“…We will evaluate the risk of bias using the modified Cochrane tool and certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations methodology. The analysis will be primarily descriptive. …”
Get full text

Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study by Frederic Dutheil, Dahlia Tharwat, Marion Trousselard, Mélanie Balès, Anne-Laure Sutter-Dallay, Dominique Fromage, Elisabeth Spitz, Dominique Dallay, Thierry Harvey, Eric Welter, Frédéric Coatleven, Lydie Cherier, Frédérique Teissèdre, Jean-Luc Pouly, Anaïs M Duffaud

“…We aim to disseminate the findings through international conferences and international peer-reviewed journals.Trial registration number NCT03088319; Pre-results.…”
Get full text

Effectiveness of intraoperative peritoneal lavage (IOPL) with saline in patient with intra-abdominal infections: a systematic review and meta-analysis protocol by Wenbo Meng, Nan Yang, Qi Zhou, Jingyi Zhang, Xufei Luo, Yaolong Chen, Kehu Yang, Zijun Wang, Qianling Shi, Xuan Yu, Jianjian Wang, Yanfang Ma, Yangqin Xun, Siya Zhao, Bobo Zheng, Robert Sawyer

“…The Grading of Recommendations Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. …”
Get full text

Comparison of biodegradable and metal occluders in patients with PFO and migraine: study design and rationale of BioMetal Trial by Ziping Li, Jie Dong, Jing Dong, Yiming Yan, Manchen Gao, Fang Fang, Fengwen Zhang, Wenbin Ouyang, Shouzheng Wang, Chuangshi Wang, Xiangbin Pan, BioMetal investigators

“…While existing trials with metal occluders have shown promise in reducing migraine burden, concerns over long-term complications and the impact of metal devices on migraine exacerbation have prompted the development of biodegradable alternatives. Methods The Comparison of Biodegradable and Metal Occluders in Patients with PFO and Migraine (BioMetal) trial is a prospective, multicenter, single-blind, randomized controlled, superiority study comparing a biodegradable occluder with a nickel-titanium alloy occluder in PFO patients with medication-refractory migraine with aura (ClinicalTrials.gov Identifier: NCT06203873). …”
Get full text

Rifaximin treatment in patients with severe alcohol-associated hepatitis: A multicenter, randomized controlled, open-label, pilot trial by Do Seon Song, Jin Mo Yang, Young Kul Jung, Hyung Joon Yim, Hee Yeon Kim, Chang Wook Kim, Soon Sun Kim, Jae Youn Cheong, Hae Lim Lee, Sung Won Lee, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim

“…Clinical trial registration: The study was registered on ClinicalTrials.gov (number: NCT02485106).…”
Get full text

Orofacial functions with emphasis on breathing and chewing patterns in individuals with and without molar incisor hypomineralisation: observational study protocol conducted in a de... by Ana Paula Taboada Sobral, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Amanda Rafaelly Honório Mandetta, Cinthya Cosme Gutierrez Duran, Caroline Diniz Pagani Vieira Ribeiro, Fabiana Car Pernomiam, Caroline Cristina Batista Camargo, Iara Maria Freitas Romano

“…The collected data will be available on request.Trial registration number NCT06692257.…”
Get full text

Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial... by Jeffrey J Swigris, Toby M Maher, Tamera J Corte, Aryeh Fischer, Hong Xiao, Lisa Lancaster, Takafumi Suda, Xiaojiang Zhan, Jonathan G Goldin, Scott M Palmer, Hideaki Watanabe, Takashi Ogura, Anne Minnich, Giridhar S Tirucherai, Brandon Elpers, R Adam Smith, Edgar D Charles

“…Results will be reported in a peer-reviewed publication.Trial registration number NCT04308681.…”
Get full text

Open-label, multicentre, single-arm trial of monthly injections of depot buprenorphine in people with opioid dependence: protocol for the CoLAB study by Adrian Dunlop, Louisa Degenhardt, Michael Farrell, Marian Shanahan, Suzanne Nielsen, Briony Larance, Kari Lancaster, Marianne Byrne, Nicholas Lintzeris, Jason Grebely, Jeyran Shahbazi, Gregory Dore, Robert Ali, Carla Treloar, Stella Nalukwago, Craig Rodgers, Michael McDonough, Jon Cook, Mark Montebello, Michael Aufgang, Robert Weiss, Zoe Griffin

“…Introduction Opioid agonist treatment is effective for opioid dependence and newer extended-release buprenorphine (BUP-XR) injections represent a significant development. The Community Long-Acting Buprenorphine (CoLAB) study aims to evaluate client outcomes among people with opioid dependence receiving 48 weeks of BUP-XR treatment, and examines the implementation of BUP-XR in diverse community healthcare settings in Australia.Methods and analysis The CoLAB study is a prospective single-arm, multicentre, open-label trial of monthly BUP-XR injections in people with opioid dependence. …”
Get full text

Efficacy of zinc supplementation for young infants with clinical severe infection in Tanzania: study protocol for a randomised controlled trial by Christopher R Sudfeld, Wafaie W Fawzi, Rodrick Kisenge, Mohamed Bakari, Enju Liu, Christopher P Duggan, Nahya Salim, Karim P Manji, Sarah Somji, Upendo Kibwana, Abuu S Kisumuni, Neema Mafie, Fredrick A Maleko

“…Introduction Innovative interventions will be essential for countries in sub-Saharan Africa to achieve the 2030 Sustainable Development Goal for child mortality. Infections among young infants, including sepsis, meningitis and pneumonia, continue to cause a large burden of morbidity and mortality in low-income and middle-income countries. …”
Get full text

Collaborative tailoring of the Reach Out, Stay Strong Essentials (ROSE) program for pregnant veterans in the U.S. Veterans Health Administration: a qualitative case study of contex... by Erin P. Finley, Alison B. Hamilton, Ismelda Canelo, La Shawnta S. Jackson, Rachel Lesser, Rebecca S. Oberman, Julia Yosef, Joya G. Chrystal, Erica H. Fletcher, Bevanne Bean-Mayberry, Tannaz Moin, Melissa M. Farmer, Ariel J. Lang

“…As both REP and EBQI support adaptation to meet local needs, the EMPOWER 2.0 implementation team and participating sites have collaboratively developed adaptations of ROSE to better serve pregnant veterans. …”
Get full text

Personalised, GIS-based counselling to promote habitual walking in mobility-limited and chronically ill older adults: protocol of the MOBITEC-Routes randomised controlled trial by Timo Hinrichs, René Schilling, Alexandros Sofios, Denis Infanger, Luisa Prechtl, Nora Stauffer, Viviane Eichenberger, Eleftheria Giannouli, Taina Rantanen, Erja Portegijs, Corina Schuster-Amft, Anna Mai, Arno Schmidt-Trucksäss, Christina Röcke, Robert Weibel

“…If the personalised GIS-based approach is successful, it could be seamlessly integrated into preventive healthcare strategies. Trial registration ISRCTN17473086 (Registration date 22/11/2024).…”
Get full text

Implementation strategies: lessons learned during an e-learning intervention to improve dietary behaviors and feeding practices in early childhood education and care by Henrik Lian, Nina Cecilie Øverby, Frøydis Nordgård Vik, Anine Christine Medin, Natalie Garzon Osorio, Christine Helle, Tormod Bjørkkjær, Penelope Love, Harry Rutter, Mary Elizabeth Barker, Elisabet Rudjord Hillesund, Sissel Heidi Helland

“…Five main themes were developed by qualitative analysis: 1) Being a champion resembles what I already do. 2) Educational meetings are fine but take time. …”
Get full text

Digital Assessment of Wellbeing in New Parents (DAWN-P): protocol of a randomised feasibility trial comparing digital screening for maternal postnatal depression with usual care sc... by Emily Eisner, Ria Agass, Elizabeth Camacho, Adedamola Falana, Mark Hann, Anulika Ifezue, Henna Lemetyinen, Holly Myers, Charlotte Stockton-Powdrell, Clare Tower, Kylie Watson, Pauline Whelan, Anja Wittkowski, Shôn Lewis

“…To improve detection, we developed a digital screening system (CareLoop PND) whereby mothers use an app to monitor their mood daily using a validated measure (Edinburgh Postnatal Depression Scale; EPDS), with real-time responses uploaded to a secure server. …”
Get full text

Does completion of radical hysterectomy improve oncological outcomes of women with clinical early-stage cervical cancer and intraoperative detection of nodal involvement?: protocol... by Hui Xu, Qing Liu, Yu Xu, Yi Du, Ai Zheng, Cui Hu, Ya Jia, Qianwen Zhang, Yue-Dong He, Shuang-Shuang Cui, Yong Tian, Lin Ran, Fengmei Ke

“…The grade of evidence will be evaluated by two independent members of our team using the Grading of Recommendations, Assessment, Development and Evaluations approach.Ethics and dissemination Ethical approval is not required because there will no primary data collected. …”
Get full text

Understanding the trends, and drivers of emigration, migration intention and non-migration of health workers from low-income and middle-income countries: protocol for a systematic... by Oghenebrume Wariri, Paul Ikhurionan, Yakubu Kevin Kwarshak, Ekhosuehi T Agho, Itua C G Akhirevbulu, Josephine Atat, Franca Erhiawarie, Emmanuel O Gbejewoh, Chinelo Iwegim, Ukachi Nnawuihe, Uyoyo Odogu, Jermaine Okpere, Efe E Omoyibo, Efetobo Victor Orikpete, Uwaila Otakhoigbogie, Avwebo Ukueku, Patience Ugwi

“…We propose a systematic review to understand the determinants of HWs out-migration, intention to migrate and non-migration from LMICs.Methods and analysis This protocol was designed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols guideline for the development and reporting of systematic review protocols. …”
Get full text