Immunomodulatory therapies in community-acquired pneumonia: a protocol for a systematic review and network meta-analysis by Dominique-Laurent Couturier, Luke Flower, Charlotte Summers, Joseph Newman, Martin Law

“…A subset of patients with pneumonia develops aberrant immune responses, resulting in harmful inflammation, tissue damage and significant mortality. …”
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A Web-Based Mind-Body Intervention to Improve Resilience Among Patients With Nontraumatic Painful Upper-Extremity Conditions and Comorbid Risky Substance Use: Protocol for a Mixed... by Nadine Levey, Neal Chen, Joseph Ditre, Louisa Sylvia, Chaitanya Mudgal, Abhiram Bhashyam, Rohit Garg, David Ring, Ana-Maria Vranceanu, Jafar Bakhshaie

“…MethodsIn aim 1, we will conduct live video qualitative interviews (n=20) with care-seeking adult patients with NPUC and comorbid risky substance use to inform the development and refinement of Web-TIRELESS and study procedures. …”
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TreatmENT of AnastomotiC LeakagE after colon cancer resection: the TENTACLE – Colon study by Jobbe M. G. Lemmens, Sander Ubels, Nynke G. Greijdanus, Kiedo Wienholts, Marleen M. H. J. van Gelder, Albert Wolthuis, Jérémie H. Lefevre, Kilian Brown, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Martin Rutegård, Susan L. Gearhart, Thomas Pinkney, Muhammed Elhadi, Roel Hompes, Pieter J. Tanis, Johannes H. W. de Wilt

“…Objectives (1) To identify predictive factors associated with 90-day mortality and 90-day Clavien-Dindo grade 4–5 complications amongst patients who developed AL following colon cancer resection with subsequent development and validation of prediction models, and (2) to explore and compare the effectiveness of various treatment strategies for AL following colon cancer resection, adjusting for type of index surgery, different leak entities and patient factors. …”
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Bench studies of a small axial pump for implantation in patients with low anthropometry by A. S. Buchnev, A. P. Kuleshov, A. A. Drobyshev, V. A. Elenkin, G. A. Shevchenko, N. V. Grudinin

“…The axial pump was investigated using a custom-developed hydrodynamic test bench simulating the cardiovascular system. …”
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Efficacy of non-wearable VR-based behavioral training for preschool children with high-functioning autism spectrum disorder: a protocol for an upcoming randomized clinical trial by Naichi Kuo, Yukai Yao, Chenhuan Ma, Liting Chu, Jinjin Chen, Chunling Wan, Dandan Wang, Dingjie Lu, Xiaoqian Li, Yu Wang

“…However, long-term, intensive, and individualized rehabilitation training strategies are lacking, and new rehabilitation tools therefore urgently need to be developed. Virtual reality (VR) is a promising digital rehabilitation tool that may support the development of essential life skills, such as social communication and daily living abilities, in many children and adolescents with ASD. …”
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A large-scale retrospective study in China explores risk factors for disease severity in plaque psoriasis by Huiwei Wang, Jialiang Shi, Suchun Hou, Xiaojing Kang, Chen Yu, Hongzhong Jin, Bin Yang, Yuling Shi, Fuqiu Li, Wei Li, Jun Gu, Mingjun Lei, Youkun Lin, Lin Dang, Jialin Lin, Qing Guo, Gang Wang, Xiaoming Liu

“…“Nomogram-10” provides clinicians with a practical tool to develop personalized intervention strategies based on an individual’s risk profile. …”
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Knowledge translation and exercise for degenerative meniscal pathology and early osteoarthritis  (KNEE-DEeP): Protocol for a single arm feasibility study [version 1; peer review: 2... by Clodagh Toomey, Helen O'Leary, Helen P French, Liam G Ryan, Katie Robinson, Karen McCreesh, Liam Glynn

“…Physiotherapists will work with patients to develop a collaborative action plan focussing on self-management and exercise. …”
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Point spread function estimation with computed wavefronts for deconvolution of hyperspectral imaging data by Miroslav Zabic, Michel Reifenrath, Charlie Wegner, Hans Bethge, Timm Landes, Sophia Rudorf, Dag Heinemann

“…To address this challenge, we have developed a method for PSF estimation in HSI systems based on computed wavefronts. …”
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Tailored therapy with turoctocog alfa pegol according to patient’s lifestyle and hemorrhagic phenotype: from clinical trial to real-life by Ilaria Nichele, Giuseppe Carli, Alberto Tosetto

“…Turoctocog alfa pegol is a glycoPEGylated recombinant factor VIII (FVIII) with an extended half-life (EHL), developed for prophylaxis, treatment of bleeds, and perioperative management in patients with hemophilia A. …”
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INdependenT prEscribinG in community phaRmAcy; whaT works for whom, why and in what circumstancEs (INTEGRATE): Realist review study protocol [version 1; peer review: 2 approved] by Andrew Sturrock, Tony Kelly, Vivienne Hibberd, Ian Maidment, Ola Amr Abdelfatah, Nia Roberts, Ellen Schafheutle, Andrea Hilton, Keith Holden, Geof Wong, Nick Haddington, Lesley Scott

“…Stage 6 focuses on refining programme theories and identifying key mechanisms that lead to desired outcomes. PROSPERO registration: CRD42023468451…”
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PRO-DIALOG—the effect of a novel dialogue-based parent-teacher conference on mental health in kindergarten children: a cluster randomized controlled trial by Ingvar Bjelland, Gro Janne Wergeland, Christopher Gillberg, Rolf Gjestad, Adrijana Višnjić-Jevtić, Veronica Kibbe Lisæth, Carmela Miniscalco, Amanda Louise Flygel Tufta, Ida Lygre Vermeer, Alicja Renata Sadownik, Philip Wilson, Maj-Britt Posserud

“…To address the need for a kindergarten-specific method for secondary prevention, we have developed Dialogue-Based Early Detection (DBED) in close collaboration with educators and parents in eight different kindergartens. …”
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The prediction of haemophilic arthropathy progression based on MRI findings and clinical characteristics by Lu Zhang, Jinxia Guo, Shufang Wei, Jiajia Li, Yincong Dou, Tianming Cheng, Yinghui Ge, Tuo Zhang

“…Abstract Objective To identify magnetic resonance imaging (MRI) and clinical characteristics that are closely associated with the progression of haemophilic arthropathy (HA) after different therapies and to establish a prediction model for HA progression using Cox proportional hazards regression, thus facilitating the development of personalized clinical replacement therapy plans. …”
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Exploring the Application Capability of ChatGPT as an Instructor in Skills Education for Dental Medical Students: Randomized Controlled Trial by Siyu Huang, Chang Wen, Xueying Bai, Sihong Li, Shuining Wang, Xiaoxuan Wang, Dong Yang

“…Although technology-assisted instruction, such as virtual reality and simulators, is increasingly being integrated, direct guidance from instructors remains the cornerstone of skill development. ChatGPT, an advanced conversational artificial intelligence model developed by OpenAI, is gradually being used in medical education. …”
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Cultivating compassion in care: evaluating a compassion-training intervention and exploring barriers to compassionate care in postgraduate medical education in Pakistan: a mixed-me... by Marib Ghulam Rasool Malik, Sana Saeed, Bisma Aziz, Shahzil Abdur Rehman Malik, Syed Ahsan Ali, Fareed Shaikh, Shahzadi Resham, Amna Subhan Butt, Qamar Riaz

“…A 4-hour compassion-training session was delivered to develop compassion as a clinical competency. Quantitative data on satisfaction and self-reported compassion competence were collected using the Sinclair Compassion Questionnaire-Healthcare Provider Competence Self-Assessment (SCQ-HCPCSA) and analyzed via paired t-tests. …”
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Influence of activities of daily living on feelings of uselessness among older adults in China by Jing GUO, Yao YANG, Pei WANG, Yanan WANG, He LIU, Zirui WANG, Libo ZHOU, Yuan YAO

“…ObjectiveTo understand the influence of activities of daily living (ADL) on feelings of uselessness among older adults in China, and the role of attitudes toward aging and age on this relationship, to provide a reference for developing health education and intervention strategies for older adults, and to effectively address the challenges of population aging. …”
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Indoor environmental quality and learning outcomes: protocol on large-scale sensor deployment in schools by Maartje Willeboordse, Juan Palacios Temprano, Piet Eichholtz, Nils Kok

“…Environmental conditions may also influence cognitive development of children, but epidemiological evidence is scant. …”
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Centering peers in design and training for a peer-delivered contingency management program for self-identified harm reduction and treatment goals by Linda Peng, Erin Stack, Alexis Cooke, Bryan Hartzler, Ryan Cook, Gillian Leichtling, Christi Hildebran, Judith Leahy, Kelsey Smith Payne, Lynn Kunkel, Kim Hoffman, P. Todd Korthuis

“…Methods We used a community based participatory research (CBPR) process to develop a CM program focused on self-identified goals for harm reduction and treatment engagement. …”
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SMALL INTESTINAL BACTERIAL OVERGROWTH IN PEOPLE WITH CYSTIC FIBROSIS: SYSTEMATIC REVIEW by Maria Lidiane Lavor LANDIM, José Dirceu RIBEIRO, Daniela de Souza Paiva BORGLI, Danielle Rossana Queiroz Martins BONILHA, Elizete Aparecida LOMAZI, Maria de Fátima Correa Pimenta SERVIDONI

“…ABSTRACT Background: In patients with cystic fibrosis (pwCF) acid suppression therapy, gastrointestinal dysmotility, and post-operative bowel status, may predispose to the development of small intestinal bacterial overgrowth (SIBO). …”
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A Gamified Assessment Tool for Antisocial Personality Traits (Antisocial Personality Traits Evidence-Centered Design Gamified): Randomized Controlled Trial by Yaobin Tang, Yongze Xu, Qunli Zhou, Ran Bian

“…ObjectiveThis study aimed to develop and validate an evidence-based design for a gamified assessment tool (Antisocial Personality Traits Evidence-Centered Design Gamified assessment tool; ASP-ECD-G) to measure 7 antisocial personality traits (manipulative, callous, deceptive, hostile, risk taking, impulsive, and irresponsible) as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). …”
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Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study by Dagfinn Lunde Markussen, Jannicke Slettli Wathne, Christian Ritz, Cornelis H. van Werkhoven, Sondre Serigstad, Rune Oskar Bjørneklett, Elling Ulvestad, Siri Tandberg Knoop, Synne Jenum, Harleen M. S. Grewal

“…Trial registration NCT04660084.…”
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