Effectiveness of resistance training of masticatory muscles for patients with temporomandibular disorders: protocol for a systematic review by Deborah Falla, Filippo Maselli, Giacomo Asquini, Andrea Giusti, Giulia Pisacane, Giovanni Galeoto, Firas Mourad, Paolo Bizzarri, Edoardo Balli, Cecilia Bagnoli, Anna Manzari, Marco Pernici

“…Two independent reviewers will conduct the screening of articles for inclusion, data extraction, risk-of-bias assessment using the revised Cochrane risk-of-bias tool for included studies and will evaluate the overall quality of evidence following the Grading of Recommendations Assessment, Development and Evaluation framework. A meta-analysis will be performed where applicable. …”
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Effects of an extended therapeutic strategy versus standard-of-care therapy on persistent acute kidney injury in high-risk patients after major surgery: study protocol for the rand... by Joachim Gerss, Melanie Meersch, Carola Wempe, Alexander Zarbock, John Kellum, Christian Strauss, Thilo von Groote, Mahan Sadjadi, Hendrik Booke, Ludwig Maximilian Schöne, Leonie Sauermann

“…The primary endpoint is a composite of the development of persistent severe (stage 3) AKI, need for renal replacement therapy or death within 72 hours. …”
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Comprehensive spinal correction rehabilitation (CSCR) study: a randomised controlled trial to investigate the effectiveness of CSCR in children with early-onset idiopathic scoliosi... by Tongtong Zhang, Xin Li, Xuan Zhou, Qing Du, Yingxian Li, Qimeng Fan, Juping Liang, Zhengquan Chen, Haibin Guo, Lili Cai

“…Any interim analyses and full results will be published in an international peer-reviewed journal.Trial registration number The study protocol was registered at www. …”
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The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects c... by Elisabeth F C van Rossum, Amir H Zamanipoor Najafabadi, Wouter A Moojen, Nienke R Biermasz, Wouter R van Furth, Onno C Meijer, Clemens M F Dirven, Anne-Sophie C A M Koning, Djaina D Satoer, Christiaan H Vinkers, Rishi D S Nandoe Tewarie, Alberto M Pereira

“…It is an investigator-initiated study with financial support by The Netherlands Organisation for Health Research and Development (ZonMw) and the Dutch Brain Foundation. …”
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Predictive utilities of lipid traits, lipoprotein subfractions and other risk factors for incident diabetes: a machine learning approach in the Diabetes Prevention Program by Samuel Dagogo-Jack, Søren Brunak, Carlos Lorenzo, Kieren J Mather, Marinella Temprosa, Tibor V Varga, Jinxi Liu, Ronald B Goldberg, Guannan Chen, Xavier Pi-Sunyer

“…Introduction Although various lipid and non-lipid analytes measured by nuclear magnetic resonance (NMR) spectroscopy have been associated with type 2 diabetes, a structured comparison of the ability of NMR-derived biomarkers and standard lipids to predict individual diabetes risk has not been undertaken in larger studies nor among individuals at high risk of diabetes.Research design and methods Cumulative discriminative utilities of various groups of biomarkers including NMR lipoproteins, related non-lipid biomarkers, standard lipids, and demographic and glycemic traits were compared for short-term (3.2 years) and long-term (15 years) diabetes development in the Diabetes Prevention Program, a multiethnic, placebo-controlled, randomized controlled trial of individuals with pre-diabetes in the USA (N=2590). …”
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Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia by Nutchaninad Tanuphol B.ATM, Neti Waranuch PhD, Vanuchawan Wisuitiprot PhD, Wudtichai Wisuitiprot PhD, Kamonlak Insumrong PhD, Prapapan Temkitthawon PhD, Nungruthai Suphrom PhD, Katechan Jampachaisri PhD, Corine Girard PhD, Kornkanok Ingkaninan PhD

“…A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. …”
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High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease by Hao Wang, Junzhao Ye, Youpeng Chen, Yanhong Sun, Xiaorong Gong, Hong Deng, Zhiyong Dong, Lishu Xu, Xin Li, Bihui Zhong

“…Abstract Background Whether include high-sensitivity C-reactive protein (Hs-CRP) in diagnostic flow remains debatable during the updated definition to metabolic dysfunction-associated steatotic liver disease (MASLD) despite systemic inflammation contributes to the disease development and progression. We aimed to identify values of hs-CRP compared to other inflammatory markers derived from routine blood tests in MASLD. …”
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Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities by Marie-Claude Bourgeois-Daigneault, Victor Mullins-Dansereau, Marie-Lou Myre, Angelina Bardoul, Karen Geoffroy, Marco J Rallo Pita, Delphine Béland, Kim Leclerc Desaulniers, Dominic Guy Roy

“…Our findings deepen our understanding of the immune mechanisms underlying the use of oncolytic viruses as anticancer vaccination platforms and will allow for the development of a new generation of improved oncolytic virus vaccine adjuvants.Trial registration number NCT02285816.…”
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Autologous blood products: Leucocyte and Platelets Rich Fibrin (L-PRF) and Platelets Rich Plasma (PRP) gel to promote cutaneous ulcer healing – a systematic review by Paramjit Gill, Anju Adhikari, Samuel I Watson, Richard J Lilford, Dilip Shrestha, Rolina Dhital, Onaedo Ilozumba, Sopna Choudhury, Indra B Napit, Karuna Neupane, Rachita Koirala, Lovin Gopali

“…The last date of the search was performed on 29 August 2022.Data extraction and synthesis Independent reviewers identified eligible studies, extracted data, assessed risk of bias using V.2 of the Cochrane risk-of-bias tool for randomised trials tool and assessed certainty of evidence by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.Main outcome measures Time to complete healing, proportion healed at a given time and rate of healing.Results Seven studies met the inclusion criteria, five using PRP gel and two using L-PRF gel. …”
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Non-operative treatment for lumbar spinal stenosis with neurogenic claudication: an updated systematic review by Carlo Ammendolia, Andrea D Furlan, André Bussières, Carol Cancelliere, James J Young, Corey Hofkirchner, Joshua Plener, Michael J Schneider, Kent Stuber, Aksa Ahmed, Aleisha Adeboyejo, Joseph Ornelas

“…Grading of Recommendations Assessment, Development and Evaluation was used for evidence synthesis.Results Of 15 200 citations screened, 156 were assessed and 23 new trials were identified. …”
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Evidence-based general practice: a scoping review by Yu Cheng, Chuan Zou, Chaojie Liu, Yu Jia, Rong Yang, Yonggang Zhang, Jianjun Han, Yi Lei, Xiaoyang Liao

“…This definition provides a solid foundational framework for the development of EBGP guidelines and policies. Registration number https://doi.org/10.17605/OSF.IO/2UNX7 .…”
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Outcomes of perfluorocarbon liquid vs. posterior retinotomy as adjuncts during pars-plana vitrectomy for the surgical repair of rhegmatogenous retinal detachment: a randomized clin... by Ehab Mohamed Elsayed Saad, Hazem Elbadry Mohammed Mohammed, Mohamed Mohamed-Aly Ibrahim, Omar Hassan Salama Selim, Sayed Mostafa Elsayed Abdelhafeez, Ahmed Mohammed Sakr, Fathy Mohamed Abo Elftouh Elsalhy, Ahmed Abdelmohsen Ali Ayoub, Ehab Abdelsamea Alazab, Ehab Tharwat, Tamer Gamal El Sayed Mostafa

“…Primary outcomes included retinal reattachment rates and the number of operations; secondary outcomes included BCVA, IOP changes, complications like cataract development, retinal redetachment, epiretinal membrane (ERM) formation, and single-surgery success. …”
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Practical Anemia Bundle for Sustained Blood Recovery (PABST-BR) in critical illness: a protocol for a randomised controlled trial by Laurie Meade, Andrea Cheville, Matthew A Warner, Phillip J Schulte, Daryl J Kor, Ognjen Gajic, Ronald S Go, William B Beam, Jonathan E Charnin, Kim A Droege, Brenda K Anderson, Matthew L Johnson, Brad Karon

“…The PABST-BR trial will inform the development of a larger multicentre clinical trial.Trial registration number NCT05167734.…”
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Protocol of a randomised controlled trial to assess medical staff’s inhalation exposure to infectious particles exhaled by patients during oesophagogastroduodenoscopy and the effic... by Li Liu, Aiming Yang, Xi Wu, Shengyu Zhang, Zhiyu Yan, Yuheng Zhang, Mengjie Duan

“…There is a need for quantitative evidence on medical staff’s risk of multiroute exposure to infectious particles exhaled by patients during OGD to enable the development of practical, feasible and economical methods of risk-reduction for use in OGD and related procedures. …”
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Barriers and facilitators of HIV pre-exposure prophylaxis (PrEP) uptake and use in Canada: a scoping review protocol by Pascal Djiadeu, LaRon E Nelson, Sean B Rourke, Carolyn Ziegler, Amani Chabikuli, Debapriya Chakraborty, Kelly Mgbatogu, Ezinne Ifeanacho, Olaoluwa Ajiboye, Jason Lo Hog Tian, Judith Odhiambo, Wale Ajiboye

“…By identifying these factors, the review aims to inform future research, policy development and interventions to improve PrEP access and its integration into HIV prevention strategies in Canada.Methods and analysis This scoping review will focus on studies involving HIV-seronegative individuals in Canada who are either eligible for or currently using PrEP as an HIV prevention option. …”
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Improving mental health and well-being of hospital staff: mixed-methods process evaluation of the SEEGEN trial by Bernd Puschner, Maja Stiawa, Martin Peters, Peter Angerer, Felicitas Rapp, Florian Junne, Melanie Genrich-Hasken, Andreas Müller, Imad Maatouk, Madeleine Helaß, Nadine Mulfinger, Harald Gündel

“…A step backwards seems indicated, i.e. the further evaluation of smaller components of the intervention, added by theory development and refinement. Trail registration DKRS, DRKS00017249. …”
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A multidisciplinary approach to weight management and reproductive care: a retrospective cohort study on weight loss through personalized and patient-centered care by Samantha Schon, Jocelyn Spizman, Daria Stelmak, Mark Chames, Stacey Pilarz, Jamila Abdur-Rahman, Charley Jiang, Amal Othman, Marie Menke

“…Conclusions We describe the development and implementation of a multidisciplinary program for women with reproductive disorders and obesity seeking weight management. …”
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Impact of perioperative esketamine on the perioperative neurocognitive dysfunction: a systematic review and meta-analysis of randomised controlled studies by Lu Chen, Chao Li, Xin Yuan, Yanan Zhao, Shufang Liu, Jiayu Zhu, Xuesen Su, Zixuan Wang, Yihe Tian, Shouyuan Tian

“…The overall evidence quality was appraised using the Grading of Recommendations Assessment, Development and Evaluation framework.Results 10 RCTs were included in our meta-analysis, involving 854 surgical patients. …”
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Prevention of relapses with levamisole as adjuvant therapy in children with a first episode of idiopathic nephrotic syndrome: study protocol for a double blind, randomised placebo-... by Lotte Haverman, Ron A A Mathôt, Floor Veltkamp, Djera H Khan, Christa Reefman, Susan Veissi, Hedy A van Oers, Elena Levtchenko, Sandrine Florquin, Joanna A E van Wijk, Michiel F Schreuder, Antonia H M Bouts

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Demographic, Chemical, and Helicobacter pylori Positivity Assessment in Different Types of Gallstones and the Bile in a Random Sample of Cholecystectomied Iranian Patients with Cho... by Mohammad Bagher Jahantab, Amir Abbas Safaripour, Sajad Hassanzadeh, Mohammad Javad Yavari Barhaghtalab

“…This work provides an objective basis for further research into gallbladder stone formation; meanwhile, it has great significance in the treatment and prevention of gallbladder stones. Trial registration. The project was found to be in accordance to the ethical principles and the national norms and standards for conducting research in Iran with the approval ID IR.YUMS.REC.1399.147 and date 2020.09.23, and this project is the result of a residency dissertation to obtain the specialty in general surgery, which has been registered with the research project number 960159 in the Vice Chancellor for Research and Technology Development of the Yasuj University of Medical Sciences, Yasuj, Iran, URL: https://ethics.research.ac.ir/EthicsProposalViewEn.php?…”
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