Direct comparison of cardioprotective effects of necroptosis inhibitors against global ischemia-reperfusion in the isolated rat heart by Yu. V. Dmitriev, S. M. Minasian, V. K. Bayrasheva, E. A. Demchenko, M. M. Galagudza

“…This fact, along with low toxicity and optimal EC50, makes Nec-1s and NSA perspective candidates for preclinical and clinical development as cardioprotective agents.…”
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Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinica... by Si-Jing Chen, Jian-Yu Que, Ngan Yin Chan, Le Shi, Shirley Xin Li, Joey Wing Yan Chan, Weizhen Huang, Chris Xie Chen, Chi Ching Tsang, Yuen Lam Ho, Charles M Morin, Ji-Hui Zhang, Lin Lu, Yun Kwok Wing

“…<h4>Background</h4>Increasing evidence suggests that insomnia plays an important role in the development of depression, supporting insomnia intervention as a promising approach to prevent depression in youth. …”
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Mifepristone as a non-emergency contraceptive among women of reproductive age: a protocol for systematic review and meta-analysis by Kristina Gemzell-Danielsson, Rebecca Gomperts, Lisa Haddad, Miriam Nkangu, Caroline Frisendahl, Chelsea Polis, Tracy Chen, Evan Sterling, Marlena Plagianos

“…Grades of Recommendation, Assessment, Development and Evaluation will be used to assess the quality of the evidence. …”
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Promoting family functioning through physical activity: a randomized trial to evaluate the “All in the Family” program by Alfred S. Y. Lee, Chris M. Blanchard, Mark R. Beauchamp, Valerie Carson, Sheri Madigan, Shaelyn Strachan, Leigh M. Vanderloo, Evangeline Streight, Sandy Courtnall, Ryan E. Rhodes

“…Abstract Background Effective family functioning, such as communication, family organization, and family cohesion, is essential for family well-being and child development. Promoting family physical activity (PA) through shared activities offers a promising strategy for enhancing family dynamics. …”
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Feasibility and acceptability of NIDUS-Professional, a training and support intervention for homecare workers caring for clients living with dementia: a cluster-randomised feasibil... by Iain Lang, Victoria Vickerstaff, Kenneth Rockwood, Jill Manthorpe, Daniel Kelleher, Kathryn Lord, Penny Rapaport, Claudia Cooper, Kate Walters, Julie A Barber, Sara Banks, Larisa Duffy, Sedigheh Zabihi, Ayesha Dar, Freya Koutsoubelis, Clare Mason, Sandra Duggan, Helen Kales

“…There are concerns that homecare is often unable to meet the needs of this client group, with limited evidence regarding effective interventions to improve it for people living with dementia. We have developed a training and support programme for homecare workers (NIDUS-Professional) to be delivered alongside support sessions for people living with dementia and their family carers (NIDUS-Family). …”
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Anti-Inflammatory Versus Antifibrotic Therapies for the Management of Rheumatoid Arthritis–Associated Interstitial Lung Disease: Protocol for a Systematic Review and Meta-Analysis... by Sneh Sonaiya, Alexandra Jianu, Nicholas Jianu, Kavita Batra

“…In contrast, antifibrotic therapies such as pirfenidone and nintedanib, initially developed for idiopathic pulmonary fibrosis, are now being explored for their potential in treating fibrosing variants of RA-ILD. …”
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Serum analytes as predictors of disease recurrence and the duration of invasive disease-free survival in patients with triple negative breast cancer enrolled in the OXEL trial trea... by Renee N Donahue, Jeffrey Schlom, Nicole J Toney, Claudine Isaacs, Filipa Lynce, Candace Mainor, Megan T Lynch

“…Furthermore, logistic regression and Cox proportional hazard models, developed using machine learning methods, demonstrated that combinations of serum analytes were more predictive of disease recurrence and iDFS duration than analyses of single serum analytes. …”
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Protocol for the economic evaluation of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression by Patrick Doherty, David Reeves, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies

“…Metacognitive therapy (MCT), is a recent treatment development that is effective in treating anxiety and depression in mental health settings and is being evaluated in CR patients. …”
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Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma: a phase I... by Lixia Yi, Haoqi Pan, Zhouyu Ning, Litao Xu, Hena Zhang, Longfei Peng, Yaowu Liu, Yifan Yang, Waimei Si, Ying Wang, Xiaoyan Zhu, Shenglin Huang, Zhiqiang Meng, Jing Xie

“…An immune/metabolism score integrating the features of six genes was developed as a predictive biomarker for immunotherapy response in multiple cohorts, allowing for the selection of patients most likely to experience positive outcomes from this therapy regimen. …”
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Relationship between endotoxin core and staphylococcal antibody levels and outcome following transcatheter aortic valve implantation (TAVI) by Andrew Smith, James Fullerton, John Whittle, James Moon, Michael Mullen, Paul Scully, Colin Hamilton-Davies

“…Primary outcome measure was post-procedure length of stay (LOS) in hospital with secondary outcome being development of infective complications. Correlations were examined using Spearman rank order or Kendall Tau-b methods. …”
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New opportunities for preclinical diagnostics of antitumor therapy cardiotoxicity: results of an observational study by Yu. A. Vasyuk, D. A. Vyzhigin, E. Y. Shupenina, E. O. Novosel, E. A. Ulyanova

“…During the observation of oncological patients receiving chemo- and targeted therapy, it was found that a specific pattern, previously not described, was revealed in patients with developed systolic dysfunction upon visual assessment of the longitudinal strain of the LV. …”
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Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…Abstract Purpose Conventional radiotherapy (CRT) has limited local control and poses a high risk of severe toxicity in large lung tumors. This study aimed to develop an integrated treatment plan that combines CRT with lattice boost radiotherapy (LRT) and monitors its dosimetric characteristics. …”
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Study protocol: A national cross‐sectional study on psychology and behavior investigation of Chinese residents in 2023 by Diyue Liu, Siyuan Fan, Xincheng Huang, Wenjing Gu, Yifan Yin, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Han Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Yajing Zhou, Yong Dong, Yan Qian, Chen Chen, Yujie Zhao, Yimiao Li, Yujia Zheng, Rongyi Chen, Xiaomeng Li, Yuke Han, Yaoyao Xia, Huixin Xu, Zhaolin Wu, Mingyou Wu, Xinrui Wu, Junyi Hou, Yuelai Cai, Xiaofan Dai, Wenbo Li, Ting Nie, Chongzhe Zhang, Xiaoya Wang, Dan Li, Siyao Yan, Zhiheng Yi, Chenxi Liu, Xinyue Zhang, Lei Shi, Haomiao Li, Feng Jiang, Xiaoming Zhou, Xinying Sun, Yibo Wu, Psychology and Behavior Investigation of Chinese Residents project team

“…Discussion Data collection has been finished, and scientific outputs based on this data will support the development of health promotion strategies in China and globally. …”
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Effectiveness and safety of acupuncture therapy for inflammatory bowel disease: a protocol of systematic review and meta-analysis by Fan-rong Liang, Ning Sun, Rui-Rui Sun, Yuan-Fang Zhou, Shi-Rui Cheng, Xiao-Dong Deng, Xiang-Yin Ye, Zheng-Jie Li, Gui-Xing Xu, Yu-Zhu Qu, Liu-Yang Huang

“…The quality of evidence will be evaluated by using the Grading of recommendation Assessment, Development and Evaluation application. The meta-analysis will be performed if heterogeneity analysis conducted on the RevMan software (V.5.3) is insignificant. …”
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MultiAgency, prospective, exploratory, non-intervention, cohort Study on Human Impact Exposure oNboard high-speed boats (MASHIEN): protocol by Stephen D Myers, Ola Rolfson, Yohan Robinson, Spyros D Masouros, John J Fraser, Yann Daniel, Johan Ullman, Kai-Thorsten Bretschneider, Karen R Kelly, Victor Hurpin, Justus Kaehler, Jan Ivar Kåsin, Knut Hveding, Neil Mansfield, Daniel Perl, Nicole Wijnands, Isabelle Vallee, Veerle Stevens

“…Data analysis assesses correlations between exposure and reported pain, enabling the identification of risk factors and the development of safety guidelines for high-speed boat operations.Ethics and dissemination The study has received ethical approval from the relevant ethics committees, including the Swedish Ethics Review Authority (no. 2022-04931-01). …”
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Viral evolution sustains a dengue outbreak of enhanced severity by Catherine Inizan, Marine Minier, Matthieu Prot, Olivia O’Connor, Carole Forfait, Sylvie Laumond, Ingrid Marois, Antoine Biron, Ann-Claire Gourinat, Marie-Amélie Goujart, Elodie Descloux, Anavaj Sakuntabhai, Arnaud Tarantola, Etienne Simon-Lorière, Myrielle Dupont-Rouzeyrol

“…These mutations, however, may have modified DENV strains antigenicity, altering the anti-DENV immune response in some patients, in turn favoring the development of severe forms.Trial registration: ClinicalTrials.gov identifier: NCT04615364.…”
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A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland by Juliette Besson, Régine Audran, Maxime Karlen, Alix Miauton, Hélène Maby-El Hajjami, Loane Warpelin-Decrausaz, Loredana Sene, Sylvain Schaufelberger, Vincent Faivre, Mohamed Faouzi, Mary-Anne Hartley, François Spertini, Blaise Genton

“…Conclusions The favourable safety profile and cellular responses observed support further development of PepGNP-Covid19. Trial registration ClinicalTrials.gov, NCT05113862, approved 09.11.2021.…”
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Effectiveness and safety of acupuncture for angina pectoris: An overview of systematic reviews by Wen-Chuan Qi, Hong-Juan Fu, Rui-Rui Sun, Xiang Li, Ding-Jun Cai, Chao Wang, Fan-Rong Liang

“…The quality of the methodology, reporting, and evidence were assessed by the Assess Systematic Reviews 2 (AMSTAR-2), the Preferred Reporting Item for Systematic Review and Meta-analysis for Acupuncture (PRISMA-A), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. …”
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An investigator-blinded, 24-month, parallel-group, non-inferiority study to compare aesthetic restorations in primary anterior teeth in a paediatric dental clinic: study protocol f... by Ana Paula Taboada Sobral, Elaine Marcilio Santos, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Elza Padilha Ferri, Juliana Maria Altavista Sagretti Gallo, Thais Gimenez, José Carlos Pettorossi Imparato

“…Introduction Children who suffer from severe caries in childhood may have negative impacts on the growth, development, nutritional problems and quality-of-life problems related to the oral health of the child and their family. …”
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Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded... by Jing Zhao, Hui Zhang, Ziyu Zheng, Baobao Gao, Lini Wang, Chong Lei, Hailong Dong, Taoyuan Zhang, Jiao Gao, Lihong Hou

“…CPSP is defined as a new development of pain or increase in the intensity of pain at the surgical area or projected onto the innervation area of a nerve in this area after a surgical procedure that persists for at least 3 months. …”
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