Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…Data supports further clinical development of AUP1602-C. Trial registration: The study was registered in ClinicalTrials.gov (NCT04281992) and ClinicalTrialsRegister.eu (2018-003415-22).…”
Get full text

Effects of sodium tanshinone IIA sulfonate injection on pro-inflammatory cytokines, adhesion molecules and chemokines in Chinese patients with atherosclerosis and atherosclerotic c... by Fan Xie, Xiaoying Fu, Wenbo Li, Yujin Bao, Feng Chang, Yun Lu, Yuqiong Lu

“…BackgroundInflammation, as the basic pathogenic mechanism of atherosclerosis, promotes the development of atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD). …”
Get full text

Rationale and design of randomized non-inferiority clinical trial to compare the safety and efficacy of ticagrelor monotherapy with dual antiplatelet therapy in chronic coronary sy... by Seyed Alireza Mirhosseini, Mohammadreza Akbari, Davar Aldavood, Hooyar Zarifkar, Armin Attar, Javad Kojuri

“…While current guidelines recommend dual antiplatelet therapy (DAPT) with aspirin and clopidogrel, the development of drug-eluting stents (DES) and more potent agents has sparked interest in shorter DAPT regimens, followed by P2Y12 inhibitor monotherapy, as a potential alternative. …”
Get full text

CLINICAL FEATURES OF PREGNANT WOMEN WITH EARLY GESTOSIS by Halina Hvozdetska, Natalia Henyk

“…Lanovyi Department of Obstetrics and Gynecology "Development of diagnostic tactics and pathogenetic substantiation of effective methods of preserving and restoring reproductive potential and improving the quality of life of women in obstetric and gynecological pathology" (state registration number 0121U109269).…”
Get full text

User Experiences of and Preferences for Self-Guided Digital Interventions for the Treatment of Mild to Moderate Eating Disorders: Systematic Review and Metasynthesis by Lauryn Gar-Mun Cheung, Pamela Carien Thomas, Eva Brvar, Sarah Rowe

“…We need to understand user experiences and preferences for digital interventions to support the design and development of user-centered digital interventions that are engaging and meet users’ needs. …”
Get full text

ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial by Christian Burisch, Abhav Bellary, Frank Breuckmann, Jan Ehlers, Serge C Thal, Timur Sellmann, Daniel Gödde

“… BackgroundThe increasing development and spread of artificial and assistive intelligence is opening up new areas of application not only in applied medicine but also in related fields such as continuing medical education (CME), which is part of the mandatory training program for medical doctors in Germany. …”
Get full text

Diagnostic accuracy of isolated-check visual evoked potentials for glaucoma: a systematic review and meta-analysis by Yongran Li, Yanling Lu, Tulong Lin

Get full text

Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study by Anja Degenaar, Ruan Kruger, Adriaan Jacobs, Catharina M. C. Mels

“…Trial Registration: ClinicalTrials.gov identifier: NCT03292094…”
Get full text

Protocol for the PLAYshop randomised controlled trial: examining efficacy of a virtually delivered parent-focused physical literacy intervention for early childhood on child-specif... by Sam Liu, Ryan Rhodes, Patti-Jean Naylor, Valerie Carson, Madison Boyd, Morgan Potter

“…To assess the primary outcome of physical literacy, five fundamental movement skills (overhand throw, underhand throw, horizontal jump, hop, one leg balance) will be measured virtually at baseline and 2-month follow-up using the Test of Gross Motor Development (TGMD) and the Movement Assessment Battery for Children-Second Edition (MABC-2) tools. …”
Get full text

Four-week Nordic hamstring exercise intervention for individuals with ACL reconstruction via hamstrings tendon autograft: feasibility of a pilot randomized controlled trial by Grant E. Norte, Neal R. Glaviano, David A. Sherman, Justin L. Rush, Amanda M. Murray

“…Understanding the feasibility of NHE as a means of enhancing hamstring function may aid in the development of evidence-based recommendations to guide hamstring recovery. …”
Get full text

Implementation of the Symptom Navi © Programme for cancer patients in the Swiss outpatient setting: a study protocol for a cluster randomised pilot study (Symptom Navi© Pilot Study... by Marika Bana, Karin Ribi, Susanne Kropf-Staub, Sabin Zürcher-Florin, Ernst Näf, Tanja Manser, Lukas Bütikofer, Solange Peters, Manuela Eicher

Get full text

The importance of antibacterial therapy of whooping cough in children at the outpatient stage of treatment by L. V. Puzyreva, N. A. Sabaeva, L. N. Paimanova, E. A. Gashina, E. F. Lobova, N. V. Golovanova, E. P. Shefer

“…The influence of early administration of antibacterial therapy on clinical manifestations and the development of complications in children with whooping cough was revealed.However, the laboratory diagnosis of whooping cough was not affected by outpatient treatment.Conclusion. …”
Get full text

Expression and polymorphism of lTLR4 receptors in pathogenesis of chronic obstructive pulmonary disease: a modern view by V. A. Beloglazov, I. A. Yatskov, Rean Hayrievna Useinova

“…By recognizing the pathogen-associated molecular patterns (PAMPs) expressed on infectious agents, TLRs mediate the production of cytokines necessary for the development of effective immunity. Different TLRs exhibit distinct expression patterns. …”
Get full text

Artificial intelligence for difficult airway assessment: a protocol for a systematic review with meta-analysis by Dan Liu, Tingting Li, Li Du, Jianqiao Zheng, Yujie Huang, Weiyi Zhang

“…Furthermore, the quality of evidence concerning the outcomes will be assessed based on the Grading of Recommendations Assessment, Development and Evaluation criteria for diagnostic tests. …”
Get full text

Melamine regulatory assessment for endocrine disruption by Isabelle Charron, Brigitte Le Magueresse-Battistoni, René Habert, Marie-Chantal Canivenc-Lavier, Sakina Mhaouty-Kodja, Cécile Michel-Caillet

Get full text

Loddon Mallee healthcare worker COVID-19 study—protocol for a prospective cohort study examining the health and well-being of rural Australian healthcare workers during the COVID-1... by Stephen Begg, Mark McEvoy, Timothy C Skinner, Carol Parker, Angela Crombie, Peter Faulkner, Anne McEvoy, Laura Bamforth, Gabriel Caccaviello

Get full text

Ischemic heart disease: medical certificate of cause of death analysis by I. V. Samorodskaya, T. K. Chernyavskaya, E. P. Kakorina, V. Yu. Semyonov

“…A high proportion of deaths with unspecified acute and chronic forms of IHD as the cause of death, especially in young men, requires a comprehensive study and development by the Russian Society of Cardiology of criteria for death from various IHD forms.…”
Get full text

The effects of public long-term care insurance on the long-term care industry in China: a quasi-experimental study by Zhongbin Huang, Anqi Jian, Jing Wang, He Chen

“…The development of the LTC industry in each city was measured using two dependent variables: the annual increase in the number and registered capital of LTC organizations. …”
Get full text

Diagnostic performance of the DISQVER metagenomic sequencing tool for the identification of pathogens in febrile neutropenic patients: the ADNEMIA trial by Geneviève Héry-Arnaud, Christophe Burucoa, Marie Kempf, David Boutoille, Yohann Foucher, Philippe Lanotte, Maxime Pichon, Stéphane Corvec, Cécile Le Brun, Helene Pailhories

“…Sequencing technologies have led to the development of diagnostic approaches based on the detection of circulating DNA in blood. …”
Get full text

Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled t... by Baoping Xu, Peng Han, Yunxiao Shang, Huanji Cheng, Zhiying Han, Lin Zhao, Shaoru He, Min Lu, Enmei Liu, Kunling Shen

Get full text