Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parentera... by J Brian de Souza, Uduak Okomo, Neal D Alexander, Naveed Aziz, Benjamin M J Owens, Harparkash Kaur, Momodou Jasseh, Sant Muangnoicharoen, Percy F Sumariwalla, David C Warhurst, Stephen A Ward, David J Conway, Luis Ulloa, Kevin J Tracey, Brian M J Foxwell, Paul M Kaye, Michael Walther

“…<h4>Background</h4>Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid public health impact. …”
Get full text

Efficacy and safety of left bundle branch area pacing versus biventricular pacing in heart failure patients with left bundle branch block: study protocol for a randomised controlle... by Lin Zhao, Liting Cheng, Junmeng Zhang, Zefeng Wang, Mengge Zhou, Zhuo Liang, Jieruo Chen, Yongquan Wu

Get full text

A randomized trial to evaluate the pharmacokinetics, pharmacodynamics, and safety of vadadustat in patients with anemia associated with chronic kidney disease receiving hemodialysi... by Pamela Navarro-Gonzales, Ajit Chavan, Don Wang, Steven K. Burke, Kevin Dykstra

“…These findings will contribute to the development of higher-dose regimens for further investigation in phase 3 studies. …”
Get full text

Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. by Jasper V Been, Marlies J Lugtenberg, Eline Smets, Constant P van Schayck, Boris W Kramer, Monique Mommers, Aziz Sheikh

“…Given the projected global increases in children surviving preterm births, research now needs to focus on understanding underlying mechanisms, and then to translate these insights into the development of preventive interventions.<h4>Review registration</h4>PROSPERO CRD42013004965.…”
Get full text

Efficacy of a Web-Based Integrated Growth Mindset Intervention on Reducing Anxiety Among Social Work and Counseling Practicum Trainees: Protocol for a 2-Arm Randomized Controlled T... by Yongyi Wang, An Xi, Stella S K Wong, Kong Yam, Janet Tsin Yee Leung, Shimin Zhu

“… BackgroundPracticum is indispensable for the development of professional practitioners; yet, trainees may encounter psychological distress, especially anxiety, brought on by new challenges. …”
Get full text

Retrospective analysis of malaria prevalence over ten years (2015-2024) at Bichena Primary Hospital, Amhara Region, Ethiopia. by Awoke Minwuyelet, Delenasaw Yewhalaw, Getnet Atenafu

“…<h4>Background</h4>Malaria remains a significant public health challenge in Ethiopia, hindering the country's productivity and development. While malaria incidence had decreased by 2018, and Ethiopia is working towards eliminating the disease by 2030, outbreaks still occur even in areas of low endemicity. …”
Get full text

Organisational and social work-environment experiences after care manager implementation: a repeated cross-sectional study in Swedish primary care by Pia Augustsson, Eva-Lisa Petersson, Cecilia Björkelund, Sven Persson Kylén, Carl Wikberg

Get full text

The impact of the Change4Life Food Scanner app on children’s diets and parental psychological outcomes: a randomised pilot and feasibility study by Sundus Mahdi, Jim Chilcott, Nicola J. Buckland

“…Recommendations are provided for future app development and full-scale trial design. Trial registration ISRCTN12169303; 12th May 2025. …”
Get full text

The potential of the ultrasound method in diagnosing pulmonary edema in critically ill patients with liver failure by D. N. Martsinkevich, P. S. Prilutskiy, A. M. Dzyadzko, T. A. Sevruk, S. A. Tochilo

“…Some patients had a systemic inflammatory response syndrome with the development of multiple organ failure and clinical signs of redistribution shock. …”
Get full text

Determinant factors and coping strategies for depression among pregnant women: an intervention-based qualitative study in Lahore, Pakistan by Quratulain Ahsan, Javeria Saleem, Muhammad Ishaq, Rubeena Zakar, Saira Abbas, Ruhma Shahzad, Sohail Mahmood Khan, Florian Fischer

“…Furthermore, four themes emerged in the post-intervention stage: (1) development of positivity in thinking and attitude, (2) learning about stress management through the provision of compassion and sharing avenues, (3) gaining self-esteem to address matters positively, and (4) improving relationships with the unborn child and family. …”
Get full text

Late Survival After Aortic Valve Replacement in Patients With Moderately Reduced Kidney Function by Natalie Glaser, Veronica Jackson, Martin J. Holzmann, Anders Franco‐Cereceda, Ulrik Sartipy

“…Methods and Results All patients who underwent primary AVR in Sweden 1997–2013 were identified from the Swedish Web system for Enhancement and Development of Evidence‐based care in Heart disease Evaluated According to Recommended Therapies register. …”
Get full text

Psychological outcomes in paediatric major trauma patients who require invasive management: protocol for a systematic review and meta-analysis by Stephen H Thomas, Veronica Phillips, Owen Hibberd, Spyridon Karageorgos, Caroline E Thomas, Sarah Gentle, Sandi Angus

“…Certainty and confidence in cumulative evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.Ethics and dissemination Ethical review is not required as no original data will be collected. …”
Get full text

The Effect of Deworming on Growth in One-Year-Old Children Living in a Soil-Transmitted Helminth-Endemic Area of Peru: A Randomized Controlled Trial. by Serene A Joseph, Martín Casapía, Antonio Montresor, Elham Rahme, Brian J Ward, Grace S Marquis, Lidsky Pezo, Brittany Blouin, Mathieu Maheu-Giroux, Theresa W Gyorkos

“…Children were enrolled during their routine 12-month growth and development clinic visit and followed up at their 18 and 24-month visits. …”
Get full text

Design of a Randomized Sham-Controlled Trial: Strengthening Positive Treatment Expectations Using a Communication Model for Maximized Antiemetic Effects of Acupuncture and Antiemet... by Widgren Ylva MSP, Fransson Per PhD, Englund Erling PhD, Efverman Anna PhD

Get full text

Identification of risk factors for the progression of age-related macular degeneration: a systematic review and meta-analysis of cohort studies by Moqi Tian, Baike Zhang

“…This study aimed to identify the risk factors influencing the development of AMD using a meta-analysis approach.MethodsWe systematically searched the PubMed, Embase, and Cochrane Library databases from their inception until November 2024. …”
Get full text

Prospective exploration of the effect of adiposity and associated microbial factors on healing and progression of diabetic foot ulcers in Tanzania: study protocol of a longitudinal... by Fredirick Mashili, Agricola Joachim, Mabulla Mchembe, Faraja Chiwanga, Agbor Ako, Zulfiqar Abbas

Get full text

A systematic review of natural language processing applications in Trauma & Orthopaedics by Luke Farrow, Arslan Raja, Mingjun Zhong, Lesley Anderson

“…Open science is an important part of research transparency that should be encouraged in NLP algorithm development and reporting. Cite this article: Bone Jt Open 2025;6(3):264–274.…”
Get full text

Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial. by Menglu Ouyang, Anila Anjum, Francisca Gonzalez Mc Cawley, Mohammad Wasay, Lu Ma, Xin Hu, Xiaoying Chen, Alejandra Malavera, Xi Li, Paula Muñoz Venturelli, H Asita de Silva, Nguyen Huy Thang, Kolawole W Wahab, Jeyaraj D Pandian, Octavio M Pontes-Neto, Carlos Abanto, Venessa Cano-Nigenda, Antonio Arauz, Chao You, Stephen Jan, Lili Song, Craig S Anderson, Hueiming Liu, INTERACT3 Investigators

“…Facilitating factors included good communication and collaboration with staff in emergency departments, the development of pathways within available resources, and regular training and monitoring. …”
Get full text

The effect of telemedicine employing telemonitoring instruments on readmissions of patients with heart failure and/or COPD: a systematic review by Georgios M. Stergiopoulos, Anissa N. Elayadi, Edward S. Chen, Panagis Galiatsatos

Get full text

Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic... by Abhishek Abhishek, Danielle van der Windt, Christopher Carroll, Matthew J Grainge, Richard Riley, Joanna Leaviss, Munira Essat, Tim Card

“…Two independent reviewers assessed risk of bias using Quality in Prognostic factor Studies tool and assessed the quality of evidence using a Grading of Recommendations Assessment, Development and Evaluation-informed framework.Results Fifty-six studies from 58 papers were included. …”
Get full text