Effectiveness of pharmacological and non-pharmacological interventions for treatment-resistant depression in older patients: a systematic review and meta-analysis by Claudia Cooper, Peter Falkai, Alice Jane Larsen, Giulia Teobaldi, Rosario Isabel Espinoza Jeraldo

“…We assessed bias with the Cochrane Risk of Bias (RoB) 2 tool, meta-analysed remission rates and evaluated evidence using GRADE (Grading of Recommendations Assessment, Development, and Evaluation) criteria.Results 14 studies (11 newly identified, 3 from previous review) involving 1196 participants (mean age 65.0, male/female 548/648) met the inclusion criteria; 10 were placebo controlled and 4 were rated as low RoB. …”
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Identification of distinct disease activity trajectories in patients with psoriatic arthritis receiving tofacitinib: a post hoc analysis of two phase 3 studies by Laura C Coates, Dafna Gladman, Mikhail Volkov, David Gruben, William Tillett, Stefanie Hahne

“…Identifying characteristics that impact treatment response may aid personalised treatment algorithm development.Trial registration numbers NCT01877668/NCT01882439.…”
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Hyperangulated videolaryngoscope for difficult airway management: a protocol for a systematic review with meta-analysis and trial sequential analysis by Dan Liu, Tingting Li, Li Du, Jianqiao Zheng, Yujie Huang, Weiyi Zhang

“…Additionally, the quality of evidence regarding each outcome will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation. The reliability of all outcomes will be appraised via trial sequential analysis. …”
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Recent changes in the pharmacovigilance system in the Russian Federation and the EAEU by G. N. Gildeeva, A. V. Belostotsky

“…This group of regulations contains basic documents on the inspection of production lines, the assessment of generic equivalence, the development of biological drugs, and the pharmacovigilance (PV). …”
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Acupuncture for substance use disorders: a protocol of systematic review and meta-analysis of randomised controlled trials by Yingying Wang, Meng Qiao, Chao-ren Tan, JIN CHANG, Shu-Min Chen

“…The risk of bias and quality of evidence will be assessed by the revised Cochrane risk-of-bias tool for randomised trials and guidelines of the Grading of Recommendations Assessment, Development and Evaluation working group, respectively. …”
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Effectiveness of an online sexual and reproductive health educational program on knowledge, attitudes, and behaviours among senior primary school students: a cluster randomized con... by Ruru Guo, Wen Pan, Wei Zhao, Mingli Zhao, Jingjing Wang

“…Results At baseline, no significant differences were found between groups in sociodemographic or physical development. In the intervention group, 71.4% completed the program with an average test accuracy of 86.6%, indicating good adherence and content comprehension. …”
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FACT: a randomised controlled trial to assess the feasibility of QbTest in the assessment process of attention deficit hyperactivity disorder (ADHD) for young people in prison—a fe... by Charlotte Lucy Hall, Prathiba Chitsabesan, Charlotte Lennox, Lesley-Anne Carter, Susan Young, Abdullah Kraam, Nikki Brown, Lloyd Wilkinson-Cunningham, Mindy Reeves

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Influence of perinatal antibiotic on neonatal gut microbiota: a prospective cohort study by Faiza Iqbal, Padmaja A. Shenoy, Leslie Edward S. Lewis, N. Siva, Jayashree Purkayastha, Vandana Kalwaje Eshwara

“…Abstract Introduction Given the significant role of the gut microbiota in early immune and metabolic development, the impact of perinatal antibiotic administration on the neonatal gut microbiome remains a crucial area of investigation. …”
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Palivizumab and prevention of childhood respiratory syncytial viral infection: protocol for a systematic review and meta-analysis of breakthrough infections by Meghan Sebastianski, Robin Featherstone, Shelly Jun, Joan Robinson

“…Findings from this review will inform recommendations for best practices regarding palivizumab use for childhood RSV infection as well as research priorities in RSV vaccine development.Methods and analysis We will conduct a systematic review of primary population-based studies that examine the incidence of palivizumab breakthrough infections in children, published between 1997 to present. …”
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Digital Intervention in Children With Developmental Language Disorder: Systematic Review by Zhaowen Zhou, Cheng Deng, Dongling Yin, Qiaoxue Yang, Zhuoming Chen

“…Further higher-level evidence, such as randomized controlled trial studies in this area, is needed to direct the development of digital programs.…”
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Effectiveness of specialist involvement in case discussion conferences with primary healthcare providers on the management of type 2 diabetes patients: a study protocol for a clust... by Jia Li, Jiawei Li, Chao Long, Aoqi Ge, Luping Hei, Zhikai Yang, Juanjuan Li, Xianjing Qin, Xinlu Song, Beibei Yuan

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Systemic inflammation in young adults is associated with abnormal lung function in middle age. by Ravi Kalhan, Betty T Tran, Laura A Colangelo, Sharon R Rosenberg, Kiang Liu, Bharat Thyagarajan, David R Jacobs, Lewis J Smith

“…In particular, elevated CRP may identify vulnerability to COPD among individuals who smoke.<h4>Trial registration</h4>ClinicalTrials.gov NCT00005130.…”
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Current state of mental health research in Mozambique: a scoping review protocol by Mariano Joaquim Creyghton Pedro, Castro Ananias Nhamahango, Luciano Jose Mariquele

“…This fragmentation highlights the need for a comprehensive scoping review to map the current state of mental health research in the country and to guide future studies, policy development and clinical practice.Methods and analysis This scoping review aims to map the existing scientific literature on mental health in Mozambique over the past 15 years, focusing on study types, target populations, methodological approaches and key findings. …”
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End-of-life care preparedness and educational needs among nursing staff of long-term care facilities: a cross-sectional study by Soo Jung Chang, Seongmi Moon, Na Kyoung Lee

“…Trial registration Approved by the Institutional Review Board of GangneungWonju National University (No. …”
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Comparing physiological and psychological effects of virtual reality vs. traditional high-intensity interval training in healthy individuals: results from a preliminary pilot rando... by Jonathan Robinson, Mohammad Haziq Bin Abdul Razak

“…Abstract Background Physical inactivity is a growing concern, contributing significantly to the development of chronic diseases. Virtual reality and active video games have emerged as potential solutions to promote physical activity by integrating immersive experiences with exercise. …”
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The effect of post-exercise heat exposure (passive heat acclimation) on endurance exercise performance: a systematic review and meta-analysis by Thomas P. J. Solomon, Matthew J. Laye

“…Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. Results Ten studies (199 participants: 156 male, 43 female, age 20–32 years) were included. …”
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Treating sleep problems in young people at ultra-high-risk of psychosis: study protocol for a single-blind parallel group randomised controlled feasibility trial (SleepWell) by Apostolos Tsiachristas, Daniel Freeman, Thomas Kabir, Felicity Waite, Louise Johns, Jill Mollison, Ariane Petit, Emma Černis, Daniel Maughan

“…Insomnia is a common clinical issue that is problematic in its own right but that also leads to the development and persistence of psychotic experiences. …”
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Mapping the risk of Zika virus infections in pregnant persons and microcephaly in newborns in relation to socioeconomic indicators in Recife, Pernambuco, Brazil: A spatial analysis... by Ana Carolyne de Carvalho Lucena Sá, André Luiz Sá de Oliveira, Demócrito de Barros Miranda-Filho, Celina Maria Turchi Martelli, Thalia Velho Barreto de Araújo, Elizabeth B Brickley, Ricardo Arraes de Alencar Ximenes, Ulisses Ramos Montarroyos

“…<h4>Conclusion</h4>During the epidemic and post-epidemic periods in Recife, cases of ZIKV in pregnant persons and microcephaly were concentrated in census tracts with relatively higher socioeconomic vulnerability, reinforcing the need for research to inform the development of social protection and environmental policies to mitigate ZIKV-related risks.…”
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Combining cognitive bias modification training (CBM) and transcranial direct current stimulation (tDCS) to treat binge eating disorder: study protocol of a randomised controlled fe... by Gemma Gordon, Timo Brockmeyer, Ulrike Schmidt, Iain C Campbell

“…Results will be published in peer-reviewed journals.Trial registration number ISRCTN35717198…”
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Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis by Lehana Thabane, Mark Loeb, Jessica J Bartoszko, Dominik Mertz, Zeyad Elias, Paulina Rudziak, Carson K L Lo

“…We rated the certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluation approach.Results One randomised trial and 40 observational studies were eligible (n=1918 patients). …”
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