Effectiveness and acceptability of exergaming in people with mild cognitive impairment: protocol for an overview of systematic reviews and network meta-analysis by Xi Chen, Dian Jiang, Yifei Chen, Yishu Zhu, Hongting Ning, Hui Feng

“…Systematic review registration PROSPERO CRD42023421052.…”
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Effects of dexmedetomidine on delirium and mortality during sedation in ICU patients: a systematic review and meta-analysis protocol by Rao Sun, Shuo Wang, Shiyong Li, Chun Yang, Yilin Zhao, Ailin Luo

“…At last, the quality of evidence of the main outcomes will be rated using the Grading of Recommendations Assessment, Development and Evaluation system.Ethics and dissemination The present study is a meta-analysis based on published studies, thus ethical approval is not needed. …”
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Vitamin D deficiency or supplementation and the risk of human herpesvirus infections or reactivation: a systematic review protocol by Charlotte Warren-Gash, Liang-Yu Lin, Ketaki Bhate, Sinéad Langan

“…We will assess the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation framework, and display the results in a summary of findings table.Ethics and dissemination Ethical review is not required for a systematic review. …”
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Acupuncture for angina post percutaneous coronary intervention: a protocol for systematic review and meta-analysis by Xin Zhou, Yulan Ren, Wen Xie, Yanwei Li, Yongjun Yin, Yilan Wang

“…The systematic review will be published in peer-reviewed journals.PROSPERO registration number CRD42024562116.…”
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A Double-Blind Randomized Controlled Trial of Maternal Postpartum Deworming to Improve Infant Weight Gain in the Peruvian Amazon. by Layla S Mofid, Martín Casapía, Eder Aguilar, Hermánn Silva, Antonio Montresor, Elham Rahme, William D Fraser, Grace S Marquis, Jozef Vercruysse, Lindsay H Allen, Brittany Blouin, Hugo Razuri, Lidsky Pezo, Theresa W Gyorkos

“…<h4>Background</h4>Nutritional interventions targeting the critical growth and development period before two years of age can have the greatest impact on health trajectories over the life course. …”
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Rationale and Design of a Randomized Controlled Trial of Bivalirudin with a Prolonged High-Dose Infusion Versus Heparin Monotherapy During Primary Percutaneous Coronary Interventio... by Zhenyang Liang, Yi Li, Gregg W. Stone, Yaling Han

“…In the heparin group, the use of glycoprotein IIb/IIIa inhibitors will be reserved for the development of procedural thrombotic complications. …”
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A Double-blind Randomized Comparative Phase I Study to Assess Biosimilarity and Immunogenicity of "Trastuzumab" (LLC "Mabscale", Russia) and Herceptin® (F. Hoffmann-La Roche Ltd.,... by M. A. Kolganova, E. E. Beketov, V. V. Pisarev, A. V. Ivanov, S. V. Vasiliev, I. E. Shokhin

“…Despite the fact that more than 10 biosimilars of trastuzumab are now in the pipeline around the world, including Russia, the development and registration of trastuzumab biosimilars still remain relevant.Aim. …”
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Barriers and facilitators to the implementation of PHAROS, a perioperative pharmaceutical management intervention for older adults – a qualitative interview study from the perspect... by Moritz Sebastian Schönfeld, Julia Rinke, Claudia Langebrake, Levente Kriston, Cynthia Olotu, Rainer Kiefmann, Corinna Bergelt

“…The Consolidated Framework for Implementation Research (CFIR) was used to guide development of interview guide, data coding, analysis, and reporting of findings. …”
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Continuous heart rate variability monitoring—understanding patterns of stress and recovery and their relationship with self-reported burnout, resilience and well-being in doctors:... by Kathryn R Martin, Daniel Powell, Leia Kane, Derek Ball

“…Following initial analysis of the quantitative data, participants of interest will be invited to take part in semistructured interviews, which will be thematically analysed and presented alongside the quantitative data.Ethics and dissemination This study was approved by the University of Aberdeen, School of Medicine, Medical Sciences and Nutrition ethics review board (ref. 3389193) and the NHS Grampian research and development team. Results will be disseminated in international peer-reviewed journals.Trial registration number NCT06721312.…”
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Vocational interventions to help adults with long-term health conditions or disabilities gain and maintain paid work: an overview of systematic reviews by William Mark Magnus Levack, Joanna Kirstin Fadyl

“…We used Grading of Recommendations Assessment, Development and Evaluation to evaluate strength of evidence underpinning overview findings.Results We identified 26 reviews (5 high-quality and 21 critically low to moderate quality) that focused on vocational interventions for acquired brain injury, autism, intellectual disability, multiple sclerosis, mental health conditions, spinal cord injury and general disability populations. …”
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Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines. by Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, Tomáš Hanke

“…<h4>Conclusions</h4>The high rate of discovery of novel CD8+ T-cell effector epitopes warrants further epitope mining in recipients of the conserved-region vaccines in other populations and informs development of HIV-1/AIDS vaccines.<h4>Trial registration</h4>ClinicalTrials.gov NCT01151319.…”
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Safety and Immunogenicity of EBA-175 RII-NG Malaria Vaccine Administered Intramuscularly in Semi-Immune Adults: A Phase 1, Double-Blinded Placebo Controlled Dosage Escalation Study... by Kwadwo A Koram, Bright Adu, Josephine Ocran, Yaa S Karikari, Susan Adu-Amankwah, Michael Ntiri, Benjamin Abuaku, Daniel Dodoo, Ben Gyan, Karl C Kronmann, Francis Nkrumah

“…In conclusion, the EBA-175 RII-NG vaccine was safe, well tolerated and immunogenic in malaria semi-immune Ghanaian adults. Its further development is recommended.<h4>Trial registration</h4>ClinicalTrials.gov. …”
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The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a rand... by Stephen Nash, Alexander J Mentzer, Swaib A Lule, Dennison Kizito, Gaby Smits, Fiona R M van der Klis, Alison M Elliott

“…It has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial.…”
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Optical Coherence Tomography with Angiography in the Diagnosis of Changes in the Organ of Vision at Atherosclerosis by M. S. Kasimova, D. K. Mahkamova

“…The use of OCTA allows to detect changes in hemoperfusion in all layers of the retina and optic nerve in the early stages of AS development, which will allow early diagnosis and monitoring of the disease.…”
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A randomized controlled study protocol of the TOBBI trial: the effect of a 6 weeks intervention with synbiotics on the recovery speed of the gut microbiota after antibiotic treatme... by Kelly Klomp, Maaike Alkema, Jan Knol, Anna M. Malinowska, Clara Belzer

“…Abstract Background Antibiotic-induced disruption of the gut microbiome in the first 1000 days of life is linked to an increased risk of the development of immunological, metabolic, and neurobehavioral childhood-onset conditions. …”
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Improving neurodevelopment in Zika-exposed children: A randomized controlled trial. by Randall Waechter, Kemi S Burgen, Bianca Punch, Roberta Evans, Karen Blackmon, Trevor Noël, Michelle Fernandes, Barbara Landon

“…<h4>Background</h4>While microcephaly is a significant adverse outcome of prenatal exposure to the Zika virus (ZIKV), subtle malformations of cortical development (MCD) have been observed in Zika-exposed children (ZEC), including delays in language, cognition, and motor domains, and visual acuity deficits. …”
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The Procedure for Accreditation of Medical Laboratories for Compliance with the Requirements of GOST R ISO 15189-2015 «Medical Laboratories. Particular Requirements for Quality and... by L. A. Kornoukhova, A. M. Ivanov, A. B. Belevitin, V. L. Emanuel

“…The provisions of the regulations of the Ministry of Economic Development are a priority for the Federal Accreditation Service. …”
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Effects of interventions aimed at improving nurses’ work engagement in the workplace: a systematic review and meta-analysis protocol by Norito Kawakami, Kotaro Imamura, Kazuto Kuribayashi, Akiko Inagaki

“…The methodological quality of the included studies will be evaluated using the Grading of Recommendation Assessment, Development and Evaluation approach. A meta-analysis will be conducted for statistical synthesis and publication bias will be assessed using Egger’s test and a visual funnel plot. …”
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Lung mucosal immunity to NTHi vaccine antigens: Antibodies in sputum of chronic obstructive pulmonary disease patients by Federica Baffetta, Cecilia Buonsanti, Luca Moraschini, Susanna Aprea, Martina Canè, Stefano Lombardi, Mario Contorni, Simona Rondini, Ashwani Kumar Arora, Monia Bardelli, Oretta Finco, Davide Serruto, Silvia Rossi Paccani

“…Bacteria in the lungs play a role in exacerbation development, and the most common pathogen is non-typeable Haemophilus influenzae (NTHi). …”
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Qualitative study of perceptions of factors contributing to success or failure among participants in a US weight loss trial of financial incentives and environmental change strateg... by Kevin G Volpp, Justin Clapp, Karen Glanz, Collin Kather, Annie Chung, Ji Rebekah Choi

“…Making incentives more salient may make them more effective for participants with greater extrinsic motivation.Trial registration number NCT02878343…”
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