CO37 | Assessment of clotting factor activity and sterility in thawed fresh frozen plasma supplied to helicopter emergency medical services for prehospital transfusion

“…In these plasma units, we observed reductions in FVIII levels of 34.24% and 26.27% compared to the QC plasmas before storage, and after one month of storage at -30°C, respectively. …”
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Xuebijing alleviates high-voltage electrical burn-induced acute kidney injury by inhibiting neutrophils and inflammation by Xiaopei He, Na Li, Leilei Ma, Meng Yang, Liqing Ren, Jiawen Hao, Xin Xue, Yinghui Pang

“…Adverse reactions were recorded. The sample size was determined based on previous similar studies indicating clinically significant differences with comparable group sizes. …”
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Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…Growth in carapace width was similarly affected, with reductions of 21.5 %, 42.3 %, and 62.5 %, respectively. …”
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Chemical Characteristics of PM10 at Background Stations of Central and Eastern China in 2016-2017 by Jiao Jian, Jia Xiaofang, Yan Peng, Cao Fang, Fang Dongqing, Ma Qianli, Yu Dajiang, Chu Jinhua

“…The water-soluble ions (F-, Cl-, NO3-, SO42-, PO43-, Na+, K+, NH4+, Ca2+, Mg2+), carbon-containing compounds (OC, EC) and main elements in PM10 samples are analyzed. The average PM10 concentration at Lin'an (62.2±36.6 μg·m-3) during the whole period is the highest, followed by Jinsha (57.6±31.8 μg·m-3), and that at Longfengshan (57.5±55.3 μg·m-3) is the lowest. …”
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Establishment of an animal model of immune‐related adverse events induced by immune checkpoint inhibitors by Yuan Meng, Yingge Lv, Meng Shen, Wenwen Yu, Yumeng Liu, Ting Liu, Gen Liu, Shiya Ma, Zhenzhen Hui, Xiubao Ren, Liang Liu

“…Results Mice treated with PD‐1 and CTLA‐4 inhibitors showed significant reductions in tumor volume and body weight. The tissue inflammatory scores in the experimental group were significantly higher than those in the control group. …”
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Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort s... by Yifan Li, Mao Li, Miao Wang, Jiarui Yao, Fengzhu Li, Siyu Chen, Xi Yin, Zhongbao Gao

“…However, to confirm these findings, well-designed studies with larger, well-characterized samples are necessary.…”
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Prognostic value of EMT-related genes and immune cell infiltration in thyroid carcinoma by Shuping Wu, Shuping Wu, Yu Liu, Yu Zeng, Xianhui Ruan, Mei Tao, Wenrong Lin, Chang Liu, Hongbin Chen, Hui Liu, Yu Wu

“…Furthermore, this study examined the presence of various immune cells within the THCA samples using three distinct algorithms, namely ssGSEA, xCell, and MCPcounter. …”
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Molecular Docking, Bioinformatic Analysis, and Experimental Verification for the Effect of Naringin on ADHD: Possible Inhibition of GSK-3β and HSP90 by Hatem I. Mokhtar, Sawsan A. Zaitone, Karima El-Sayed, Rehab M. Lashine, Nada Ahmed, Suzan M. M. Moursi, Shaimaa A. Shehata, Afaf A. Aldahish, Mohamed A. Helal, Mohamed K. El-Kherbetawy, Manal S. Fawzy, Noha M. Abd El-Fadeal

“…Treatment with naringin (50 or 100 mg per kg) produced significant shortening in the grooming time (31% and 27% reductions), as well as a higher percentage of mice succeeding in crawling with the rope (50% and 83%, respectively). …”
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Polymorphic Distribution of Human Homeostatic Iron Regulator Gene H63D rs1799945 and Clinico‐Hematological Parameters of Sickle Cell Anemia Patients: A Case‐Control Study in Northe... by Samuel Kwasi Appiah, Charles Nkansah, Samira Daud, Gabriel Abbam, Felix Osei‐Boakye, Larry Adom, Rekhiatu Oboirien Abdul Rauf, Godfred Takyi Addae, Lydia Sarpong, Godfred Amoah Appiah, Charles Agnaatah Derigubah, Jennifer Obeng Mensah, Onwuka Chima Kalu, Victor U. Usanga, Boniface Nwofoke Ukwah, Ejike Felix Chukwurah

“…Ethylenediaminetetraacetic acid (EDTA)‐anticoagulated blood samples were used for complete blood count estimation using a 5‐part hematology autoanalyzer (URIT‐5250 China). …”
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PIBF1 expression and survival outcome in TNBC and Non-TNBC breast cancer patients with lymph node metastasis who undertaken chemotherapy by Eunju Shin, Jewon Ryu, Tae-Kyung Yoo, Sae Byul Lee, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Jun Hyeong Lee, Kyunggon Kim, Sang-wook Lee, Byung Ho Son

“…A correlation between PIBF1 expression in breast cancer cell lines (BT549, HCC70, BT20, and HS578T) and their sensitivity to paclitaxel was shown in vitro, with certain cell lines showing significant viability reductions and also resisting the treatment after PIBF1 knockdown. …”
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HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study by Irma Wati Ngadimon, Devi Mohan, Mohd Farooq Shaikh, Ching Soong Khoo, Hui Jan Tan, Yu Mey Lee, Nor Syazwani Chamhuri, Farizal Fadzil, Nursyazwana Zolkafli, Alina Arulsamy, Jegan Thanabalan, Angel Aledo‐Serrano, Wing Loong Cheong

“…This prospective longitudinal study investigated whether serum HMGB1 levels are associated with PTE development and cognitive decline over 12 months post‐TBI. Methods Serum samples were collected from 41 TBI patients, including mild and moderate to severe, at baseline, 6, and 12 months following TBI. …”
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Hospitalizations among adults with chronic kidney disease in the United States: A cohort study. by Sarah J Schrauben, Hsiang-Yu Chen, Eugene Lin, Christopher Jepson, Wei Yang, Julia J Scialla, Michael J Fischer, James P Lash, Jeffrey C Fink, L Lee Hamm, Radhika Kanthety, Mahboob Rahman, Harold I Feldman, Amanda H Anderson, CRIC Study Investigators

“…Hospitalization rates in CRIC were compared with rates in the Nationwide Inpatient Sample (NIS) from 2012. Of the 3,939 CRIC participants, 45.1% were female, and 41.9% identified as non-Hispanic black, with a mean age of 57.7 years, and the mean eGFR is 44.9 ml/min/1.73m2. …”
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Impacts of multisectoral cash plus programs after four years in an urban informal settlement: Adolescent Girls Initiative-Kenya (AGI-K) randomized trial. by Beth Kangwana, Karen Austrian, Erica Soler-Hampejsek, Nicole Maddox, Rachel J Sapire, Yohannes Dibaba Wado, Benta Abuya, Eva Muluve, Faith Mbushi, Joy Koech, John A Maluccio

“…For the older subsample there were larger and significant reductions in the percent ever having had sex (8.2 pp), HSV-2 prevalence (7.5 pp) and HSV-2 incidence (5.6 pp) in the VE arm. …”
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Evaluation of the physical and mechanical behaviour of rammed earth by incorporation of recycled glass by Jacinto Canivell, Juan Jesús Martin-del-Rio, Mario Solís, José Daniel Rodríguez-Mariscal, Vicente Flores-Alés, Francisco Pontiga

“…The superior performance in cement-stabilized samples is due to a pozzolanic reaction absent in lime mixtures. …”
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Liposomal bupivacaine versus conventional anesthetics in adductor canal block for total knee arthroplasty: a meta-analysis of randomized controlled trials by Xiaoli Ye, Kaixi Shang, Lina Zhao, Quan Liang, Huanzhen Luo, Jing Shi

“…However, these findings should be interpreted cautiously due to the limited sample size (4 RCTs, 343 patients). Larger, well-designed RCTs are required to confirm its long-term clinical efficacy.…”
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Contraceptive use intention and determinants among nonuser reproductive-aged married women in Ethiopia based on the theory of planned behavior by Fitsum Tariku Fantaye, Kelemua Menegesha Sene, Solomon Abrha Damtew

“…This choice is closely linked to significant health benefits, including reductions in unintended pregnancies and unsafe abortions, ultimately contributing to improved maternal and infant health outcomes. …”
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Biosynthesis of Silver Nanoparticles via <i>Medusomyces gisevii</i> Fermentation with <i>Origanum vulgare</i> L. Extract: Antimicrobial Properties, Antioxidant Properties, and Phyt... by Aiste Balciunaitiene, Syeda Hijab Zehra, Mindaugas Liaudanskas, Vaidotas Zvikas, Jonas Viskelis, Yannick Belo Nuapia, Arturas Siukscius, Pradeep Kumar Singh, Valdimaras Janulis, Pranas Viskelis

“…During the characterization of biosynthesized nanoparticles by scanning electron microscopy (SEM), AgNPs demonstrated a uniform spherical shape with even distribution. The sample’s elemental composition was confirmed with a signal of 3.2 keV using energy-dispersive X-ray spectroscopy (EDS) analysis. …”
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Effectiveness of a brief behavioural intervention on psychological distress among women with a history of gender-based violence in urban Kenya: A randomised clinical trial. by Richard A Bryant, Alison Schafer, Katie S Dawson, Dorothy Anjuri, Caroline Mulili, Lincoln Ndogoni, Phiona Koyiet, Marit Sijbrandij, Jeannette Ulate, Melissa Harper Shehadeh, Dusan Hadzi-Pavlovic, Mark van Ommeren

“…<h4>Conclusions</h4>Among a community sample of women in urban Kenya with a history of GBV, a brief, lay-administered behavioural intervention, compared with EUC, resulted in moderate reductions in psychological distress at 3-month follow-up.…”
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Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental... by Kaeley M. Simpson, Robert J. W. McHardy, J. Grace Zhou, Sydney Levasseur-Puhach, Cynthia M. Côté, Millie Braun, Fiona Clement, Anna L. MacKinnon, Nathan Nickel, Tracie O. Afifi, Gerald F. Giesbrecht, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Terry P. Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M. Hensel, James M. Bolton, Jo Ann M. Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E. Roos

“…Clinical trials to date evaluating BEAM have shown promising results, demonstrating reductions in parent depression, suicidality, anxiety, and harsh parenting practices. …”
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Mid-Term Recovery of Right Ventricular Function and Improvement of Left Ventricular Function After Da Silva Cone Procedure for Ebstein Anomaly by Krithika Sundaram, Veenah Stoll, Luciana Da Fonseca Da Silva, Adam Christopher, Arvind Hoskoppal, Jacqueline Kreutzer, David Liddle, Laura Olivieri, Jacqueline Weinberg, Craig P. Dobson, José P. Da Silva, Tarek Alsaied

“…RV function declined postoperatively with reductions in FAC (35% to 21%), TAPSE (2.0 to 0.8 cm), and S′ (13 to 5 cm/s), all <i>p</i> < 0.001. …”
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